Session Overview | |
Location: Club A 170 1st floor |
| |
9:00am - 9:50am | KN-3: High Pressure Crystallography Unlimited Location: Club A Session Chair: Arthur Haozhe Liu Leonid Dubrovinsky |
|
High pressure crystallography unlimited Bayreuth University, Bayreuth, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=53
|
10:20am - 12:45pm | MS-2: Validation of cryoEM structures and maps Location: Club A Session Chair: Jose-Maria Carazo Session Chair: Elena Orlova Invited: Florence Tama (Japan), Pavel Afonine (USA), G. Kleywegt (Germany) |
|
10:20am - 10:50am
Protein hydrogen bond parameters as a new validation tool 1Lawrence Berkeley National Laboratory, Berkeley, United States of America; 2International Center for Quantum and Molecular Structures, Shanghai University, Shanghai 200444, People's Republic of China; 3Bioscience Division, Los Alamos National Laboratory, Mail Stop M888, Los Alamos, NM 87545, USA; 4New Mexico Consortium, Los Alamos, NM 87544, USA; 5Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA 10:50am - 11:20am
Integrative modeling to characterize structure and dynamics of biomolecules Nagoya University & RIKEN, Nagoya, Japan 11:20am - 11:50am
Community recommendations on validating cryo-EM models and data EMBL EBI, Cambridge, United Kingdom 11:50am - 12:05pm
Cryo-EM Validation Metrics in EMDA MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, Biomedical Campus, Cambridge, CB2 0QH, UK 12:05pm - 12:20pm
FSC-Q: A method for quality analysis of cryoEM-derived models CNB-CSIC, Madrid, Spain 12:20pm - 12:35pm
Outcomes from EMDataResource model challenges 1Rutgers University, NJ, USA; 2University of California Davis, CA, USA; 3Stanford University/SLAC, Stanford, CA, USA 12:35pm - 12:50pm
Quantifiying resolvability of atomic features in cryo-EM maps using Q-scores 1Stanford University; 2Stanford University, SLAC National Accelerator Laboratory; 3Stanford University, SLAC National Accelerator Laboratory |
2:45pm - 5:10pm | MS-09: Structure guided drug design and antibiotic resistance targets Location: Club A Session Chair: Begoña Heras Session Chair: Anton V. Zavialov Invited: Vibha Gupta (India), Jade Forwood (Australia) |
|
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:20pm
Understanding viral host interactions that modulate nuclear transport and innate immunity 1School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia; 2Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, USA; 3Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia; 4Australian Synchrotron, Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC, Australia External Resource: https://www.xray.cz/iucrv/vidp.asp?id=66
3:20pm - 3:50pm
Novel targets in old rouges: Integrative structural biology approach for discovery of natural product inhibitors Jaypee Institute of Information Technology, A-10, Sector-62, Noida, U.P., India External Resource: https://www.xray.cz/iucrv/vidp.asp?id=67
3:50pm - 4:10pm
The structure of the ABC transporter PsaBC shows that bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life. 1The University of Melbourne, Parkville, Australia; 2University of Gothenburg, Gothenburg, Sweden.; 3Australian National University, Canberra, Australia; 4Kyoto University, Kyoto, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=68
4:10pm - 4:30pm
Uncovering the structures and mechanisms for the largest group of bacterial surface virulence factors. 1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia; 2Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Herston, Queensland, Australia; 3Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia; 4Macromolecular Crystallography, Australian Synchrotron, Clayton, Victoria, Australia External Resource: https://www.xray.cz/iucrv/vidp.asp?id=69
4:30pm - 4:50pm
Inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex through the novel macrocyclic peptides 1The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland, 4072, Australia; 2The University of Queensland, School of Biomedical Sciences, St Lucia, Queensland, 4072, Australia; 3Department of Biological Sciences, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; 4Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK; 5Department of Chemistry, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan; 6Sydney Analytical, the University of Sydney, Camperdown, New South Wales 2050, Australia External Resource: https://www.xray.cz/iucrv/vidp.asp?id=70
4:50pm - 5:10pm
