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Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 29th Apr 2024, 08:37:43pm CEST

Session Overview

Session

Poster - 41 Receptors: Structural biology of receptors, membrane proteins

Time:

Friday, 20/Aug/2021:

5:10pm - 6:10pm

Session Chair: SUSAN KAY BUCHANAN
Session Chair: Michael Parker

Presentations

ID: 1968 / Poster - 41 Receptors: 1
Poster session abstracts
Poster

Poster session abstracts

Radomír Kužel

ID: 709 / Poster - 41 Receptors: 2
Bursary application
Oral/poster
MS: Structural biology of receptors, signaling and membrane proteins
Posters only: Macromolecular and biological crystallography (if it does not fit to any specific topics)
Keywords: RTKs; crystal structure; secondary structural changes; mutations; cancer; change in intramolecular interactions

Structural anomalies in the Eph receptor due to clinically relevant mutations and the subsequent effect on kinase domain

Shubhashish Chakraborty^1,2, Ashok Kumar Varma^1,2

¹Advanced centre for Treatment, Research and Education in cancer, Kharghar, Navi Mumbai, Maharashtra – 410210,INDIA; ²Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, Maharashtra – 400094 ,INDIA.

Bibliography
Comparative structural analysis of clinically relevant cancer mutations reported in EphA7 receptor tyrosine kinase*.

*Manuscript in process.

External Resource:

ID: 998 / Poster - 41 Receptors: 3
Biological and macromolecular crystallography
Poster
MS: Structural biology of receptors, signaling and membrane proteins
Keywords: NK cell; NKp30; B7-H6; glycosylation; oligomerization

Influence of glycosylation on the structure of human natural killer cell receptor NKp30 in complex with its tumor ligand B7-H6

Tereza Skalova¹, Ondřej Skořepa², Barbora Kalousková², Jan Bláha², Celeste Abreu², Jan Dohnálek¹, Ondrej Vaněk²

¹Institute of Biotechnology CAS, v.v.i., Vestec, Czech Republic; ²Department of Biochemistry, Faculty of Science, Charles University Prague, Hlavova 8, 128 40 Praha, Czech Republic

External Resource:

ID: 1467 / Poster - 41 Receptors: 4
Biological and macromolecular crystallography
Poster
MS: Structural bioinformatics, Structural biology of eukaryotic immune systems, Structural biology of receptors, signaling and membrane proteins
Posters only: Macromolecular and biological crystallography (if it does not fit to any specific topics)
Keywords: TCR repertoire, cholesterol-dependent cytolysins, T cell epitopes, pneumolysin

CD4⁺ T cell recognition of pneumolysin, a pore-forming cytolysin derived from Streptococcus pneumoniae presented by a common HLA allotype

Lisa Ciacchi¹, Martijn D. B. van de Garde², Jan Petersen¹, Carine Farenc¹, Martien C. M. Poelen², Hugh H. Reid¹, Kristin Ladell³, David A. Price³, Cecile A. C. M. van Els², Jamie Rossjohn¹

¹Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia; ²Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; ³Cardiff University School of Medicine, Cardiff, United Kingdom

External Resource:

ID: 1627 / Poster - 41 Receptors: 5
Biological and macromolecular crystallography
Poster
MS: Structural biology of receptors, signaling and membrane proteins
Keywords: CD160/BY55; HVEM/TNFRSF14; immune receptor; immunological synapse; receptor-ligand interaction

Molecular characterization of the native (non-linked) CD160-HVEM protein complex revealed by initial crystallographic analysis

Simona Lenhartová¹, Marek Nemčovič², Radka Šebová¹, Mário Benko¹, Dirk Zajonc^3,4, Ivana Nemčovičová¹

¹Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovak Republic; ²Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia; ³Division of Immune Regulation, La Jolla Institute for Immunology, La Jolla, CA, USA; ⁴Cancer Immunology Discovery, Pfizer Inc., San Diego, CA, USA

External Resource:

ID: 1534 / Poster - 41 Receptors: 6
Biological and macromolecular crystallography
Oral/poster
MS: Structural biology of receptors, signaling and membrane proteins, Structure guided drug design and antibiotic resistance targets
Keywords: X-ray, Cryo-EM, drug design, membrane proteins

Structure-based drug discovery enabled for membrane protein targets

Michael Hennig

leadXpro AG, Villigen, Switzerland

External Resource:

ID: 1453 / Poster - 41 Receptors: 7
Biological and macromolecular crystallography
Poster
MS: Structural biology of receptors, signaling and membrane proteins, Protein design and engineering
Posters only: Macromolecular and biological crystallography (if it does not fit to any specific topics)
Keywords: antibody labeling, epitope insertion, antibody-assisted structural analysis, electron microscopy, protein crystallography

Optimization of the NZ-1 labeling technique for the application to 3D structure analysis

Rie Aruga¹, Risako Tamura-Sakaguchi¹, Mika Hirose², Toru Ekimoto¹, Rika Oi¹, Mika K. Kaneko³, Yukinari Kato^3,4, Mitsunori Ikeguchi^1,5, Kenji Iwasaki⁶, Terukazu Nogi¹

¹Graduated School of Medical Life Science, Yokohama-city University, Japan; ²Institute for Protein Research, Osaka University, Japan; ³Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Japan; ⁴New Industry Creation Hatchery Center, Tohoku University, Japan; ⁵Center for Computational Science, RIKEN, Japan; ⁶Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan

External Resource:

ID: 1633 / Poster - 41 Receptors: 8
Biological and macromolecular crystallography
Oral/poster
MS: Structural bioinformatics, CryoEM for macromolecules - from single particles to microcrystals, Structural biology of receptors, signaling and membrane proteins, Macromolecular machines and hybrid methods to crystallography, Structural bioinformatics
Posters only: Hot structures of biological importance
Keywords: cryoEM, bacterial toxins, phylogenetics, membrane proteins, pore-forming proteins

Structure, function and evolution of the orally active insecticidal toxin complex, YenTc

Sarah Piper^1,2, Lou Brillault^1,2, Joseph Box¹, Yu Shang Low¹, Irene Chassagnon¹, Gabriel Foley¹, Nadezhda Aleksandrova¹, Lauren Hartley-Tassell⁴, Cassandra Pegg¹, Ben Schulz¹, Thomas Ve⁴, Shaun Lott³, Mark Hurst⁵, Michael Landsberg^1,2

¹School of Chemistry and Molecular Bioscience, The University of Queensland, St Lucia, Australia; ²Institute for Molecular Bioscience, The University of Queensland; ³School of Biological Sciences, The University of Auckland; ⁴Institute for Glycomics; ⁵AgResearch NZ

ID: 1729 / Poster - 41 Receptors: 9
All topics
Poster
MS: Structural biology of receptors, signaling and membrane proteins
Keywords: TLR signalling pathway

Understanding the structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling

Mengqi Pan, Andrew Hedger, Jeff Nanson, Bostjan Kobe

the University of Queensland, St Lucia, Australia

External Resource:

ID: 1920 / Poster - 41 Receptors: 10
Poster sessions
Poster
Posters only: Structural biology of receptors, membrane proteins
Keywords: Toll-like receptors, Negative-stain EM, TLR signaling

Structural basis of higher-order assembly formation in Toll-like receptors 1,2 and 6 signaling pathway

YAN LI

The University of Queensland, St Lucia, Australia