Veranstaltungsprogramm

MAdCAM-1-dependend intestinal leukocyte trafficking regulates metabolism and inflammation in mice with obesity

Katharina Müser¹, Nadim Tabaza¹, Maximilian Neuhaus¹, Naresh Ganesh¹, Anmol Kapoor¹, Rutuja Salgundi¹, Luis Quintana¹, Maximilian Sausen¹, Martin Reugels¹, Susanne Just¹, Dina Zelener¹, Berkan Kurt¹, Jens Spießhoefer², Angela Schippers³, Holger Winkels⁴, Norbert Wagner³, Michael Lehrke⁵, Nikolaus Marx¹, Florian Kahles¹

1: Uniklinik RWTH Aachen, Medizinische Klinik I, Aachen, Deutschland; 2: Uniklinik RWTH Aachen, Medizinische Klinik V, Aachen, Deutschland; 3: Uniklinik RWTH Aachen, Klinik für Kinder- und Jugendmedizin, Aachen, Deutschland; 4: Universitätsklinikum Köln, Medizinische Klinik III - Innere Medizin, Köln, Deutschland; 5: Kliniken Südostbayern AG Klinikum Traunstein, Kardiologie, Traunstein, Deutschland

CRISPR/dCas9 long-term transcriptional activation of apolipoprotein A1 and paraoxonase 1 in hepatocytes to ameliorate endothelial cell dysfunction

Jessica I. C. Hărătău¹, Loredan S. Niculescu¹, Elena V. Fuior¹, Anca V. Sima¹, Shlomo Sasson², Camelia S. Stancu¹, Laura Toma¹

1: Institute of Cellular Biology and Pathology “Nicolae Simionescu” of the Romanian Academy, Bucharest, Romania; 2: Institute for Drug Research, Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

Cathelicidin antimicrobial peptide limits bacterial inflammation in monocytes and endothelial cells

Michael Malysa¹, Andreas Schmid², Bernhard Schieffer¹, Karsten Grote³

1: University Hospital of Marburg, Department of Cardiology, Angiology, and Intensive Care Medicine, Germany; 2: Department of Internal Medicine III, University of Giessen, Germany; 3: Philipps-University Marburg, Germany

PACAP influences the morphology of mitochondria, as well as the migratory ability of HCASMC

Julia Brauschke, Gabriel Bonaterra, Ralf Kinscherf, Anja Schwarz

Philipps-University Marburg

Olfr2 induces lipid metabolic stress in macrophages

Yein Park^1,2, Felix Picard^1,2, Jonathan Rühlmann^1,2, Inês Mahú³, Jens Alber³, Jens Brüning³, Marco Orecchioni⁴, Martin Mollenhauer^1,2, Holger Winkels^1,2

1: University of Cologne and University Hospital Cologne, Cologne, Germany; 2: Center for Molecular Medicine Cologne, Cologne, Germany; 3: Max Planck Institute for Metabolism Research, Cologne, Germany; 4: Immunology Center of Georgia, Augusta University, Augusta, Georgia, United States

A CHIP model: Differential hypomethylation and gene expression in hiPSC-derived DNMT3A-deficient HSC and monocytes

Debora Scheuermann¹, Tsai-Sang Dederichs¹, Virginia Haacke¹, Tamara Antonela Vico¹, Alexander von Ehr^1,2, Ruba Hammad³, Jamal Alzubi³, Richard Schäfer³, Claudio Mussolino³, Toni Cathomen³, Sebastian Preissl⁴, Dirk Westermann¹, Ingo Hilgendorf^1,2

1: Universitätsklinikum Freiburg, Universitäts-Herzzentrum Freiburg-Bad Krozingen, Klinik für Kardiologie und Angiologie, Freiburg im Breisgau, Deutschland; 2: Deutsches Herzzentrum der Charité (DHZC), Campus Virchow-Klinikum, Klinik für Kardiologie, Angiologie und Intensivmedizin, Berlin, Deutschland; 3: Universitätsklinikum Freiburg, Institut für Transfusionsmedizin und Gentherapie, Freiburg im Breisgau, Deutschland; 4: Universität Freiburg, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Freiburg im Breisgau, Deutschland

