Veranstaltungsprogramm

Adipositas: Aktuelle therapeutische Optionen als Weg zur Reduktion des CV Risikos

Martin Merkel

Endokrinologikum Hamburg, Hamburg, Deutschland

CV Risiko bei Typ 1 Diabetes und CV Prävention

Dirk Müller-Wieland

Universitätsklinikum Aachen RWTH Aachen, Aachen, Deutschland

Inkretin-basierte Therapien

Florian Kahles

Uniklinikum Aachen, Aachen, Deutschland

Kardiovaskuläre Prävention – welche Möglichkeiten haben wir?

Jörg Haas

Köln

Elektive Bildgebung bei kardiovaskulären Hochrisikopatienten und was dann?

Felix Sebastian Nettersheim

University Hospital Cologne, Cologne, Deutschland

Ergebnisse der VESALIUS-CV Studie

Ioanna Gouni-Berthold

Universitätsklinikum Köln (AöR), Köln, Deutschland

Panel Diskussion

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ChemR23 in Macrophages: A Link Between PVAT Dysfunction and Vascular Inflammation in Atherosclerosis

Julia Schulz^1,2, Bryce Evans^2,3, Manovriti Thakur^2,3, Nico Angliker^2,3, Mark Siegrist^2,3, Emiel van der Vorst⁴, Yvonne Jansen⁵, Marc Schindewolf³, Alexander Bartelt^5,6, Drosos Kotelis¹, Yvonne Döring^2,3,5,6

1: Department of Vascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland; 2: Cardiovascular Research Cluster, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland; 3: Department of Angiology, Inselspital, Bern University Hospital, Bern, Switzerland; 4: Institute for Molecular Cardiovascular Research (IMCAR), RWTH University Hospital Aachen, Aachen, Germany; 5: Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich (LMU), Munich, Germany; 6: DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

Hepatic CRISPR/dCas9-mediated overexpression of apolipoprotein A1 and paraoxonase 1 reduces the atherosclerotic burden in apoE deficient mice

Teodora Barbalata¹, Gabriela M. Sanda¹, Laura Toma¹, Jessica I.C. Haratau¹, Elena V. Fuior¹, Madalina I. Fenyo¹, Loredan S. Niculescu¹, Shlomo Sasson², Anca V. Sima¹, Camelia S. Stancu¹

1: Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, Bucharest, Romania; 2: Department of Pharmacology, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel

Short-term senolysis mitigates obesity-driven proarrhythmic cardiac remodeling

Camila Zöhner¹, Stephan Angendohr¹, Julian Wagner², Ashley Duplessis¹, Kevin Brors¹, Sara Kreci¹, Christin Elster¹, Joleen Kirchmann¹, Susanne Pfeiler¹, Malte Kelm^1,4, Obaida Rana^1,3, Nikolaj Klöcker^3,4, Norbert Gerdes^1,3, Alexander Lang¹

1: Division of Cardiology, Pulmonology and Vascular Medicine, Düsseldorf, Germany; 2: Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany; 3: Cardiovascular Research Institute Düsseldorf, (CARID), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; 4: nstitute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany

The role of Fumarate hydratase 1 (FH1) in atherosclerosis

Jan Wrobel^1,2,3, Dennis Kagan^1,2,3, Sina Steinhofer^1,2,3, Désirée Schatton⁴, Mehrnaz Babaki³, Marie Depuydt⁵, Eva Bartok⁶, Harshal Nemade^1,2,3, Samuel Jung^1,2,3, Katharina Tinaz^1,2,3, Patrik Schelemei^1,2,3, Siting Wei^7,8, Michal Mokry^7,8, Menno de Winter⁹, Manolis Pasparakis^3,10, Martin Mollenhauer^1,2,3, Stephan Baldus^1,2,3, Christian Frezza^4,10, Holger Winkels^1,2,3

1: Uniklinik Köln, Köln, Deutschland; 2: Center of Cardiovascular Medicine (CCM ABCD) – Aachen, Bonn, Cologne, Düsseldorf; 3: Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; 4: University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany; 5: Division of Biotherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Netherlands; 6: Institute of Experimental Hematology and Transfusion Medicine Bonn, Bonn, Germany; 7: Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands.; 8: Central Diagnostics Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands; 9: Amsterdam University Medical Centers, University of Amsterdam, Experimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam, the Netherlands; 10: University of Cologne, Faculty of Mathematics and Natural Sciences, Institute for Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany

Comparison of high-sensitivity C-reactive protein and leukocyte-derived scores in prediction of cardiovascular risk in hospitalized patients

Konstantin Rex¹, Berkan Kurt¹, Anna Giacin¹, Marieke Mertens¹, Alessandra Antwerpen¹, Justus Bornemann¹, Kaan Aygar¹, Martin Reugels¹, Rutuja Salagundi¹, Susanne Just¹, Jens Spießhöfer², Andrea Milzi³, Kinan Kneizeh¹, Jörg Schröder¹, Dirk Müller-Wieland¹, Edgar Dahl⁴, Michael Lehrke¹, Nikolaus Marx¹, Florian Kahles¹

1: Department of Internal Medicine I — Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 2: Department of Internal Medicine V — Pneumology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 3: Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland; 4: RWTH cBMB at the Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Germany

GLP-1 levels predict adverse cardiovascular events in hospitalized patients with residual inflammatory risk

Berkan Kurt¹, Marieke Mertens¹, Alessandra Antwerpen¹, Konstantin Rex¹, Justus Bornemann¹, Kaan Aygar¹, Anna Giacin¹, Martin Reugels¹, Rutuja Salagundi¹, Susanne Just¹, Jens Spießhöfer², Andrea Milzi³, Kinan Kneizeh¹, Jörg Schröder¹, Dirk Müller-Wieland¹, Edgar Dahl⁴, Michael Lehrke¹, Nikolaus Marx¹, Florian Kahles¹

1: Department of Internal Medicine I — Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 2: Department of Internal Medicine V — Pneumology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 3: Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland; 4: RWTH cBMB at the Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Germany

Evolution: ApoC3-Hemmung der nächsten Generation beim Familiären Chylomikronämie-Syndrom - ein Vergleich

Ulrike Schatz

Universitätsklinikum Dresden, Dresden, Deutschland

Revolution: Bedeutung der TG-reichen Lipoproteine für das kardiovaskuläre und Pankreatitis Risiko

Ulrich Laufs

Universitätsklinikum Leipzig, Leipzig, Deutschland

Dokumentation: CareHigh TG und die Genotyp-Phänotyp-Korrelation

Winfried März

Synlab Holding Deutschland GmbH, Mannheim, Deutschland

Evaluation: Erste Erfahrungen in Deutschland

Ioanna Gouni-Berthold

Universitätsklinikum Köln (AöR), Köln, Deutschland

Hauss Award: 1-phosphatidylinositol 3-phosphate 5-kinase inhibition by Apilimod promotes an adipocytelike vascular smooth muscle cell phenotype and prevents arterial calcification

Andrea Gorgels¹, Nicolas Hense¹, Bilal Mir¹, et al. -²

1: Department of Internal Medicine I, Cardiology, University Hospital, Medical Faculty, RWTH Aachen, Aachen, Germany; 2: et al.