Veranstaltungsprogramm

C-reactive protein and cardiovascular risk in 454,203 individuals without ASCVD

Berkan Kurt¹, Martin Reugels¹, Kai Markus Schneider², Andrea Milzi¹, Alessandra Antwerpen¹, Konstantin Rex¹, Kaan Aygar¹, Justus Bornemann¹, Naresh Ganesh¹, Anna Giacin¹, Susanne Just¹, Anmol Kapoor¹, Marieke Mertens¹, Katharina Müser¹, Maximilian Neuhaus¹, Luis Quintana¹, Rutuja Salagundi¹, Maximilian Sausen¹, Nadim Tabaza¹, Alexander Gombert³, Michael Lehrke¹, Nikolaus Marx¹, Carolin Victoria Schneider², Florian Kahles¹

¹Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin (Medizinische Klinik I), Uniklinik RWTH Aachen, Aachen, Deutschland; ²Klinik für Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin (Medizinische Klinik III), Uniklinik RWTH Aachen, Aachen, Deutschland; ³Klinik für Gefäßchirurgie, Uniklinik RWTH Aachen, Aachen, Deutschland

Characterizing the leukocyte diversity of the arterial vasculature in healthy mice by nuclear and single-cell RNA sequencing

Anton Christian Alexander, Timoteo Marchini, Xiaowei Li, Mark Colin Gissler, Dirk Westermann, Dennis Wolf, - et al

University Hospital Freiburg, Freiburg im Breisgau, Deutschland

CKD triggers enhanced cardiac dysfunction, inflammation and metabolic alterations after myocardial infarction

Corinna Schulte¹, Sina Hourtz¹, Wollenhaupt Julia¹, Möllmann Julia², Kohlhaas Michael³, Jankowski Vera¹, Boor Peter⁴, Maack Christoph³, Marx Nikolaus², Noels Heidi¹

¹Institute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, Germany; ²Department of Internal Medicine I, Cardiology, Uniklinik RWTH Aachen, Aachen, Germany; ³Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Germany; ⁴Institute of Pathology, Uniklinik RWTH Aachen, Aachen, Germany

Comparative Effects of Nano/Microparticles on NF-κB Activation: Implications for Inflammation Beyond Microplastics

Hannes Schiebisch, Michael Malysa, Bernhard Schieffer, Karsten Grote

Cardiology and Angiology, Philipps-University Marburg, Germany

Effect of Myocardial Infarction on the immune response in the melanoma tumor immune microenvironment

Kristel Martinez Lagunas¹, Wiebke Kreuzberg¹, Katharina Tinaz¹, Felix Picard¹, Franziska Schneppenheim³, Tobias Bald³, Stephan Baldus¹, Holger Winkels^1,2

¹Department III of Internal Medicine, Heart Center, University Hospital, University of Cologne, Cologne, Germany; ²Center for Molecular Medicine Cologne, Cologne, Germany; ³Institute of Experimental Oncology, University of Bonn, Bonn, Germany

Exposure to dietary α-amylase-trypsin inhibitors (ATI) induces vascular inflammation and endothelial dysfunction

Simon Lange¹, Karin Keppeler¹, Aline Pesi², Manjusha Neerukonda², Henning Ubbens¹, Lea Strohm¹, Ivana Kuntic¹, Marin Kuntic¹, Alexandra Rosenberger¹, Detlef Schuppan², Philipp Lurz¹, Andreas Daiber¹, David Leistner³, Sebastian Steven³

¹Laboratory for Molecular Cardiology, University Hospital Mainz, Germany; ²Institute of Translational Immunology, University Hospital Mainz, Germany; ³Department of Medicine, Cardiology, Goethe University Hospital, Frankfurt, Germany

Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after stroke

Vikramjeet Singh¹, Ali Ata Tuz¹, Nils Hoerenbaum¹, Özgür Ulusoy¹, Adel Ahmadi¹, Alana Gerlach¹, Alexander Beer¹, Andreas Kraus¹, Anja Hasenberg¹, Nina Hagemann³, Dirk M Hermann³, Matthias Gunzer^1,2

¹Institute of Experimental Immunology and Imaging, University of Duisburg-Essen, Essen, Germany; ²Leibniz-Institut für Analytische Wissenschaften - ISAS -e.V., Dortmund, Germany; ³Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Inhibition of B cell activation by Ibrutinib improves cardiac function in experimental myocardial infarction in mice

Xiaowei Li, Timoteo Marchini, Hauke Horstmann, Lucia Mitre, Timothy Mwinyella, Simon Heitlinger, Scheu-Tijiani Abogunloko, Dirk Westmann, Dennis Wolf

University Heart Centre Freiburg-Bad Krozingen, Medical Centre, University of Freiburg, Germany

Kynurenine predicts outcome in pulmonary infections with a link to cardiac dysfunction

