XXV General Assembly and Congress of the
International Union of Crystallography - IUCr 2021
August 14 - 22, 2021 | Prague, Czech Republic
Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
Please note that all times are shown in the time zone of the conference. The current conference time is: 1st Nov 2024, 12:49:52am CET
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Session Overview |
Session | ||
MS-74: Structural biology of receptors, signaling and membrane proteins
Invited: Robert Keenan (USA), Isabel Moraes (UK) | ||
Session Abstract | ||
Receptor biology and signal transduction is an important area of research that is related to many diseases. This microsymposium will focus on new structural advances in the field of signal transduction. For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below. | ||
Introduction | ||
Presentations | ||
10:20am - 10:25am
ID: 1805 / MS-74: 1 Introduction Oral/poster Introduction to session 10:25am - 10:55am
ID: 1004 / MS-74: 2 Biological and macromolecular crystallography Invited lecture to session MS: Ultra-high resolution macromolecular crystallography and quantum biocrystallography, Structural biology of receptors, signaling and membrane proteins Keywords: Membrane Proteins, Photoreceptor, Receptor sensitization, Microbial rhodopsins Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization 1National Physical Laboratory, Teddington, TW11 0LW, UK; 2Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK; 3Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK 10:55am - 11:25am
ID: 1383 / MS-74: 3 Biological and macromolecular crystallography Invited lecture to session MS: Structural biology of receptors, signaling and membrane proteins Keywords: membrane protein biogenesis, cryo-EM, translocon, multi-pass, TMCO1 An ER translocon for multi-pass membrane protein biogenesis 1University of Chicago, Chicago, United States of America; 2University of California, San Francisco, United States of America 11:25am - 11:45am
ID: 1296 / MS-74: 4 All topics Oral/poster MS: CryoEM for macromolecules - from single particles to microcrystals, Structural biology of receptors, signaling and membrane proteins Keywords: GPCR, melanocortin, obesity, cryo-EM To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a “hunger switch” initiating satiety signaling. 1Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel; 2Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 3Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK; 4Faculty of Agriculture, The Hebrew University, Israel 11:45am - 12:05pm
ID: 809 / MS-74: 5 Biological and macromolecular crystallography Oral/poster MS: Structural biology of receptors, signaling and membrane proteins Keywords: Crystallography, Membrane Trafficking, Multidisciplinary, Mass Spectrometry, ISOLDE Unravelling the molecular architecture of the Commander assembly 1The University of Queensland, Brisbane, Australia; 2University of Melbourne, Melbourne, Australia; 3Cambridge Institute fo Medical Research, Cambridge, United Kingdom 12:05pm - 12:25pm
ID: 466 / MS-74: 6 Bursary application Poster MS: CryoEM for macromolecules - from single particles to microcrystals, Integrative structural biology: The next 50 years of the Protein Data Bank, Structural biology of receptors, signaling and membrane proteins Keywords: pore-forming toxin, bacterial proteins, membrane proteins, protein-membrane interactions Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis 1Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia; 2ACRF Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia ; 3Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA Bibliography
Christie, M.P., Johnstone, B.A., Tweten, R.K., Morton, C.J., Parker, M.W. (2018). Cholesterol-dependent cytolysins: from water-soluble state to membrane pore. Biophys Rev, 10: 1337. https://doi.org/10.1007/s12551-018-0448-x 12:25pm - 12:45pm
ID: 689 / MS-74: 7 Biological and macromolecular crystallography Oral/poster MS: Structural biology of receptors, signaling and membrane proteins Keywords: Synergy, binding cooperativity, supramolecular ligands, structural dynamics Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures 1Center for Structural Biology, Montpellier, France; 2Laboratoire de Spectrométrie de Masse Bioorganique, Strasbourg, France; 3Institut de Recherche en Cancérologie, Montpellier, France; 4Muséum National d'Histoire Naturelle, Paris, France |
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