Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 26th Nov 2022, 12:48:47pm CET

Session Overview
MS-10: Structural biology of eukaryotic immune systems
Sunday, 15/Aug/2021:
2:45pm - 5:10pm

Session Chair: Bostjan Kobe
Session Chair: Savvas Savvides
Location: Club B

50 1st floor

Invited: Tsan Sam Xiao (USA), Raul Olivier Martin (USA), Wen Song (Germany)

Session Abstract

Defence mechanisms play a key role in higher organisms but are also invovled in patologies, for example those with inflamatory resposnes.. Particularly interesting are recent advances in our understanding of the innate, hard-wired immune response. These will be highlighted in this session.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below.

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2:45pm - 2:50pm

Introduction to session

Bostjan Kobe, Savvas Savvides

2:50pm - 3:20pm

Catching fire: inflammatory responses mediated by inflammasomes, caspases, and gasdermins

Zhonghua Liu1, Chuanping Wang1, Jie Yang2, Tsan Sam Xiao1

1Case Western Reserve University, Cleveland, OH, USA; 2The Scripps Research Institute, La Jolla, CA, USA.

3:20pm - 3:50pm

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

Raoul Olivier Martin1,3,4, Tiancong Qi2,3,4, Haibo Zhang2, Furong Liu3,4, Miles King3,4, Claire Toth5, Eva Nogales5,6,7, Brian Staskawicz3,4

1Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA; 2Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; 3Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 USA; 4Innovative Genomics Institute, University of California, Berkeley, CA 94720 USA.; 5Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA; 6Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.; 7Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.

3:50pm - 4:20pm

Structural mechanism of NAD+ cleavage by plant TIR domain

Wen Song

Max Planck Institute for Plant Breeding Research, Köln, Germany

4:20pm - 4:40pm

The structure of the marsupial γμ T cell receptor defines a third T cell lineage in vertebrates

Kim Morrissey1, Marcin Wegrecki2, Praveena Thirunavukkarasu2,3, Victoria Hansen1, Komagal Sivaraman2, Sam Darko4, Daniel Douek4, Jamie Rossjohn2,3,5, Robert Miller1, Jerome Le Nours2,3

1Center for Evolutionary & Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA; 2Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; 3Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, 3800, Australia; 4Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; 5Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK

4:40pm - 5:00pm

Bacterial lipopolysaccharide recognition by surfactant protein D

Annette K Shrive1, Jamie R Littlejohn1,2, Harry M Williams1,3, William Neale1, Stacey Collister1, Derek Hood4, Stefan Oscarson5, Jens Madsen6, Howard Clark6, Trevor J Greenhough1

1School of Life Sciences, Keele University, Keele, United Kingdom; 2Current address: School of Biochemistry, University of Bristol, Bristol, United Kingdom; 3Current address: Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany; 4Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom; 5School of Chemistry, University College Dublin, Dublin, Ireland; 6EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, United Kingdom

5:00pm - 5:20pm

Molecular basis underpinning metabolite-mediated T-cell immunity

Wael Awad1, Geraldine Ler2, Jeffrey Y. W. Mak2, Jérôme Le Nours1, James McCluskey3, Alexandra J. Corbett3, David P. Fairlie2, Jamie Rossjohn1

1Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia; 2Institute for Molecular Bioscience, The University of Queensland, Australia; 3Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia

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