August 14 - 22, 2021 | Prague, Czech Republic
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
Please note that all times are shown in the time zone of the conference. The current conference time is: 26th Sept 2023, 10:08:39am CEST
MS-74: Structural biology of receptors, signaling and membrane proteins
Invited: Robert Keenan (USA), Isabel Moraes (UK)
Receptor biology and signal transduction is an important area of research that is related to many diseases. This microsymposium will focus on new structural advances in the field of signal transduction.
For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below.
10:20am - 10:25am
Introduction to session
10:25am - 10:55am
Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
1National Physical Laboratory, Teddington, TW11 0LW, UK; 2Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK; 3Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK
11:25am - 11:45am
To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a “hunger switch” initiating satiety signaling.
1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel; 2Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 3Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK; 4Faculty of Agriculture, The Hebrew University, Israel
12:05pm - 12:25pm
Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis
1Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia; 2ACRF Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia ; 3Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA
12:25pm - 12:45pm
Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures
1Center for Structural Biology, Montpellier, France; 2Laboratoire de Spectrométrie de Masse Bioorganique, Strasbourg, France; 3Institut de Recherche en Cancérologie, Montpellier, France; 4Muséum National d'Histoire Naturelle, Paris, France
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