A History of Periodontal Inflammation Exacerbates Experimental Aortic Aneurysm Formation

Jan Wrobel^1,2,3, Alexander Phili^1,2,3, Patrik Schelemei^1,2,3, Jasmin Rettkowski⁴, Simon Grimm^1,2,3, Nadja Klein^1,2,3, Katharina Tinaz^1,2,3, Stephan Baldus^1,2,3, Martin Mollenhauer^1,2,3, Nina Cabezas Wallscheid⁴, Holger Winkels^1,2,3

1: University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany; 2: Center of Cardiovascular Medicine (CCM ABCD) – Aachen, Bonn, Cologne, Düsseldorf; 3: Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; 4: Laboratory of Stem Cell Biology and Ageing, Department of Health Sciences and Technology, ETH Zürich, Switzerland

Lipoprotein apheresis meets the UK Biobank

Reinhard Klingel for the Pro(a)LiFe Study Group

Apherese Forschungsinstitut, Köln, Deutschland

Comparative efficacy and safety of olezarsen versus volanesorsen in familial chylomicronemia syndrome: results from a matching-adjusted indirect comparison (MAIC)

Handrean Soran¹, Elisabete Rodrigues², Erik Stroes³, Ulrike Schatz⁴, Ursula Kassner⁵, Koo Wilson⁶, Zalmai Hakimi⁶, Aletta Falk⁶, Asia Sikora Kessler⁷, Montserrat Vera Llonch⁷, Veronica J. Alexander⁷, Paul Serafini⁸, Divya Pushkarna⁸

1: NIHR/Welcome Trust Clinical Research Facility and Manchester University Hospital NHS Foundation Trust, Manchester, UK; 2: Department of Endocrinology, ULS Sao Joao, Faculty of Medicine, the University of Porto (FMUP), Porto, Portugal; 3: Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, Netherlands; 4: Department of internal medicine III of the University Hospital Dresden, Technical University of Dresden, Dresden, Germany; 5: Department of Endocrinology, Division of Lipid Disorders, Berlin, Germany; 6: Sobi, Stockholm, Sweden; 7: Ionis Pharmaceuticals Inc., Carlsbad, California, USA; 8: Evidinno Outcomes Research Inc., Vancouver, BC, Canada

Preventing pancreatitis in severe hypertriglyceridemia: clinical response to olezarsen, an LPL-independent triglyceride-lowering therapy

Laura Volpi¹, Knut Mai^1,2,3,4, Thomas Bobbert¹, Ursula Kassner¹

1: Charité–Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Endocrinology and Metabolism; European Reference Network on Rare Endocrine Diseases (ENDO-ERN), 10117 Berlin, Germany; 2: German Center for Diabetes Research (DZD), München-Neuherberg, Germany; 3: DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany; 4: Department of Human Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany

Circulating GLP-2 levels predict cardiovascular death in hospitalized patients with atherosclerotic cardiovascular disease

Alessandra Antwerpen¹, Berkan Kurt¹, Marieke Mertens¹, Anna Giacin¹, Konstantin Rex¹, Kaan Aygar¹, Justus Bornemann¹, Martin Reugels¹, Rutuja Salagundi¹, Susanne Just¹, Jens Spießhöfer², Andrea Milzi³, Kinan Kneizeh¹, Jörg Schröder¹, Dirk Müller-Wieland¹, Edgar Dahl⁴, Michael Lehrke¹, Nikolaus Marx¹, Florian Kahles¹

1: Department of Internal Medicine I — Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 2: Department of Internal Medicine V — Pneumology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; 3: Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland; 4: RWTH cBMB at the Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Germany

SHASTA-5 Rationale and Design: Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Plozasiran Efficacy For Reduction of Pancreatitis Risk

Patrick Moriarty¹, Christie Ballantyne², Stefano Romeo³, Ran Fu⁴, Jennifer Hellawell⁴, Julia Mader⁵, Daniel Gaudet⁶

