Session | ||
MS-33: CryoEM for macromolecules - from single particles to microcrystals
Invited: Nenad Ban (Switzerland), Dimple Karia (Netherlands) | ||
Session Abstract | ||
Cryogenic electron microscopy (cryo-EM) rivals X-ray crystallography in terms of resolution and can be used to determine atomic structures of macromolecules that are either refractory to crystallization or difficult to crystallize in specific functional states. Electron diffraction can yield structures of proteins even when crystals are smaller than the wavelength of light. The session focuses on examples of both methods. We encourage people working on both single particle cryo-EM of biological macromolecules and electron diffractions of microcrystals to submit their abstract and to attend the Microsymposium entitled “Cryo-EM for macromolecules – from single particles to microcrystals”.
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Introduction | ||
Presentations | ||
10:20am - 10:25am
Introduction to session 10:25am - 10:55am
Structural basis of SARS-CoV-2 translational shutdown and programmed ribosomal frameshifting ETH Zurich, Zurich, Switzerland External Resource: https://www.xray.cz/iucrv/vidp.asp?id=256
10:55am - 11:25am
Home source for cryo-EM 1Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, Netherlands; 2Thermo Fisher Scientific Brno s.r.o, Materials & Structural Analysis, Brno, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=257
11:25am - 11:50am
High-resolution structures of immature and chimeric flaviviruses reveal key features redefining viral architecture and maturation 1Monash University, Clayton, VIC, Australia; 2The University of Queensland, Brisbane, QLD, Australia External Resource: https://www.xray.cz/iucrv/vidp.asp?id=258
11:50am - 12:15pm
Receptor induced rearrangements of capsid and genome prime rhinovirus 14 for activation and uncoating CEITEC MU, Brno, Czech Republic External Resource: https://www.xray.cz/iucrv/vidp.asp?id=259
12:15pm - 12:40pm
M. tuberculosis enolase: Crystal and Cryo-EM structures provide insights into 2-phosphoglycerate binding and catalysis 1National Institute of Immunology, New Delhi, India; 2National Centre for Biological Sciences, Bangalore 560065, India; 3Alagappa University ,Karaikudi, Tamil Nadu 630003, India; 4Infectious Disease Research Institute, 1616 Eastlake Avenue E, Suite 400, Seattle,WA98102, United States |