Introduction to session

Begoña Heras, Anton V. Zavialov

Understanding viral host interactions that modulate nuclear transport and innate immunity

S. Tsimbalyuk¹, K.M. Smith¹, M.R. Edwards², J. Batra², T.P. Soares da Costa³, D. Aragao⁴, C.F. Basler², J.K. Forwood¹

¹School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia; ²Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, USA; ³Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia; ⁴Australian Synchrotron, Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC, Australia

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Novel targets in old rouges: Integrative structural biology approach for discovery of natural product inhibitors

Vibha Gupta, Monika Antil, Sunita Gupta, Deepali Verma, Juhi Mathur

Jaypee Institute of Information Technology, A-10, Sector-62, Noida, U.P., India

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The structure of the ABC transporter PsaBC shows that bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life.

Stephanie L. Neville¹, Jennie Sjöhamn², Jacinta A. Watts¹, Hugo MacDermott-Opeskin³, Stephen J. Fairweather³, Katherine Ganio¹, Alex Carey Hulyer¹, Andrew J. Hayes¹, Aaron P. McGrath¹, Tess. R. Malcolm¹, Mark R. Davies¹, Norimichi Nomura⁴, Iwata So⁴, Megan L. O’Mara³, Christopher A. McDevitt¹, Megan J. Maher¹

¹The University of Melbourne, Parkville, Australia; ²University of Gothenburg, Gothenburg, Sweden.; ³Australian National University, Canberra, Australia; ⁴Kyoto University, Kyoto, Japan

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Uncovering the structures and mechanisms for the largest group of bacterial surface virulence factors.

Jason Paxman¹, Julieanne Vo¹, Gabriella Martínez Ortiz¹, Makrina Totsika², Alvin Lo³, Lilian Hor¹, Santosh Panjikar⁴, Mark Schembri³, Begoña Heras¹

¹Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia; ²Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Herston, Queensland, Australia; ³Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia; ⁴Macromolecular Crystallography, Australian Synchrotron, Clayton, Victoria, Australia

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Inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex through the novel macrocyclic peptides

Kai-En Chen¹, Qian Guo¹, Timothy A. Hill¹, Yi Cui², Amy K. Kendall³, Natalya Leneva⁴, Zhe Yang², David P. Fairlie¹, Hiroaki Suga⁵, Lauren P. Jackson³, Rohan D. Teasdale², Toby Passioura⁶, Brett M. Collins¹

¹The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Queensland, 4072, Australia; ²The University of Queensland, School of Biomedical Sciences, St Lucia, Queensland, 4072, Australia; ³Department of Biological Sciences, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; ⁴Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK; ⁵Department of Chemistry, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan; ⁶Sydney Analytical, the University of Sydney, Camperdown, New South Wales 2050, Australia

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Structural and mechanistic studies on carbapenem-hydrolysing class D serine β-lactamases leading to improved inhibitor design

Clyde Smith¹, Nichole Stewart², Marta Toth², Sergei Vakulenko²

¹Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USA; ²Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

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