Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 6th Dec 2022, 02:09:38am CET

Session Overview
MS-34a: Structural biology of enzymes, mechanism and regulation
Tuesday, 17/Aug/2021:
10:20am - 12:45pm

Session Chair: Mirjam Czjzek
Location: Club B

50 1st floor

Invited: Liang Wu (UK), Orsolya Barabas (Germany)

Session Abstract

How does crystallography provide understanding of enzymes. This topic could also include recent advances in the area of time resolved crystallography.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below. The session continues in MS-92.

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10:20am - 10:25am

Introduction to session

Mirham Czjzek

10:25am - 10:55am

Adventures in heparan sulfate degradation

Liang Wu1, Zachary Armstrong2, Casper de Boer3, Vincent Lit3, Gijs Ruijgrok3, Uri Barash4, Ilanit Boyango4, Neta Ilan4, Israel Vlodavsky4, Hermen S Overkleeft3, Gideon J Davies2

1The Rosalind Franklin Institute, Didcot, OX11 0FA, United Kingdom; 2Department of Chemistry, University of York, York, YO10 5DD, United Kingdom; 3Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands; 4Technion Integrated Cancer Center (TICC), The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel

10:55am - 11:25am

High-resolution structure and reaction cycle of Fatty Acid Photodecarboxylase: anatomy of a crime scene

Damien Sorigue1, Kyprianos Hadjidemetriou2, Stéphanie Blangy1, Guillaume Gotthard3, Pierre Legrand4, Didier Nurizzo3, Antoine Royant3, Catherine Berthomieu1, Martin Weik2, Tatiana Domratcheva5, Klaus Brettel6, Martin Vos7, Ilme Schlichting8, Pavel Muller6, Fred Beisson1, Pascal Arnoux1

1CEA, Saint Paul lez Durance, France; 2IBS, Grenoble, France; 3ESRF, Grenoble, France; 4SOLEIL, Gif-sur-Yvette, France; 5Lomonosov Moscow State University, Moscow, Russia; 6I2BC,Gif-sur-Yvette, France; 7Ecole Polytechnique, Palaiseau, France; 8MPI, Heidelberg, Germany

11:25am - 11:45am

Structural insights into the enzymatic mechanism of lytic polysaccharide monooxygenases

Flora Meilleur

NC State / ORNL, Raleigh, United States of America

11:45am - 12:05pm

Structural studies on a unique glucosamine kinase unveil a novel enzyme family

Jose Antonio Manso1,2, Daniela Nunes Costa3,4, Sandra Macedo Ribeiro1,2, Nuno Empadinhas3,4, Pedro Jose Barbosa Pereira1,2

1IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; 2Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; 3CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; 4PhD Program in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal

12:05pm - 12:25pm

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides

Jorge Ripoll-Rozada1,2, Mafalda Costa3, José Antonio Manso1,2, Ana Maranha3, Vanessa Miranda4, André Sequeira4, Maria Rita Ventura4, Sandra Macedo-Ribeiro1,2, Nuno Empadinhas3,5, Pedro José Barbosa Pereira1,2

1IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; 2Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; 3CNC – Center for Neuroscience and Cell Biology, 3004-504 Coimbra, Portugal.; 4ITQB – Instituto de Tecnologia Química Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.; 5IIIUC - Interdisciplinary Research Institute, University of Coimbra, 3004-504 Coimbra, Portugal.

12:25pm - 12:45pm

Time-resolved serial femtosecond crystallography on photoswitchable fluorescent proteins

Kyprianos Hadjidemetriou

Institut de Biologie Strucutrale, Grenoble, France

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