Veranstaltungsprogramm

Longitudinal Assessment of Sub-clinical Arterial Inflammation in Patients Receiving Immune-Checkpoint Inhibitors by Sequential [18F]FDG PET Scans

Niklas Hempfling, Lucas Bacmeister, Dennis Wolf, Christian Goetz, Dirk Westermann

Uniklinik Freiburg, Freiburg, Germany

Hyperinsulinemia promotes atherosclerosis by inducing metabolic reprogramming of autoreactive CD4+ T cells

Felix Sebastian Nettersheim^1,2, Marco Orecchioni^1,3, Payel Roy^1,3, Monica Billitti^1,3, Thomas Riffelmacher¹, Mohammad Oliaeimotlagh³, Simon Brunel¹, Qingkang Lyu³, Sujit S. Armstrong¹, Yuko Tada¹, Martina Zoccheddu³, Fabrizio Drago^4,5, Coleen A McNamara^4,5,6, Chris A Benedict¹, Klaus Ley^1,3

¹La Jolla Institute for Immunology, La Jolla, CA, USA; ²Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; ³Immunology Center of Georgia (IMMCG), Augusta University, Augusta, GA, USA; ⁴Carter Immunology Center, University of Virginia, Charlottesville, VA, United States; ⁵Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States; ⁶Division of Cardiovascular Medicine/Department of Medicine, University of Virginia, Charlottesville, VA, United States

Adenosine deaminase acting on RNA-2 (ADAR2) controls atherosclerosis progression in mice and humans

Michael Amponsah-Offeh¹, Simon Tual-Chalot², Georgios Georgiopoulos³, Kimon Stamatelopoulos³, Konstantinos Stellos¹

¹Department of Cardiovascular Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; ²Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.; ³Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Bidirectional crosstalk between macrophages and the heart: drivers of function and dysfunction post-injury.

Tamara Antonela Vico¹, Virginia Haacke¹, Bianca Dufner¹, Stefanie Perez Feliz², Christoph Koentges³, Tsai-Sang Dederichs¹, Alexander von Ehr¹, Sebastian Preißl⁴, Dirk Westermann¹, Ingo Hilgendorf¹

¹Universitätsklinikum Freiburg, Freiburg, Germany; ²Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Germany; ³Institute for Disease Modelling and Targeted Medicine (IMITATE), University Clinic Freiburg, Germany; ⁴Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany

Intestinal leukocytes regulate cardiac remodeling after myocardial infarction

Nadim Tabaza¹, Rutuja Salagundi¹, Maximilian Neuhaus¹, Naresh Ganesh¹, Anmol Kapoor¹, Luis Quintana¹, Maximilian Sausen¹, Martin Reugels¹, Katharina Müser¹, Maria C. Arrivas¹, Susanne Just¹, Berkan Kurt¹, Jens Spießhoefer², Kai Markus Schneider³, Angela Schippers⁴, Holger Winkels⁵, Norbert Wagner⁴, Michael Lehrke¹, Carolin V. Schneider³, Nikolaus Marx¹, Florian Kahles¹

¹Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin (Medizinische Klinik I), Uniklinik RWTH Aachen, Aachen, Deutschland; ²Klinik für Pneumologie und Internistische Intensivmedizin (Medizinische Klinik V), Uniklinik RWTH Aachen, Aachen, Deutschland; ³Klinik für Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin (Medizinische Klinik III), Uniklinik RWTH Aachen, Aachen, Deutschland; ⁴Klinik für Kinder- und Jugendmedizin, Uniklinik RWTH Aachen, Aachen, Deutschland; ⁵Department III of Internal Medicine, Heart Center, University Hospital of Cologne

Accumulation of gut-derived metabolite phenylacetylglutamine in chronic kidney disease promotes cardiac remodeling and is associated with cardiovascular and overall mortality

Maren Gesper¹, Andreas Pütz¹, Ward Zadora², Martin Berger¹, Henriette de Loor², Kirsten Thiele¹, Philipp Thissen¹, Andreas Napp¹, Matthias Rau¹, Edgar Dahl¹, Chao-Chung Kuo⁴, Julia Franzen⁴, Katharina Marx-Schütt¹, Nikolaus Marx¹, Björn Meijers^2,3, Ben A. Kappel¹

¹Uniklinik RWTH Aachen, Department of Cardiology, Angiology and Critical Care (Medical Clinic 1), Aachen, Germany; ²Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; ³Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium; ⁴Uniklinik RWTH Aachen, Interdisciplinary Center for Clinical Research (IZKF) Genomics Facility, Aachen, Germany

Characterization of IFNIC macrophages as potential therapeutic target in experimental aneurysm using scRNA- and CITE-sequencing

Christin Elster¹, Alexander Lang¹, Noura Kharrat¹, Miriam Ommer-Bläsius¹, Marius Böttenberg¹, Susanne Pfeiler¹, Tobias Lautwein², Holger Winkels³, Malte Kelm¹, Susanne V. Schmidt⁴, Norbert Gerdes¹

¹Division for Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; ²Genomics and Transcriptomics Laboratory, Biologisch-Medizinisches-Forschungszentrum (BMFZ), Heinrich-Heine University Düsseldorf, Germany; ³Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; ⁴Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany