Conference Agenda

9:00am - 9:12am
ID: 263 / 7.1: 1

AI-DRIVEN CAUSAL COUNTERFACTUAL DIGITAL TWIN OF THE LEFT ATRIAL APPENDAGE

H. J. Hortua^1,2, S. Ortega-Martorell^1,2, T. Fairbairn², G. Y. Lip², I. Olier^1,2

1: AI and Digital Technologies Research Institute, Liverpool John Moores University; 2: Liverpool Centre for Cardiovascular Sciences, Liverpool John Moores University, University of Liverpool, and Liverpool Heart and Chest Hospital

9:12am - 9:24am
ID: 276 / 7.1: 2

IMPACT OF FIBROSIS ON BLOOD FLOW IN THE LEFT ATRIUM

Y. Stöcker¹, C. Augustin², A. Gonzalo³, Å. Telle³, M. Guerrero-Hurtado^4,5, O. Flores⁵, N. Akoum³, P. Boyle³, J. C. del Alamo³, M. García-Villalba¹

1: TU Wien, Austria; 2: Medical University of Graz, Austria; 3: University of Washington, USA; 4: Hospital General Universitario Gregorio Marañón, Spain; 5: Universidad Carlos III de Madrid, Spain

9:24am - 9:36am
ID: 286 / 7.1: 3

FUNCTIONAL LAGRANGIAN TRACKING: QUANTIFYING THE INFLUENCE OF WALL MOTION ON LEFT ATRIAL HEMODYNAMICS

P. Casademunt¹, X. Morales Ferez¹, M. Barrouhou¹, P. Cepas², A. Doltra², X. Freixa², O. Camara¹

1: Universitat Pompeu Fabra, Department of Engineering, Barcelona, Spain; 2: Hospital Clínic, Universitat de Barcelona, Cardiovascular Institute, Barcelona, Spain

9:36am - 9:48am
ID: 314 / 7.1: 4

MODELLING THROMBUS FORMATION IN THE LEFT ATRIAL APPENDAGES BY SMOOTHED PARTICLE HYDRODYNAMICS

S. Laha¹, V. Ivannikov², K. Polak-Kraśna¹

1: Institute of Active Polymers, Helmholtz-Zentrum Hereon, Germany; 2: Institute of Material Systems Modeling, Helmholtz-Zentrum Hereon, Germany

9:48am - 10:00am
ID: 376 / 7.1: 5

PREDICTIVE MODELLING OF ANTICOAGULANT EFFICACY AND FIBRINOLYTIC DYNAMICS IN ATRIAL FIBRILLATION

A. M. Lo Presti^1,2, A. Tamburini², E. Napoli², G. Burriesci^1,2,3, A. Monteleone¹

1: Ri.MED Foundation, Italy; 2: Engineering Department, University of Palermo, Italy; 3: UCL Mechanical Engineering, University College London, UK

10:00am - 10:12am
ID: 458 / 7.1: 6

EVALUATING DEVICE-DEPENDENT HEMODYNAMICS AFTER LEFT ATRIAL APPENDAGE OCCLUSION: A NUMERICAL WORKFLOW

B. M. Fanni¹, C. Bonfanti^1,2, A. Brambilla³, I. Verdirame^1,4, R. Buongiorno¹, E. Gasparotti¹, F. Berti², S. Berti⁵, G. Pennati², L. Petrini³, S. Celi¹

1: BioCardioLab, Bioengineering Unit, Fondazione Monasterio, Italy; 2: LaBS, Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Italy; 3: Department of Civil and Environmental Engineering, Politecnico di Milano, Italy; 4: Department of Information Engineering, University of Pisa, Italy; 5: Adult Cardiology Unit, Fondazione Monasterio, Italy

10:12am - 10:24am
ID: 453 / 7.1: 7

MULTISCALE FRAMEWORK FOR THROMBUS RISK ASSESSMENT AND ANTITHROMBOTIC MANAGEMENT AFTER LEFT ATRIAL APPENDAGE OCCLUSION.

M. Molla¹, M. Segarra-Queralt¹, M. Barrouhou¹, C. Albors³, A. L. Olivares³, P. Cepas², J. Mill³, G. Bernardino¹, X. Freixa², O. Camara¹

1: Universitat Pompeu Fabra, Spain; 2: Hospital Clínic de Barcelona, Spain; 3: Virtest Technologies SL, Spain

9:00am - 9:12am
ID: 424 / 7.2: 1

COMPARISON OF ANGIOGRAPHY- AND CCTA-BASED CORONARY RECONSTRUCTIONS FOR WALL SHEAR STRESS ESTIMATION

V. Lissoni¹, A. Marrone¹, M. Pellicano¹, A. Ielasi¹, G. Guagliumi¹, F. Migliavacca², D. Pellegrini¹

1: IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy; 2: Deparment of Chemistry, Materials and Chemical Engineering “Giulio Natta” Department, Politecnico di Milano, Italy

9:12am - 9:24am
ID: 392 / 7.2: 2

ON THE VARIABILITY OF THE INTRAMURAL RIGHT CORONARY ARTERY: A STATISTICAL SHAPE ANALYSIS

C. Catalano¹, A. Chiavetta², M. Conti^2,3, S. Pasta^1,4, A. Rosato², M. Lo Rito⁵

1: Department of Research, IRCCS ISMETT, via Tricomi, 5, Palermo, Italy; 2: 3D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy; 3: Department of Civil Engineering and Architecture, University of Pavia, Pavia 27100, Italy; 4: Department of Engineering, Università degli Studi di Palermo, Viale Delle Scienze Ed.8, Palermo, Italy; 5: Department of Congenital Cardiac Surgery, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy

9:24am - 9:36am
ID: 394 / 7.2: 3

DEVELOPMENT OF A PATIENT-SPECIFIC DIGITAL-TWIN FOR HCM RISK STRATIFICATION USING EXPLAINABLE AI

M. Taconné¹, N. Faiem², A. Kallonen², M. Torquati², V. Corino^1,3, P. Cerveri^1,4, L. Mainardi¹, M. van Gils²

1: Politecnico di Milano (DEIB), Italy; 2: Tampere University, Faculty of Medicine and Health Technology, Finland; 3: IRCCS Centro Cardiologico Monzino, Italy; 4: University of Pavia, Italy

9:36am - 9:48am
ID: 289 / 7.2: 4

PERSONALISATION OF CORONARY BLOOD FLOW IN HEALTHY VOLUNTEERS DURING EXERCISE

G. H. Faulkner^1,2, X. Xu^1,2, J. Gunn^1,2,3, R. Gosling^1,2,3, P. Morris^1,2,3, I. Halliday^1,2,3

1: University of Sheffield, United Kingdom; 2: INSIGNEO, United Kingdom; 3: Sheffield Teaching Hospitals, United Kingdom

9:48am - 10:00am
ID: 516 / 7.2: 5

TOWARDS A PATIENT-SPECIFIC FRAMEWORK FOR THE PREDICTION OF CORONARY IN-STENT RESTENOSIS

A. Ranno, K. Linka, F. Vogt, M. Behr

RWTH Aachen University, Germany

10:00am - 10:12am
ID: 595 / 7.2: 6

IMPACT OF SEGMENTATION UNCERTAINTY ON CORONARY ARTERY HEMODYNAMICS: A CFD SENSITIVITY ANALYSIS

G. Frigerio, L. Mariani, F. Morelli, A. Redaelli

Politecnico di Milano, Italy

10:12am - 10:24am
ID: 619 / 7.2: 7

TOWARD A PHYSIOLOGY-INFORMED DIGITAL TWIN FOR STRESS-INDUCED CORONARY DYNAMICS IN AAOCA

A. Rosato¹, M. Lo Rito¹, M. L. Agnifili¹, F. Bedogni¹, M. Conti^1,2

1: IRCCS Policlinico San Donato, Italy; 2: Università degli Studi di Pavia, Italy

9:00am - 9:12am
ID: 253 / 7.3: 1

IN SILICO DESIGN AND ASSESSMENT OF A NOVEL ARTIFICIAL SPHINCTER FOR INTESTINAL STOMA CONTINENCE

V. Bosco¹, G. Properzi¹, I. Toniolo^1,2, F. Vittadello³, G. Sarzo³, E. L. Carniel^1,2, C. G. Fontanella^1,2

1: Department of Industrial Engineering, University of Padova, Italy; 2: Centre for Mechanics of Biological Materials, University of Padova, Italy; 3: Padova University Hospital, Italy

9:12am - 9:24am
ID: 275 / 7.3: 2

ROUGHNESS-INDUCED LIFTING OF PLATELET-LIKE PARTICLES: A NUMERICAL STUDY

G. Malaguzzi¹, B. Thibaud¹, C. Raveleau¹, S. Mendez¹, F. Nicoud^1,2

1: University of Montpellier, France; 2: Institute Universitaire de France, Paris, France

9:24am - 9:36am
ID: 281 / 7.3: 3

UNCERTAINTY ANALYSIS OF IN SILICO BIOHEAT TRANSFER MODELING IN THE HUMAN HEAD EXPOSED TO BLUETOOTH RADIATION

I. D. Horvat¹, J. Wedel², K. Vidjak³, D. Poljak³, J. Ravnik¹

1: University of Maribor, Faculty of Mechanical Engineering, Slovenia; 2: Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; 3: University of Split, Faculty of Electrical Engineering, Croatia

9:36am - 9:48am
ID: 305 / 7.3: 4

CLINICALLY-BASED FE FOOT MODELING FOR OA PATIENTS

B. Viguié, B. Pierrat, W. S. Han, J. Molimard

Mines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Saint-Etienne, France

9:48am - 10:00am
ID: 354 / 7.3: 5

A COMPUTATIONAL FRAMEWORK OF SHEAR WAVE ELASTOGRAPHY TO ASSESS PRETERM BIRTH RISK

C. Duarte¹, E. Katz¹, I. Rosado-Mendez², K. Myers¹

1: Columbia University, United States of America; 2: University of Wisconsin Madison, United States of America

10:00am - 10:12am
ID: 498 / 7.3: 6

SEX-SPECIFIC COMPUTATIONAL MODELLING FOR AMS 800 ARTIFICIAL URINARY SPHINCTER

M. V. Mascolini^1,2, C. Quinn^1,2, E. Cunnane³, B. Watschke⁴, T. Sinnott⁵, N. Smith⁵, C. Lally^1,2

1: Trinity Centre for Biomedical Engineering, Trinity College Dublin, Ireland; 2: Advanced Materials and BioEngineering Research Centre (AMBER) & School of Engineering, Trinity College Dublin, Ireland; 3: Bernal Institute and School of Engineering, University of Limerick, Ireland; 4: Urology, Boston Scientific Corp, Inc, Minnetonka, USA; 5: Urology, Boston Scientific Corp, Inc, Clonmel Co, Ireland

10:12am - 10:24am
ID: 523 / 7.3: 7

BIOMECHANICAL BENEFIT OF CERVICAL CERCLAGE DURING PREGNANCY: A COMPUTATIONAL STUDY

A. Laughlin¹, E. Louwagie¹, A. Delagarza¹, H. Haider¹, M. Mourad², M. House³, K. Myers¹

1: Columbia University, United States of America; 2: Columbia University Irving Medical Center, United States of America; 3: Tufts Medical Center, United States of America

9:00am - 9:12am
ID: 112 / 7.4: 1

RADIOMICS AND IN SILICO ASSESSMENT OF TUMOUR ENVIRONMENT FOR PREDICTING RECURRENCE AFTER RT

V. Septiers^1,2, H. Chourak¹, C. Sosa-Marrero¹, A. Briens¹, J. Le Guévelou¹, R. De Crevoisier¹, M. A. Zuluaga², O. Acosta¹

1: Univ Rennes – CLCC Eugène Marquis – INSERM – LTSI – UMR 1099, Rennes, France; 2: EURECOM, Data Science Department, Biot, France

9:12am - 9:24am
ID: 158 / 7.4: 2

MODELLING AND SENSITIVITY ANALYSIS OF HYPOXIA-ACTIVATED DRUGS IN SOLID TUMORS

A. Coclite¹, R. Montanelli Eccher², L. Possenti³, P. Vitullo², P. Zunino²

1: Department of Electrical and Information Engineering, Politecnico di Bari, Italy; 2: MOX, Department of Mathematics, Politecnico di Milano, Italy; 3: Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy

9:24am - 9:36am
ID: 190 / 7.4: 3

DIGITAL TWINS FOR THE OPTIMISATION OF INTRA-ARTERIAL THERAPY IN LIVER CANCER

E. Cutrì^1,2, P.-A. Eliat³, F. de Gaetano⁴, A. Petit⁵, M. Rochette⁶, Y. Rolland², H. Saint-Jalmes², J. Bezy Wendling²

1: Université de technologie de Compiègne, CNRS, Alliance Sorbonne Université, BMBI, Compiègne, France, France; 2: Univ Rennes, CLCC Eugène Marquis, Inserm, LTSI - UMR 1099, F-35000, Rennes, France; 3: INRAE, INSERM, Univ Rennes, Nutrition Metabolisms and Cancer, NuMeCan, St Gilles,Rennes, France; 4: Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, 20133, Milano, Italy; 5: Therenva, F-35000, France; 6: ANSYS, Villeurbanne, France

9:36am - 9:48am
ID: 198 / 7.4: 4

PATIENT-SPECIFIC PREDICTION OF GLIOBLASTOMA GROWTH VIA REDUCED ORDER MODELLING AND NEURAL NETWORKS

S. Gazzoni¹, D. Cerrone¹, D. Riccobelli², P. Vitullo¹, F. Ballarin³, J. Falco⁴, F. Acerbi⁴, A. Manzoni¹, P. Zunino¹, P. Ciarletta¹

1: Mox Laboratory - Politecnico di Milano, Milan, Italy; 2: Sissa, Trieste, Italy; 3: Università Cattolica del Sacro Cuore, Brescia, Italy; 4: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy

9:48am - 10:00am
ID: 214 / 7.4: 5

A 3D–1D OPTIMIZATION FRAMEWORK FOR THE SIMULATION OF ANGIOGENESIS AND TUMOR PROGRESSION

D. Grappein¹, C. Giverso², S. Scialò²

1: Politecnico di Milano, Italy; 2: Politecnico di Torino, Italy

10:00am - 10:12am
ID: 220 / 7.4: 6

ESTIMATING PROSTATE CANCER RADIOSENSITIVITY THROUGH A DIGITAL TWIN (VHT) OF TUMOUR RESPONSE TO RADIOTHERAPY

E. Kolokotroni¹, S. Spohn², A.-L. Grosu², D. Baltas², C. Zamboglou², I. Sachpazidis², G. Stamatakos¹

1: National Technical University of Athens, School of Electrical and Computer Engineering, Institute of Communication and Computer Systems, Greece; 2: University of Freiburg, Department of Radiation Oncology, Freiburg, Germany

10:12am - 10:24am
ID: 657 / 7.4: 7

A PARALLEL-DISTRIBUTED FINITE ELEMENT FRAMEWORK FOR 3D/2D CHEMO-MECHANICAL COUPLING IN CELL MOTILITY

M. Serpelloni¹, P. Tesini², A. Salvadori¹

1: Department of Mechanical and Industrial Engineering, Università di Brescia, Brescia, Italy; 2: Department of Civil, Environmental, Architectural Engineering and Mathematics, Università di Brescia, Brescia, Italy

9:00am - 9:12am
ID: 646 / 7.5: 1

ILLUMINATING MECHANISMS: FROM FLUORESCENT SARCOMERES TO IDENTIFIABLE MODELS OF ARRHYTHMIA DYNAMICS

F. Sonak, M. Baur, J. Timmer, V. Timmermann

University of Freiburg, Germany

9:12am - 9:24am
ID: 351 / 7.5: 2

A CAUSAL AI-DRIVEN DIGITAL TWIN OF CARDIAC ELECTROPHYSIOLOGY

D. Mistry^1,2, S. Ortega-Martorell^1,2, Z. Mahmood^1,2, H. J Hortua^1,2, R. Lotto^1,2, E. Dawson^1,2, G. Y. Lip², I. Olier^1,2

1: AI and Digital Technologies Research Institute, Liverpool John Moores University, UK; 2: Liverpool Centre for Cardiovascular Sciences, Liverpool John Moores University, University of Liverpool, and Liverpool Heart and Chest Hospital, UK

9:24am - 9:36am
ID: 366 / 7.5: 3

MULTIMODAL OPTIMISATION OF CARDIAC ELECTROPHYSIOLOGY MODELS USING 12-LEAD ECG AND CT IMAGING

B. LY¹, N. Cedilnik², M. Pop², J. Duchateau^1,3, F. Sacher^1,3, P. Jaïs^1,3, H. Cochet^1,3, M. Sermesant^1,2

1: Institut Hospitalo-Universitaire Liryc, France; 2: Centre Inria Université Nice Côte d'Azur, France; 3: Bordeaux University Hospital, France

9:36am - 9:48am
ID: 546 / 7.5: 4

OPTIMIZATION STRATEGIES FOR VENTRICULAR ACTIVATION PERSONALIZATION FROM SURFACE ECG

G. García-Isla¹, J. Sánchez¹, S. Perez-Herrero¹, J. Saiz¹, G. Plank², E. Zappon²

1: Center for Research and Innovation in Bioengineering (Ci2B), Universitat Politècnica de València; 2: Division of Biophysics and Medical Physics, Gottfried Schatz Research Center Medical University of Graz

9:48am - 10:00am
ID: 255 / 7.5: 5

PHYSIOBLOCKS: AN OPENSOURCE PYTHON LIBRARY FOR SIMULATING BLOCK DIAGRAMS OF PHYSIOLOGICAL SYSTEMS

D. Chapelle^1,2, C. Drieu^1,2, F. Kimmig^1,2

1: Inria, France; 2: CMAP, Ecole Polytechnique, CNRS, Institut Polytechnique de Paris, France