1: University of Kansas Medical Center Research Institute, Inc., Kansas City, Kansas, USA; 2: Baylor College of Medicine and the Texas Heart Institute, Houston, Texas, USA; 3: Sahlgrenska Universitetssjukhuset, Goteborg, Sweden; 4: Arrowhead Pharmaceuticals, Pasadena, CA, USA; 5: Medical University of Graz, Graz, Austria; 6: Université de Montréal and ECOGENE 21, Montréal, Québec, Canada

Analysis of CD40-CD40L plasma levels and potentially associated signaling molecules in diabetic and non-diabetic patients following acute myocardial infarction

Robert Gödecke, Susanne Pfeiler, Christian Jung, Alexander Lang, Norbert Gerdes

Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

CKD increases cardiac dysfunction, inflammation and metabolic alterations after myocardial infarction

Corinna Schulte¹, Sina Hourtz¹, Julia Wollenhaupt¹, Julia Möllmann², Michael Kohlhaas³, Emiel van der Vorst¹, Vera Jankowski¹, Christoph Maack³, Nikolaus Marx², Heidi Noels¹

1: Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Germany; 2: Department of Internal Medicine I, Cardiology, University Hospital RWTH Aachen, Germany; 3: Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg

Increased CCL15 chemokine associated with disease progression and cardiovascular risk in chronic kidney disease

Xinglin Chu¹, Thimoteus Speer², Carolin V. Schneider³, Sina Hourtz¹, Claudia Goettsch⁵, Sikander Hayat⁴, Heidi Noels¹

1: Institute for Molecular Cardiovascular Research (IMCAR), RWTH University Hospital Aachen, Aachen, Germany; 2: Department of Internal Medicine IV, Goethe University Frankfurt, Frankfurt am Main, Germany; 3: Department for Gastroenterology, Metabolic Disorders and Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany; 4: Department of Internal Medicine II, Uniklinik RWTH Aachen, Aachen, Germany; 5: Institute of Physiology, Technical University Dresden, Germany

Establishment and characterization of a murine model of mitral valve insufficiency

Per Arkenberg, Moritz Banzhaf, Conradin Willers, Suchitra Narayan, Holger Winkels, Tom Riffelmacher, Stephan Baldus, Martin Mollenhauer

Universitätsklinik Köln, Köln, Deutschland

Myocardial infarction accelerates tumor growth of chronic lymphocytic leukemia

Florian Zimmermann¹, Kristel Martinez Lagunas¹, David Peters¹, Katharina Tinaz¹, Wiebke Kreuzberg¹, Stuart Blakemore^2,3,4, Phuong-Hien Nguyen^2,3,4, Thomas Riffelmacher¹, Christian Pallasch^2,3,4, Stephan Baldus^1,4, Holger Winkels^1,4

1: Clinic III for Internal Medicine, Heart center, University Hospital Cologne; 2: Department I of Internal Medicine, University Hospital Cologne; 3: Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), Cologne; 4: Center for molecular medicine (CMMC), Cologne

Myocardial infarction accelerates melanoma growth in mice

David Peters¹, Kristel Martinez-Lagunas¹, Florian Zimmermann¹, Wiebke Kreuzberg¹, Katharina Tinaz¹, Jan Wrobel¹, Franziska Schneppenheim², Tobias Bald², Tom Riffelmacher¹, Stephan Baldus^1,3, Holger Winkels^1,3

1: Clinic III for Internal Medicine, Heart Center of the University of Cologne, Cologne; 2: Institute for Experimental Oncology, University Hospital Bonn, Bonn; 3: CMMC, Center for Molecular Medicine Cologne

Myocardial infarction promotes neutrophil-like monocyte expansion in the bone marrow via interleukin-6 signaling

Aldo Moggio¹, Xinghai Li¹, Giuseppe Mocci², Andrea Elisabeth Köthe¹, Heribert Schunkert¹, Thorsten Kessler¹, Hendrik B. Sager¹

1: TUM Klinikum Deutsches Herzzentrum, Munich, Germany; 2: Karolinska Institutet, Department of Medicine, Huddinge, Sweden

