Poster session abstracts

Radomír Kužel

Structural characterisation of mitochondrial complex IV assembly factors

Shadi Magool¹, Luke Formosa², Dinesha Cooray³, David Stroud⁴, David Aragão⁵, Michael Ryan², Megan Maher¹

¹School of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia; ²Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton 3800, Australia; ³Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Australia; ⁴Department of Biochemistry and Molecular Biology and The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia; ⁵Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK

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Chemical biology and structural studies on the mechanism of regulation of phosphoinositide-dependent protein kinase 1 (PDK1)

Lissy Z. F. Gross¹, Mariana Sacerdoti¹, Alejandro E. Leroux¹, Abhijeet Ghode⁴, Ganesh S. Anand⁴, Jörg O. Schulze², Melissa A. Graewert⁵, Dmitri I. Svergun⁵, Sebastian Klinke³, Ricardo M. Biondi^1,2

¹IBioBA - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentine Republic; ²Department of Internal Medicine I, Universitätsklinikum Frankfurt, Germany; ³Leloir Institute - CONICET, Buenos Aires, Argentine Republic; ⁴Department of Biological Sciences, National University of Singapore, Singapore; ⁵European Molecular Biology Laboratory (EMBL), DESY Hamburg, Germany

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Structure of the Caulobacter Crescentus suppressor of copper sensitivity protein C

Guillaume A. Petit¹, Karrera Y. Djoko², Jennifer L. Martin^1,3, Maria A. Halili¹

¹Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia; ²Department of Biosciences, Durham University, UK; ³Vice-Chancellor’s Unit, University of Wollongong, NSW, Australia

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The structural panorama of L-asparaginases includes an alien from nitrogen-fixing bacteria

Mariusz Jaskolski¹, Joanna Loch², Mirek Gilski¹, Barbara Imiolczyk³

¹Faculty of Chemistry, A.Mickiewicz University, Poznan, Poland, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland; ²Faculty of Chemistry, Jagiellonian University, Cracow, Poland; ³Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

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Structures of a DYW domain shed first light on a unique plant RNA editing regulation principle

Mizuki Takenaka¹, Sachi Takenaka¹, Tatjana Barthel², Brody Frink¹, Sascha Haag³, Daniil Verbitskiy³, Bastian Oldenkott⁴, Mareike Schallenberg-Rüdinger⁴, Christian Feiler², Manfred S. Weiss², Gottfried J. Palm⁵, Gert Weber²

¹Department of Botany, Graduate School of Science, Kyoto University, Kyoto, Japan; ²Helmholtz-Zentrum-Berlin (HZB), Berlin, Germany; ³Molekulare Botanik, Universität Ulm, Germany; ⁴IZMB – Institut für Zelluläre und Molekulare Botanik, Abt. Molekulare Evolution, University of Bonn, Bonn, Germany; ⁵University of Greifswald, Molecular Structural Biology, Greifswald, Germany

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Seeing is believing: glycosylation in the crystal structure of human myeloperoxidase

Lucas Krawczyk¹, Shubham Semwal¹, Goedele Roos¹, Pierre Van Antwerpen², Julie Maria Jozefa Bouckaert¹

¹Centre National de REcherche Scientifique, Villeneuve d'Ascq, France; ²Laboratory of Pharmaceutical Chemistry and Analytical Platform, Faculty of Pharmacy, Université libre de Bruxelles, CP205/05, Boulevard du Triomphe, 1050 Brussels, Belgium

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14-3-3 protein dependent modulation of ubiquitin ligase Nedd4-2

Pavel Pohl^1,2, Tomáš Obšil^1,3, Veronika Obšilová¹

¹Intitute of physiology, CAS, Vestec, Czech Republic; ²Second Faculty of Medicine, Charles University in Prague, Czech Republic; ³Dept. of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, Czech Republic

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Bacillithiol disulfide reductase Bdr - insight into a new type of FAD-containing NADPH-dependent oxidoreductases

Marta Hammerstad¹, Ingvild Gudim¹, Hans-Petter Hersleth^1,2

¹University of Oslo, Department of Biosciences, Oslo, Norway; ²University of Oslo, Department of Chemistry, Oslo, Norway

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Exploring Polysaccharide lyases of PL-5 family through the lens of structure, function, and dynamics

Prerana Dash^1,2, Rudresh Acharya^1,2

¹National Institution of science education and research, Bhubaneswar, India; ²Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, Maharashtra, India

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Structural and functional characterization of a DNA binding protein of pIP501– a broad-host-range plasmid

Tamara Margot Isamel Berger¹, Nina Gubensäk¹, Walter Keller¹, Verena Kohler²

¹University of Graz, Graz, Austria; ²University of Stockholm, Stockholm, Sweden

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First crystallographic study of a glutathione transferase from cyanobacteria

