Conference Agenda

MACHINE-LEARNING-SUPPORTED PERSONALISATION OF ZERO-DIMENSIONAL CARDIOVASCULAR MODEL WITH BAROREFLEX

K. Tlałka, I. Halliday, A. Narracott, M. Malawski

PARAMETER ESTIMATION OF A LUMPED-PARAMETER CARDIOVASCULAR MODEL, WITH A NOVEL UNSCENTED KALMAN FILTER

A. L. Thornton, I. Halliday, R. H Clayton, H. Saxton, X. Xu

AN INTEGRATED 1D 0D MODEL OF THE CARDIORESPIRATORY SYSTEM WITH SHORT TERM CARDIOPULMONARY CONTROL MECHANISMS

C. Dalmaso, P. J. Blanco, L. O. Müller

PARAMETER IDENTIFICATION IN AN ECMO PHANTOM CIRCULATION MODEL

A. Utrera, C. Bertoglio, W. Huberts, M. Rutten

MODELING VENOUS HEMODYNAMICS: A 1D FRAMEWORK FOR INVESTIGATING VALVES AND EXTERNAL COMPRESSION

S. Ferlito, M. Reda, A. Sen, J. Alastruey, S. Avril

A 0D MODEL REPRESENTING HUMAN RESPONSE TO HYPERGRAVITY

K. Czechowicz, A. Narracott, R. D. Hose, R. Anderton, I. Halliday, P. D Morris

ESTIMATION OF ARTERIAL WALL MATERIAL PARAMETERS FROM NON-INVASIVELY MEASURABLE BLOOD PRESSURE SIGNALS

K. Pálfalvi, R. Wéber

SECONDARY FLOWS INSIDE ARTIFICAL VESSEL GEOMETRIES

P. Friedrich, B. Csippa, G. Paál

MULTISCALE HEMODYNAMIC MODELING OF ECMO-INDUCED ALTERATIONS IN MICROVASCULAR FILTRATION AND THROMBOTIC RISK

R. Wéber, M. Judit, F. Romano

TURBULENCE-INDUCED HEMOLYSIS IN A TAYLOR-COUETTE-DEVICE: DESIGN AND EXPERIMENTAL CHARACTERIZATION

M. Wiegand, A. Groh, S. Bender, K. Pölkow, C. N. Nayeri, K. Vellguth, V. Froese, J. Brüning, S. Martinke, O. Paschereit, L. Goubergrits

ELECTROMECHANICAL SIMULATION OF LEFT VENTRICULAR CONTRACTION AFTER MYOCARDIAL INFARCTION

A. Schlief, L. Obermeier, L. Verbeek, C. Knosalla, N. Solowjowa, L. Goubergrits

THE ROLE OF LAYER-SPECIFIC COMPOSITION AND FIBER ORIENTATION ON THE MECHANICAL RESPONSE OF PORCINE PULMONARY ARTERIES

J. A Peña, M. A Martinez, E. Peña

LATENT DYNAMICS NEURAL NETWORK MODELS OF CARDIAC ELECTROPHYSIOLOGY IN A PATIENT-SPECIFIC LEFT ATRIUM

M. Di Ridolfi, S. Pagani, F. Caforio, F. Regazzoni, L. Dede', L. Preziosi

HIGH SPEED ACUTE CARDIAC INFARCTION SIMULATIONS USING THE NEURAL NETWORK FINITE ELEMENT METHOD

B. Thomas, M. Sacks

PATIENT-SPECIFIC 1D–3D SIMULATIONS OF BLOOD AND CONTRAST FLOW IN STENTED VENOUS SEGMENTS

M. Baragona, W. Mhaouch, P. Haulez, A. van der Horst, S. Shulepov, J.-M. Armengol Collado, B. Frackowiak

COUPLING BAYESIAN INFERENCE AND SENSITIVITY ANALYSIS FOR IN-SILICO THERAPY GUIDANCE OF HYPOTENSION DURING SURGERY

J.-N. Thiel, M. Zlicar, U. Steinseifer, B. Kirn, M. Neidlin

REDUCED ORDER MODELS FOR REAL-TIME PATIENT-SPECIFIC CARDIOVASCULAR SIMULATIONS VIA WEB-SERVER

G. Rozza

EVALUATION OF A DIGITAL TWIN FOR REAL-TIME CARDIAC CONTRACTILITY ESTIMATION USING SYNTHETIC AND IN VIVO DATA

S. Snijders, M. Rutten, J. Sels, P. Tonino, W. Huberts

INVESTIGATING THE TRANSLATION GAP TO UNLOCK THE POTENTIAL OF DIGITAL TWINS IN HEALTHCARE

S. Bridio, G. Luraghi, J. F. Rodriguez Matas, G. Dubini, F. Migliavacca, M. Whelan

AN INTEGRATED DECISION SUPPORT SYSTEM FOR HYPERTROPHIC CARDIOMYOPATHY DISEASE MANAGEMENT

N. Faiem, A. Kallonen, M. van Gils

DIGITAL TWIN INTEGRATING MULTISCALE DATA AND MODELS FOR STRATIFICATION OF HYPERTROPIC CARDIOMYOPATHY

J. Hyttinen, K. Aalto-Setälä, A. Afantitis, F. Agakov, A. Oravio Bueno, T. Crist, K. Curran, V. Le Rolle, L. Mainardi, S. Severi, i. Olivetto, M. van Gils, M. von Tottleben

CAN MAKING CARDIOVASCULAR SYSTEM MODELS EASY TO CALIBRATE BRIDGE THE GAP TO THE INTENSIVE CARE UNIT?

