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Trends in the personalized design and manufacture of next generation implants
1Center fo Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria; 2Ludwig Boltzmann Institute for Cardiovascular Research, Austria; 3Austrian Cluster for Tissue Regeneration, Austria
New tools lead to progress, but inevitably also to new challenges.
With the development of advanced Additive Manufacturing (AM) processes and materials, recent years have seen a steady increase in their application in medicine, especially in personalized medicine. The design and manufacturing freedom typical of AM, combined with increasing digitalization of these processes, enables the development of medical treatments that are highly tailored to the needs of the patient. Pre-operative planning tools and models, patient-specific surgical instruments and devices, and implantable prostheses customized for the individual patient have been introduced into medical treatment. In parallel, conventional tissue engineering has also benefited from AM with the establishment of multicellular tissue-like structures reproducing, at small scale, even simple biological functions.
The design of next-generation implants has evolved in recent years from implants fulfilling basic functions (e.g. biomechanics) to a more integrated design that perfectly matches patient and tissue anatomy, biomechanics and electrophysiology at the macroscopic and microscopic cellular level, while supporting tissue regeneration. With these advances, new challenges inevitably arise as new methodologies need to be developed to guide design within this wider range of possibilities now available.
This presentation will address trends, current advances and challenges in the design and manufacture of next generation implants.