Eva Mocchetti¹, Arnaud Hecker², Benoît Guillot¹, Sandrine Mathiot¹, Franck Chauvat³, Corinne Cassier-Chauvat³, Claude Didierjean¹

¹CRM2, UL, CNRS, Nancy, France; ²IAM, UL, INRAE, Nancy, France; ³I2BC, UPS, CNRS, CEA, Paris-Saclay, France

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Structural insights into the ferroxidase and iron sequestration mechanisms of ferritin from Caenorhabditis elegans

Tess R. Malcolm¹, Sanjeedha Mohamed Mubarak¹, Eric Hanssen², Hamish G. Brown², Gawain McColl³, Megan J. Maher^1,4, Guy N.L. Jameson¹

¹Bio21 Molecular Science and Biotechnology Institute, Parkville, Australia; ²Ian Holmes Imaging Centre, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia; ³The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; ⁴Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

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Precise Redox-dependent Structural Change of the plant-type Ferredoxin revealed by X-ray structures at 0.77 Å resolution, originated and propagating from the [2Fe-2S] cluster

Yusuke Ohnishi^1,2, Hideki Tanaka¹, Genji Kurisu¹

¹Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita city, Osaka 565-0871, Japan; ²School of Pharmaceutical Sciences, Wakayama Medical University, 25-1 Shichibancho, Wakayama city, Wakayama 640-8156, Japan

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Crystal structure of carbohydrate esterase SmAcE1 from Sinorhizobium meliloti

Changsuk Oh¹, Truc Kim¹, T. Doohun Kim², Kyeong Kyu Kim¹

¹Department of Precision Medicine, Sungkyunkwan University, Suwon, Korea, Republic of Korea; ²Department of Chemistry, College of Natural Science, Sookmyung Women's University, Seoul, 04310, Republic of Korea

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Half way to hypusine. Structural characterization of human deoxyhypusine synthase.

Elżbieta Wątor, Piotr Wilk, Przemysław Grudnik

Małopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland

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On substrate binding cavity of hyoscyamine 6β-hydroxylase from devil’s trumpet

Anna Kluza¹, Beata Mrugala¹, Katarzyna Kurpiewska^1,2, Przemyslaw J Porebski^1,3, Ewa Niedzialkowska^1,3, Wladek Minor³, Manfred S Weiss⁴, Maksymilian Chruszcz⁵, Tomasz Borowski¹

¹Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Krakow, Poland; ²Department of Crystal Chemistry and Crystal Physics, Faculty of Chemistry, Jagiellonian University, Krakow, Poland; ³Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA; ⁴Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Germany; ⁵Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA

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Control of hydroxylation regioselectivity by hyoscyamine 6β-hydroxylase as revealed by crystallographic and QM/MM studies

Zuzanna Wojdyla, Anna Kluza, Tomasz Borowski

Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Krakow, Poland

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Domain movements of NADPH–cytochrome P450 oxidoreductase (CPR) are required for the smooth electron transfer from CPR to heme–heme oxygenase-1 (HO-1) complex

Masakazu Sugishima¹, Junichi Taira², Mikuru Iijima³, Hideaki Sato¹, Kei Wada⁴, Masato Noguchi¹, Keiichi Fukuyama⁵, Mitsunori Takano³, Hiroshi Sakamoto², Ken Yamamoto¹

¹Kurume University School of Medicine, Kurume, Japan; ²Kyushu Institute of Technology, Iizuka, Japan; ³Waseda University, Tokyo, Japan; ⁴University of Miyazaki, Miyazaki, Japan; ⁵Osaka University, Toyonaka, Japan

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Conservation of a glutamate residue in ATP-citrate lyase and succinyl-CoA synthetase

Marie Elizabeth Fraser, Ji Huang

University of Calgary, Calgary, Canada

Monitoring the crystallization of two enzymes in real time by dynamic light-scattering

Kévin Rollet^1,2, Raphaël de Wijn¹, Sylvain Engilberge³, Alastair G. McEwen⁴, Oliver Hennig², Heike Betet², Mario Mörl², François Riobé⁵, Olivier Maury⁵, Philippe Bénas¹, Bernard Lorber¹, Claude Sauter¹

¹Université de Strasbourg, ARN, CNRS UPR9002, IBMC, Strasbourg, France; ²Institute for Biochemistry, Leipzig University, Leipzig, Germany; ³Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France; ⁴Université de Strasbourg, IGBMC, CNRS UMR 7104, INSERM U 1258, Illkirch, France; ⁵Université Lyon 1, ENS Lyon, CNRS-UMR 5182, Lyon, France

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Investigating The Structural Dynamics of the Water and Proton Channels Using snap-shots of Photosystem II

Mohamed Ibrahim

HU-Berlin, Berlin, Germany

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