Conference Agenda

8:30am - 8:42am
ID: 122 / 4.4: 1

DECOUPLING INTER- FROM INTRA-CELLULAR STRESSES

R. Aparicio Yuste^1,2, L. Hundsdorfer¹, E. Bastounis¹, M. J. Gomez-Benito³

¹Interfaculty Institute of Microbiology and Infection Medicine, Cluster of Excellence “Controlling Microbes to Fight Infections” (CMFI, EXC 2124), University of Tübingen, Germany; ²Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany; ³Engineering Research Institute of Aragon (I3A), University of Zaragoza, Spain.

8:42am - 8:54am
ID: 135 / 4.4: 2

TOWARDS AN IN SILICO MODEL OF THE GUT-BRAIN AXIS: FROM GASTROINTESTINAL STIMULATION TO COGNITIVE PERCEPTION

E. L. Carniel¹, I. Toniolo¹, A. Berardo¹, C. G. Fontanella¹, B. Pomaro¹, G. Mazzucco¹, L. Polese¹, S. Perretta²

¹Centre for Mechanics of Biological Materials, University of Padova, Italy; ²Department of General Surgery, CHRU Strasbourg, IHU Strasbourg, France

8:54am - 9:06am
ID: 557 / 4.4: 3

THE ECOSYSTEM WITHIN US: SIMULATING MICROBIOME DYNAMICS TOWARDS A DIGITAL TWIN OF THE HUMAN GUT

S. Qathan¹, D. Popp², F. Centler¹

¹University of Siegen, Germany; ²University of Leipzig Medical Center, Germany

9:06am - 9:18am
ID: 419 / 4.4: 4

[LIB]OPENCOR: MOVING COMPUTATIONAL BIOLOGY TO THE WEB

A. Garny, D. P Nickerson, P. J Hunter

University of Auckland, New Zealand

9:18am - 9:30am
ID: 171 / 4.4: 5

FROM NEURAL DYNAMICS TO PRECISION THERAPY FOR PARKINSON’S DISEASE: A MULTISCALE IN SILICO MODEL OF CORTICAL EXCITABILITY AND NETWORK IMBALANCE,

J. Jung^1,3, H.-Y. Chu^2,3, W. Lytton^1,3

¹Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, NY., USA; ²Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington DC., USA; ³Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland, USA

9:30am - 9:42am
ID: 404 / 4.4: 6

A SYSTEMS APPROACH TO REELIN-NOTCH SIGNALING TO DECIPHER REGULATORY DYNAMICS IN LYMPHANGIOGENESIS

S. Bekisz¹, Y. Graine¹, A. Noël², L. Geris^1,3, L. Ladeira¹

¹Biomechanics Research Unit, University of Liège, Belgium; ²Laboratory of Biology of Tumor and Development, University of Liège, Belgium; ³Skeletal Biology and Engineering Research Center, KU Leuven, Belgium

9:42am - 9:54am
ID: 322 / 4.4: 7

A PBK-TD GUT MICROBIOME MODEL OF THE FIRST 1000 DAYS OF LIFE: TOWARDS A PREVENTIVE HEALTHCARE DIGITAL TWIN

T.-K. LY, A. G. HOEKSTRA, V. M. SHERATON

Computational Science Lab, Informatics Institute, Faculty of Science, University of Amsterdam, The Netherlands

9:54am - 10:06am
ID: 302 / 4.4: 8

PERSONALIZED MODELS TO UNVEIL MECHANISMS OF ENGINEERED T-CELL THERAPY IN MULTIPLE MYELOMA

S. Orozco-Ruiz^1,2,3, V. Noël^1,2,3, G. Stoll^1,2,3, S. Pankaew^1,2,3, L. Gasull-Celades⁴, E. van Vliet⁴, P. Hernández-López⁴, P. Brazda⁴, F. Keramati⁴, C. Kuhn⁵, M. Rade⁵, D. Fandrei^5,7,9, M. Alb⁶, Z. Sebestyén^4,10, M. Merz^5,7,8,9, J. Kuball^4,10, K. Reiche^5,11,9,12, E. Barillot^1,2,3, L. Calzone^1,2,3

¹Institut Curie, Université PSL, F-75005, Paris, France; ²INSERM, U1331, F-75005, Paris, France; ³Mines ParisTech, Université PSL, F-75005, Paris, France; ⁴Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; ⁵Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; ⁶Department of Internal Medicine II, Chair of Cellular Immunotherapy, University Hospital Würzburg; ⁷Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital of Leipzig; ⁸Myeloma and Cellular Therapy Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA; ⁹Cancer Center Central Germany (CCCG) Leipzig-Jena, University Hospital of Leipzig, Leipzig, Germany; ¹⁰Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; ¹¹Institute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany; ¹²Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Leipzig, Germany

10:06am - 10:09am
ID: 137 / 4.4: 9

TOWARDS A DIGITAL TWIN OF THE HUMAN GUT: A MULTISCALE COUPLED PDE MODEL OF HOST-MICROBIOTA INTERACTION

E. Pastremoli, B. Laroche, L. Sala

INRAE, France

10:09am - 10:12am
ID: 356 / 4.4: 10

REAL-TIME PREDICTION OF EARLY LIVER ALLOGRAFT DYSFUNCTION USING AN IMAGE-BASED MULTISCALE BIOMECHANICAL MODEL

L. Mandl^1,2, S. Gerhäusser¹, A. Schnurpel², A.-L. Hoh², U. Dahmen³, M. König⁴, T. Ricken¹, H.-M. Tautenhahn²

¹University of Stuttgart, Germany; ²University of Leipzig Medical Center, Germany; ³Jena University Hospital, Germany; ⁴Humboldt University of Berlin, Germany

10:12am - 10:15am
ID: 555 / 4.4: 11

SMOOTH MUSCLE CELL POPULATION VARIATION

N. Anderton¹, O. Noita¹, F. Menna², J. Suihkonen¹, A. Ben-Tolila², J. Koivumäki¹, J. Duprez², V. Le Rolle², J. Hyttinen¹

¹Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; ²University of Rennes, CHU Rennes, Inserm, LTSI-UMR, Rennes, France

10:15am - 10:18am
ID: 594 / 4.4: 12

A REPRODUCIBLE FRAMEWORK FOR COUPLING TISSUE-LEVEL AND INTRACELLULAR KINETIC MODELS OF HEPATOCYTES

M. Pedrazzi¹, P. Kottman¹, M. Cascante de Serratosa², D. Drasdo¹

¹Inria Saclay, France; ²Barcelona University, Spain

10:18am - 10:21am
ID: 607 / 4.4: 13

A COMPUTATIONAL MODEL OF OXYGEN SENSING IN THE RODENT CAROTID BODY GLOMUS CELL.

P. Neethirajan, D. Sasis, M. Shafiezadegan, G. Maso Talou, F. Argus

The University of Auckland, New Zealand

10:21am - 10:24am
ID: 638 / 4.4: 14

BONE REMODELING MULTISCALE COMPUTACIONAL MODEL: COUPLING CELLULAR AND TISSUE DYNAMICS

A. Verly, P. Amaral, F. Bastos, L. Assis, B. Quintela

Federal University of Juiz de fora, Brazil