10:00am - 10:12am
ID: 659 / 7.5: 6

MATRIX-FREE ALGORITHMS FOR CARDIAC ELECTROMECHANICAL SIMULATIONS

A. Tonini, L. Dede’

MOX, Dipartimento di Matematica, Politecnico di Milano, Italy

9:00am - 9:12am
ID: 331 / 7.6: 1

BINARY OUTPERFORMS MULTI-CLASSIFICATION NEURAL NETWORK MODELS FOR PREDICTION OF OUTCOMES IN PPCM

J. Nagawa¹, K. L. Sack^1,2, S. Kraus¹, M. Sirry³, N. A. Ntusi^1,4, N. H. Davies¹, K. Sliwa¹, T. Franz^1,5

1: University of Cape Town, South Africa; 2: Medtronic Inc, USA; 3: International University Kuwait, Kuwait; 4: SAMRC, South Africa; 5: University of Southampton, United Kingdom

9:12am - 9:24am
ID: 416 / 7.6: 2

TOWARD REAL-TIME HEMODYNAMIC EVALUATION OF STENTED INTRACRANIAL ANEURYSMS USING GRAPH NEURAL NETWORKS

V. Lannelongue, U. Pelissier, P. Garnier, C. Faitini, P. Meliga, E. Hachem

CEMEF, Mines Paris PSL, France

9:24am - 9:36am
ID: 473 / 7.6: 3

AN IN SILICO PLATFORM FOR OPTIMIZING STROKE TREATMENT DEVICES

J. Cruts¹, T. Kuipers^1,2, K. Lopez¹, M. Mojtahedi¹, M. Oetelmans¹, H. Marquering^1,2, T. Kerbusch¹

1: InSteps, the Netherlands; 2: Amsterdam UMC, the Netherlands

9:36am - 9:48am
ID: 127 / 7.6: 4

ON THE INFLUENCE OF THE LARYNX IN THE ADMINISTRATION OF INHALED MEDICATIONS

M. Malvè¹, C. Sánchez Matás², J. L. López Villalobos³, R. Fernández Parra⁴

1: Universidad Pública de Navarra, Spain; 2: Hospital Universitario ‘Virgen de la Arrixaca’, Spain; 3: Hospital Universitario ‘Virgen del Rocío’, Spain; 4: Hospital Veterinario UCV, Universidad Católica de Valencia San Vicente Mártir, Spain

9:48am - 10:00am
ID: 197 / 7.6: 5

AI–MECHANISTIC FRAMEWORK FOR SYNERGISTIC DRUG REPURPOSING AND PRECLINICAL DOSE-RATIO OPTIMIZATION

G. Brachet, A. Alioui, G. Arbia, N. Mackenzie, D. Baron, M. Murray

CXS Therapeutics, France

10:00am - 10:12am
ID: 337 / 7.6: 6

GRAPH NEURAL NETWORKS FOR MULTIPHYSICS LEARNING OF THROMBOSIS FORMATION IN INTRACRANIAL ANEURYSMS

U. Pelissier, V. Sterlin, P. Meliga, E. Hachem

CEMEF - Mines Paris - PSL University, France

10:12am - 10:24am
ID: 371 / 7.6: 7

BAYESIAN OPTIMIZATION FOR COMPUTATIONAL DESIGN OF OCULAR DRUG DELIVERY SYSTEMS

E. A. Chacin Ruiz¹, K. E. Swindle-Reilly², A. N. Ford Versypt¹

1: University at Buffalo, The State University of New York, United States of America; 2: The Ohio State University, United States of America

9:00am - 9:12am
ID: 200 / 7.7: 1

CREDIBILITY ASSESSMENT OF DATA-DRIVEN PREDICTORS: APPLICATION TO SURROGATE MODELLING

A. A. La Mattina¹, A. Aldieri², S. Moscato³, V. A. Arcobelli³, S. Mellone³, M. Viceconti²

1: Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Italy; 2: Department of Industrial Enginering, AlmaMater Studiorum - University of Bologna, Italy; 3: Department of Electrical, Electronic and Information Engineering, Alma Mater Studiorum - University of Bologna, Italy

9:12am - 9:24am
ID: 247 / 7.7: 2

A MORPHING-BASED FRAMEWORK FOR PERSONALIZED UTERINE ANATOMICAL MODELING

N. M. Ferreira¹, A. Ramos Silva¹, M. Parente¹, S. Brandão², E. Silva¹

1: LAETA/INEGI, Faculty of Engineering of the University of Porto, Portugal; 2: CESPU/H2M (Health and Human Movement Unit), Polytechnic University of Health, Vila nova de Famalicão

9:24am - 9:36am
ID: 358 / 7.7: 3

TOWARDS A CORNEAL DIGITAL TWIN: EXPERIMENTAL VALIDATION OF A MODEL OF CORNEAL DEFORMATION

E. Redaelli, J. Birkenfeld

The Spanish National Research Council, Madrid, Spain

9:36am - 9:48am
ID: 367 / 7.7: 4

ISO RECOMMENDATIONS AND REQUIREMENTS FOR PREDICTIVE COMPUTATIONAL MODELS IN PERSONALISED MEDICINE

M. Golebiewski¹, L. Lopez-Perez², E. Martinelli³, T. Poli³

1: HITS gGmbH, Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany; 2: Universidad Politécnica de Madrid-Life Supporting Technologies Research Group, ETSIT, 28040 Madrid, Spain; 3: Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy

9:48am - 10:00am
ID: 512 / 7.7: 5

ASSESSING THE ROBUSTNESS OF RETINAL VASCULAR GRAPH COMPLETION FOR DIGITAL TWIN HAEMODYNAMIC MODELLING

E. Brown^1,2, V. Bedi¹, P. Keshavanarayana¹, R. Rajendram^1,3, S. Walker-Samuel¹

1: Centre for Computational Medicine, UCL, United Kingdom; 2: Moorfields Eye Hospital, United Kingdom; 3: Institute of Ophthalmology, United Kingdom

10:00am - 10:12am
ID: 635 / 7.7: 6

12 LABOURS DIGITAL-TWINS PLATFORM: ENABLING VALIDATION AND CLINICAL TRANSLATION OF VIRTUAL HUMAN TWINS

T. Babarenda Gamage¹, C. Lin¹, L. Gao¹, A. Elsayed¹, J. Xu¹, G. Sands¹, K. Atalag¹, M. Golebiewski², X. Hu², J. Huh¹, C. Rye¹, C. R. Chen¹, M. Pestle¹, N. Jones¹, C. K. Jin³, R. Whittaker³, A. Doyle³, M. Nash¹, P. Hunter¹, M. Tawhai¹, D. Nickerson¹

1: University of Auckland, New Zealand; 2: Heidelberg Institute of Theoretical Studies, Germany; 3: Health New Zealand – Te Whatu Ora, New Zealand

10:12am - 10:24am
ID: 652 / 7.7: 7

VIVARIA: VIRTUAL LABORATORY FOR 3RS-ALIGNED ANIMAL PROCEDURE TRAINING

M. Verzeni¹, F. Riva², B. Grossi¹, F. Migliavacca¹, L. Mainardi¹, P. Cerveri^1,3

1: Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; 2: Department of Veterinary Medicine and Animal Science, Università degli Studi di Milano, Milan, Italy; 3: Department of Industrial and Information Engineering, Università degli Studi di Pavia, Pave, Italy

11:00am - 11:12am
ID: 114 / 8.1: 1

DIGITAL TWINS FOR POSTOPERATIVE OUTCOME PREDICTION IN TEVAR: A PROOF-OF-CONCEPT STUDY

A. Ramella^1,2, G. De Campo¹, S. Barati^1,2, G. Luraghi¹, I. Fulgheri³, G. Piffaretti⁴, R. Heijmen⁵, F. Migliavacca^1,3, S. Trimarchi³

1: Politecnico di Milano, Italy; 2: AllStent srl, Italy; 3: IRCCS Cà Granda, Policlinico di Milano, Italy; 4: ASST Sette Laghi, Italy; 5: Radboud University Medical Centre, Netherlands

11:12am - 11:24am
ID: 155 / 8.1: 2

A VIRTUAL PATIENT PLATFORM FOR PREDICTING ATRIAL FIBRILLATION BURDEN AFTER CATHETER ABLATION

A. Dasí¹, H. Valli², I. Sim², T. Wong², S. Haldar², C. Roney¹

1: Queen Mary University of London, United Kingdom; 2: Royal Brompton & Harefield NHS Foundation Trust London, United Kingdom

