Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 26th Sept 2023, 10:08:39am CEST

Session Overview
MS-74: Structural biology of receptors, signaling and membrane proteins
Friday, 20/Aug/2021:
10:20am - 12:45pm

Session Chair: Michael Parker
Location: Club A

170 1st floor

Invited:  Robert Keenan (USA), Isabel Moraes (UK)

Session Abstract

Receptor biology and signal transduction is an important area of research that is related to many diseases. This microsymposium will focus on new structural advances in the field of signal transduction.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below.

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10:20am - 10:25am

Introduction to session

Susan Kay Buchanan, Michael Parker

10:25am - 10:55am

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Isabel Moraes1, Peter J. Judge2, Juan F. Bada Juarez2, Danny Axford3, Tristan Kwan1, Anthony Watts2

1National Physical Laboratory, Teddington, TW11 0LW, UK; 2Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK; 3Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK

External Resource:
Video Link

10:55am - 11:25am

An ER translocon for multi-pass membrane protein biogenesis

Philip T McGilvray1, S Andrei Anghel1, Arunkumar Sundaram1, Frank Zhong1, Michael J Trnka2, James R Fuller1, Hong Hu1, Alma L Burlingame2, Robert J Keenan1

1University of Chicago, Chicago, United States of America; 2University of California, San Francisco, United States of America

External Resource:
Video Link

11:25am - 11:45am

To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a “hunger switch” initiating satiety signaling.

Oksana Degtjarik1, Hadar Israeli1,2, Li F. Chan3, Danny Ben-Zvi2, Masha Y. Niv4, Peter J. McCormick3, Moran Shalev-Benami1

1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel; 2Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 3Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK; 4Faculty of Agriculture, The Hebrew University, Israel

External Resource:
Video Link

11:45am - 12:05pm

Unravelling the molecular architecture of the Commander assembly

Michael David Healy1, Joanna Sacharz2, Tristan Croll3, David A Stroud2, Brett M Collins1

1The University of Queensland, Brisbane, Australia; 2University of Melbourne, Melbourne, Australia; 3Cambridge Institute fo Medical Research, Cambridge, United Kingdom

External Resource:
Video Link

12:05pm - 12:25pm

Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis

Bronte A Johnstone1, Sara L Lawrence2, Michelle P Christie1, Rodney K Tweten3, Craig J Morton1, Michael W Parker1,2

1Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia; 2ACRF Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia
; 3Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA

External Resource:
Video Link

12:25pm - 12:45pm

Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures

Vanessa Delfosse1, Tiphaine Huet1, Deborah Harrus1, Meritxell Granell1, Maxime Bourguet2, Caroline Gardia-Parège3, Barbara Chiavarina3, Marina Grimaldi3, Sébastien Le Mével4, Pauline Blanc1, David Huang1, Jakub Gruszczyk1, Barbara Demeneix4, Sarah Cianférani2, Jean-Baptiste Fini4, Patrick Balaguer3, William Bourguet1

1Center for Structural Biology, Montpellier, France; 2Laboratoire de Spectrométrie de Masse Bioorganique, Strasbourg, France; 3Institut de Recherche en Cancérologie, Montpellier, France; 4Muséum National d'Histoire Naturelle, Paris, France

External Resource:
Video Link

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