F. Argus, B. Ghitti, M. Shafieizadegan, A. Sharifzadeh-Kermani, M. Gee, S. Creamer, B. Ebrahimi, E. Guy, J. Fisher, J. G. Chase, M. Tawhai, G. Maso Talou

TOWARDS REAL-TIME TAVR DIGITAL TWINS: 2D NAVIER-STOKES PINN IN STENOTIC FLOWS AND CORONARY ASSESSMENT

J. Gosselin, R. Leask, R. Cecere, F. Couët, S. Lalancette, R. Mongrain

AN OPTIMIZATION FRAMEWORK FOR DESIGNING MECHANICALLY INFORMATIVE SOFT TISSUE EXPERIMENTS

U. Manack, B. Alheit, N. Famaey, M. Peirlinck

SINO-ATRIAL NODE MODEL FOR INFERRING AUTONOMIC ACTIVITY FROM HEART RATE VARIABILITY

C. Dong, G. Talou, K. Tran, F. Argus

A COMPARATIVE INVESTIGATION ON DIFFERENT SOLUTIONS OF 1D MODEL OF BLOOD FLOW

E. Vaezi, J. Hernández, E. Soudah

PREDICTING POST-TEER HEMODYNAMICS IN MITRAL REGURGITATION USING PATIENT-SPECIFIC MODELLING

J. Franz, F. Barbieri, V. Exarchos, K. Vellguth, J. Brüning, A. Borzistaia, M. Reinthaler, T. Kühne, L. Goubergrits

INFLUENCE OF AORTIC ARCH MORPHOLOGY ON CARDIOGENIC EMBOLIC STROKE RISK: A CFD-BASED FRAMEWORK

C. Bettinelli, I. Ianniruberto, F. Morelli, Y. Tatari, A. Arzani, D. Mazzaccaro, E. Votta, F. Sturla

SEMI-AUTOMATED GENERATION OF SURGICAL BAFFLE GEOMETRY FOR BIVENTRICULAR REPAIR

E. S. Martinez, A. D. Kaiser, A. K. Reed, S. W. Stocker, A. Sharir, P. S. Choi, S. A. Maskatia, M. R. Ma, A. L. Marsden

MACHINE LEARNING SURROGATE MODEL FOR HIPSC CARDIOMYOCYTE ELECTROMECHANICS

O. Ylinen, O. Noita, A. Ahola, J. Koivumäki, J. Hyttinen

AI-DRIVEN HEART FAILURE RISK PREDICTION FROM ECG VERSUS TRADITIONAL CLINICAL RISK MEASURES: WHICH PERFORMS BETTER?

X. An, W. Sun, S. V Kalmady, J. A White, A. J Swift, R. Greiner, P. Kaul, C. Chen

A METHODOLOGY FOR DESIGNING OPTIMIZED PATIENT-SPECIFIC BONE SCAFFOLD FROM ROUTINE CLINICAL IMAGES

N. Olivera, L. D'Andrea, E. Zamengo, P. Vena

GENERATING AN ATLAS OF PAEDIATRIC SKELETAL MODELS FOR MORPHOLOGICAL ASSESSMENT

H. Talbott, G. Allison, A. Moayedi, M. Cohen, E. Dall'Ara, A. Offiah, X. Li

CHARACTERIZING HEALTHY HIP DEVELOPMENT IN KIDS USING A STATISTICAL SHAPE AND APPEARANCE MODEL

S. Attar, H. Isaksson, M. K Karlsson, C. J. Tiderius, L. Grassi

UNCERTAINTY EVALUATION OF AN ARTIFICIAL INTELLIGENCE MODEL FOR LEG-LENGTH ESTIMATION IN A CLINICAL SETTING.

M. Ronat, S. Beddiaf, R. Philippot, L. Cheze

STATISTICAL SHAPE MODELING TO ASSESS THE MORPHOLOGICAL VARIABILITY OF TIBIAL MEDULLARY CANAL

F. Montigiani, G. Galteri, L. Cristofolini

PHYSICS-INFORMED MACHINE LEARNING FOR ESTIMATING CONSTITUENT-SPECIFIC PROPERTIES OF CARTILAGE

P. Tanska, A. Salo, M. E. Mononen

UISS-BMR: A MECHANISTIC AGENT-BASED MODEL OF IMMUNE– BONE CROSSTALK DURING FRACTURE HEALING

F. Cernuto, V. Russo

THE MECHANICAL INTERPLAY BETWEEN BONE AND SCAFFOLD - A COMPUTATIONAL ANALYSIS

H. Souhail, L. D'Andrea, E. Zamengo, S. Blouin, A. Berzlanovich, M. A. Hartmann, P. Vena, D. Ruffoni

DESIGN, MANUFACTURING, AND TESTING OF A SYSTEM FOR IN VITRO SKELETAL MUSCLE TISSUE MECHANICAL STIMULATION.

N. Klein Hofmeijer, C. Rivares Benitez, J. Rouwkema, M. Sartori

SOFT TISSUE DRIVEN BONE REMODELLING – A FRAMEWORK FOR PATIENT-SPECIFIC DENTAL PROTHESIS DESIGN

J. Chen, J. Zhong, M. Swain, Q. Li, L. Wang

DECOUPLING INTER- FROM INTRA-CELLULAR STRESSES

R. Aparicio Yuste, L. Hundsdorfer, E. Bastounis, M. J. Gomez-Benito

TOWARDS AN IN SILICO MODEL OF THE GUT-BRAIN AXIS: FROM GASTROINTESTINAL STIMULATION TO COGNITIVE PERCEPTION

E. L. Carniel, I. Toniolo, A. Berardo, C. G. Fontanella, B. Pomaro, G. Mazzucco, L. Polese, S. Perretta

THE ECOSYSTEM WITHIN US: SIMULATING MICROBIOME DYNAMICS TOWARDS A DIGITAL TWIN OF THE HUMAN GUT

S. Qathan, D. Popp, F. Centler

[LIB]OPENCOR: MOVING COMPUTATIONAL BIOLOGY TO THE WEB

A. Garny, D. P Nickerson, P. J Hunter

FROM NEURAL DYNAMICS TO PRECISION THERAPY FOR PARKINSON’S DISEASE: A MULTISCALE IN SILICO MODEL OF CORTICAL EXCITABILITY AND NETWORK IMBALANCE,

J. Jung, H.-Y. Chu, W. Lytton

A SYSTEMS APPROACH TO REELIN-NOTCH SIGNALING TO DECIPHER REGULATORY DYNAMICS IN LYMPHANGIOGENESIS

S. Bekisz, Y. Graine, A. Noël, L. Geris, L. Ladeira

A PBK-TD GUT MICROBIOME MODEL OF THE FIRST 1000 DAYS OF LIFE: TOWARDS A PREVENTIVE HEALTHCARE DIGITAL TWIN

T.-K. LY, A. G. HOEKSTRA, V. M. SHERATON

PERSONALIZED MODELS TO UNVEIL MECHANISMS OF ENGINEERED T-CELL THERAPY IN MULTIPLE MYELOMA

S. Orozco-Ruiz, V. Noël, G. Stoll, S. Pankaew, L. Gasull-Celades, E. van Vliet, P. Hernández-López, P. Brazda, F. Keramati, C. Kuhn, M. Rade, D. Fandrei, M. Alb, Z. Sebestyén, M. Merz, J. Kuball, K. Reiche, E. Barillot, L. Calzone