11:24am - 11:36am
ID: 201 / 8.1: 3

IN SILICO EVALUATION OF ARRHYTHMIA IN PRESENCE OF CARDIOMYOPATHY-RELATED ELECTRICAL REMODELING

A. Corda¹, M. Maines², S. Pagani³, M. Sermesant⁴, D. Catanzariti², M. Del Greco², C. Vergara¹

1: LaBS, Dip. di Chimica, Materiali e Ingegneria Chimica, Politecnico di Milano, Italy; 2: Dept. of Cardiology, S. M. del Carmine Hospital, Rovereto, Italy; 3: MOX, Dip. di Matematica, Politecnico di Milano, Italy; 4: Inria, Université Côte d'Azur, IHU Liryc, 3IA Côte d'Azur, France

11:36am - 11:48am
ID: 240 / 8.1: 4

A PATIENT SPECIFIC HYDRODYNAMIC– SOFT ROBOTIC CARDIOPULMONARY SIMULATOR TO INVESTIGATE COMBINED VA ECMO AND MECHANICAL VENTILATION THERAPIES

L. Fresiello¹, T. Trapman¹, F. Colombi¹, D. W. Donker^1,2

1: Cardiovascular and Respiratory Physiology group, TechMed Centre, University of Twente, Enschede, The Netherlands; 2: Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands

11:48am - 12:00pm
ID: 362 / 8.1: 5

PATIENT-SPECIFIC COMPUTATIONAL ANALYSIS OF ASCENDING TEVAR: ASSESSING DEVICE DEPLOYMENT AND HEMODYNAMICS

G. De Campo¹, J. de Kort^2,6, A. Ramella¹, G. Luraghi¹, S. Barati¹, I. Fulgheri², S. Trimarchi^2,3, G. Piffaretti^4,5, F. Migliavacca^1,2

1: Politecnico di Milano, Italy; 2: IRCCS Policlinico di Milano, Italy; 3: Università degli Studi di Milano, Italy; 4: Department of Medicine and Surgery, University of Insubria School of Medicine, Varese; 5: ASST Settelaghi, University Teaching Hospital, Varese; 6: Department of Vascular Surgery, University Medical Centre Utrecht, Utrecht, The Netherlands

11:00am - 11:12am
ID: 116 / 8.2: 1

A TOPOLOGY OPTIMIZATION COMPUTATIONAL FRAMEWORK FOR FEMORAL STENT DESIGN: EXPERIMENTAL ASSESSMENT

D. Carbonaro^1,2, N. Ferro³, F. Mezzadri⁴, E. Torta¹, E. Temellini⁵, S. Zambon¹, D. Gallo¹, S. Perotto⁵, U. Morbiducci¹, C. Chiastra¹

1: Politecnico di Torino, Italy; 2: Università della Calabria, Italy; 3: Università Ca’ Foscari Venezia, Italy; 4: Università di Modena e Reggio Emilia, Italy; 5: Politecnico di Milano, Italy

11:12am - 11:24am
ID: 411 / 8.2: 2

STRUCTURAL AND HEMODYNAMIC ANALYSIS OF A SMART STENT DESIGN TOWARDS A DIGITAL TWIN PLATFORM

M. Vafaeefar¹, M. J. Kraśny², M. Farooq², I. Soares², D. O'Keeffe³, A. Elahi², M. Colombo⁴, T. Vaughan¹

1: Biomechanics Research Centre, University of Galway, Ireland; 2: Translational Medical Devices (TMD) Lab and Electrical & Electronic Engineering, University of Galway, Ireland; 3: Health Innovation Via Engineering (HIVE) Laboratory, University of Galway, Ireland; 4: University of Aarhus, Denmark

11:24am - 11:36am
ID: 570 / 8.2: 3

CONSTITUTIVE FRAMEWORK FOR COUPLED MULLINS-TYPE SOFTENING AND FINITE VISCOELASTICITY IN ARTERIES

E. Peña^1,2, J. A. Peña¹, M. A Martínez^1,2

1: Universidad de Zaragoza, Spain; 2: CIBER-BBN, Centro de Investigación en Red en Bioingeniería, Spain

11:36am - 11:48am
ID: 579 / 8.2: 4

INFLUENCE OF INTER-FIBRE CONTACTS ON THE MECHANICS OF BIOPOLYMER NETWORKS

P. Ramya¹, F. Gijsen^1,2, B. Fereidoonnezhad¹

1: Delft University of Technology, Delft, The Netherlands; 2: Erasmus Unversity Medical Centre, Rotterdam, The Netherlands

11:48am - 12:00pm
ID: 626 / 8.2: 5

THE IMPORTANCE OF INELASTICITY WHEN SIMULATING BALLOON DEPLOYMENT IN DISEASED ARTERIES

S. Renon¹, S. McGinty¹, A. Aggarwal¹, R. Good²

1: James Watt School of Engineering, University of Glasgow, UK; 2: School of Cardiovascular & Metabolic Health, University of Glasgow, UK

11:00am - 11:12am
ID: 353 / 8.3: 1

BIO-DIGITAL TWIN OF THE FIRST TRIMESTER PLACENTA FOR DRUG RISKS ASSESSMENT

M. Gasik¹, A. Manzin², J. Petiti², C. DiVieto², R. Ferrero², V. Kuzmenko³, C. Silva³, I. Mendes Pinto⁴, M. Neves⁴, B. Pais⁴, R. Grillari⁵, M. Wieser⁵, L. Muiznieks⁶, O. Fournier⁶, R. Ramakrishnan⁷, A. Daly⁷, C. Baldasso⁸, N. Saccenti⁸, F. Franchini⁸, A. Cruz⁹, H. Olivera⁹

1: Seqvera Ltd. Oy, Finland; 2: INRIM, Italy; 3: CellInk Bioprinting AB, Sweden; 4: i3S, Portugal; 5: Evercyte GmbH, Austria; 6: Microfluidics Innovation Center, France; 7: National University of Ireland Galway, Ireland; 8: Enginsoft s.p.a., Italy; 9: INL, Portugal

11:12am - 11:24am
ID: 469 / 8.3: 2

FINITE ELEMENT MODEL OF BONE INFLAMMATION-ON-CHIP TO CALIBRATE MACROPHAGE MECHANOBIOLOGY

E. Borgiani^1,2, G. Nasello^1,2, A. Kose^1,2, L. Geris^1,2

1: Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium; 2: Division of Biomechanics, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium

11:24am - 11:36am
ID: 531 / 8.3: 3

MULTI-PHYSICS COMPUTATIONAL MODEL OF METASTATIC BONE REMODELLING

C. Villette^1,2, L. Geris^2,3

1: Queen Mary University of London, United Kingdom; 2: KU Leuven, Belgium; 3: University of Liege, Belgium

11:36am - 11:48am
ID: 534 / 8.3: 4

COMPUTATIONAL EVALUATION OF PDAC-ON-CHIP RELEVANCE FOR RADIOBIOLOGICAL AND CHEMO-RADIATION STUDIES

S. Tartaro¹, A. Beretta², M. Aznar³, P. Zunino⁴, T. Rancati¹, S. Pasquali², L. Possenti¹

1: Fondazione IRCCS Istituto Nazionale dei Tumori, Data Science Unit, Milan, Italy; 2: Fondazione IRCCS Istituto Nazionale dei Tumori, Molecular Pharmacology Unit, Milan, Italy; 3: Division of Cancer Sciences, The University of Manchester, Manchester, United Kindom; 4: Politecnico di Milano, Department of Mathematics, Milan, Italy

11:48am - 12:00pm
ID: 552 / 8.3: 5

A POROELASTIC MIXED FINITE ELEMENT FORMULATION FOR MODELLING THE INTERVERTEBRAL DISC

L. Sierra Fisher¹, C. Runcie¹, A. Shvarts¹, L. Kaczmarczyk¹, J. Noailly²

1: University of Glasgow, United Kingdom; 2: Universitat Pompeu Fabra, Spain

11:00am - 11:12am
ID: 217 / 8.4: 1

SYNTHETIC POPULATION OF ALZHEIMER’S DISEASE TO TRAIN MACHINE LEARNING PREDICTIVE ALGORITHMS

C. Pollicini^1,3, R. Reggio^1,3, B. Baldini^1,3, V. I. D'Alessandro^2,3, L. De Palma², A. De Nisio², A. Lanzolla², T. Basileo², F. Attivissimo², E. Merlo Pich¹

1: IFAB, International Foundation for Artificial Intelligence and Big Data for Human Development, Italy; 2: Department of Electric and Information Engineering, Polytechnic University, Bary, Italy; 3: The first 4 authors equally contributed to this project

11:12am - 11:24am
ID: 347 / 8.4: 2

IN SILICO MUSCULOSKELETAL ANALYSIS OF WEAR IN HIP RESURFACING: COMPARISON OF WALKING AND RUNNING

A. T. Alpkaya¹, Z. Altai^2,3, A. Kumar², L. Gao⁴, A. Soliman⁵, S. McDonnell⁶, W. Guo⁷, S. Maas⁵, N. Cortes², B. X. W. Liew²

1: Kırklareli University, Kırklareli, Turkey; 2: School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester, Essex, United Kingdom; 3: Institute of Public Health and Wellbeing, University of Essex, United Kingdom; 4: Department of Engineering, Nottingham Trent University, United Kingdom; 5: Department of Engineering, Faculty of Science, Technology and Medicine, University of Luxembourg, Luxembourg; 6: Division of Trauma and Orthopaedic Surgery, University of Cambridge, Addenbrooke's Hospital; 7: School of Mathematics, Statistics and Actuarial Science, University of Essex, Colchester, Essex, United Kingdom

11:24am - 11:36am
ID: 417 / 8.4: 3

A NETWORK-BASED PHYSIOLOGY-INFORMED RISK SCORE FOR POSTOPERATIVE PULMONARY COMPLICATIONS

D V. Anand, N. Tetlow, J. Whittle, V. Diaz, N. Ovenden, R. Shipley

University College London, United Kingdom

11:36am - 11:48am
ID: 640 / 8.4: 4

CLINICIAN ENGAGEMENT: TURNING SURVEY RESULTS INTO ACTIONABLE BEST PRACTICES

J. R. Rangarajan^1,2, F. JR Catling^3,4, C. Capelli⁴, Z. Vanhorenbeeck^1,2, E. Beaucage-Gauvreau², I. E. Vignon-Clementel⁵, L. Geris^1,2,6

1: VPH Society, Belgium; 2: KU Leuven, Belgium; 3: Imperial College London, UK; 4: University College London, UK; 5: INRIA, Centre de Recherche de Paris, France; 6: University of Liège, Belgium

11:48am - 12:00pm
ID: 650 / 8.4: 5

IN SILICO MODELS TO SUPPORT THE OFF-LABEL USAGE OF POLYESTER BANDS FOR LUMBAR ISTHMIC RECONSTRUCTION

C. Milani¹, D. Maritato¹, L. Scaramuzzo^2,3, F. Giudici², L. La Barbera¹

1: LaBS, Dept. of Chemistry Materials and Chemical Engineering “G.Natta”, Politecnico di Milano, Italy; 2: IRCCS Galeazzi-Sant’Ambrogio Hospital, Milan, Italy; 3: IRCCS Agostino Gemelli University Policlinic, Rome, Italy

11:00am - 11:12am
ID: 385 / 8.5: 1

DEVELOPMENT AND VALIDATION OF DIGITAL TWINS FOR CHD: ENDOVASCULAR PULMONARY FLOW RESTRICTION PROCEDURE

S. Bonfanti^1,2, M. Severi¹, P. Di Vincenzo¹, M. A. Cetatoiu¹, E. Gasparotti², B. M. Fanni², S. Celi², G. Pennati¹, F. Berti¹

1: LaBS – Dept of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Italy; 2: BioCardioLab – Bioengineering Unit, Fondazione Toscana “Gabriele Monasterio”, Massa, Italy

11:12am - 11:24am
ID: 451 / 8.5: 2

PERSONALIZATION OF PATIENT-SPECIFIC CARDIAC ELECTROPHYSIOLOGY MODELS IN CONGENITAL HEART DISEASE

J. Jilberto Vallejos, E. Martinez, H. Chubb, A. Marsden

Stanford University, United States of America

11:24am - 11:36am
ID: 614 / 8.5: 3

MULTISCALE SIMULATION FRAMEWORK TO INVESTIGATE ARRHYTHMIA MECHANISMS IN PAEDIATRIC-LIKE VENTRICLES

L. L. Riebel¹, Z. J. Wang¹, H. Martinez-Navarro¹, M. Levin², B. Rodriguez¹

1: University of Oxford, United Kingdom; 2: Departments of Medicine, Pediatrics, and ACE-WS, University of Pennsylvania School of Medicine, USA

11:36am - 11:48am
ID: 310 / 8.5: 4

STUDY OF ELECTROMECHANICAL SIMULATIONS OF RIGHT BUNDLE BRANCH BLOCK IN PAEDIATRIC PATIENTS

A. Montañés¹, J. Sánchez¹, S. Pérez¹, I. Hernández¹, J. Krauß³, F. Prats², F. Roses², J. Saiz¹, B. Trénor¹

1: Research Center for Biomedical Engineering and Innovation (Ci2B), Universitat Politècnica de València, Spain; 2: Department of Paediatric Cardiology, Vall d’Hebron University Hospital, Barcelona, Spain; 3: Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany

11:48am - 12:00pm
ID: 479 / 8.5: 5

QUANTIFYING THE ENERGETIC BURDEN OF FONTAN STENOSES: A PATIENT-SPECIFIC CFD STUDY

J. Brüning^1,2, A. Schlief^1,2, M. Schafstedde^1,2,3, A. Schleiger^2,3, P. Kramer^2,3

1: Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany; 2: Charité - Universitätsmedizin Berlin, Berlin, Germany; 3: Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease, Berlin, Germany

11:00am - 11:12am
ID: 196 / 8.6: 1

QUANTIFYING THE BIOLOGICAL SIGNIFICANCE OF UNCERTAINTY IN HAEMODYNAMIC MODELS OF INTRACRANIAL ANEURYSMS

N. Benson, A. Marzo, M. Gul, J. Serbanovic-Canic

The University of Sheffield, United Kingdom

11:12am - 11:24am
ID: 545 / 8.6: 2

CALCIFICATION MORPHOLOGY AND HEMODYNAMICS IN THE INTRACRANIAL CAROTID ARTERY: A 3D AND 1D FSI FRAMEWORK

F. Fontana^1,2, P. Ramya¹, M. J. B. M. Pourquie¹, F. J. H. Gijsen^1,2, D. Bos², A. C. Akyildiz^1,2, S. Pirola¹

1: Delft University of Technology, Delft, The Netherlands; 2: Erasmus Medical Center, Rotterdam, The Netherlands

11:24am - 11:36am
ID: 426 / 8.6: 3

EXPLORATION OF FLOW DIVERSION FOR BIFURCATION ANEURYSMS

B. Csippa¹, L. Sándor¹, G. Paál¹, I. Szikora²

1: Budapest University of Technology and Economics Department of Hydrodynamic Systems, Hungary; 2: Semmelweis University, Department of Neurosurgery and Neurointerventions

11:36am - 11:48am
ID: 431 / 8.6: 4

PATIENT-SPECIFIC HAEMODYNAMIC MODELLING OF THROMBECTOMY EXTRACTION FORCE

N. Ruseckaite¹, A. H. Ashok², T. Matys², Y. Joshi², R. Mudkavi³, G. Toumbas⁴, J. Kaggie², N. Evans⁵, S. Singh-Gryzbon¹

1: Department of Chemical Engineering and Biotechnology, University of Cambridge, United Kingdom; 2: Department of Radiology, University of Cambridge, United Kingdom; 3: East & North Hertfordshire Teaching NHS Trust, Stevenage, UK; 4: School of Clinical Medicine, University of Cambridge, United Kingdom; 5: Department of Clinical Neurosciences, University of Cambridge, United Kingdom

11:48am - 12:00pm
ID: 526 / 8.6: 5

CFD-BASED IDENTIFICATION OF VASOSPASM PREDICTORS IN ANEURYSMAL SUBARACHNOID HEMORRHAGE

E. Criseo¹, M. Di Feliciantonio², K. Negri², L. Caschera², L. Mariani¹, T. Zoerle², G. Conte², A. Redaelli¹

1: Politecnico di Milano, Italy; 2: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Italy

11:00am - 11:12am
ID: 147 / 8.7: 1

ELECTRICAL IMPEDANCE-BASED ORAL CANCER DIAGNOSIS USING COMPUTATIONAL AND IN VITRO MODELS

M. Matella¹, R. Furmidge², M. Paterson³, C. Murdoch², H. Colley², Z.-Q. Lang³, D. Walker¹

1: School of Computer Science, University of Sheffield, United Kingdom; 2: School of Clinical Dentistry, University of Sheffield, United Kingdom; 3: School of Electrical and Electronic Engineering, University of Sheffield, United Kingdom

11:12am - 11:24am
ID: 317 / 8.7: 2

ATLAS: INTEGRATING AI, KNOWLEDGE GRAPHS, AND COMPUTATIONAL LIVER MODELS FOR TUMOR BOARD DECISION SUPPORT IN LIVER ONCOLOGY

A. Schnurpel¹, M. Nayyeri², M. Myshkina³, L. Mandl^1,2, S. Nickel¹, M. König³, S. Staab², T. Ricken², H.-M. Tautenhahn¹

1: University of Leipzig Medical Center, Germany; 2: University of Stuttgart, Germany; 3: Humboldt University of Berlin, Germany

11:24am - 11:36am
ID: 505 / 8.7: 3

UTERINE DEFORMATION TRAJECTORIES ACROSS GESTATION REVEAL THE EVOLVING MECHANICAL STATE OF PREGNANCY

E. Xu¹, E. Louwagie¹, T. Schneider², D. Zorin³, D. Panozzo³, K. Myers¹

1: Columbia University, United States of America; 2: University of Victoria, Canada; 3: New York University, United States of America

