Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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Daily Overview |
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STE PS_B1: Special Session INSPIRE 1/2 Location: Room U I6 Session Chair: Mona Arhire, Transilvania University of Brașov Session Chair: Cornel Samoila, Transylvania University of Brasov Special Session: Intelligent Systems Promoting Innovation in Research & Education - Consortium for Doctoral Students (INSPIRE) | |
| Presentation 5 | |
3:42pm - 4:00pm
Genetic Processor Networks as a Formal Bio-CAD Framework for CRISPR/Cas Biocomputers 1: Transilvania University of Brașov (UniTBv); 2: University of Informatics Sciences,Cuba CRISPR/Cas-based biocomputation has enabled the design of advanced logic circuits analogous to CPUs. However, the scalability of these systems is limited by the lack of formal verification frameworks. Synthetic genetic circuits (SGCs) fail unpredictably due to resource competition (metabolic load), off-target effects, and crosstalk. The design-build-test cycle is slow and incapable of guaranteeing robustness. This article explores the use of Evolutionary (NEP) and Genetic (NGP) Processor Networks as a unified Bio-CAD (Biological Computer-Aided Design) framework. A conceptual mapping is presented where NGP processors model logic gates, strings model gRNAs and mRNA, and formal filters (rc_s, rc_w) model binding specificity. We argue that the inherently parallel and distributed architecture of NGP, and its demonstrated ability to solve NP-complete problems in linear time, directly reflects the massive parallelism of molecular computation in vivo. This approach would allow for the formal design and verification of fidelity, robustness, and scalability of biocomputers before their costly wetware synthesis. | |