Andreas Pütz¹, Martin Berger¹, Victoria Michalczyk¹, Philipp Thissen¹, Maren Gesper¹, Jens Spiesshoefer², Philipp Hohlstein³, Alexander Koch³, Henriette de Loor⁴, Alexander Kersten¹, Marlo Verket¹, Edgar Dahl⁵, Andreas Napp¹, Matthias Rau¹, Michael Dreher², Björn Meijers⁴, Nikolaus Marx¹, Ben Arpad Kappel¹

¹Uniklinik RWTH Aachen, Medizinische Klinik 1, Aachen, Deutschland; ²Uniklinik RWTH Aachen, Medizinische Klinik 5, Aachen, Deutschland; ³Uniklinik RWTH Aachen, Medizinische Klinik 3, Aachen, Deutschland; ⁴Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; ⁵Uniklinik RWTH Aachen, Institut für Pathologie, RWTH centralized Biomaterial Bank, Aachen, Deutschland

Ligature-induced Periodontitis Alters Hematopoiesis and Aggravates Atherosclerotic Plaque Formation in Mice

Samuel Jung^1,2,3, Henning Guthoff^1,2, Sina Steinhofer^1,2,3, Katharina Tinaz^1,2,3, Simon Grimm^1,2,3, Anton Windfelder⁵, Matti Adam^1,2,3, Stephan Baldus^1,2,3, Marc Driessen⁴, Anna Greta Barbe⁴, Sonja Henny Maria Derman⁴, Holger Winkels^1,2,3, Martin Mollenhauer^1,2,3, Jan Wrobel^1,2,3

¹University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany; ²Center of Cardiovascular Medicine (CCM ABCD) – Aachen, Bonn, Cologne, Düsseldorf; ³Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ⁴Polyclinic for Operative Dentistry and Periodontology, Faculty of Medicine and University Hospital Cologne; ⁵Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Gießen

Liver fat content predicts cardiovascular events in 39,953 individuals without ASCVD

Martin Reugels¹, Berkan Kurt¹, Kai Markus Schneider^2,3, Nikolaus Marx¹, Carlin Victoria Schneider^2,4, Florian Kahles¹

¹Department of Internal Medicine I – Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH Aachen, Germany; ²Department of Medicine III – Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Germany; ³Medical Department 1, Technische Universität Dresden, Germany; ⁴The Institute for Translational Medicine and Therapeutics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

Mex3a protects against atherosclerosis: evidence from mice and humans.

James Henderson^1,2, Donato Santovito^1,2,3

¹Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität, Munich, Germany; ²German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Germany; ³Institute for Genetic and Biomedical Research, Unit of Milan, National Research Council, Italy

Neutrophils Extracellular Traps Myeloperoxidase and Elastase Predict Cerebral Vasospasms after Aneurysmal Subarachnoid Hemorrhage

Saba Sajjad¹, Michael Hewera², Majeed Rana¹, Michael Gliem³, Igor Fischer², Dilaware Khan²

¹Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Düsseldorf, Germany; ²Medical Faculty and University Hospital Düsseldorf, Düsseldorf, Deutschland; ³Department of Neurology, University Hospital Düsseldorf, Düsseldorf, Germany

Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Changjun Yin^1,2

¹The first affiliated Hospital of Sun Yat Sen University; ²Institute for cardiovascular prevention, LMU, Munich

Product problems of in vitro diagnostics for differential diagnostics of myocardial infarction and pulmonary embolism – Analysis of field safety notes published by BfArM between 2014 and 2023

Rüdiger Siekmeier¹, Angela Patricia Moissl², Winfried März³

¹Pharmazeutisches Institut Universität Bonn, Bonn, Deutschland; ²Institut für Ernährungswissenschaften, Friedrich-Schiller-Universität Jena; ³Synlab Akademie, Mannheim

Role of complement in adhering platelets and immune cells to endothelium of various organs

Serena Gregori¹, Manuela Sauter¹, Sonja Ebenhöch², Frederic Emschermann², Harald Langer¹, Daniel Dürschmied¹

¹UMM, Mannheim, Deutschland; ²Eberhard Karls Universität Tübingen

Senolytic Therapy Reduces IL-6-Mediated Inflammation in the Diabetic Heart

Alexander Lang¹, Ashley-Jane Duplessis¹, Camila Zöhner¹, Diana Klees¹, Stephan Angendohr¹, Maria Grandoch², Dennis Sohn³, Malte Kelm¹, Norbert Gerdes¹

¹1Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; ²Institute for Translational Pharmacology, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; ³Molecular Radiooncology Clinic for Radiation Therapy and Radiooncology, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany

Senolytics restore diabetes-induced aortic dysfunction in DIO mice

Camila Zöhner¹, Diana Klees¹, Ashley Duplessis¹, Antonia Chira¹, Vithya Yogathasan¹, Isabella Solga-Kamp¹, Lina Hofer¹, Ramesh Chennupati¹, Julia Duvenbeck¹, Maria Grandoch^2,3, Elvira Weber⁴, Hug Aubin⁴, Malte Kelm^2,3, Norbert Gerdes^1,3, Alexander Lang¹