Structural and mechanistic studies on carbapenem-hydrolysing class D serine β-lactamases leading to improved inhibitor design 1Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USA; 2Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=71
|
6:10pm - 7:00pm | KN-6: The Coronavirus Structural Task Force Location: Club A Session Chair: Marcin Nowotny Andrea Thorn |
|
The Coronavirus Structural Task Force Universität Hamburg, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=62
|
| |
9:00am - 9:50am | KN-9: Crystalline sponge, metal-organic assembles Location: Club A Session Chair: Masaki Kawano Makoto Fujita |
|
Crystalline Sponge Method: Recent Updates and Applications The University of Tokyo, School of Engineering, Tokyo, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=65
|
10:20am - 12:45pm | MS-17: Automation in bio-crystallography: tools, perspectives and applications Location: Club A Session Chair: Santosh Panjikar Session Chair: Melanie Vollmar Invited: Katherine McAuley (UK), Jose Marquez (France) |
|
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Online Crystallography: Automated, Remote Controlled Protein-to-Structure Pipelines for Drug Design European Molecular Biology Laboratory, Grenoble, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=147
10:55am - 11:25am
Automated data collection at the Swiss Light Source macromolecular crystallography beamlines Paul Scherrer Institut, Villigen, Switzerland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=148
11:25am - 11:45am
Fully automated data collection and remote access in macromolecular crystallography beamlines at the Photon Factory, Japan 1Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki, Japan; 2School of High Energy Accelerator Science, The Graduate University for Advanced Studies, 1-1 Oho, Tsukuba, Ibaraki, Japan; 3Mechanical Engineering Center, Applied Research Laboratory, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=149
11:45am - 12:05pm
Millisecond Time-Resolved Crystallography using Film Mixing and Plunge Cooling 1Cornell University, Ithaca NY, United States of America; 2University of Waterloo, Waterloo ON, Canada External Resource: https://www.xray.cz/iucrv/vidp.asp?id=150
12:05pm - 12:25pm
Automated ML-based sample centering for macromolecular X-ray crystallography with MXAimbot MAX IV Laboratory, Lund, Sweden External Resource: https://www.xray.cz/iucrv/vidp.asp?id=151
12:25pm - 12:45pm
xia2.multiplex: a multi-crystal data analysis pipeline Diamond Light Source Ltd, Oxfordshire, United Kingdom External Resource: https://www.xray.cz/iucrv/vidp.asp?id=151
|
2:45pm - 5:10pm | MS-25: Structural biology against coronavirus/covid-1 Location: Club A Session Chair: Sarah EJ Bowman Session Chair: Lu Zhang Session Chair: Gianluca Santoni Invited: Xuhui Huang (China) |
|
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:20pm
Millisecond Functional Dynamics of RNA Polymerases Elucidated by Markov State Models The Hong Kong University of Science and Technology, Kowloon, Hong Kong S.A.R. (China) External Resource: https://www.xray.cz/iucrv/vidp.asp?id=202
3:20pm - 3:40pm
Co-crystallization of hepatitis C virus NS3/4A inhibitors and SARS-CoV-2 main protease using high density acoustic droplet ejection (ADE) 1Center for BioMolecular Structure, NSLS-II, Brookhaven National Laboratory, Upton, NY 11973-5000, United States; 2Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, United States; 3National Virtual Biotechnology Laboratory (NVBL), US Department of Energy, Washington, DC, United States External Resource: https://www.xray.cz/iucrv/vidp.asp?id=203
3:40pm - 4:00pm
Structural basis of mRNA cap modification by SARS-CoV-2: Role of metal ions and implications for COVID-19 severity by emerging variants 1University of Texas Health at San Antonio, San Antonio, USA; 2New England Biolabs, Ipswich, USA; 3Texas Biomedical Research Institute, San Antonio, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=204
4:00pm - 4:20pm
Crystallographic fragment screening of SARS-CoV-2 drug discovery targets 1Diamond Light Source Ltd, Didcot, United Kingdom; 2Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK; 3Centre for Medicines Discovery, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK; 4Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa External Resource: https://www.xray.cz/iucrv/vidp.asp?id=205
4:20pm - 4:40pm
A structure-guided, taxonomic-based approach to the design of broad-spectrum coronavirus protease inhibitors Purdue University, W Lafayette, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=206
4:40pm - 5:00pm
