Veranstaltungsprogramm

B cell immunity in atherosclerosis

Christoph Binder

Medical University of Vienna, Austria

Understand Genetics – Nomenklatur und neue Gene bei schwerer HTG

Winfried März

Synlab Holding Deutschland GmbH, Mannheim

Save the Pancreas – interdisziplinäres Management von HTG-Pankreatitiden

Ahmed Madisch

Centrum Gastroenterologie Bethanien, Frankfurt a.M.

Prevent Pancreatitis – aus der Sicht des Lipidologen

Ulrich Laufs

Universitätsklinikum Leipzig

Phänotypologie und Klassifizierungsscores

Oliver Weingärtner

Universitätsklinikum Jena

Polygenic risk score - pro (therapieweisend)

Winfried März

Synlab Holding Deutschland GmbH, Mannheim

Polygenic risk score - against (noch ein weiterer score?)

Wolfgang Koenig

Deutsches Herzzentrum München

CV and Gut

Arash Haghikia

Charite Universitätsmedizin Berlin

Kidney and CV

Claudia Göttsch

Universitätsklinikum Aachen, Deutschland

Deciphering the role of the liver as a driver of cardiovascular diseases

Carolin Schneider

Universitätsklinikum Aachen - RWTH Aachen

Lp(a) in der kardiovask. Risikostratifizierung …in der Klinik

Ulrike Schatz

Universitätsklinikum Dresden

Lp(a) in der kardiovask. Risikostratifizierung …in der Niederlassung

Jens Ringel

DIAMEDIKUM Potsdam

Intervallfasten und Herzinsuffizienz

Jochen Dutzmann

Universitätsklinikum Halle (Saale)

Sport, aber wie(viel)?

Ulrich Laufs

Universitätsklinikum Leipzig

Ess‘ ich‘s oder lass ich‘s lieber sein?

Stefan Lorkowski

Friedrich-Schiller-Universität Jena

Chronic colitis reprograms bone marrow myeloid progenitors thereby accelerating atherosclerosis

Maria Grandoch

Institut für Translationale Pharmakologie, Düsseldorf

Olfactory receptors in CVD

Holger Winkels

Universität zu Köln

Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

Yvonne Döring

Universitätsspital Bern, Schweiz

Activation of the GLP-1 receptor reduces systemic inflammation in acute and chronic disease models

Luis Berkan Quintana Selek, Maximilian Sausen, Nadim Tabaza, Naresh Ganesh, Maximilian Neuhaus, Robert Mertens, Paul Idel, Susanne Just, Maria C. Arrivas, Julia Möllmann, Nikolaus Marx, Michael Lehrke, Florian Kahles

Uniklinik RWTH Aachen, Aachen, Deutschland

Changes in macrophage transcriptome in response to cardiac injuries are determined by the type of lesion rather than their ontogenetic nature

Carolin Ehlert, Tamara Vico, Guusje Witte, Meret Taglinger, Alexander von Ehr, Dirk Westermann, Ingo Hilgendorf

Universitätsklinikum Freiburg, Freiburg, Deutschland

Clonal hematopoiesis of indeterminate potential (CHIP) affects cardiovascular disease severity via pro-inflammatory myeloid cells without increased plaque-side accumulation

Tsai-Sang Dederichs¹, Carolin Ehlert¹, Assel Yerdenova¹, Hauke Horstmann¹, Tamara Vico¹, Simone Nübling⁶, Remy Peyronnet⁶, Heiko Becker², Dietmar Pfeifer², Christoph Niemoeller², Nathaly Anto-Michel³, Andreas Zirlik³, Christoph Bode¹, Dennis Wolf¹, Constantin von zur Mühlen¹, Klaus Kaier⁴, Sebastian Preissl⁵, Timo Heidt¹, Dirk Westermann¹, Ingo Hilgendorf¹

1: Department of Cardiology and Angiology I, University of Freiburg, Germany; 2: Department of Internal Medicine I, Faculty of Medicine, Medical Center, University of Freiburg, Germany; 3: Department of Cardiology, University Hospital Graz, Austria; 4: Center of Big Data Analysis in Cardiology (CeBAC), Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Germany; 5: Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany; 6: Institute of Experimental Cardiovascular Medicine, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Germany

