Session | ||
MS-25: Structural biology against coronavirus/covid-1
Invited: Xuhui Huang (China) | ||
Session Abstract | ||
This session covers the efforts of the crystallographic community to find drug candidates for COVID-19 both in-silico and in the lab by using structural models of viral proteins. For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below. | ||
Introduction | ||
Presentations | ||
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:20pm
Millisecond Functional Dynamics of RNA Polymerases Elucidated by Markov State Models The Hong Kong University of Science and Technology, Kowloon, Hong Kong S.A.R. (China) External Resource: https://www.xray.cz/iucrv/vidp.asp?id=202
3:20pm - 3:40pm
Co-crystallization of hepatitis C virus NS3/4A inhibitors and SARS-CoV-2 main protease using high density acoustic droplet ejection (ADE) 1Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY 11973-5000, United States; 2Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, United States; 3National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, United States External Resource: https://www.xray.cz/iucrv/vidp.asp?id=203
3:40pm - 4:00pm
Structural basis of mRNA cap modification by SARS-CoV-2: Role of metal ions and implications for COVID-19 severity by emerging variants 1University of Texas Health at San Antonio, San Antonio, USA; 2New England Biolabs, Ipswich, USA; 3Texas Biomedical Research Institute, San Antonio, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=204
4:00pm - 4:20pm
Crystallographic fragment screening of SARS-CoV-2 drug discovery targets 1Diamond Light Source Ltd, Didcot, United Kingdom; 2Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK; 3Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK; 4Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa External Resource: https://www.xray.cz/iucrv/vidp.asp?id=205
4:20pm - 4:40pm
A structure-guided, taxonomic-based approach to the design of broad-spectrum coronavirus protease inhibitors Purdue University, W Lafayette, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=206
4:40pm - 5:00pm
Structure of SARS-CoV-2 papain-like protease PLpro reveals a framework for antiviral inhibitor design 1Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany.; 2Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany.; 3Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi-75270, Pakistan.; 4Hamburg Centre for Ultrafast Imaging (CUI), Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany. External Resource: https://www.xray.cz/iucrv/vidp.asp?id=207
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