Conference Agenda

Session
Poster - 48 Fragment screening: Fragment screening
Time:
Saturday, 21/Aug/2021:
5:10pm - 6:10pm

Session Chair: Alice Douangamath
Session Chair: Lisa J. Keefe

 


Presentations
ID: 1975 / Poster - 48 Fragment screening: 1
Poster session abstracts
Poster

Poster session abstracts

Radomír Kužel



ID: 1479 / Poster - 48 Fragment screening: 2
Biological and macromolecular crystallography
Poster
MS: Fragment screening - 1 project, 100 datasets
Keywords: crystallographic fragment screening, spliceosome, protein-protein interaction, structure-guided drug design

Hundreds of starting points for spliceosomal PPI modulators identified by crystallographic fragment screening with the F2X-Universal Library

Tatjana Barthel1,3, Jan Wollenhaupt1, Gustavo M. A. Lima2, Markus C. Wahl3, Manfred S. Weiss1

1Helmholtz-Zentrum Berlin, Macromolecular Crystallography, Albert-Einstein-Str. 15, 12489 Berlin, Germany; 2MAX IV Laboratory, BioMAX, Fotongatan 2, 224 84 Lund, Sweden; 3Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Takustraße 6, 14195 Berlin, Germany



ID: 1404 / Poster - 48 Fragment screening: 3
Biological and macromolecular crystallography
Poster
MS: Fragment screening - 1 project, 100 datasets, Structure guided drug design and antibiotic resistance targets, Structural biology of enzymes, mechanism and regulation
Posters only: Macromolecular and biological crystallography (if it does not fit to any specific topics)
Keywords: Anaemia, Hypoxia-inducible factor (HIF), Prolyl-hydroxylases (PHDs), Oxygenases, Molidustat

HIF-Prolyl-Hydroxylase 2 Clinical Inhibitor Complex Structure and XChem Fragment-Based Screen Obtained with Succinate Co-Product Used as a Crystallisation Tool.

William D. Figg Jr1, Michael A. McDonough1, Yu Nakashima1,3, Rasheduzzaman Chowdhury1,2, Christopher J. Schofield1

1Department of Chemistry, University of Oxford, Oxford, United Kingdom; 2Cardiovascular Research Institute, University of California, San Fransciso, CA, United States; 3Institute of Natural Medicine, University of Toyama, Toyama, Japan



ID: 1062 / Poster - 48 Fragment screening: 4
Biological and macromolecular crystallography
Oral/poster
MS: Fragment screening - 1 project, 100 datasets
Keywords: fragment screening, protein crystallography, drug discovery

Updates from FragMAX, a crystallographic fragment screening platform at MAX IV Laboratory

Tobias Krojer

MAX IV Laboratory, Lund University, PO Box 118, S-221 00 Lund, Sweden