Exposure to dietary α-amylase-trypsin inhibitors (ATI) induces vascular inflammation and endothelial dysfunction

Simon Lange¹, Karin Keppeler¹, Aline Pesi², Manjusha Neerukonda², Henning Ubbens¹, Lea Strohm¹, Ivana Kuntic¹, Marin Kuntic¹, Alexandra Rosenberger¹, Detlef Schuppan², Philipp Lurz¹, Andreas Daiber¹, David Leistner³, Sebastian Steven^1,3

1: Laboratory for Molecular Cardiology, University Hospital Mainz, Germany; 2: Institut for Translational Immunology, University Hospital Mainz, Germany; 3: Department of Cardiology, Goethe University Frankfurt am Main, Germany

Follow – up in specialized lipid clinics optimizes lipid – lowering therapies in patients with ST – elevation myocardial infarction: a two – year follow – up of “Jena auf Ziel”

Franz Härtel¹, Jens-Arndt Geiling¹, Umidakhon Makhmudova², Sylvia Otto¹, P.Christian Schulze¹, Oliver Weingärtner¹

1: Klinik für Innere Medizin I, Jena, Deutschland; 2: Klinik für Kardiologie, Angiologie und Intensivmedizin, Charité, Berlin, Deutschland

Inhibition of B cell activation by Ibrutinib improves cardiac function in experimental myocardial infarction in mice

Xiaowei Li, Timoteo Marchini, Timothy Mwinyella, Simon Heitlinger, Sheu-Tijani Olawale Abogunloko, Dirk Westmann, Dennis Wolf

1University Heart Centre Freiburg-Bad Krozingen, Medical Centre, University of Freiburg, Germany

Intensive lipid – lowering therapy is highly cost effective in patients with ST – elevation myocardial infarction: a two – year follow – up of “Jena auf Ziel”

Franz Härtel¹, Jens - Arndt Geiling¹, Umidakhon Makhmudova², Thomas Kraeplin¹, Sylvia Otto¹, Winfried Maerz³, P. Christian Schulze¹, Oliver Weingärtner¹

1: Klinik für Innere Medizin I, Jena, Deutschland; 2: Klinik für Kardiologie, Angiologie und Intensivmedizin, Charité, Berlin, Deutschland; 3: SYNLAB Holding Deutschland GmbH, Augsburg, Deutschland

Loss of B cell-ACKR3 reduces atherosclerosis by decreasing plasma cells and pro-inflammatory antibody production

Anais Yerly^1,2, Yvonne Jansen³, Bryce Evans^1,2, Maria Berenice Martinez Salazar^1,2, Nico Angliker^1,2, Mark Siegrist¹, Julia Schulz^1,2, Manovriti Thakur^1,2, Sarah Maike Bernhard¹, Drosos Kotelis⁴, Marc Schindewolf¹, Yvonne Döring^1,2,3

1: Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital , Switzerland; 2: DBMR affiliation Department for BioMedical Research, University of Bern, Switzerland; 3: Institute of Cardiovascular Prevention, Department of Medicine, Ludwig-Maximilians-University Munich , Munich, Germany; 4: Division of vascular surgery, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Switzerland

Macrophages require mechano-sensing via Piezo1 to preserve the murine heart

Christina Zehender, Hauke Horstmann, Tamara Vico, Sebastian Preissl, Remi Peyronnet, Eva Rog-zielinska, Dirk Westermann, Ingo Hilgendorf

Universitätsklinikum Freiburg, Freiburg, Deutschland

Modulating cardiac wound healing: profound impact of all-trans retinoic acid (ATRA) on emergency hematopoiesis following myocardial infarction

Jan Wrobel¹, Jasmin Rettkowski², Hana Seung⁴, Carolin Wadle², Ingo Hilgendorf³, Constantin von zur Mühlen³, Dirk Westermann³, Nina Cabezas-Wallscheid², Timo Heidt^3,5

1: Uniklinik Köln, Köln, Deutschland; 2: Max-Planck-Institut für Immunbiologie und Epigenetik, Freiburg, Deutschland; 3: Uniklinik Freiburg, Freiburg, Deutschland; 4: Center for Systems Biology Massachusetts General Hospital, Boston, USA; 5: Max Grundig Klinik, Bühl, Deutschland

