Conference Agenda

THERAPEUTIC STRATEGIES FOR KCNQ4-ASSOCIATED HEARING LOSS

Heon Yung Gee

Yonsei University College of Medicine, Republic of Korea

A ROLE OF KCNQ-INDUCED PLASTICITY ON NOISE-INDUCED NEURAL AND PERCEPTUAL HYPERSENSITIVITY TO SOUND

Thanos Tzounopoulos

University of Pittsburgh, Pittsburgh Hearing Research Center, United States of America

TOWARD SCALABLE PRECISION THERAPEUTICS FOR KCNQ2-DEE

Aubrie Soucy Verran¹, Miwa Higashi¹, Emma Sherrill¹, Margaret Meserve¹, Tojo Nakayama², Timothy Yu¹

¹Boston Children's Hospital, Boston, MA, USA; ²Nucleotide and Peptide Drug Discovery Center, Institute of Science Tokyo, Tokyo, Japan

DEVELOPMENT AND EVALUATION OF SYSTEMIC AAV GENE THERAPY TO TREAT NEONATAL KCNQ2 EPILEPTIC ENCEPHALOPATHY

Rana Eser¹, Acacia Mayfield¹, Michael Elowitz^1,2, Viviana Gradinaru^1,2

¹California Institute of Technology, Pasadena, CA, United States of America; ²Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, United States of America

ASO–MEDIATED RESCUE OF ELECTROPHYSIOLOGICAL NETWORK DYSFUNCTION IN IPSC-DERIVED KCNQ2 GAIN-OF-FUNCTION NEURONS

Lidia Carotenuto^1,2,3,4, Marcus Kaji^1,2,3,4, Nina Dirkx^1,5, Noor Zonnekein^1,5, Els De Vriendt¹, Giusy Carleo⁶, Francesco Miceli⁶, Maurizio Taglialatela⁶, Sarah Weckhuysen^1,2,3,4

¹VIB Center for Molecular Neurology, Belgium; ²μNeuro Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.; ³Division of Neurology, University Hospital Antwerp, Antwerp, Belgium.; ⁴Translational Neurosciences, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium; ⁵Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; ⁶Division of Pharmacology, Department of Neuroscience, University of Naples Federico II, Naples, Italy