Structure of SARS-CoV-2 papain-like protease PLpro reveals a framework for antiviral inhibitor design 1Universität Hamburg, Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, 22607 Hamburg, Germany.; 2Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany.; 3Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi-75270, Pakistan.; 4Hamburg Centre for Ultrafast Imaging (CUI), Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany. External Resource: https://www.xray.cz/iucrv/vidp.asp?id=207
|
6:10pm - 7:00pm | KN-12: Structural hybrid methods to probe membrane transport nanomachines in pathogenic bacteria Location: Club A Session Chair: Julie Bouckaert Natalie Strynadka |
|
Hybrid structural methods to probe atomic features of the Type III Secretion Injectisome of Pathogenic Bacteria UBC, Vancouver, Canada External Resource: https://www.xray.cz/iucrv/vidp.asp?id=34
|
| |||
9:00am - 9:50am | KN-15: Time resolved macromolecular crystallography Location: Club A Session Chair: Ivana Kuta Smatanova Arwen R Pearson | ||
|
9:00am - 10:00am
Time-resolved macromolecular crystallography: no longer a niche pursuit? University of Hamburg, Hamburg, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=37
| ||
10:20am - 12:45pm | MS-33: CryoEM for macromolecules - from single particles to microcrystals Location: Club A Session Chair: Jan Pieter Abrahams Session Chair: Jiri Novacek Invited: Nenad Ban (Switzerland), Dimple Karia (Netherlands) | ||
|
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Structural basis of SARS-CoV-2 translational shutdown and programmed ribosomal frameshifting ETH Zurich, Zurich, Switzerland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=256
10:55am - 11:25am
Home source for cryo-EM 1Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, Netherlands; 2Thermo Fisher Scientific Brno s.r.o, Materials & Structural Analysis, Brno, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=257
11:25am - 11:50am
High-resolution structures of immature and chimeric flaviviruses reveal key features redefining viral architecture and maturation 1Monash University, Clayton, VIC, Australia; 2The University of Queensland, Brisbane, QLD, Australia External Resource: https://www.xray.cz/iucrv/vidp.asp?id=258
11:50am - 12:15pm
Receptor induced rearrangements of capsid and genome prime rhinovirus 14 for activation and uncoating CEITEC MU, Brno, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=259
12:15pm - 12:40pm
M. tuberculosis enolase: Crystal and Cryo-EM structures provide insights into 2-phosphoglycerate binding and catalysis 1National Institute of Immunology, New Delhi, India; 2National Centre for Biological Sciences, Bangalore 560065, India; 3Alagappa University ,Karaikudi, Tamil Nadu 630003, India; 4Infectious Disease Research Institute, 1616 Eastlake Avenue E, Suite 400, Seattle,WA98102, United States | ||
1:00pm - 2:00pm | Meeting 3 - Journals: Commission on Journals open meeting Location: Club A Session Chair: Andrew Allen Session Chair: Peter Raymond Strickland |
| |
9:00am - 9:50am | KN-18: Electron density, and its interplay with the energy and properties of molecules and solids Location: Club A Session Chair: Catharine Esterhuysen Julia Contreras-Garcia |
|
Electron density, and its interplay with the energy and properties of molecules and solids Sorbonne Université-CNRS, Paris, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=40
|
10:20am - 12:45pm | MS-42: Novel techniques and insights into in vitro and in situ crystallisation for X-ray and electron diffraction. Location: Club A Session Chair: Lars Redecke Session Chair: Fasseli Coulibaly Invited: Haruki Hasegawa (USA), Alexandra Ros (USA) |
|
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Concurrent crystallization of multiple proteins in a single cell without interfering each other’s phase separation events Amgen Inc, South San Francisco, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=313
10:55am - 11:25am
Microfluidic Tools Reducing Sample Amount in Serial Crystallography with XFELs Arizona State University, Tempe, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=314
11:25am - 11:45am
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography 1Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia; 2Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden; 3School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia; 4Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA; 5Institute for Glycomics, Griffith University, Southport, Queensland, Australia.; 6EMBL Australia Node in Single Molecule Science, University of New South Wales, Kensington, New South Wales, Australia; 7Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia; 8Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; 9Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA.; 10Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia. External Resource: https://www.xray.cz/iucrv/vidp.asp?id=315
