Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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STE PS_D3: Special Session STIAM Location: Room U I2 Session Chair: Cristian Ravariu, UNSTPB University, Bucharest Special Session: Simulation Tools - from Industry Applications to bio-Medical engineering (STIAM) | |
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9:52am - 10:05am
Label-Free Computational Microscopy for Rapid On-Site Evaluation (ROSE) of Thyroid Fine-Needle Aspiration Cytology: Quantitative Phase Imaging (QPI) on Unstained Cytology smears 1: Emory University School of Medicine, United States of America; 2: Kennesaw State University, Kennesaw, GA, USA; 3: Morehouse School of Medicine, Atlanta, GA, USA; 4: Drake University, Des Moines, IA, USA; 5: Grady Memorial Hospital, Atlanta, GA, USA Background: Ultrasound-guided fine-needle aspiration (FNA) is the cornerstone for triaging thyroid nodules and diagnosing thyroid malignancy. Rapid on-site evaluation (ROSE) can reduce non-diagnostic sampling and repeat procedures while it is resource-intensive, with increased labor demands at a time when many health systems face constraints in pathology staffing and distribution. Objective: To describe and preliminarily evaluate a label-free computational microscopy workflow for thyroid FNA ROSE that couples standardized cytology smear preparation with quantitative phase imaging (QPI), enabling immediate digital review without chemical stains. Methods: Unstained cytology smears were imaged with a proprietary computational microscope that reconstructs quantitative phase maps and renders diagnostically interpretable cytology-like images. Matched slides were stained with Diff-Quik for qualitative comparison. Results: Label-free QPI images preserved key cytomorphologic information (cellularity, architectural patterns, nuclear-to-cytoplasmic relationships and background characteristics) relevant to adequacy assessment and preliminary categorization. Conclusions: A stain-free QPI workflow on conventional cytology smear preparations for thyroid FNA may support rapid adequacy assessment and tele-enabled ROSE while preserving material for ancillary studies. Further prospective validation with larger cohorts and quantitative performance metrics are warranted. | |