TOWARDS A DIGITAL TWIN OF THE HUMAN GUT: A MULTISCALE COUPLED PDE MODEL OF HOST-MICROBIOTA INTERACTION

E. Pastremoli, B. Laroche, L. Sala

REAL-TIME PREDICTION OF EARLY LIVER ALLOGRAFT DYSFUNCTION USING AN IMAGE-BASED MULTISCALE BIOMECHANICAL MODEL

L. Mandl, S. Gerhäusser, A. Schnurpel, A.-L. Hoh, U. Dahmen, M. König, T. Ricken, H.-M. Tautenhahn

SMOOTH MUSCLE CELL POPULATION VARIATION

N. Anderton, O. Noita, F. Menna, J. Suihkonen, A. Ben-Tolila, J. Koivumäki, J. Duprez, V. Le Rolle, J. Hyttinen

A REPRODUCIBLE FRAMEWORK FOR COUPLING TISSUE-LEVEL AND INTRACELLULAR KINETIC MODELS OF HEPATOCYTES

M. Pedrazzi, P. Kottman, M. Cascante de Serratosa, D. Drasdo

BONE REMODELING MULTISCALE COMPUTACIONAL MODEL: COUPLING CELLULAR AND TISSUE DYNAMICS

A. Verly, P. Amaral, F. Bastos, L. Assis, B. Quintela

IN SILICO DESIGN OF MG-BASED DEGRADABLE POROUS SCAFFOLDS FOR THE REPAIR OF CRITICAL-SIZE DEFECTS

S. Nguyen, M. Barzegari, L. Geris

MECHANICS OF DIFFUSIVE CROSSLINKERS IN BIOPOLYMER NETWORKS: A CONTINUUM APPROACH

L. Pacheco, M. Parente, J. Ferreira

PRECLINICAL TOOL TO ESTIMATE OSTEOPOROTIC WOVEN BONE MECHANICS BASED ON EXPERIMENTAL DATA

J. J. Toscano-Angulo, J. Mora-Macías, P. Blázquez-Carmona, E. Reina-Romo

ESTIMATION OF ACTIVE MYOCARDIAL CONTRACTILITY VIA PHYSICS-INFORMED NEURAL NETWORKS FOR SCAR DETECTION

M. Höfler, F. Regazzoni, S. Pagani, E. Karabelas, C. Augustin, G. Haase, G. Plank, F. Caforio

PERSONALIZED TRACKING OF CORE TEMPERATURE FROM WEARABLES VIA A PHYSICS-GUIDED BAYESIAN ODE

Y. Cao, Y. Cao

PRE-OPERATIVE, DIAGNOSIS-ADJUSTED RISK PREDICTION OF PROLONGED HOSPITALISATION AFTER PAEDIATRIC CARDIAC SURGERY WITH CARDIOPULMONARY BYPASS

F. E. G. Kessler, A. Zenonos, R. Issitt, V. Muthurangu

UNSUPERVISED MATERIAL MODEL DISCOVERY OF MYOCARDIAL TISSUE BEHAVIOR

M. Peirlinck

SCALABLE INFERENCE OF GUT MICROBIOTA LOTKA–VOLTERRA MODELS WITH PHYSICS-INFORMED NEURAL NETWORKS

L. Sala

A FEASIBILITY PIPELINE: STRUCTURING MULTIMODAL REAL-WORLD DATA FOR DIGITAL TWIN DEVELOPMENT

A. SANDRALEGAR, E. Golubeva, L. Bührer, S. Morel, P. Bijlenga

ADAPTIVE MODEL REDUCTION FOR EFFICIENT DATA AUGMENTATION FOR MACHINE LEARNING CLASSIFICATION

M. Stefanati, S. Gahima, J. F. Rodríguez Matas, A. García‑González, P. Díez

ROBUST LEARNING DOMAIN FORMULATION FOR DEEP LEARNING MODELS IN A SMALL DATA REGIME

K. Zhao, B. Ghitti, M. Nash, G. Maso Talou

PATIENT-SPECIFIC 0D CIRCULATION MODELING WITH REGRESSION-BASED PARAMETER UPDATES TO PREDICT POST-HEPATECTOMY OUTCOMES

F. Songia, K. Hakkakian, S. Roullet, A. Coilly, N. Golse, I. Vignon-Clementel

LLM + MULTISCALE MODELING FOR NEUROLOGY

W. Lytton, G. Cedersund, J. Lee, R. McDougal, A. Newton, C. Kelley, J. Jung, M. DiStasio

GLUCODIFFSURV: TREATMENT-AWARE CONTINUOUS-TIME DIFFUSION FORECASTING WITH TIME-TO-HYPOGLYCEMIA RISK

S. Maqsood, E. Belousovienė, T. Tamosuitis, R. Maskeliūnas

GNN-BASED SURROGATE MODEL FOR OBSTETRIC INJURY PREDICTION

R. Moura, D. Oliveira, D. Antunes, D. Fidalgo, M. Parente

IDENTIFIABILITY OF LATENT TRAJECTORIES WITH NEURAL ODES IN SMALL DATA REGIMES

T. Rachel, H. Yang, T. Litwin, M. Karakioulaki, M. Hess

HUMAN-LEVEL MRS SCORING FROM NEUROSURGICAL LETTERS USING A LARGE LANGUAGE MODEL

A. SANDRALEGAR, A. Bornet, E. Benguettat, F. Ravarelli, P. E. Constanthin, A. Lavé, J. Haemmerli, I. Janssen, J. Issa, E. Qaderdan, E. G. Godin, K. Schaller, D. Teodoro, P. Bijlenga