11:45am - 12:05pm
The crystallomics pipeline, a shotgun approach on native proteomes to (re)discover the unsuspected 1Swiss Light Source, Paul Scherrer Institut, Forschungsstrasse 111, Villigen-PSI, 5232, Switzerland; 2European Synchrotron Radiation Facility, 38043 Grenoble, France; 3Max-Planck-Institut für Marine Mikrobiologie, Celsiusstraße 1, 28359, Bremen, Germany; 4Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, 305-0801, Japan.; 5Institut de Biologie Structurale (IBS), Universite ́ Grenoble Alpes, CEA, CNRS, 71 avenue des Martyrs, Grenoble Cedex 9, 38044, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=316
12:05pm - 12:25pm
Protein crystallization assisted by the crystallophore. 1Institut de Biologie Structurale, Grenoble, France; 2Ecole Normale Supérieure, Lyon, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=317
12:25pm - 12:45pm
Protein crystallisation in agarose gel, a cheap and versatile technique 1CSIC, Granada, Spain; 2Politecnico di Torino, Torino, Italy; 3Structural Biology, Molecular Biology Institute of Barcelona, Barcelona, Spain External Resource: https://www.xray.cz/iucrv/vidp.asp?id=318
|
1:00pm - 2:00pm | Workshop - Journals: Journal Author Workshop. From data to publication Location: Club A Session Chair: Andrew Allen Session Chair: Michele Zema Panelists: Elspeth Garman (Acta D); Chiara Massera (Acta E); Andrew Allen (Editor-in-Chief) Managing editors and IUCr staff: Louise Jones (Acta D); Michele Zema (Executive Outreach Officer) |
2:45pm - 5:10pm | MS-49: Protein design and engineering Location: Club A Session Chair: Charlotte Uetrecht Session Chair: Sheena McGowan |
|
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:20pm
Using Ancestral Sequence Reconstruction to Create Robust, Highly Expressed Proteins for Crystallography 1The University of Queensland, Brisbane, Australia; 2University of Michigan, Ann Arbor, MI, Unites States External Resource: https://www.xray.cz/iucrv/vidp.asp?id=355
3:20pm - 3:50pm
Protein cage directed nanoparticle superlattices Aalto University, Espoo, Finland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=356
3:50pm - 4:10pm
The bright-side and the dark-side of computational protein stabilization 1Masaryk University, Brno, Czech Republic; 2International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=357
4:10pm - 4:30pm
Enzyme engineering by random mutagenesis: structural and functional studies of modified plant-type L-asparaginase (EcAIII) 1Jagiellonian University, Faculty of Chemistry, Krakow, Poland; 2Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, Poland; 3Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; 4Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=358
4:30pm - 4:50pm
Computational design of symmetric eight and nine-bladed β-propellers KU Leuven, Heverlee, Belgium External Resource: https://www.xray.cz/iucrv/vidp.asp?id=359
4:50pm - 5:10pm
Structural evidence for the bleaching caused by oxygen in rsCherry 1Biochemistry, Molecular and Structural Biology; Department of Chemistry, KU Leuven, Belgium; 2Chemistry of Biological Processes, Collège de France, Paris, France; 3Laboratory of Molecular Bacteriology, Rega Institute, KU Leuven, Belgium External Resource: https://www.xray.cz/iucrv/vidp.asp?id=360
|
6:10pm - 7:00pm | KN-21: How limitless antibodies are generated by V(D)J recombination Location: Club A Session Chair: Marcin Nowotny Wei Yang |
|
How limitless antibodies are generated by V(D)J recombination 1National Institutes of Health, USA, Bethesda, United States of America; 2Pohang University, South Korea External Resource: https://www.xray.cz/iucrv/vidp.asp?id=44
|
| |
9:00am - 9:50am | KN-24: Regulation of gene expression by transcription factors and RNA-binding proteins Location: Club A Session Chair: Pavlína Řezáčová Udo Heinemann |
|
Regulation of gene expression by transcription factors and RNA-binding proteins Max Delbrück Center for Molecular Medicine, Berlin, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=47
|
10:20am - 12:45pm | MS-58: Ultra-high resolution macromolecular crystallography and quantum biocrystallography Location: Club A Session Chair: Christian Jelsch Session Chair: Alexander Wlodawer Invited: Paulina Dominiak (Poland), Maciej Kubicki (Poland) |