11:36am - 11:48am
ID: 535 / 8.7: 4

PATIENT SPECIFIC CERVICAL MATERIAL STIFFNESS QUANTIFIED FROM IN-VIVO ASPIRATION AND ULTRASOUND-DERIVED PREGNANCY IN-SILICO MODEL

A. Laughlin¹, E. Louwagie¹, A. Delagarza¹, L. Shi², M. House³, M. Mourad⁴, K. Myers¹

1: Columbia University, United States of America; 2: Kennesaw State University, United States of America; 3: Tufts Medical Center, United States of America; 4: Columbia University Irving Medical Center, United States of America

11:48am - 12:00pm
ID: 571 / 8.7: 5

EVOLUTIONARY DIGITAL TWIN FRAMEWORK FOR OPTIMAL AMINOGLYCOSIDE DOSING IN NEONATES WITH SUSPECTED SEPSIS

M. Prunella¹, C. Romano^2,3, A. Borri^2,3, N. Altini¹, M. D. Di Benedetto², P. Annaert⁴, K. Allegaert^5,6,7, A. Smits^6,8, V. Bevilacqua¹

1: Department of Electrical and Information Engineering, Polytechnic University of Bari, Italy; 2: Center of Excellence for Research DEWS, Department of Information Engineering, Computer Science and Mathematics, Università degli Studi dell'Aquila, Italy; 3: CNR-IASI Biomathematics Laboratory, National Research Council of Italy, Italy; 4: Laboratory for Pharmacotechnology and Biopharmacy, KU Leuven, Belgium; 5: Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium; 6: Department of Development and Regeneration, KU Leuven, Belgium; 7: Department of Hospital Pharmacy, Erasmus MC, The Netherlands; 8: Neonatal intensive care unit, University Hospitals Leuven, Belgium

2:00pm - 2:12pm
ID: 104 / 9.1: 1

INTRAVENTRICULAR TRANSPORT ORGANIZATION AND WASHOUT EFFICIENCY UNDER GRADED LEFT VENTRICULAR WALL MOTION INSUFFICIENCY

O. Barannyk, D. Suresh, M. Bianchi, A. Rangchian, V. Phath

Edwards Lifesciences, United States of America

2:12pm - 2:24pm
ID: 163 / 9.1: 2

IN SILICO MODELLING OF LEFT VENTRICULAR PHYSIOLOGY: A FRAMEWORK FOR STUDYING AGE- AND SEX-RELATED CHANGES

M. Zattoni^1,2, P. Segers¹, A. Caenen^1,3, M. Peirlinck²

1: Ghent University, Belgium; 2: TU Delft, The Netherlands; 3: KU Leuven, Belgium

2:24pm - 2:36pm
ID: 165 / 9.1: 3

IMAGE‑DRIVEN COMPUTATIONAL MODELLING OF RIGHT‑HEART HEMODYNAMICS

E. Xhelo¹, F. Renzi², G. Puppini³, S. Hoxha⁴, G. B. Luciani¹, C. Vergara²

1: Department of Surgery, Dentistry, Pediatrics, and Obstetrics/Gynecology, University of Verona, Verona; 2: LaBS, Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, Milan, Italy; 3: Department of Diagnostic and Public Health, University of Verona, Verona, Italy; 4: U.O.C. Cardiochirurgia, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy

2:36pm - 2:48pm
ID: 268 / 9.1: 4

ARTIFICIAL INTELLIGENCE-BASED DECISION SUPPORT SYSTEM FOR RISK STRATIFICATION AND EARLY DETECTION OF HEART FAILURE

N. Filipovic¹, D. Jakovljevic², Z. Bosnic³, D. Boucharas⁴

1: Faculty of Engineering, University of Kragujevac, BIOIRC doo Kragujevac, Serbia; 2: University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK; 3: University of Ljubljana, Faculty of Computer and Information Science, Ljubljana, Slovenia; 4: Department of Biomedical Research, Foundation for Research and Technology Hellas, Greece

2:48pm - 3:00pm
ID: 574 / 9.1: 5

TOWARDS DIGITAL TWIN FRAMEWORKS FOR MONITORING VENTRICULAR SEPTAL DEFECT

M. Colebank¹, E. Mahan¹, H. Baker²

1: University of South Carolina, United States of America; 2: Medical University of South Carolina, United States of America

3:00pm - 3:12pm
ID: 612 / 9.1: 6

IN VIVO DEFORMATION OF THE HUMAN SINGLE VENTRICLE

B. Thomas¹, R. Chabiniok², M. Sacks¹

1: University of Texas at Austin, United States of America; 2: University of Texas Southwestern Medical Center, United States of America

3:12pm - 3:24pm
ID: 629 / 9.1: 7

A PROBABILISTIC MULTIPHYSICS COMPUTATIONAL MODEL FOR VENTRICULAR DYSSYNCHRONY AND CRT

E. Bergantin¹, F. Caforio^2,3,4, C. Augustin^3,4, S. Pezzuto¹

1: University of Trento, Italy; 2: Department of Mathematics and Scientific Computing, NAWI Graz, University of Graz, Graz, Austria; 3: Gottfried Schatz Research Center: Division of Biophysics, Medical University of Graz, Graz, Austria; 4: BioTechMed-Graz, Graz, Austria

2:00pm - 2:12pm
ID: 206 / 9.2: 1

IN SILICO MODEL OF THE STRUCTURAL RESPONSE OF FLOW DIVERTERS FOR ENDOVASCULAR CEREBRAL TREATMENTS

G. Boezi, A. Mastrofini, M. Marino

Università degli Studi di Roma "Tor Vergata", Italy

2:12pm - 2:24pm
ID: 218 / 9.2: 2

ESTABLISHING CREDIBILITY OF A CALIBRATED DROPLET MODEL TO CAPTURE RED BLOOD CELL DEFORMATION IN SILICO

H. Palahnuk¹, N. Tobin¹, K. Manning^1,2

1: The Pennsylvania State University, United States of America; 2: Penn State Hershey Medical Center, United States of America

2:24pm - 2:36pm
ID: 245 / 9.2: 3

CREDIBILITY ASSESSMENT OF A COMPUTATIONAL PHYSIOLOGICAL SIMULATOR FOR HEART-LUNG INTERACTION

F. Colombi¹, M. P. Mulder¹, M. Hallbäck², K. Rumindo², F. Jalde², E. Maksuti², D. W. Donker^1,3, L. Fresiello¹

1: Cardiovascular and Respiratory Physiology, TechMed Centre, University of Twente, Enschede, The Netherlands; 2: Getinge, Acute Care Therapies, Maquet Critical Care AB, Solna, Sweden; 3: Intensive Care Center, University Medical Center Utrecht, Utrecht, The Netherlands

2:36pm - 2:48pm
ID: 292 / 9.2: 4

UNCERTAINTY QUANTIFICATION OF TAVI SIMULATIONS

L. M. Perri^1,2, B. Grossi^3,2,1, C. Bramante¹, F. Migliavacca^1,4, G. Condorelli^3,2, G. Luraghi¹

1: Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Milan, Lombardy, Italy; 2: Department of Biomedical Sciences, Humanitas University, Milan, Lombardy, Italy; 3: IRCCS Humanitas Research Hospital, Milan, Lombardy, Italy; 4: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Lombardy, Italy

2:48pm - 3:00pm
ID: 307 / 9.2: 5

ROBUST HEMODYNAMIC DESCRIPTORS FOR DIGITAL TWIN-BASED ASSESSMENT OF AORTIC FLOW RESTORATION

T. Wang¹, T. Lemainque², C. Quast³, T. Zeus³, M. Neidlin¹

1: Cardiovascular Engineering, Applied Medical Engineering, RWTH Aachen University, Germany; 2: Dept of Diagnostic and Interventional Radiology, RWTH Aachen University, Germany; 3: Dept of Cardiology, Pulmonary Diseases and Vascular Medicine, Heinrich-Heine University, Germany

3:00pm - 3:12pm
ID: 349 / 9.2: 6

DEE LEARNING RAPID ESTIMATION OF PULSATILE INTRACRANIAL ANEURYSM WALL SHEAR STRESS

W. Ding¹, Y. Sheng², d. Roi³, H. L. Leo², C. H. Yap¹

1: Imperial College London, Dept of Bioengineering, London, United Kingdom; 2: National University of Singapore, Dept of Biomedical Engineering, Singapore; 3: Imperial College NHS Trust, London, United Kingdom

3:12pm - 3:24pm
ID: 364 / 9.2: 7

COMPARISON OF UNCERTAINTY QUANTIFICATION METHODS FOR ANEURYSM HEMODYNAMICS

D. Miklós¹, K. Zając², L. Sándor¹, B. Csippa¹, G. Paál¹

1: Budapest University of Technology and Economics, Faculty of Mechanical Engineering, Department of Hydrodynamic Systems, Hungary; 2: Sano - Centre for Computational Medicine, Poland

