XXV General Assembly and Congress of the
International Union of Crystallography - IUCr 2021
August 14 - 22, 2021 | Prague, Czech Republic
Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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Session Overview |
Session | ||
KN-24: Regulation of gene expression by transcription factors and RNA-binding proteins
Udo Heinemann | ||
Presentations | ||
Regulation of gene expression by transcription factors and RNA-binding proteins Max Delbrück Center for Molecular Medicine, Berlin, Germany In each human cell, only a subset of the genes is transcribed into RNA and translated into proteins, because gene expression is tightly regulated. The regulation of gene expression is a complex process involving several hierarchical stages, beginning in the nucleus with the control of transcription initiation by transcription factors. After maturation, mRNAs are translocated into the cytosol, where their stability, translation and, ultimately, degradation is under the control of RNA-binding proteins. The central event at all stages of gene expression regulation involves the recognition of DNA or RNA sequence motifs by transcription factors or RNA-binding proteins. Structural studies in my laboratory have highlighted crucial aspects of transcriptional and translational regulation. Transcriptional target gene recognition in bacteria (1) and eukaryotes (2,3) proceeds according to common principles, but differs in crucial aspects. Half-life and translation of mRNAs are controlled by proteins often binding to the 3’-untranslated regions of mRNAs. RNA-binding proteins studied in my laboratory promote mRNA degradation by recruiting nucleolytic degradation complexes (4,5) or through their intrinsic ribonuclease activity (6). References
External Resource: https://www.xray.cz/iucrv/vidp.asp?id=47
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