|
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Experimental studies of the details of electron density distribution in a Z-DNA hexamer: new insights, new problems 1Faculty of Chemistry, Adam Mickiewicz University in Pozna, Poznan, Poland; 2Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; 3Laboratoire de Cristallographie, Institut Jean Barriol, Université de Lorraine, Nancy, Franc; 4Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne National Laboratory, Argonne, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=402
10:55am - 11:25am
Moving quantum crystallography from sub-atomic XRD to near-atomic 3D ED Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warszawa, Poland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=403
11:25am - 11:50am
Principles of the mechanism of interfacial activation of a lipase: open and closed states and lipid – enzyme interactions in the limbus region of Candida antarctica Lipase B Università Politecnica Delle Marche, Ancona, Italy External Resource: https://www.xray.cz/iucrv/vidp.asp?id=404
11:50am - 12:15pm
Investigating the redox cycle of tryparedoxin at ultra-high resolution University of Wuerzburg, Wuerzburg, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=405
12:15pm - 12:40pm
Theoretical electrostatic potential maps of macromolecules calculated with multipolar electron scattering factors Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, Warsaw, Poland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=406
|
1:00pm - 2:30pm | ECA - GIG-1: ECA - GIG-1 Young Crystallographers Location: Club A |
2:45pm - 5:10pm | MS-69a: Complex crystal structures - chemical crystallography Location: Club A Session Chair: Marie Colmont Session Chair: Sergey V. Krivovichev |
|
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:15pm
Tellurides with monovalent Ga and In – from chains to networks 1Leipzig University, Leipzig, Germany; 2University of Amsterdam, Amsterdam, Netherlands External Resource: https://www.xray.cz/iucrv/vidp.asp?id=478
3:15pm - 3:40pm
Elucidation and quantification of the factors underlying bond-length variation in inorganic solids for the design of non-oxide materials with superior functional properties 1Geophysical Laboratory, Carnegie Institution for Science, 5251 Broad Branch Rd. NW, Washington D.C., 20015 USA; 2Department of Geological Sciences, University of Manitoba, 125 Dysart Rd, Winnipeg, MB, Canada External Resource: https://www.xray.cz/iucrv/vidp.asp?id=479
3:40pm - 4:05pm
Synthesis and investigation of the 4H and newly discovered 6H perovskite polymorphs of BaRhO3 between 7 – 22 GPa. 1Institute for Chemical Research, Kyoto University, Kyoto, Japan; 2Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China; 3Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=481
4:05pm - 4:30pm
Enhancing the Chemical Flexibility of Hybrid Perovskites by Introducing Divalent Ligands 1School of Physical Sciences, University of Kent, Canterbury, Kent, United Kingdom; 2Department of Materials Engineering, Indian Institute of Science (IISc), Bangalore, Karnataka, India; 3Centre for X-ray Analytics, Empa – Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, Switzerland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=482
4:30pm - 4:55pm
Temperature dependent structural studies of incommensurately modulated Rb2ZnCl4 1Laboratory of Crystallography, University of Bayreuth, 95447 Bayreuth, Germany; 2DESY, Notkestrasse 85, 22607 Hamburg, Germany; 3Univ. Grenoble Alpes, CNRS, Grenoble INP, BP 75, 38402 Saint Martin d'Hères Cedex, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=483
|
6:10pm - 7:00pm | KN-25: A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process and the Discovery of Inhibitors Location: Club A Session Chair: Julie Bouckaert Glaucius Oliva |
|
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process 1Institute of Physics of Sao Carlos, University of Sao Paulo, Brazil; 2BioMAX, MAX IV Laboratory, Lund, Sweden; 3Brazilian Synchrotron Light Laboratory (LNLS), Campinas, Brazil External Resource: https://www.xray.cz/iucrv/vidp.asp?id=48
|
| |
9:00am - 9:50am | KN-30: Structure guided inhibitor discovery targeting a membrane receptor involved in atherosclerosis Location: Club A Session Chair: Julie Bouckaert Arockiasamy Arulandu |
|
