Conference Agenda

Keynote Lecture 2
Thursday, 22/Sept/2022:
1:30pm - 2:00pm

Session Chair: Katarzyna Kowalczyk-Gajewska
Location: Seminarroom AEU1-5

Karlsplatz 13, Staircase 2

1:30pm - 2:00pm

Mathematical modeling of innate immune response to viral infection

F. Grabowski, M. Kochanczyk, W. Prus, Z. Korwek, M. Czerkies, T. Lipniacki

IPPT PAN, Poland


Recognition of viral RNA initiates a signaling cascade culminating in synthesis of interferons (IFNs). Secreted IFNs, by activation of transcription factors of STAT family in surrounding cells, prompt them to prepare for viral infection. Viruses, in turn, convey non-structural proteins to impede the innate immune response. Based on results obtained using single-cell techniques, we proposed an agent (single cell)-based, stochastic, computational model and used it to explain how a infected population of cells can stratify into distinct subpopulations. The winning cells, in response to viral RNA, produce IFN╬▓ (warning yet not infected cells), loosing cells express viral proteins that inhibit innate immune signaling. The proposed model reproduces the experimentally observed complex spatial patterns of respiratory syncytial virus (RSV) spread and dichotomous cell responses.