Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 6th Dec 2022, 02:46:29am CET

Session Overview
MS-2: Validation of cryoEM structures and maps
Sunday, 15/Aug/2021:
10:20am - 12:45pm

Session Chair: Jose-Maria Carazo
Session Chair: Elena Orlova
Location: Club A

170 1st floor

Invited: Florence Tama (Japan), Pavel Afonine (USA), G. Kleywegt (Germany)

Session Abstract

New achievements in Cryo-electron microscopy enabled a revolution in structural biology and over the last few years reached resolutions comparable with crystallography. Still, quantitative assessment of these structures is urgently needed, and essential for the validation of all these new EMDB and PDB entries. New algorithms tailored to the nature of these data need to be developed and made widely available to the community. This session will present the advancements in this field.

For all abstracts of the session as prepared for Acta Crystallographica see external PDF, or individual abstracts below.

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10:20am - 10:50am

Protein hydrogen bond parameters as a new validation tool

Pavel Afonine1, Oleg Sobolev1, Nigel Moriarty1, Yanting Xu1,2, Thomas Terwilliger3,4, Paul Adams1,5

1Lawrence Berkeley National Laboratory, Berkeley, United States of America; 2International Center for Quantum and Molecular Structures, Shanghai University, Shanghai 200444, People's Republic of China; 3Bioscience Division, Los Alamos National Laboratory, Mail Stop M888, Los Alamos, NM 87545, USA; 4New Mexico Consortium, Los Alamos, NM 87544, USA; 5Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA

10:50am - 11:20am

Integrative modeling to characterize structure and dynamics of biomolecules

Florence Tama

Nagoya University & RIKEN, Nagoya, Japan

11:20am - 11:50am

Community recommendations on validating cryo-EM models and data

Gerard Kleywegt

EMBL EBI, Cambridge, United Kingdom

11:50am - 12:05pm

Cryo-EM Validation Metrics in EMDA

Rangana Warshamanage, Keitaro Yamashita, Garib N. Murshudov

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, Biomedical Campus, Cambridge, CB2 0QH, UK

12:05pm - 12:20pm

FSC-Q: A method for quality analysis of cryoEM-derived models

Erney Ramírez-Aportela, David Maluenda, Yunior C. Fonseca, Pablo Conesa, Roberto Marabini, Carlos Oscar S. Sorzano, Jose M. Carazo

CNB-CSIC, Madrid, Spain

12:20pm - 12:35pm

Outcomes from EMDataResource model challenges

Catherine Lawson1, Andriy Kryshstafovych2, Wah Chiu3

1Rutgers University, NJ, USA; 2University of California Davis, CA, USA; 3Stanford University/SLAC, Stanford, CA, USA

12:35pm - 12:50pm

Quantifiying resolvability of atomic features in cryo-EM maps using Q-scores

Greg Pintilie1, Michael Schmid2, Wah Chiu3

1Stanford University; 2Stanford University, SLAC National Accelerator Laboratory; 3Stanford University, SLAC National Accelerator Laboratory

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