Structure guided inhibitor discovery targeting a membrane receptor involved in atherosclerosis 1International Centre for Genetic Engineering and Biotechnology, New Delhi, India; 2University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States; 3University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States. External Resource: https://www.xray.cz/iucrv/vidp.asp?id=54
|
10:20am - 12:45pm | MS-74: Structural biology of receptors, signaling and membrane proteins Location: Club A Session Chair: SUSAN KAY BUCHANAN Session Chair: Michael Parker Invited: Robert Keenan (USA), Isabel Moraes (UK) |
|
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization 1National Physical Laboratory, Teddington, TW11 0LW, UK; 2Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK; 3Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK External Resource: https://www.xray.cz/iucrv/vidp.asp?id=517
10:55am - 11:25am
An ER translocon for multi-pass membrane protein biogenesis 1University of Chicago, Chicago, United States of America; 2University of California, San Francisco, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=518
11:25am - 11:45am
To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a “hunger switch” initiating satiety signaling. 1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel; 2Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 3Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK; 4Faculty of Agriculture, The Hebrew University, Israel External Resource: https://www.xray.cz/iucrv/vidp.asp?id=519
11:45am - 12:05pm
Unravelling the molecular architecture of the Commander assembly 1The University of Queensland, Brisbane, Australia; 2University of Melbourne, Melbourne, Australia; 3Cambridge Institute fo Medical Research, Cambridge, United Kingdom External Resource: https://www.xray.cz/iucrv/vidp.asp?id=520
12:05pm - 12:25pm
Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis 1Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia; 2ACRF Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia ; 3Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=521
12:25pm - 12:45pm
Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures 1Center for Structural Biology, Montpellier, France; 2Laboratoire de Spectrométrie de Masse Bioorganique, Strasbourg, France; 3Institut de Recherche en Cancérologie, Montpellier, France; 4Muséum National d'Histoire Naturelle, Paris, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=522
|
1:00pm - 2:30pm | ECA - SIG-11: ECA - SIG-11 Crystallography under Extreme Conditions Location: Club A |
2:45pm - 5:10pm | MS-81: Nucleic acids and binding proteins structure and function Location: Club A Session Chair: Stephen Neidle Session Chair: Charles Bond Invited: Millie Georgiadis (USA), Liliya Yatsunyk (USA) |
|
2:45pm - 2:50pm
Introduction to session 2:50pm - 3:20pm
Non-canonical DNA structures and their interactions with small molecule ligands Swarthmore College, 500 College Ave, Swarthmore, PA, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=564
3:20pm - 3:50pm
Structural properties of Alien DNA, an alternative genetic system 1Indiana University School of Medicine, Indianapolis, Indiana, United States of America; 2Foundation for Applied Molecular Evolution, Alachua, Florida, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=565
3:50pm - 4:10pm
APE1 Exonuclease Distinguishes Various DNA Substrates by an Induced Space-Filling Mechanism. 1Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan; 2Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 30068, Taiwan; 3Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 30068, Taiwan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=566
4:10pm - 4:30pm
Structural characterization of clinically reported missense mutations identified in BRCA1 Tata Memorial Centre Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India External Resource: https://www.xray.cz/iucrv/vidp.asp?id=567
4:30pm - 4:50pm
Solid-solid phase transition in adenine riboswitch crystals driven by large conformational changes induced by ligand 1Center for Structural Biology, Centre for Cancer Research, National Cancer Institute, Frederick, MD-21702, USA.; 2Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.; 3X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=568
Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72 1Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; 2RIKEN SPring-8 Center, Hyogo, Japan; 3Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=569
|
6:10pm - 7:00pm | KN-33: Overview of Global Neutron Sources, Instruments and Initiatives Location: Club A Session Chair: Jiri Kulda Ken Andersen |
|
