Conference Agenda

TDP-43-DEPENDENT MIS-SPLICING OF KCNQ2 TRIGGERS INTRINSIC NEURONAL HYPEREXCITABILITY IN ALS/FTD

Evangelos Kiskinis

Northwestern University, United States of America

TUNING KV7/KCNQ CHANNEL DENSITY THROUGH ENDOSOMAL 2CL-/H+ EXCHANGE: IMPLICATIONS FOR NEURONAL EXCITABILITY

Raul E. Guzman, Qi Guanxiao, Alberto Diaz-Castillo, Christoph Aretzweiler, Lilly Steinmetz, Stefanie Bungert-Plümke, Frank Müller, Dirk Feldmeyer

Research Center Juelich, Germany

GΒΓ DUALLY REGULATES THE M‑CURRENT VIA INCREASED PIP2 SENSITIVITY AND TRAFFICKING

Boris Shalomov¹, Julia Papa-Dmitrieva¹, Tal Keren-Raifman¹, Sharon Weiss1¹, Flavia De Martino², Maurizio Taglialatela², Vincenzo Barrese², Iain Greenwood³, Ilana Lotan¹, Nathan Dascal¹

¹Department of Neuroscience and Brain Disorders, Gray school of medicine, Tel Aviv university, Tel Aviv, Israel; ²Division of Pharmacology, Department of Neuroscience, University of Naples Federico II, Naples, Italy.; ³Vascular Biology Research Group, Institute of Molecular and Clinical Sciences, St George's University of London, London, United Kingdom.

KV7.2 PORE STABILITY SHAPES REGULATION BY PHARMACOLOGICAL ACTIVATORS

Thomas Hammond, Shawn Lamothe, Harley Kurata

University of Alberta, Canada

AN UPSTREAM OPEN READING FRAME REPRESSES TRANSLATION OF KCNQ2

Dalton Huey¹, Eduardo Guadarrama¹, Jean-Marc DeKeyser¹, Carlos Vanoye¹, Christine Simmons¹, Qianru Li¹, Emily Stroup¹, Zhe Ji^1,2, Alfred George¹

¹Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America; ²Current address: State Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences; Shanghai Academy of Natural Sciences (SANS), Shanghai, China 200031