Quality Management of Retinal Optical Coherence Tomography-Angiography in the Berlin Long Term Observation of Vascular Events Study (BeLOVE)

Hadi Salih¹, Lukas Reeß^1,2,3, Frederike Cosmia Oertel^1,3,4, Charlotte Bereuter¹, Lidia Kilinska¹, Kai-Uwe Eckardt^5,6, Knut Mai^7,8, Ulf Landmesser^2,9,10, Leif-Hendrik Boldt^11,12, Matthias Endres^13,14,15, Joachim E. Weber^2,10,12,, Holger Gerhardt^2,10,16, Dominik N. Müller^1,2,10,17, Tobias Pischon^2,18,19, Ulrike Grittner^2,20, Antonia M. Joussen²¹, Friedemann Paul^1,3,21, Oliver Zeitz²¹, Hanna G. Zimmermann^1,3,22

1: Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 2: Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; 3: Neuroscience Clinical Research Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 4: Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 5: Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 6: Department of Nephrology and Hypertension, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; 7: Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 8: NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany; 9: Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin; 10: German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany; 11: Department of Internal Medicine and Cardiology, Charité–Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Virchow-Klinikum, Augustenburger Platz1, Berlin, 13353, Germany; 12: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology, Berlin, Germany; 13: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany; 14: NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 15: German Center for Neurodegenerative Diseases (DZNE), Partner Site Berlin, Berlin, Germany; 16: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; 17: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 18: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany; 19: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany; 20: Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Institute of Biometry and Clinical Epidemiology; 21: Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 22: Einstein Center Digital Future, Berlin, Germany

Senolytical treatment attenuates the susceptibility to ventricular arrhythmias in prediabetes

Camila Zöhner¹, Stephan Angendohr¹, Ashley-Jane Duplessis¹, Joachim Schmit^2,3, Tanu Srivastava³, Malte Kelm^1,2, Norbert Gerdes^1,2, Alexander Lang¹

1: Division of Cardiology, Pulmonology and Vascular Medicine, Duisburg, Deutschland; 2: Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; 3: Institute for Pharmacology, Heinrich-Heine-University Düsseldorf, Germany

T regulatory cells lose their protective phenotype in patients with coronary artery disease (CAD)

Ana-Sophia Burkard, Timoteo Marchini, Sophie Hansen, Tijani Olawale Abogunloko, Dirk Westermann, Dennis Wolf

Universitäts-Herzzentrum Freiburg-Bad Krozingen, Freiburg, Deutschland

The role of ChemR23 in the bidirectional crosstalk between perivascular adipose tissue and arterial vasculature in atherosclerosis

Julia Schulz^1,2, Bryce Evans^1,3, Anaïs Yerly^1,3, Manovriti Thakur^1,3, Nico Angliker^1,3, Mark Siegrist^1,3, Emiel van der Vorst⁴, Yvonne Jansen⁵, Marc Schindewolf³, Alexander Bartelt^5,6, Drosos Kotelis², Yvonne Döring^1,3,5,6

1: Department for BioMedical Research (DBMR),University of Bern, Bern, Schweiz; 2: Department of Vascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland; 3: Department of Angiology, Inselspital, Bern University Hospital, Bern, Switzerland; 4: Institute for Molecular Cardiovascular Research (IMCAR), RWTH University Hospital Aachen, Aachen, Germany; 5: Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich (LMU), Munich, Germany; 6: DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

Upregulation of endothelial cannabinoid receptor 1 by pro-atherogenic shear stress promotes vascular inflammation

Aishvaryaa Prabhu¹, Bingni Chen¹, Lucia Natarelli¹, Stephan Herzig^2,3, Raquel Guillamat Prats¹, Sabine Steffens^1,3

1: LMU Klinikum der Universität München, München, Germany; 2: Institute for Diabetes and Cancer, Helmholtz Zentrum Munich, Neuherberg, Germany; 3: DZHK (German Center for Cardiovasular Research), Partner Site Munich Heart Alliance, Munich

Lomitapide for the treatment of paediatric homozygous familial hypercholesterolaemia patients - Results from the efficacy phase of the APH-19 study