Overview of Global Neutron Sources, Instruments and Initiatives Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=57
|
| |
9:00am - 9:50am | KN-34: Fabrication and Characterization of Inhomogeneity-free Polymer Gels Location: Club A Session Chair: Marijana Đaković Mitsushiro Shibayama |
|
Fabrication and characterization of inhomogeneity-free polymer gels 1Comprehensive Research Organization for Science and Society, Tokai, Japan; 2The University of Tokyo, Kashiwa, Japan External Resource: https://www.xray.cz/iucrv/vidp.asp?id=58
|
10:20am - 12:45pm | MS-92 (34b): Structural biology of enzymes, mechanism and regulation II Location: Club A Session Chair: Mirjam Czjzek |
|
10:20am - 10:50am
Structural insights into the transposition of antibiotic resistance 1University of Geneva, Geneva, Switzerland; 2Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany; 3European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK External Resource: https://www.xray.cz/iucrv/vidp.asp?id=621
10:50am - 11:20am
Extraordinary Structures of Orphan Methyltransferases with Their Substrate DNA Department of Epigenetics and Molecular Carcinogenesis, The University of Texas -M.D. Anderson Cancer Center, Houston TX, USA External Resource: https://www.xray.cz/iucrv/vidp.asp?id=622
11:20am - 11:40am
Structural and mechanistic basis for protein glutamylation by the kinase fold 1UT Southwestern Medical Center, Dallas, United States of America; 2Warsaw University of Life Sciences, Warsaw, Poland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=623
11:40am - 12:00pm
Mechanism of RNA stimulated ATP hydrolysis by tick-borne encephalitis virus NS3 helicase Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=624
12:00pm - 12:20pm
Quinol-dependent Nitric Oxide Reductases are dimers in cryoEM structures University of Liverpool, Liverpool, United Kingdom External Resource: https://www.xray.cz/iucrv/vidp.asp?id=625
12:20pm - 12:40pm
Interactive GUI for the calculation of Fobs-Fobs electron density difference maps and extrapolated structure factors based on the cctbx toolbox 1Institut de Biologie Structurale, Université de Grenoble Alpes, CEA, CNRS, 38044 Grenoble, France; 2Institut Laue-Langevin, 38044 Grenoble, France; 3Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany External Resource: https://www.xray.cz/iucrv/vidp.asp?id=626
|
2:45pm - 5:10pm | MS-101 (18b): Phase transitions in complex materials (structure and magnetism) II Location: Club A Session Chair: Yuichi Shimakawa Session Chair: Alexandra Gibbs |
|
2:45pm - 3:05pm
Towards an iterative exploration of novel materials exhibting electronic phase transitions Northwestern University, Evanston, United States of America External Resource: https://www.xray.cz/iucrv/vidp.asp?id=8
3:05pm - 3:25pm
Negative X-ray expansion in cadmium cyanide 1Department of Chemistry, Cambridge, U. K, CB2 1EW; 2Inorganic Chemistry Laboratory , Oxford, U. K., OX1 3QR; 3Diamond Light Source, Didcot, Oxfordshire OX11 0DE, U. K; 4Nanochemistry Department, Max Planck Institute for Solid State Research, Stuttgart, Germany, 70569; 5ISIS Facility, Didcot, Oxfordshire, U. K., OX11 0QX External Resource: https://www.xray.cz/iucrv/vidp.asp?id=91
3:25pm - 3:45pm
Crystal structure, complex phase diagram and re-entrant phase transition in NaSrPO4 Malvern Panalytical, Almelo, Netherlands, The External Resource: https://www.xray.cz/iucrv/vidp.asp?id=92
3:45pm - 4:05pm
Crystal structure of a new polymorph of Sr2TiO4 with tetrahedral titanium University of Geneva, Quai Ernest-Ansermet 24, 1205 Geneva, Switzerland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=93
4:05pm - 4:25pm
Revisiting the crystal structure and magneto-elastic coupling in MnZnSb 1Department of Physics, University of Liverpool, United Kingdom; 2Department of Chemistry, University of Liverpool, United Kingdom; 3Institut Laue-Lengevin, France External Resource: https://www.xray.cz/iucrv/vidp.asp?id=94
4:25pm - 4:45pm
Phase transitions and magnetic structures in Epsilon-Fe2O3 nanoparticles 1Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Bellaterra, Spain; 2CELLS-ALBA synchrotron, Cerdanyola del Vallès, Spain; 3Instituto de Diseño para la Fabricación, Universitat Politècnica de València, Valencia, Spain External Resource: https://www.xray.cz/iucrv/vidp.asp?id=95
4:45pm - 5:05pm
Polytypism in layered AB2 solids 1Department of Chemistry, Imperial College London, London, United Kingdom; 2Inorganic Chemistry, University if Oxford, Oxford, United Kingdom External Resource: https://www.xray.cz/iucrv/vidp.asp?id=96
|