SYNTHETIC PATIENTS TO ENHANCE MULTIPLE SCLEROSIS TRIAL DESIGN VIA COVARIATE ADJUSTMENT

M. Franzese, R. Reggio, E. Dolcetti, M. Aiello, A. Colacino, D. Centonze, R. Gomeni, E. Merlo Pich, M. Salvatore

FEMUR FRACTURE PREDICTION IN POSTMENOPAUSAL WOMEN: MULTI-COHORT CLINICAL VALIDATION OF BBCT-HIP PIPELINE

J. A. Szyszko, A. La Mattina, M. Amabile, C. Ripamonti, L. Lisi, P. Bhattacharya, F. Baruffaldi, A. Aldieri, M. Viceconti

PHANTOMLESS CALIBRATION FOR THE ESTIMATION OF BONE STRENGTH IN PAEDIATRIC FEMORA

G. Allison, S. Almutairi, A. C Offiah, X. Li

FROM ASTM F543 PHYSICAL TESTING TO IN SILICO EVIDENCE: CREDIBILITY ASSESSMENT OF A DEVICE-AGNOSTIC FE MODEL

D. Benoit, F. Le Navéaux, L. Degueldre, M.-H. Beauséjour, Y. Petit, É. Wagnac, J. Clin

TOWARDS THE VIRTUAL MOUSE TWIN FOR PRE-CLICNICAL TESTING OF NEW TREATMENTS FOR OSTEOPOROSIS

E. Dall'Ara, T. Valerio, S. Singh, S. Dirstaru, S. Farage-O'Reilly, V. S. Cheong, P. Pivonka

A DYNAMIC MUSCULAR-ARTICULAR DATASET FOR LOWER LIMB DIGITAL TWINS: FIRST APPLICATION AND IN VIVO VALIDATION

M. Conconi, M. Romeo, N. Sancisi, R. Dumas

PHANTOM TYPE MATTERS: A BENCHTOP VALIDATION OF FEMUR STRENGTH DETERMINATION WITH FINITE ELEMENT MODELS

E. S Galliker, A. Dams, D. Jha, G. Galteri, A. Baker, S. Väänänen, L. Grassi, V. San Cheong, H. Isaksson, L. Cristofolini, S. J Ferguson, B. Helgason

INTER-RATER VARIABILITY OF BONE FRAGMENT SEGMENTATION AND SURGICAL REDUCTION IN COMPLEX TIBIA FRACTURES

S. Comtesse, L. Sommerhalder, L. Zamboni, A. Crotta, T. Zumbrunn, B. Helgason, S. J. Ferguson

CLINICAL METRIC ERRORS INDUCED BY THE PROPAGATION OF LANDMARKING UNCERTAINTY IN AUTOMATED TKA PLANNING

Y. Roch, D. Lozano, N. Fougeron, B. Gaulin, C. Horteur, M. Bucki, Y. Payan, A. Perrier

SIMULATION OF THE ABDOMINAL WALL FOR PERSONALIZED HERNIA ASSESSMENT

E. Antoniadi, M. P. Ferraz, M. Parente, E. Silva

GEMINI: DIGITAL TWIN FOR PERSONALIZED ISCHEMIC STROKE TREATMENT DEVICE SELECTION: A STUDY PROTOCOL

T. Brouwer, B. Emmer, J. Coutinho, B. Roozenbeek, S. Cornelissen, H. Lingsma, L. Bontempi, G. Luraghi, C. Majoie, H. Marquering

CALIBRATION OF A BIOCHEMO-MECHANO MULTI-SCALE COMPUTATIONAL MODEL TO PREDICT BONE ADAPTATION

S. Dirstaru, S. Farage-O'Reilly, V. San Cheong, S. Singh, I. Bellantuono, P. Pivonka, E. Dall'Ara

CREDIBILITY ASSESSMENT APPROACH FOR VIRTUAL IMPLANT TESTING OF CUSTOM-MADE CRANIOMAXILLOFACIAL DEVICES

S. Herrmann, T. Koett, L. Alarcon Rueda, S. Aberle, A. Beckmann

FROM STANDARDS TO PRACTICE: SCALABLE CREDIBILITY ASSESSMENT OF VIRTUAL PHYSIOLOGICAL HUMAN MODELS

K. Zając, M. Kasztelnik, P. Połeć, P. Nowakowski

VERIFICATION AND VALIDATION OF MDSIM’S ATLAS SPINE MODEL: APPLICATION TO A PATIENT-SPECIFIC DEFORMITY CASE

M. Tarquini, M. Rasouligandomani, S. T. Dukkipati, D. Kaçar, R. Assaker, L. Adam

GAIT AND MRI-DERIVED DISC MORPHOLOGY ALTERATIONS IN PATIENTS WITH LUMBAR HERNIATION

I. Mendes, N. Cristino, R. Fernandes, A. Castro

DIGITAL TWINS IN HEALTHCARE: AN ANALYSIS WITHIN THE EU REGULATORY FRAMEWORK

M. Baltuzzi

ETHICAL AND TECHNICAL FRONTIERS IN VIRTUAL HUMAN TWINS FOR HEALTHCARE

M. BARBIER

FROM ALGORITHMS TO HEADLINES: MEDIA COVERAGE OF IN SILICO MEDICINE

D. Montesarchio, Z. Van Horenbeeck, M. Del Piero

THE ZERO-ENTROPY ENVIRONMENT: WHY REGULATION OF DIGITAL TWINS MUST ADDRESS HUMAN AGENCY

V. Prosseda, M. Bertolaso

IN SILICO METHODOLOGIES IN HIGH-RISK MEDICAL DEVICE DEVELOPMENT: IMPLICATIONS FOR HEALTHCARE SYSTEMS

D. Rösler, T. Czypionka, J. Brüning, S. Eisenberg, M. Kraus, M. Reiss, C. Zech

PRIVACY BY DESIGN IN MEDICAL AI: MITIGATING LIFECYCLE RISKS

M. Maouche, P. Soda, M. Barbier

MORE THAN A DATA SUBJECT: RETHINKING PATIENTHOOD IN THE DEVELOPMENT OF MEDICAL DIGITAL TWINS

Z. Van Horenbeeck, E. Elhadj, E. Lievevrouw, I. Van Hoyweghen

REAL-TIME PERSONALIZED HEART MODELS FOR HARDWARE IN THE LOOP INTERACTION WITH DEVICES

N. Adhikari, B. Allen, R. Fenwick-Rose, V. Suomi, P. Patel, D. P Nickerson, M. L Trew, W. Ai

CFD REDUCED-ORDER MODELS FOR INTERACTIVE ASSESSMENT OF CARDIAC HEMODYNAMICS FOR PEDIATRIC SURGERY

B. M. Fanni, E. Vignali, E. Costa, E. Di Meo, M. Camponeschi, V. Carbone, M. E. Biancolini, S. Celi

DIGITAL TWINS AS A “THIRD PARTY” IN CARE: ETHICAL IMPLICATIONS FOR THE PATIENT–DOCTOR RELATIONSHIP

M. BARBIER, N. DIE

MODEL-BASED DESIGN OF PHYSIOLOGICAL CLOSED-LOOP CONTROL SYSTEMS FOR MEDICAL DEVICES

V. Suomi, M. Nord

EMBEDDING ETHICS IN INSILICO HEALTH: AN EMPIRICAL ETHICS APPROACH TO VIRTUAL HUMAN TWIN DEVELOPMENT

K. Scheunpflug

UNSUPERVISED FAIRNESS ASSESSMENT TO ADDRESS INTERSECTIONALITY AND PROXY FEATURES

E. Beauxis-Aussalet

DIGITAL TWINS IN HEALTHCARE. NORMS, EPISTEMOLOGY AND ETHICS IN EUROPE

M. Baltuzzi

REGIONAL ASSESSMENT OF BRAIN MECHANICAL PROPERTIES DURING AGING

S. Zolghadr, N. Reiter, J. Hinrichsen, L. Hoffmann, S. Rampp, L. Bräuer, F. Paulsen, S. Budday

INSILICOHEALTH MSCA JOINT DOCTORAL NETWORK: TRAINING VIRTUAL TWIN PROFESSIONALS TO SUPPORT HEALTHY AGEING”

E. Beaucage-Gauvreau, R. Castro Viñuelas, L. Vangeel, I. Jonkers

PREDICTING ADVERSE EVENTS AFTER FROZEN ELEPHANT TRUNK REPAIR USING PATIENT-SPECIFIC FLUID-STRUCTURE INTERACTION SIMULATIONS

Y. Zhu, K. Wang, A. Awwad, A. Oo, M. Field, M. Radike, U. Rosendahl, S. Mirsadraee, X. Y. Xu

ADVANCING ABDOMINAL AORTIC ANEURYSM RISK ASSESSMENT THROUGH ANEURYSM MORPHOLOGICAL CHARACTERIZATION

M. L. Alfarano, E. Soudah, M. Aguirre

IS THE THIRD BRANCH OPTIMAL? A PATIENT-SPECIFIC FSI ANALYSIS OF TRIPLE-BRANCHED TEVAR

B. Li, Y. Zhu, S. Sica, M. D'Oria, G. Tinelli, S. Lepidi, X. Y. Xu

CORRELATING PATIENT-SPECIFIC RUPTURE RISK WITH NON-INVASIVE DESCRIPTORS IN ASCENDING AORTIC ANEURYSMS

J. Moutinho Gonçalves, L. Maes, N. Famaey

CAN IN SILICO GROWTH AND REMODELLING MODELS PREDICT ATAA EVOLUTION?

D. Tarantino, S. Pasta, B. Fantaci

MODELING THE ROLE OF OBESITY IN KIDNEY DISEASE TREATMENT WITH GLP-1 AGONIST

J. Mallette, R. Hester, J. Clemmer

IN SILICO COMPARISON OF SUBSTRATE-BASED ABLATION STRATEGIES IN STRUCTURAL VENTRICULAR TACHYCARDIA

N. Biasi, M. Parollo, D. Vultaggio, G. Zucchelli, A. Tognetti

IN SILICO EVALUATION OF TRANSCATHETER TRICUSPID VALVE REPLACEMENT WITH THE EVOQUE SYSTEM

M. Pillitteri, A. Zerillo, G. Sausa, S. Pasta, S. Cannata, C. Gandolfo

EFFICIENT TRANSIENT 0D MICROVASCULAR HEMODYNAMIC MODEL TO INVESTIGATE PERICYTE-INDUCED STALLS.

S. Liu, B. Ghitti, G. Maso Talou, H. Davis, F. Argus

AI-BASED GEOMETRIC AND HEMODYNAMIC BIOMARKERS FOR ABDOMINAL AORTIC ANEURYSM PREDICTION

M. Benovoy, A. Guest, A. Forneris, M. Biglioli, B. B. Ghoshhajra, G. Soulez, S. C. Muluk, B. W. Starnes, R. D. Moore, E. S. Di Martino, A. Satriano

DEVELOPMENT AND VALIDATION OF AN IN SILICO FRAMEWORK TO PREDICT FRACTURE OF METASTATIC VERTEBRAE

L. Cristofolini, G. Barbanti-Bròdano, V. Carbone, E. Dall'Ara, R. Ferenc, S. J Ferguson, J. M. Garcìa Aznar, N. Germscheid, Á. Lazáry, M. Palanca, S. Sale, P. Vajkoczy, J.-J. Verlaan, L. Vidacs, E. Voisin

CIRCADIAN RHYTHMS WITHIN THE INTERVERTEBRAL DISC

L. Baumgartner, J. Noailly

LESION SIZE AND LOCATION AFFECT THE COMPRESSIVE FAILURE LOAD OF HUMAN METASTATIC VERTEBRAE

R. Roger, R. Ghosh, Á. Lazáry, L. Guo, D. Lacroix, E. Dall'Ara

A BIOMECHANICS-BASED DECISION SUPPORT SYSTEM FOR PREDICTING METASTATIC VERTEBRAL FAILURE RISK

R. Ghosh, E. Shearman, R. Roger, M. Palanca, E. Dall'Ara, D. Lacroix

INVERSE OPTIMIZATION OF BONE-TUMOUR INTERFACE AND MATERIAL MAPPING IN METASTATIC VERTEBRAE

J. Muñoz-Allué, E. Dall’Ara, M. Palanca, M. Á. Pérez, J. M. García-Aznar

INTEGRATING IMAGING BIOMARKERS AND RADIOTHERAPY DOSE INTO CARDIOVASCULAR DIGITAL TWINS FOR LONGITUDINAL RISK MODELING

A. Catalano, E. Gioscio, F. Pisani, C. Veronese, P. Vallerio, L. Dedè, P. Zunino, A. Cicchetti

PATIENT-SPECIFIC FINITE ELEMENT ANALYSIS OF STENTING FOR SINUS VENOSUS ATRIAL SEPTAL DEFECTS

M. Chatoo, N. R. Alonso, F. Crasci, S. Schievano, G. Giusti, C. Capelli

FINITE ELEMENT MODELLING OF PERCUTANEOUS PULMONARY VALVE IMPLANTATION IN PAEDIATRIC ANATOMIES

M. Lecuona, L. Swanson, A. Salam, S. Khambadkone, G. Giusti, S. Schievano, C. Capelli

PATIENT-SPECIFIC MECHANICAL THROMBECTOMY SIMULATION: A CONVERSATION BETWEEN CLINICIANS AND ENGINEERS

T. Brouwer, V. Fregona, T. Kuipers, L. Bontempi, F. Gijsen, H. Marquering, J. F. Rodriguez Matas, F. Migliavacca, G. Luraghi, C. Majoie

