Conference Agenda

Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).

Please note that all times are shown in the time zone of the conference. The current conference time is: 1st Nov 2024, 12:21:04am CET

 
 
Session Overview
Session
KN-4: Crystal forms in pharmaceutical applications
Time:
Sunday, 15/Aug/2021:
6:10pm - 7:00pm

Session Chair: Marijana Đaković
Location: Terrace 2B

100 2nd floor

Susan Reutzel-Edens


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Presentations

Crystal forms in pharmaceutical applications: Olanzapine, a gift to crystal chemistry that keeps on giving

Susan Reutzel-Edens1, Rajni Bhardwaj2

1Cambridge Crystallographic Data Centre, Cambridge, United Kingdom; 2AbbVie, North Chicago, IL USA

We review the efforts of many scientists around the world to discover and structurally characterize olanzapine crystal forms, clearing up inconsistencies in the scientific and patent literature and highlighting the challenges in identifying new forms amidst 60+ known polymorphs and solvates.[1] Owing to its remarkable solid-state chemistry, olanzapine has emerged over the last three decades as a popular tool compound for developing new experimental and computational methods for enhanced molecular level understanding of solid-state structure, form diversity and crystallization outcomes. This presentation highlights the role of olanzapine in advancing the fundamental level understanding of crystal forms, interactions within crystal structures, and growth units in molecular crystallization, and in influencing the way in which drugs are developed to this day.

[1] Reutzel-Edens, S.M., Bhardwaj, R. M. IUCrJ (2020). 7, 955-964 https://doi.org/10.1107/S2052252520012683

External Resource:
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