The pharmacological inhibition of matrix metalloproteinase 13 for the targeted treatment of abdominal aortic aneurysm

Per Arkenberg, Marie Schwarz, Philipp Barnowski, Gerhard Sengle, Holger Winkels, Tom Riffelmacher, Stephan Baldus, Martin Mollenhauer

Universitätsklinik Köln, Köln, Deutschland

VEGFA/VEGFR2 axis regulates the crosstalk between senescent vascular smooth muscle cells and intraplaque neovessels in atherosclerosis

Clara Rossi^1,4, Reginald V.C.T van der Kwast^2,3, Yvonne Jansen⁴, Margreet R. de Vries⁵, Johan Duchene^3,4, Christian Weber^3,4,6,7, Alberto Corsini¹, Stefano Bellosta¹, Laura Parma^3,4

1: Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, University of Milan, Milan, Italy; 2: Institute of Pharmacology and Toxicology, Technical University of Munich (TUM), Munich, Germany; 3: German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Germany; 4: Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University, Munich, Germany; 5: Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands; 6: Cardiovascular Research Institute Maastricht, University of Maastricht, P. Debeyelaan, 6229HX Maastricht, the Netherlands; 7: Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

Deciphering pathophysiological roles of long non-coding RNAs MIAT and MEG3 in aortic disease

Annisa Mardianing Utami¹, Philip Roger Goody¹, Kerstin Wilhelm-Jüngling², Norbert Gerdes³, Sebastian Zimmer¹, Farhad Bakhtiary⁴, Georg Nickenig¹, Mohammed Rabiul Hosen¹

1: Department of Cardiology, Internal Medicine II, University Hospital Bonn; 2: Endothelial Signaling and Metabolism, Institute for Cardiovascular Sciences, University Hospital Bonn; 3: Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital Düsseldorf; 4: Department of Cardiac Surgery, Heart Center Bonn, University Hospital Bonn

“Wild-Athero”: Generation of an Apoe-/- mouse model with a natural microbiome to improve modeling of human immune responses in experimental atherosclerosis

Mark Colin Gissler¹, Simon Heitlinger¹, Xin Gu¹, Juana Dominguez¹, Timothy Mwinyella¹, Xiaowei Li¹, Tijani Abogunloko¹, Timoteo Marchini¹, Natalie Hoppe¹, Alexander Maier¹, Stanley Hazen², Stephan Rosshart³, Dirk Westermann¹, Dennis Wolf¹

1: Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, University Hospital Freiburg, Germany; 2: Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland, USA; 3: Department of Microbiome Research University Hospital Erlangen, Germany

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

Harshal Nemade¹, Dennis Mehrkens¹, Hannah Sophia Lottermoser¹, Zeynep Ece Yilmaz¹, Julian Mader¹, Patrik Schelemei¹, Holger Winkels¹, Stefan Baldus¹, Manolis Pasparakis², Matti Adam¹, Martin Mollenhauer¹

1: University Hospital of Cologne, Cologne, Germany; 2: Center for Molecular Medicine Cologne (CMMC), Cologne, Germany

T cell dynamics in elastase-induced abdominal aortic aneurysm formation and progression using single cell RNA-sequencing

Christin Elster¹, Alexander Lang¹, Susanne Pfeiler¹, Camila Zöhner¹, Malte Kelm^1,3, Marie Rüthing², Jasper Spitzer², Susanne V. Schmidt², Norbert Gerdes^1,3

1: Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; 2: Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Germany; 3: Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Physical Activity and its impact on immunity in CVD

Raphael Rottenkolber^1,2, Svenja Rapelius^1,2, Shriyam Bhardwaz², Aldo Moggio², Ulrike Meyer-Lindemann^1,2, Xinghai Li², Heribert Schunkert^1,2, Hendrik Sager^1,2

1: Department of Cardiology, German Heart Centre Munich, TUM School of Medicine and Health, Technical University Munich, Munich, Germany; 2: DZHK (German Centre for Cardiovascular Research), partner site Munich, Germany