Conference Agenda

2:00pm - 2:25pm

STATE-DEPENDENT KCNQ1 INHIBITOR BREAKS C4 SYMMETRY TO BLOCK ION CONDUCTION

Efthimios Kyriakis¹, Agnese Roscioni², Jodene Eldstrom¹, Luca Maragliano², Filip Van Petegem¹, David Fedida¹

¹University of British Columbia, Canada; ²Polytechnic University of Marche, Via Brecce Bianche, Ancona 60131, Italy

2:25pm - 2:50pm

CONFORMATIONS OF KV7.1 PORE MORPH WITH VOLTAGE SENSOR STATES AND REGULATORY SUBUNITS

Lei Huang¹, Nitzan Daus², Yuyin Wang¹, Guohui Zhang¹, Manar Khier², Ariel Ben-Bassat², Jingyi Shi¹, Lu Zhao¹, Borui Zhang¹, Lu Han¹, Yoni Haitin², Bernard Attali², Jianmin Cui¹

¹Washington University in St. Louis, USA, United States of America; ²Tel Aviv University, Tel Aviv, Israel

2:50pm - 3:15pm

STRUCTURE AND PHOSPHORYLATION MECHANISMS OF THE CARDIAC KCNQ1+KCNE1 CHANNEL UNDER STRESS CONDITION

Ling Zhong¹, Zhenzhen Yan¹, Xiaoqing Lin¹, Xinyu Cheng², Shuangyan Wan², Jin Zhang², Panpan Hou¹

¹Macau University Of Science And Technology, Macau S.A.R. (China); ²Nanchang University, China

3:15pm - 3:40pm

CHEMICAL TUNING REVEALS A CATION-PI GATING BRIDGE BETWEEN THE VOLTAGE-SENSOR AND PORE DOMAINS IN THE KV7.1 POTASSIUM CHANNEL

Christopher Ahern, Miranda Schene

University of Iowa, United States of America