Introduction to session

Bostjan Kobe, Savvas Savvides

Catching fire: inflammatory responses mediated by inflammasomes, caspases, and gasdermins

Zhonghua Liu¹, Chuanping Wang¹, Jie Yang², Tsan Sam Xiao¹

¹Case Western Reserve University, Cleveland, OH, USA; ²The Scripps Research Institute, La Jolla, CA, USA.

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Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

Raoul Olivier Martin^1,3,4, Tiancong Qi^2,3,4, Haibo Zhang², Furong Liu^3,4, Miles King^3,4, Claire Toth⁵, Eva Nogales^5,6,7, Brian Staskawicz^3,4

¹Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA; ²Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; ³Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 USA; ⁴Innovative Genomics Institute, University of California, Berkeley, CA 94720 USA.; ⁵Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA; ⁶Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.; ⁷Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.

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Structural mechanism of NAD+ cleavage by plant TIR domain

Wen Song

Max Planck Institute for Plant Breeding Research, Köln, Germany

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The structure of the marsupial γμ T cell receptor defines a third T cell lineage in vertebrates

Kim Morrissey¹, Marcin Wegrecki², Praveena Thirunavukkarasu^2,3, Victoria Hansen¹, Komagal Sivaraman², Sam Darko⁴, Daniel Douek⁴, Jamie Rossjohn^2,3,5, Robert Miller¹, Jerome Le Nours^2,3

¹Center for Evolutionary & Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, USA; ²Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; ³Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, 3800, Australia; ⁴Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; ⁵Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK

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Bacterial lipopolysaccharide recognition by surfactant protein D

Annette K Shrive¹, Jamie R Littlejohn^1,2, Harry M Williams^1,3, William Neale¹, Stacey Collister¹, Derek Hood⁴, Stefan Oscarson⁵, Jens Madsen⁶, Howard Clark⁶, Trevor J Greenhough¹

¹School of Life Sciences, Keele University, Keele, United Kingdom; ²Current address: School of Biochemistry, University of Bristol, Bristol, United Kingdom; ³Current address: Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany; ⁴Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom; ⁵School of Chemistry, University College Dublin, Dublin, Ireland; ⁶EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, United Kingdom

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Molecular basis underpinning metabolite-mediated T-cell immunity

Wael Awad¹, Geraldine Ler², Jeffrey Y. W. Mak², Jérôme Le Nours¹, James McCluskey³, Alexandra J. Corbett³, David P. Fairlie², Jamie Rossjohn¹

¹Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia; ²Institute for Molecular Bioscience, The University of Queensland, Australia; ³Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia

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