ENGINEERING DESIGN CHOICES - A DIRECT PATIENT COMPLICATION RISK

L. Prahl Wittberg, M. Broman

BREAKING SILOS WITH DYNAMIC DATA GOVERNANCE

M. Quaranta, A. Kremer, K. Reiche, A. Funck Hansen

TRANSLATING DIGITAL TWIN GLUCOSE PREDICTIONS INTO PATIENT ACTION THROUGH AI BEHAVIOURAL COACHING

K. Nanthakumar, R. Naranpanawa, F. Argus, E. Broadbent, M. Tawhai, G. Maso Talou

REGULATORY GAPS AND A LIFECYCLE-BASED FRAMEWORK FOR GENERAL DIGITAL TWINS UNDER THE EU MDR AND AI ACT

C. Welzel, S. Gilbert

SPINESIM: A BIOMECHANICAL DIGITAL TWIN FOR SURGERY PLANNING AND BIOMECHANICAL ANALYSIS

M. Tarquini, M. Rasouligandomani, S. T. Dukkipati, D. Kaçar, R. Assaker, L. Adam

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T. Steger-Hartmann, K. Kopanska, F. Sanz, F. Bringezu, I. Soininen

PORTAL THROMBOSIS FOLLOWING MAJOR LIVER SURGERY: THE IMPACT OF HEMODYNAMIC SHEAR

M. Garreau, A. Vlasceanu, A. Facque, G. Cardillo, A. I. Barakat, N. Golse, I. Vignon-Clementel

AGEING AS A SCAR: REDEFINING AGEING AS AN ACCUMULATION OF SMALL DAMAGES DURING LIFETIME

P.-A. Grott, M. Ousset, A. Lorsignol, L. Casteilla, P. Monsarrat, D. Peurichard, J. Paupert

DISRUPTED BRAIN DYNAMICS IN EARLY PARKINSON’S DISEASE: TOWARD DIGITAL BIOMARKERS AND BRAIN DIGITAL TWINS

D. Pischedda, M. Vitacca, F. Palesi, A. Tessitore, R. De Micco, M. Siciliano, F. Esposito, C. A. Gandini Wheeler-Kingshott, E. D'Angelo

CARDIACFOAM: TOWARDS A FRAMEWORK FOR IN-SILICO INSIGHTS INTO PIG-TO-HUMAN HEART XENOTRANSPLANTATION

S. Nieto de Castro, P. Castrillo, C. Cownay, P. Cardiff

A NOVEL ELECTROMECHANICAL MODEL OF THE MEDIAN NERVE WITH APPLICATION TO CARPAL TUNNEL SYNDROME

J. Rittelmann, O. Röhrle, C. Bleiler

NEUROANATOMY ATLAS AS A CORE FOR VIRTUAL BRAIN TWIN: SHARING THREE-DECADE-LONG EXPERIENCE

W. Nowinski

CERTAINTY: A CELLULAR IMMUNOTHERAPY VIRTUAL TWIN FOR PERSONALISED CANCER TREATMENT

M. Kreuz, U. Weirauch, M. Quaranta, A. Kremer, S. Franke, H. Fröhlich, Y. Salimi, S. Schwick, M. Merz, R. Demlova, C. Steinbeisser, K. Reiche

INTEGRATION OF SINGLE‑CELL RNA-SEQ DATA INTO VIRTUAL TWINS FOR MULTIPLE MYELOMA CAR-T CELL THERAPY

C. Kämpf, G. Popp, J. Keller, A. Scholz, N. Seeger, M. Quaranta, R. Tching, M. Merz, S. Franke, K. Reiche

I-OPADE: A MULTIMODAL BIOMARKER PLATFORM ENABLING DIGITAL TWIN-BASED PRECISION PSYCHIATRY

L. Androutsos, A. Floares, A. Zety, S. Naseer, M. Mohsin, G. Corrivetti, A. Marenna, R. Panella, C. Vecchi, F. Monao, A. Vignapiano, C. Floares, K. Palm, T. Timmusk, A. Sirp, M. Piirsalu, M. Annuk, A. Rahni, R. Maruste, H.-Y. Chiang, F. Zucchi, M. A. Isaza Ruget, C. Aristizábal Guzmán, J. Mcdouall Lombana, J. A. Castro Munoz, M. A. Palacios Ariza, E. Frigola-Capell, G. Brugues, A. Maestre, J. Serrano, R. Brugada, A. Brugada, M. Coll, L. Lopez, P. Hajduk, A. Szymanek, A. Bouwens, P. Carmellini, A. Fagiolini, M. M. ŞİMŞEK, A. Kılıç, İ. KÖSE, R. Visconti, M. Cuomo, C. Martinez Carazo, O. Ibarrola Moreno

A DATA INTEGRATION PIPELINE COMBINING FUNCTIONAL DATA ANALYSIS WITH MULTI-LAYER CORRELATION NETWORK

R. Asnaghi, A. Morabito, M. Carrara, M. Ferrario

BIOMECHANICAL EFFECT OF PERCUTANEOUS PULMONARY VALVE POSITIONING IN PATIENT-SPECIFIC MODELS

M. Arminio, D. Gallo, D. Carbonaro, R. Paz, F. Del Pin, U. Morbiducci, S. Schievano, C. Chiastra, C. Capelli

PATIENT-SPECIFIC COMPUTATIONAL FLUID DYNAMICS BEFORE AND AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION

L. Bevis, Y. Bhatti, E. Rauseo, E. Karabelas, X. Chen, R. Burns, A. Khan, S. E Petersen, C. M Augustin, A. Neic, G. Plank, C. H Roney, G. Slabaugh, A. Mathur

