Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 26th Nov 2022, 02:36:25pm CET

Session Overview
MS-09: Structure guided drug design and antibiotic resistance targets
Sunday, 15/Aug/2021:
2:45pm - 5:10pm

Session Chair: Begoña Heras
Session Chair: Anton V. Zavialov
Location: Club A

170 1st floor

Invited: Vibha Gupta (India), Jade Forwood (Australia)

Session Abstract

Structure-based drug design is a powerful tool for accelerating drug discovery. This session will cover various aspects of the method. To address the growing threats of antibiotic resistance and emergence of new viral diseases, particular emphasis will be placed on the rational design of antibacterial and antiviral drugs.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below.

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2:45pm - 2:50pm

Introduction to session

Begoña Heras, Anton V. Zavialov

2:50pm - 3:20pm

Understanding viral host interactions that modulate nuclear transport and innate immunity

S. Tsimbalyuk1, K.M. Smith1, M.R. Edwards2, J. Batra2, T.P. Soares da Costa3, D. Aragao4, C.F. Basler2, J.K. Forwood1

1School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia; 2Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, USA; 3Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia; 4Australian Synchrotron, Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC, Australia

3:20pm - 3:50pm

Novel targets in old rouges: Integrative structural biology approach for discovery of natural product inhibitors

Vibha Gupta, Monika Antil, Sunita Gupta, Deepali Verma, Juhi Mathur

Jaypee Institute of Information Technology, A-10, Sector-62, Noida, U.P., India

3:50pm - 4:10pm

The structure of the ABC transporter PsaBC shows that bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life.

Stephanie L. Neville1, Jennie Sjöhamn2, Jacinta A. Watts1, Hugo MacDermott-Opeskin3, Stephen J. Fairweather3, Katherine Ganio1, Alex Carey Hulyer1, Andrew J. Hayes1, Aaron P. McGrath1, Tess. R. Malcolm1, Mark R. Davies1, Norimichi Nomura4, Iwata So4, Megan L. O’Mara3, Christopher A. McDevitt1, Megan J. Maher1

1The University of Melbourne, Parkville, Australia; 2University of Gothenburg, Gothenburg, Sweden.; 3Australian National University, Canberra, Australia; 4Kyoto University, Kyoto, Japan

4:10pm - 4:30pm

Uncovering the structures and mechanisms for the largest group of bacterial surface virulence factors.

Jason Paxman1, Julieanne Vo1, Gabriella Martínez Ortiz1, Makrina Totsika2, Alvin Lo3, Lilian Hor1, Santosh Panjikar4, Mark Schembri3, Begoña Heras1

1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia; 2Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Herston, Queensland, Australia; 3Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia; 4Macromolecular Crystallography, Australian Synchrotron, Clayton, Victoria, Australia

4:30pm - 4:50pm

Inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex through the novel macrocyclic peptides

Kai-En Chen1, Qian Guo1, Timothy A. Hill1, Yi Cui2, Amy K. Kendall3, Natalya Leneva4, Zhe Yang2, David P. Fairlie1, Hiroaki Suga5, Lauren P. Jackson3, Rohan D. Teasdale2, Toby Passioura6, Brett M. Collins1

1The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland, 4072, Australia; 2The University of Queensland, School of Biomedical Sciences, St Lucia, Queensland, 4072, Australia; 3Department of Biological Sciences, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; 4Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK; 5Department of Chemistry, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan; 6Sydney Analytical, the University of Sydney, Camperdown, New South Wales 2050, Australia

4:50pm - 5:10pm

Structural and mechanistic studies on carbapenem-hydrolysing class D serine β-lactamases leading to improved inhibitor design

Clyde Smith1, Nichole Stewart2, Marta Toth2, Sergei Vakulenko2

1Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USA; 2Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

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