Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 26th Nov 2022, 12:38:05pm CET

Session Overview
MS-66: Integrative structural biology: The next 50 years of the Protein Data Bank
Thursday, 19/Aug/2021:
2:45pm - 5:10pm

Session Chair: Stephen K. Burley
Session Chair: Dina Schneidman
Location: Club H

100 1st floor

Invited: Andrej Sali (USA),  Fei Xu (China)

Session Abstract

Since 1971, the Protein Data Bank has provided open access to biomolecular structure data from crystallography, nuclear magnetic resonance spectroscopy, and electron microscopy. Over the next 50 years, structural biologists will shift their focus from single experimental technique studies to so-called integrative or hybrid methods investigations. The Integrative Structural Biology Microsymposium will showcase the power of combining complementary techniques of physical measurement and computational analysis to the problem of understanding the structure and function of large macromolecular machines important in fundamental biology, biomedical research, and bioenergy. The invited speakers will share their internationally-recognized expertise in macromolecular crystallography, cryo-electron microscopy, mass spectrometry, and computational structure modeling. Additional speakers, exemplifying the breadth of integrative structural biology research worldwide, will be selected from contributed abstracts.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below.

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2:45pm - 2:50pm

Introduction to session

Stephen K. Burley, Dina Schneidman

2:50pm - 3:20pm

Crystal structure of the first orphan GPCR

Fei Xu

ShanghaiTech University, Shanghai, China, People's Republic of

3:20pm - 3:50pm

From integrative structural biology to cell biology

Andrej Sali

University of California, San Francisco, San Francisco, United States of America

3:50pm - 4:10pm

Crystal and Cryo-EM structures provide insight into how pro-neurodegenerative SARM1 is activated and cleave NAD+.

Thomas Ve1, Weixi Gu2, Jeffrey D. Nanson2, Yun Shi2, Katie Cunnea3, Philip S. Kerry3, Todd Bosanac4, Robert O. Hughes4, Bostjan Kobe2

1Griffith University, Southport, Australia; 2University of Queensland, Brisbane, Australia; 3Evotec Ltd, Abingdon, Oxfordshire, UK; 4Disarm Therapeutics, a wholly-owned subsidiary of Eli Lilly & Co., Cambridge, USA

4:10pm - 4:30pm

Structural studies of Cysteine Synthase Complex obtained from Klebsiella pneumoniae.

Shubham Semwal1, Deepansh Mody2, Vibha Gupta2, Julie Bouckaert1

1Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576, CNRS, 50 Avenue Halley, 59650 Villeneuve d'Ascq, France; 2Biotechnology Department, Jaypee Institute of Information Technology (JIIT), A-10, sector-62 NOIDA, 201309, India

4:30pm - 4:50pm

Crystal structure of a complex between the electron-transfer partners arsenite oxidase and cytochrome c552, from the arsenite respiring bacterium Rhizobium sp. NT-26.

Nilakhi Poddar1, Joanne M Santini2, Megan J Maher1,3

1School of Chemistry and The Bio21 Instittute Molecular Sciences and Biotechnology Institute, The University of Melbourne, Parkville, 3052, Australia; 2Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom; 3Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

4:50pm - 5:10pm

Structural evidence for active site complementation and diverse oligomerization in two bacterial α-L-Fucosidases from the same organism

Jan Dohnálek1, Terézia Kovaľová1,2, Tomáš Kovaľ1, Jan Stránský1, Petr Kolenko1, Jarmila Dušková1, Patricie Vodičková2, Vojtěch Spiwok2, Eva Benešová2, Petra Lipovová2

1Institute of Biotechnology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic; 2University of Chemistry and Technology, 166 28 Prague, Czech Republic

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