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B. Grossi, L. Cestariolo, C. Boccaperta Schiavetti, T. Casini, L. M. Perri, G. Stefanini, G. Condorelli, G. Luraghi, F. Migliavacca, J. F. Rodriguez Matas

IN-SILICO HEMODYNAMIC MODEL FOR THE ASSESSMENT OF MITRAL REGURGITATION QUANTIFICATION METHODS

I. Vervaeke, J. Degroote, A. Caenen, P. Segers

AN IN-SILICO STUDY ON THE IMPACT OF INDIVIDUAL GEOMETRICAL FEATURES FOR PREDICTING HEART VALVE FUNCTION

P. Yevtushenko, K. Vellguth, L. Goubergrits, M. Schafstedde

PATIENT-SPECIFIC HAEMODYNAMIC DIGITAL TWIN WITH PATHOLOGICAL VALVE DYNAMICS

A. J. Escobar, O. Chehab, T. Patterson, J. Lee

A MITRAL VALVE DIGITAL TWIN FOR SURGICAL PLANNING

M. Sacks

UNCERTAINTY AND SENSITIVITY IN VENOUS MODELLING ACROSS 0D, 3D AND STATISTICAL SHAPE FRAMEWORKS

M. Otta, K. Zając, I. Halliday, C. Lim, J. Tsui, M. Malawski, A. Narracott

TOWARDS HEPATIC DIGITAL TWINS: MULTISCALE-MULTIPHYSICS MODELING AND VALIDATION OF LIVER REGENERATION

J. Hohl, A. Ebrahem, E. Jessen, D. Schillinger

CORONARY DIGITAL TWIN GENERATION FROM ULTRA HIGH-RESOLUTION PHOTON-COUNTING CT: AN ITERATIVE APPROACH

A. Arcangeli, K. Capellini, A. Aimo, M. Emdin, M. Occhipinti, M. Muca, F. Pignatelli, A. Clemente, V. Positano, S. Celi, C. De Gori

MICROSTRUCTURE-DRIVEN IN SILICO MACHINE LEARNING MODEL FOR PHOTOACOUSTIC THROMBUS CHARACTERIZATION

H. Ghodsi, S. Kumar, B. Fereidoonnezhad, S. Iskander-Rizk

A COMPUTATIONAL MODEL OF CHEMICALLY- AND MECHANICALLY-INDUCED THROMBUS FORMATION IN CEREBRAL ANEURYSMS

G. Cardillo, P. Pouponneau, A. I. Barakat

WITHIN LIVER VASCULAR NETWORKS: QUANTIFYING THE INTERPLAY BETWEEN GEOMETRY AND TRANSPORT

J. Kowalski, L. Sala, D. Drasdo, C. Debbaut, I. Vignon-Clementel

MODELLING HAEMORRHAGE AND PHYSIOLOGICAL RESPONSE IN PENETRATING TRAUMA

A. Jayakody, V. Suresh, F. Argus

LINKING CORONARY MORPHOLOGY TO CARDIAC ALLOGRAFT VASCULOPATHY THROUGH STATISTICAL SHAPE MODELLING

B. Griffo, C. Fogarasi, M. Lodi Rizzini, A. Aldieri, D. Gallo, M. Laudato, H. Bille Andersson, J. Jurga, M. Melin, J. Nickander, D. Marlevi, U. Morbiducci

HEMODYNAMIC CHARACTERIZATION OF ATHEROSCLEROTIC CAROTID BIFURCATION

V. Quartieri, F. Harte, A. Mastrofini, E. Karlöf, U. Hedin, M. Marino, T. C. Gasser

THE POTENTIAL OF SOUND ANALYSIS FOR THE SURVEILLANCE OF HEMODIALYSIS ARTEROVENOUS FISTULAE

S. Poloni, S. Zerbi, C. Ghilardini, L. Soliveri, C. G. Condemi, A. Caroli, A. Remuzzi, M. Bozzetto

IMPROVING ONE-YEAR SURVIVAL FORECASTING IN PULMONARY ARTERIAL HYPERTENSION USING MACHINE LEARNING MODELS

N. Wang, Z. M. Goh, H. Saxton, M. Paula-Ribeiro, J. Longbottom, M. Balmus, A. Rothman, M. Wilkins, R. Wilkinson, K. Worden, D. Wagg, S. Niederer, X. Xu, R. Clayton

FAST COMPUTATIONAL FRAMEWORK FOR PATIENT-SPECIFIC TEVAR PLANNING

S. Barati, A. Stellino, G. De Campo, A. Ramella, G. Luraghi, J. F. Rodriguez Matas, I. Fulgheri, S. Trimarchi, F. Migliavacca

SYNCHROTRON PHASE-CONTRAST TOMOGRAPHY REVEALS MYOCARDIAL ORGANISATION IN FETAL AORTIC STENOSIS

L. Chestnutt, J. Brunet, H. Dejea, V. Sabarigirivasan, K. Y. C. Li, A. Bonnin, M. Olbinado, B. Bijnens, M. Jongbloed, L. Houyel, A. Crucean, P. D Lee, A. Cook

SIMSCAPE-BASED CARDIOVASCULAR MODELS FOR NEXT‑GENERATION ECMO SYSTEM DEVELOPMENT

M. Nord, V. Suomi

TOWARDS A DIGITAL TWIN FOR PERSONALIZED PREDICTION OF RADIOTHERAPY RESPONSE OF PROSTATE CANCER

B. Blanco, M. A. Vicente Pardal, H. Gomez, G. Lorenzo

A CAUSAL COMPUTATIONAL FRAMEWORK FOR DIGITAL TWINS IN BREAST CANCER RADIOTHERAPY

F. Arceci, P. Vitullo, B. Dionisi Ferrera, M. Tezzele, P. Zunino, T. Rancati

ENABLING CLINICAL PROGNOSIS OF BREAST CANCER DURING NEOADJUVANT THERAPIES

F. Lovallo, M. V. De Bonis, G. Ruocco

PBPK‑DRIVEN OPTIMIZATION OF CAR‑T DELIVERY AND EFFICACY

A. G. Hadjigeorgiou, L. L. Munn, T. Stylianopoulos, R. K. Jain

TRI-PHASIC REPROGRAMMING OF THE SPHINGOSINE-1-PHOSPHATE AXIS DRIVES OVARIAN CANCER PROGRESSION AND ANOIKIS RESISTANCE

A. S. Baskin, B. Davidson, R. Reich, T. Tavor Re'em

REALISTIC IN SILICO TUMOUR SUBSTRATES FOR DW-MRI SIMULATIONS

C. Scotti, C. Tinelli, F. Casaccio, P. Fenech, G. Baroni, L. Morelli, C. Paganelli

PATIENT-SPECIFIC IN SILICO 3D MODEL OF BRAIN METASTASIS TREATMENT IN RESPONSE TO STEREOTACTIC RADIOSURGERY

E. Ioannou, C. P. Papanikas, D. Flouri, L. Siakallis, G. Karaoli, E. Papageorgiou, M. Theodorou, V. Vavourakis

UNRESOLVED CFD-DEM MODELING OF PLATELETS DYNAMICS ACCOUNTING FOR ACCURATE PARTICLE SHAPE

F. Zucchelli, J. Latt, B. Chopard

VIRTUAL PATIENTS FOR MECHANISTIC MODEL DISCOVERY IN VASCULAR MECHANOBIOLOGY

A. Mastrofini, M. Marino

GRAPH-DERIVED MECHANOCHEMICAL SIMULATIONS CAPTURE VARIABILITY IN ATHEROSCLEROSIS PROGRESSION

A. Mastrofini, A. Tziotziou, D. Bos, A. C. Akyildiz, M. Marino

MODELLING THE TRANSPORT OF OXYGEN AND CARBON DIOXIDE IN THE HUMAN VASCULAR SYSTEM

M. Viharos, R. Wéber

FROM GLOBAL HAEMODYNAMICS TO SARCOMERE MECHANICS: AN IN-SILICO MODEL APPLIED TO DILATED CARDIOMYOPATHY

A. Kamtikar, D. Donker, L. Fresiello

A MULTI-SCALE APPROACH TO MODELING SWIRLING BLOOD FLOW IN THE LEFT HEART AND AORTA

A. Gorodkov, Y. Zharkov, E. Talyguin, I. Beglov, A. Agafonov, N. Chernykh

CFD-ABM FRAMEWORK QUANTIFIES MONOCYTE NLRP3 INFLAMMASOME ACTIVATION HOTSPOTS DRIVEN BY ARTERIAL LOW-SHEAR HEMODYNAMICS

V. V. S. V. Jakka, M. Sarkissian, Y. M. Alemu, J. Noailly

PATIENT-SPECIFIC ATRIAL MODELS CALIBRATED WITH CLINICAL LOCAL ACTIVATION MAPS FROM TRIPLE-EXTRA PACING

D. De Luis Moura, C. Celotto, S. Golmaryami, M. Termenón-Rivas, G. S Romitti, E. Silva, J. Fernandez-Armenta, J. F. Rodriguez, A. Liberos, M. Rodrigo

A GRAPH NEURAL FRAMEWORK FOR FULL-CYCLE VENTRICULAR MYOCARDIAL FINITE ELEMENT BIOMECHANICS SIMULATIONS

S. Mu, W. X. Chan, C. H. Yap

VALIDATION OF A COMPUTATIONAL MODEL FOR CARDIAC PERFUSION IN MYOCARDIAL ISCHEMIA DETECTION

V. Cusumano, R. Maragna, E. Ventura, G. Nannini, G. Pontone, C. Vergara

TOWARDS THE VALIDATION OF PATIENT-SPECIFIC LEFT ATRIAL CFD SIMULATIONS: A COMPARATIVE PIV STUDY

I. Verdirame, E. Gasparotti, E. Vignali, B. M. Fanni, S. Celi

A V&V40-ALIGNED CREDIBILITY FRAMEWORK FOR REGULATORY-GRADE LEFT ATRIAL APPENDAGE OCCLUDER IN-SILICO TRIALS

O. Camara

TOWARDS CREDIBLE ECG-BASED VENTRICULAR DIGITAL TWINS: UNCERTAINTY-AWARE LIMITS OF CONDUCTION-SUBSTRATE DETECTABILITY

J. Camps, O. Camara

AUTOMATED CREDIBILITY ASSESSMENT: A MODEL-AGNOSTIC PIPELINE APPLIED TO CARDIAC DIGITAL TWINS

S. A. Creamer, A. Sharifzadeh-Kermani, F. J. Argus, D. Zhao, M. P. Nash, D. P. Nickerson

TRANSITION-LIKELIHOOD SURROGATES FOR CALIBRATING ORGAN-ON-CHIP AND TUMOUR-ON-CHIP CELL TRAJECTORIES

F. Spill, Z. Wu, B. Cardoen, H. Lyu, J. Andrews, S. Wang

COMPUTATIONAL MODELING OF TUMOR-ON-CHIP ORGANOIDS: LINKING MECHANICS AND METABOLISM

P. Garcia-Gomez, P. Guerrero-Lopez, S. Hervas-Raluy, J. M. Garcia-Aznar

SYNCHRONIZING EXPERIMENTAL AND COMPUTATIONAL MODELS OF ENDOTHELIAL BARRIER FAILURE

Ó. Paseta, A. Martín-Contreras, A. González-Loyola, J. M. García-Aznar, M. J. Gómez-Benito

SIMULATING THE FOREIGN BODY RESPONSE WITH AN AGENT-BASED MODELING APPROACH

J. Riccio, L. Presotto, G. Chirico

COMPUTATIONAL MODELING OF PROTEIN ACCUMULATION AND MIGRATION IN THE CNS IN THE CONTEXT OF EPILEPSY

L. Ribeiro, E. Toscano, M. Lobosco, B. Quintela

MECHANICAL LOADING ORGANIZES DISTINCT REGULATORY AT-TRACTOR STATES IN NUCLEUS PULPOSUS CELLS

Z. WORKINEH, J. Noailly

AUTOMATED IMAGE-BASED RECONSTRUCTION OF 3D SUBCELLULAR STRUCTURES FOR FINITE ELEMENT MODELING

W. Li, C. Wang, F. Zhao