The rapid evolution of drone technology has created new opportunities for education, particularly in fostering interdisciplinary, hands-on learning within STEM and STEAM fields. This paper presents DRONAISSANCE: Skies to Classrooms (DS2C), an Erasmus+ Cooperation Partnership in School Education that aims to empower teachers and students to integrate drones as pedagogical and experiential tools in the classroom. The project responds to European priorities on promoting STEM excellence, advancing digital readiness, and supporting teachers’ professional development. It addresses the lack of pedagogical frameworks and training on drone integration by developing two main outputs: the European Drone Educator’s Toolkit and the European Drone Education Platform. These resources equip educators with the technical, legal, ethical, and methodological knowledge required to implement drone-based learning activities across disciplines. The project also seeks to engage underrepresented groups, particularly girls, in STEM through inclusive practices and collaborative learning environments. Through transnational training, local implementation, and the organization of Drone Awareness Weeks and Drone Festivals, DS2C promotes innovation, equity, and sustainability in European school education. The paper discusses the project’s design, methodology, expected impact, and contribution to the European Drone Strategy 2.0 and the European Green Deal by fostering a digitally skilled and environmentally conscious generation.