2:00pm - 2:12pm
ID: 109 / 9.3: 1

DIGITAL TWIN CALIBRATION, VALIDATION, AND PREDICTION: A TISSUE-ENGINEERED SCAFFOLD-MANDIBLE SYSTEM

B. Ferguson¹, A. Kiapour², J. Hajibandeh³, J. Clark⁴, Q. Li¹

1: School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW, Australia; 2: Department of Neurosurgery Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; 3: Department of Oral & Maxillofacial Surgery, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; 4: Department of Head & Neck Surgery, Chris O’Brien Lifehouse, Royal Prince Alfred Hospital, Sydney NSW Australia

2:12pm - 2:24pm
ID: 254 / 9.3: 2

EXPERIMENTALLY INFORMED IN SILICO MODEL OF FOOT-INSOLE INTERACTION

S. Pettenuzzo, R. Nuzzolese, A. Berardo, E. Belluzzi, A. Pozzuoli, P. Ruggieri, E. L. Carniel, C. G. Fontanella

University of Padova, Italy

2:24pm - 2:36pm
ID: 265 / 9.3: 3

FATIGUE-DRIVEN TOPOLOGY OPTIMIZATION OF POROUS HIP IMPLANTS FOR STRESS-SHIELDING MITIGATION

R. Cromi¹, M. P. Miuccio^1,2, M. Concari^1,2, F. Berti¹, S. Foletti², T. Villa¹

1: Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” (LaBS) – Politecnico di Milano, Milan, Italy; 2: Department of Mechanical Engineering (MetaMAT Laboratory) – Politecnico di Milano, Milan, Italy

2:36pm - 2:48pm
ID: 269 / 9.3: 4

MULTISCALE BONE MORPHOLOGY AS PREDICTOR FOR MULTIAXIAL OSTEOSYNTHESIS SCREW FAILURE

A. De Cet¹, J. Silva-Henao^2,3, A. G. Reisinger^1,2

1: Karl Landsteiner University of Health Sciences, Austria; 2: TU Wien, Austria; 3: CADS GmbH, Austria

2:48pm - 3:00pm
ID: 338 / 9.3: 5

3D PRINTED HYDROXYAPATITE INTERVETREBRAL FUSION CAGES FOR PATIENT SPECIFIC APPLICATIONS

A. De Cet^1,2, M. Colombo¹, L. D'Andrea¹, I. Rota¹, L. La Barbera¹, P. Vena¹, D. Gastaldi¹

1: Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Laboratory of Biological Structure Mechanics (LaBS), Politecnico di Milano, Piazza Leonardo da Vinci 32, Milan, 20133, Italy; 2: Department of Biomechanics, Faculty of Medicine, Karl Landsteiner University, Dr. Karl-Dorrek-Straße 30, Krems, 3500, Austria

3:00pm - 3:12pm
ID: 500 / 9.3: 6

A MICROSTRUCTURE AND GRAIN ORIENTATION BASED FRAMEWORK FOR PREDICTING CORROSION IN MG WE43

F. Karamifard, T. Vaughan, P. McHugh

University Of Galway, Ireland

3:12pm - 3:24pm
ID: 566 / 9.3: 7

IN SILICO MODEL TO PREDICT THE MECHANICAL STABILITY OF TIBIAL PLATEAU FIXATION STRATEGIES

M. Spataro^1,2, M. Reul³, P. Uniyal², D. Milone¹, G. Risitano¹, H. Hoekstra⁴, T. Scheerlinck³, H. van Lenthe²

1: Department of Engineering, University of Messina, Contrada di Dio, 98166 Messina, Italy; 2: Department of Mechanical Engineering, Biomechanics Section, KU Leuven, Leuven, Belgium; 3: Department of Orthopaedic and Trauma Surgery, UZ Brussels, Brussels, Belgium; 4: Traumatology, UZ Leuven, Leuven, Belgium

2:00pm - 2:12pm
ID: 487 / 9.4: 1

DEVELOPMENT OF A COMPUTATIONAL MODEL FOR THE IN SILICO PREDICTION OF SPATIOTEMPORAL EVOLUTION, METASTATIC DISSEMINATION AND THERAPEUTIC RESPONSE IN BREAST CANCER

N. T. Papadopoulos, I. Sotiriadou, M. Tzika, M. G. Tsipouras

Department of Electrical & Computer Engineering, University of Western Macedonia, 50100 Kozani, Greece

2:12pm - 2:24pm
ID: 515 / 9.4: 2

A GENETICALLY ADJUSTED RADIATION DOSE PER THE PREDICTION OF LATE BREAST FIBROSIS AFTER RADIOTHERAPY

B. Dionisi Ferrera¹, E. Gioscio¹, W. Van Amsterdam², P. Seibold³, M. C. De Santis¹, E. La Rocca¹, A. Cicchetti¹, C. J. Talbot⁴, C. West⁵, T. Rancati¹, R. consortium⁶

1: Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 2: University Medical Center Utrecht, Netherlands; 3: Cancer Research Center, Germany; 4: Department of Genetics & Cancer Sciences, University of Leicester, United Kingdom; 5: Division of Cancer Sciences, University of Manchester, United Kingdom; 6: REQUITE consortium

2:24pm - 2:36pm
ID: 539 / 9.4: 3

OPEN-SOURCE CYTOARCHITECTONIC MAPPING OF GLIOBLASTOMA FOR SURGICAL PLANNING

P. Papaleo, M. Freddi, G. Pignoni, L. Frizziero

Alma Mater Studiorum University of Bologna, Italy

2:36pm - 2:48pm
ID: 576 / 9.4: 4

A PROTOCOL FOR IN-SILICO RADIOTHERAPY DOSE-ESCALATION OF HIGH-RISK HEAD AND NECK CANCER

E. Dalqvist^1,2, H. Hållberg^1,3, T. Rancati⁴, A. Embring^2,5, G. Alexandersson von Döbeln^5,6, E. Onjukka^1,2

1: Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden; 2: Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden; 3: Epistat AB, Uppsala, Sweden; 4: Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 5: Department of Radiotherapy, Karolinska University Hospital, Stockholm, Sweden; 6: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

2:48pm - 3:00pm
ID: 583 / 9.4: 5

A TRANSLATIONAL POROMECHANICS MODEL: APPLICATIONS TO SKIN CANCER AND LOW-GRADE GLIOMA

D. Baroli, A. Petras, L. Gerardo Giorda

OEAW, Austria

3:00pm - 3:12pm
ID: 634 / 9.4: 6

ORAL MICROBIOTA-CONDITIONED TREATMENT EFFECT ON PROGRESSION-FREE SURVIVAL IN HEAD AND NECK CANCER

M. Salerno¹, S. Alfieri¹, Y. Dong¹, N. A. Iacovelli¹, M. Franceschini¹, T. Rancati¹, L. De Cecco¹, R. Keogh², J. Iacovacci¹

1: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy; 2: Department of Medical Statistics, London School of Hygiene & Tropical Medicine, United Kingdom

3:12pm - 3:24pm
ID: 541 / 9.4: 7

COMPUTATIONAL ESTIMATES OF THE PERITUMORAL HYPOXIA LEVERAGING MICROVASCULATURE PATIENT-SPECIFIC DATA

L. Possenti¹, E. Longhi¹, E. Gioscio¹, N. A Iacovelli¹, M. Franceschini¹, G. Calareso¹, A. Cavallo¹, E. Orlandi², P. Zunino³, T. Rancati¹

1: Fondazione IRCCS Istituto Nazionale dei Tumori, Italy; 2: Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Campus della Salute, Policlinico San Matteo, Italy; 3: Department of Mathematics, Politecnico di Milano, Italy

2:00pm - 2:12pm
ID: 145 / 9.5: 1

FROM PATHWAY PERTURBATION TO MORPHOGENETIC FAILURE: VIRTUAL TISSUE NAMS FOR TOXICOLOGY

J. Glazier¹, J. Berkhout^2,3, T. Knudsen¹, H. Heusinkveld²

1: Indiana University, United States of America; 2: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), the Netherlands; 3: Institute for Risk Assessment Sciences, Utrecht University, the Netherlands

2:12pm - 2:24pm
ID: 209 / 9.5: 2

VIRTUAL SKIN: A MECHANISTIC VIRTUAL EPIDERMIS WITH APPLICATIONS TOWARDS IN SILICO DERMAL EXPOSURE

L. Veschini^1,2, A. Stephens², E.-M. Hull², L. Kinght², C. Mahony², J. Glazier¹

1: Department of Intelligent Systems Engineering and Biocomplexity Institute, USA; 2: Procter & Gamble Technical Centre, Reading, United Kingdom

2:24pm - 2:36pm
ID: 222 / 9.5: 3

LLM-BASED PSYCHOLOGICAL DIGITAL TWINS IN SOCIAL RESEARCH: APPLICATION TO ANTI-VACCINATION MOVEMENTS

P. Sobkowicz

Sano - Centre for Computational Personalized Medicine, Poland

2:36pm - 2:48pm
ID: 342 / 9.5: 4

V-CORNEA: A MULTI-SCALE IN SILICO FRAMEWORK FOR OCULAR TOXICOLOGY AND IVIVE

J. Vanin¹, M. Getz¹, C. Mahony², T. Knudsen¹, J. Glazier¹

1: Department of Intelligent Systems Engineering and Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America; 2: Procter & Gamble Technical Centre, Reading, United Kingdom

2:48pm - 3:00pm
ID: 464 / 9.5: 5

HOSPITAL-LEVEL PREDICTION OF EMERGENCY ROOM DEMAND DURING PERIODS OF EXTREME HEAT

G. Colombini¹, F. Durazzi¹, M. Santoro², A. Vesely¹, R. Miglio¹, P. Tubertini², D. Remondini¹, A. Bazzani¹

1: University of Bologna, Bologna, Italy; 2: IRCCS Sant'Orsola, Bologna, Italy

3:00pm - 3:12pm
ID: 596 / 9.5: 6

PHYSIOLOGICAL AND PHYSICOCHEMICAL DRIVERS OF INHALED VOC DOSIMETRY VIA GLOBAL SENSITIVITY ANALYSIS OF LUNG GAS EXCHANGE MODEL

R. Curnow, C. Whitfield, R. Wang, W. Ahmed, S. Fowler

University of Manchester, United Kingdom

3:12pm - 3:24pm
ID: 173 / 9.5: 7

CARDIOVERSE: COMPREHENSIVE ASSESSMENT OF CARDIAC RISK THROUGH DATA-DRIVEN IN-SILICO VIRTUAL ECOSYSTEMS

V. Carbone¹, C. Baker², N. Rosenthal², P. Robson², T. Hinson^2,3, D. Paull^2,4, D. Beard⁵, D. Röshammar¹, L. Emili¹, M. Mahoney²

1: InSilicoTrials Technologies, Italy; 2: The Jackson Laboratory, USA; 3: University of Connecticut Health Center, USA; 4: The New York Stem Cell Foundation, USA; 5: University of Michigan Medical School, USA

2:00pm - 2:12pm
ID: 471 / 9.6: 1

NUMERICAL STUDY OF MAGNETIC MICROBEADS STEERED BY MAGNETIC RESONANCE NAVIGATION FOR TUMOR EMBOLIZATION

M. Rezaei Adariani^1,2, J. Pešek¹, N. Li², C. Tous², G. Soulez², I. Vignon-Clementel¹

1: Inria (Saclay IdF), France; 2: CR-CHUM (Montreal), Canada

2:12pm - 2:24pm
ID: 493 / 9.6: 2

A MULTISCALE DIGITAL TWIN FRAMEWORK FOR MECHANISTIC PREDICTION OF CARDIAC ALLOGRAFT VASCULOPATHY

E. Serafini¹, A. Martino¹, L. Pasini¹, M. S. Lami¹, D. Amici¹, G. De Nisco², D. Gallo², C. Chiastra², S. Al-Kindi¹, C. Filgueira¹, S. Casarin¹

1: Houston Methodist Research Institute, United States of America; 2: Politecnico di Torino, Italy

2:24pm - 2:36pm
ID: 530 / 9.6: 3

SYNGROW – GLOBAL OPTIMIZATION AS A GOVERNING PRINCIPLE OF VASCULAR DESIGN IN ORGANS

E. Jessen¹, M. C. Steinbach², D. Schillinger¹

1: Institute for Mechanics, Computational Mechanics Group, Technical University of Darmstadt, Germany; 2: Institute of Applied Mathematics, Algorithmic Optimization Group, Leibniz Universität Hannover, Germany

2:36pm - 2:48pm
ID: 564 / 9.6: 4

COMPUTATIONAL MODELING OF THE CONTRACTILE BEHAVIOR OF ENGINEERED HEART TISSUES

S. Spadoni¹, S. Todros², J. M. Pioner³, P. G. Pavan^2,4, L. Marcucci¹

1: Department of Biomedical Sciences, University of Padova, Italy; 2: Department of Industrial Engineering, University of Padova, Italy; 3: Department of Biology, University of Florence, Italy; 4: Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy

2:48pm - 3:00pm
ID: 588 / 9.6: 5

USING NEURAL NETWORKS TO DETERMINE CONSTITUTIVE MODEL FORMS FOR MYOCARDIUM IN FULL 3D DEFORMATIONS

M. Sacks

Unversity of Texas at Austin, United States of America

3:00pm - 3:12pm
ID: 593 / 9.6: 6

AGENT-BASED MODELING & MACHINE LEARNING TO PREDICT MOLECULAR DETERMINANTS OF FOAM CELL FORMATION

M. Sarkissian¹, V. Llorente-Cortés², J. Noailly¹

1: Pompeu Fabra University, Spain; 2: Spanish National Research Council (CSIC)

3:12pm - 3:24pm
ID: 396 / 9.6: 7

WHOLE BODY HEMODYNAMIC MODEL FOR PATIENTS WITH CIRRHOSIS

F. Schäfer¹, L. Meyblum², P. Varsos¹, C. Ripoll³, N. Golse^4,5,6, I. Vignon-Clementel¹

1: INRIA Saclay, France; 2: Department of Interventional Radiology, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, France; 3: Internal Medicine IV. Department of Gastroenterology, Hepatology, Infectious diseases and inter-disciplinary endoscopy, Jena University Hospital, Germany; 4: AP-HP Hôpital Paul-Brousse, France; 5: Inserm UMR-S 1193, France; 6: Université Paris-Saclay, France

2:00pm - 2:12pm
ID: 264 / 9.7: 1

BETTER THAN A STAB IN THE SPINE: A COMPUTATIONAL MODEL OF INTRACRANIAL HYPERTENSION

A. Sharifzadeh-Kermani^1,2, J. Wright^1,2, B. Ghitti², F. Argus², H. Danesh-Meyer^1,3, S. Holdsworth¹, G. Maso Talou²

1: Mātai Medical Research Institute, New Zealand; 2: Auckland Bioengineering Institute, New Zealand; 3: Eye Institute, New Zealand

2:12pm - 2:24pm
ID: 328 / 9.7: 2

FMRI-DERIVED OCULOMOTOR SIGNATURES PREDICT VISUAL RECOVERY TRAJECTORIES AFTER STROKE

J. K. Argasiński^1,2, M. Turczyniak^1,2, C. Koba¹

1: Sano Centre for Computational Personalised Medicine, Poland; 2: Jagiellonian University, Krakow, Poland

2:24pm - 2:36pm
ID: 387 / 9.7: 3

BIOMECHANICAL IMPACT OF INTRAOCULAR PRESSURE ELEVATION ON CRYSTALLINE LENS DYNAMICS

J. Grasa^1,2, A. Boszczyk³, A. K Jóźwik³, M. Salimibani³, D. Siedlecki³

1: Aragón Institute of Engineering Research (I3A), Universidad de Zaragoza, Spain; 2: Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN); 3: Department of Optics and Photonics, Wrocław University of Science and Technology, Poland

2:36pm - 2:48pm
ID: 405 / 9.7: 4

TOWARDS A MULTISCALE MODEL OF AGE-DEPENDENT EYE GROWTH

B. Fantaci¹, E. Bianchini³, J. Grasa^1,2, B. Calvo^1,2

1: Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza, Spain; 2: CIBER-BBN, Spain; 3: Politecnico di Milano, Italy

2:48pm - 3:00pm
ID: 477 / 9.7: 5

INTEGRATED HYDRAULIC AND SOLUTE TRANSPORT MODELLING IN A SIMPLIFIED LAYERED RETINA–CHOROID SYSTEM

G. Sbaruffati³, R. Tripputi¹, D. Albani², C. Giordano¹, R. Repetto³, F. Boschetti¹

1: Politecnico di Milano, Milano, Italy; 2: Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 3: Università di Genova, Genova, Italy

3:00pm - 3:12pm
ID: 489 / 9.7: 6

ANATOMY-DRIVEN MULTIPHYSICS MODELING OF RETINAL LASER TREATMENTS IN HEALTHY AND PATHOLOGICAL CONDITIONS

G. Zanellati¹, D. Allegrini^2,3, F. Auricchio⁴, M. Romano^2,3, A. Cattenone⁴, G. Alaimo⁴, S. Marconi^1,4

1: Fondazione IRCCS Policlinico San Matteo, Italy; 2: Department of Biomedical Sciences, Humanitas University, Milan, Italy; 3: Department of Ophthalmology, Humanitas Gavazzeni–Castelli, Bergamo, Italy; 4: Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy

3:12pm - 3:24pm
ID: 575 / 9.7: 7

CONTINUUM AND MICROMECHANICAL MODELLING OF THE RETINA

D. Bertolo¹, F. Boschetti¹, A. Pandolfi²

1: LaBS, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano; 2: Department of Civil and Environmental Engineering, Politecnico di Milano