¹Division of Cardiology, Pulmonology and Vascular Medicine, Düsseldorf, Deutschland; ²Institute for Translational Pharmacology, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; ³Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; ⁴Division of Cardiac Surgery, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Düsseldorf, Germany

Sex-related differences of cardiovascular health in a murine model of celiac disease

Simon Lange¹, Karin Keppeler¹, Aline Pesi², Manjusha Neerukonda², Henning Ubbens¹, Lea Strohm¹, Ivana Kuntic¹, Marin Kuntic¹, Alexandra Rosenberger¹, Detlef Schuppan², Philipp Lurz¹, Andreas Daiber¹, David Leistner³, Sebastian Steven³

¹Laboratory for Molecular Cardiology, University Hospital Mainz, Germany; ²Institute of Translational Immunology, University Hospital Mainz, Germany; ³Department of Medicine, Cardiology, Goethe University Hospital, Frankfurt, Germany

T regulatory cells (Tregs) lose their protective phenotype in patients with coronary artery disease (CAD)

Timoteo Marchini, Ana-Sophia Burkard, Sophie Hansen, Sheu-Tijani Olawale Abogunloko, Mark Colin Gissler, Dirk Westermann, Dennis Wolf

Universitätsklinikum Freiburg, Freiburg, Germany

The Effects of Fasting on Leukocyte Trafficking in Organ Crosstalk

Naresh Ganesh¹, Sikander Hayat², Anne Babler², Maximilian Neuhaus¹, Nadim Tabaza¹, Luis Quintana¹, Maximilian Sausen¹, Rutuja Salagundi¹, Katharina Mueser¹, Anmol Kapoor¹, Susanne Just¹, Maria C. Arrivas¹, Berkan Kurt¹, Jens Spiesshoefer³, Michael Lehrke¹, Jochen Dutzmann⁴, Daniel Sedding⁴, Nikolaus Marx¹, Rafael Kramann², Florian Kahles¹

¹Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin (Medizinische Klinik I), Uniklinik RWTH Aachen, Aachen, Deutschland; ²Klinik für Nieren- und Hochdruckkrankheiten, Rheumatologische und Immunologische Erkrankungen (Medizinische Klinik II), Uniklinik RWTH Aachen, Aachen, Deutschland; ³Klinik für Pneumologie und Internistische Intensivmedizin (Medizinische Klinik V), Uniklinik RWTH Aachen, Aachen, Deutschland; ⁴Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum Halle (Saale), Halle (Saale), Deustchland

The human early atherosclerotic lesion: Insights from Technovit® embedding and integrative imaging

Tipack Ayothyapattanam Shanmugam¹, Annemarie Witz¹, Julia Theil¹, Meng Dong¹, Michael Torzewski²

¹Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany; ²Department of Laboratory Medicine and Hospital Hygiene, Robert-Bosch-Hospital, 70376 Stuttgart, Germany

The Role of Enzymatically Modified LDL (eLDL) and Angiopoietin-like Protein 4 (ANGPTL4) in Aortic Valve Stenosis

Annemarie Witz¹, Tipack Ayothyapattanam Shanmugam¹, Nora Goebel², Bartosz Rylski², Michael Torzewski³

¹Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP), Stuttgart, Deutschland; ²Department of Cardiovascular Surgery, Robert-Bosch-Hospital, 70376 Stuttgart, Germany; ³Department of Laboratory Medicine and Hospital Hygiene, Robert-Bosch-Hospital, 70376 Stuttgart, Germany

The role of Fumarate hydratase 1 (Fh1) in foam cell formation

Jan Wrobel^1,2,3, Sina Steinhofer^1,2,3, Désirée Schatton⁴, Mehrnaz Babaki³, Samuel Jung^1,2,3, Katharina Tinaz^1,2,3, Patrik Schelemei^1,2,3, Felix Picard^1,2,3, Christian Frezza^4,5, Stephan Baldus^1,2,3, Holger Winkels^1,2,3

¹University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany; ²Center of Cardiovascular Medicine (CCM ABCD) – Aachen, Bonn, Cologne, Düsseldorf; ³Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ⁴University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany; ⁵University of Cologne, Faculty of Mathematics and Natural Sciences, Institute of Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany

Unraveling T regulatory cell instability and protective immunity loss in murine atherosclerosis

Sheu-Tijani Olawale Abogunloko, Timoteo Marchini, Timothy Myinwella, Fabienne Ehret, Simon Hiltenger, Juana Dominguez, Xiaowei Li, Mark Colin Gissler, Dirk Westermann, Dennis Wolf

Vascular Immunology lab, Department of Cardiology and Angiology, University Heart Centre Freiburg-Bad Krozingen, Freiburg, Germany.

Lipoprotein (a) and Incident Coronary Heart Disease in the Community: Impact of Traditional Cardiovascular Risk Factors

Natalie Arnold, al et

UKE, Hamburg, Hamburg, Deutschland

Assessing the role of olfactory receptor 2 in a diet-induced obesity animal model

Yein Park

University Hospital Cologne, Cologne, Deutschland