Conference Agenda

KV7.1: FROM IX1 TO LQT-1 MOLECULAR PHYSIOLOGY AND DISEASE

Robert Kass

Columbia University, United States of America

PROMISING QT-SHORTENING EFFECT OF THE ENDOCANNABINOID N-ARACHIDONOYL-L-SERINE (ARA-S) IN A TRANSGENIC MODEL OF LONG QT SYNDROME TYPE 1

Julien Louradour¹, Miriam Barbieri¹, Lluís Matas¹, Irene Hiniesto-iñigo², Sara I Liin², H. Peter Larsson², Katja E. Odening^1,3

¹Translational Cardiology, Institute of Physiology and Department of Cardiology, University of Bern, Switzerland; ²Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; ³Department of Cardiology and Angiology I, University Heart Center Freiburg, Medical Faculty, Freiburg, Germany

ARRHYTHMIA-MUTANT R231C STABILIZES THE VOLTAGE SENSOR IN CARDIAC POTASSIUM IKS CHANNELS IN THE INTERMEDIATE STATE

Alicia De la Cruz¹, Yahnell Judah², Xiaoan Wu², Maykelis Diaz Solares², Marta E Perez², Rene Barro-Soria², Peter Larsson¹

¹Department of Biomedical and Clinical Sciences, Linköping University, Sweden; ²Department of Physiology and Biophysics, University of Miami, USA

LOSS-OF-FUNCTION OF KV7.1 LEADS TO METABOLIC DYSFUNCTION THROUGH AGE-DEPENDENT PANCREATIC BETA-CELL DECLINE

Emil Skovhøj¹, Mathilde Søndergaard¹, Liangwen Liu², Per-Eric Lund², Jørgen Kanters¹, Signe Torekov¹, Sebastian Barg², Thomas Mandrup-Poulsen¹, Anniek Lubberding¹

¹Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; ²Department of Medical Cell Biology, University of Uppsala, Uppsala, Sweden

DETERMINE THE ANTI-ARRHYTHMIC POTENTIAL OF KV7.1/KCNE1 ACTIVATORS USING LQTS ZEBRAFISH MODEL

Lucas Dauga, Alicia De la Cruz, H. Peter Larsson

Departement of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden