XXV General Assembly and Congress of the International Union of Crystallography - IUCr 2021

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Session

MS-34a: Structural biology of enzymes, mechanism and regulation

Time:

Tuesday, 17/Aug/2021:

10:20am - 12:45pm

Session Chair: Mirjam Czjzek

Location: Club B

50 1st floor

Invited: Liang Wu (UK), Orsolya Barabas (Germany)

Session Abstract

How does crystallography provide understanding of enzymes. This topic could also include recent advances in the area of time resolved crystallography.

For all abstracts of the session as prepared for Acta Crystallographica see PDF in Introduction, or individual abstracts below. The session continues in MS-92.

Introduction

Presentations

10:20am - 10:25am

Introduction to session

Mirham Czjzek

10:25am - 10:55am

Adventures in heparan sulfate degradation

Liang Wu¹, Zachary Armstrong², Casper de Boer³, Vincent Lit³, Gijs Ruijgrok³, Uri Barash⁴, Ilanit Boyango⁴, Neta Ilan⁴, Israel Vlodavsky⁴, Hermen S Overkleeft³, Gideon J Davies²

¹The Rosalind Franklin Institute, Didcot, OX11 0FA, United Kingdom; ²Department of Chemistry, University of York, York, YO10 5DD, United Kingdom; ³Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands; ⁴Technion Integrated Cancer Center (TICC), The Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel

External Resource:

10:55am - 11:25am

High-resolution structure and reaction cycle of Fatty Acid Photodecarboxylase: anatomy of a crime scene

Damien Sorigue¹, Kyprianos Hadjidemetriou², Stéphanie Blangy¹, Guillaume Gotthard³, Pierre Legrand⁴, Didier Nurizzo³, Antoine Royant³, Catherine Berthomieu¹, Martin Weik², Tatiana Domratcheva⁵, Klaus Brettel⁶, Martin Vos⁷, Ilme Schlichting⁸, Pavel Muller⁶, Fred Beisson¹, Pascal Arnoux¹

¹CEA, Saint Paul lez Durance, France; ²IBS, Grenoble, France; ³ESRF, Grenoble, France; ⁴SOLEIL, Gif-sur-Yvette, France; ⁵Lomonosov Moscow State University, Moscow, Russia; ⁶I2BC,Gif-sur-Yvette, France; ⁷Ecole Polytechnique, Palaiseau, France; ⁸MPI, Heidelberg, Germany

External Resource:

11:25am - 11:45am

Structural insights into the enzymatic mechanism of lytic polysaccharide monooxygenases

Flora Meilleur

NC State / ORNL, Raleigh, United States of America

External Resource:

11:45am - 12:05pm

Structural studies on a unique glucosamine kinase unveil a novel enzyme family

Jose Antonio Manso^1,2, Daniela Nunes Costa^3,4, Sandra Macedo Ribeiro^1,2, Nuno Empadinhas^3,4, Pedro Jose Barbosa Pereira^1,2

¹IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; ²Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; ³CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; ⁴PhD Program in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal

External Resource:

12:05pm - 12:25pm

Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides

Jorge Ripoll-Rozada^1,2, Mafalda Costa³, José Antonio Manso^1,2, Ana Maranha³, Vanessa Miranda⁴, André Sequeira⁴, Maria Rita Ventura⁴, Sandra Macedo-Ribeiro^1,2, Nuno Empadinhas^3,5, Pedro José Barbosa Pereira^1,2

¹IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; ²Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; ³CNC – Center for Neuroscience and Cell Biology, 3004-504 Coimbra, Portugal.; ⁴ITQB – Instituto de Tecnologia Química Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.; ⁵IIIUC - Interdisciplinary Research Institute, University of Coimbra, 3004-504 Coimbra, Portugal.

External Resource:

12:25pm - 12:45pm

Time-resolved serial femtosecond crystallography on photoswitchable fluorescent proteins

Kyprianos Hadjidemetriou

Institut de Biologie Strucutrale, Grenoble, France

External Resource:

Conference Agenda