Sandra Löwe¹, Luis Masana², Alberto Zambon³, Claus-Peter Schmitt⁴, Christina Taylan⁵, Joenna Driemeier⁶, Hofit Cohen⁷, Paola Sabrina Buonuomo⁸, Abdullah Alashwal⁹, Mohammed Al-Dubayee¹⁰, José Luis Díaz-Díaz¹¹, Faouzi Maatouk¹², Sergio Martínez-Hervás¹³, Brian Mangal¹⁴, Tracy Cunningham¹

1: Amryt Research Limited, Amryt Pharma, Dublin, Ireland; 2: Unitat De Medicina Vascular I Metabolisme, Hospital Universitari Sant Joan de Reus, Reus, Spain; 3: Department Of Medicine, University of Padua, Padua, Italy; 4: Centre For Pediatric And Adolescent Medicine, University of Heidelberg, Heidelberg, Germany; 5: Department Of Paediatrics, University Hospital Cologne, Cologne, Germany; 6: Department Of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 7: Sackler Faculty Of Medicine, Tel-Aviv University, Tel Aviv, Israel; 8: Rare Diseases And Medical Genetics Unit, Bambino Gesù Children's Hospital, Rome, Italy; 9: Heart Center Department, King Faisal Specialist Hospital And Research Center, Alfaisal University College of Medicine, Riyadh, Saudi Arabia; 10: Department Of Pediatrics, King Abdullah Specialist Children Hospital, Riyadh, Saudi Arabia; 11: Department Of Internal Medicine, A Coruña University Hospital, A Coruña, Spain; 12: Cardiology B Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia; 13: Department Of Endocrinology And Nutrition, Clinic University Hospital of Valencia, Valencia, Spain; 14: Consultancy, Solara Consulting Corp., North Vancouver, Canada

Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodeling via chemerin

Andy W C Man, Yawen Zhou, Gisela Reifenberg, Alica Camp, Thomas Münzel, Andreas Daiber, Ning Xia, Huige Li

Universitätsmedizin Mainz, Mainz, Deutschland

Effect of microplastics on experimental atherosclerosis, microbiome

Fabian Brüstle, Nicole Trippel, Volker Ruppert, Bernhard Schieffer, Ann-Kathrin Vlacil, Karsten Grote

Philipps-Universität Marburg, Marburg, Deutschland

CD40-TRAF6 inhibition improves functional and structural outcome in acute myocardial infarction by inhibiting pro-fibrotic macrophages

Alexander Lang^1,6, Sven Witkowski^1,6, Grace Ampem^1,6, Chiara Wernet¹, Ashley-Jane Duplessis¹, Madlen Kaldirim¹, Susanne Pfeiler¹, Stefanie Becher¹, Christin Elster¹, Tobias Lautwein², Karl Köhrer², Florian Bönner^1,3, Amin Polzin^1,3, Holger Winkels⁴, Esther Lutgens⁵, Malte Kelm^1,3, Christian Jung^1,3, Norbert Gerdes^1,3

1: Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany; 2: BMFZ, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; 3: Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; 4: Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; 5: Cardiovascular Medicine, Experimental CardioVascular Immunology Laboratory, Mayo Clinic, Rochester, MN, USA; 6: The authors contributed equally to this study

Novel fluorescence-based methods to determine infarct and scar size in murine models of myocardial infarction

Susanne Pfeiler, Ashley-Jane Duplessis, Christin Elster, Christina Engel, Alexander Lang, Madlen Kaldirim, Malte Kelm, Norbert Gerdes

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany

Lipoprotein(a) and subclinical carotid atherosclerosis: Results from the population-based Hamburg City Health Study (HCHS)

Natalie Arnold^1,2,3, Julia Waibel^1,2,3, Alena Haack^4,3, Benjamin Bay^1,2,3, Christopher Blaum^1,3, Fabian J. Brunner^1,2,3, Tanja Zeller^4,2,3, Ines Schäfer^1,3, Götz Thomalla⁵, Stefan Blankenberg^1,2,3, Bastian Cheng⁵, Raphael Twerenbold^1,2,3,4

1: University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2: German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Luebeck, Ham-burg, Germany; 3: Center for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 4: University Center of Cardiovascular Science at University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 5: Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany