2:45pm - 2:50pmIntroduction to session
Stephen Neidle, Charles Bond
2:50pm - 3:20pmNon-canonical DNA structures and their interactions with small molecule ligands
Liliya A. Yatsunyk, Dana Beseiso, Sawyer McCarthy, Erin Chen, Elizabeth Gallagher, Joanne Miao
Swarthmore College, 500 College Ave, Swarthmore, PA, United States of America
3:20pm - 3:50pmStructural properties of Alien DNA, an alternative genetic system
Millie M. Georgiadis1, Shuichi Hoshika2, Steven Benner2
1Indiana University School of Medicine, Indianapolis, Indiana, United States of America; 2Foundation for Applied Molecular Evolution, Alachua, Florida, United States of America
3:50pm - 4:10pmAPE1 Exonuclease Distinguishes Various DNA Substrates by an Induced Space-Filling Mechanism.
Tung-Chang Liu2, Chun-Ting Lin1, Kai-Cheng Chang1, Kai-Wei Guo2, Shuying Wang3, Jhih-Wei Chu4, Yu-Yuan Hsiao2
1Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan; 2Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 30068, Taiwan; 3Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 30068, Taiwan
4:10pm - 4:30pmStructural characterization of clinically reported missense mutations identified in BRCA1
Neha Mishra, Suchita Dubey, Ashok K Varma
Tata Memorial Centre Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India
4:30pm - 4:50pmSolid-solid phase transition in adenine riboswitch crystals driven by large conformational changes induced by ligand
Jason R. Stagno1, Saminathan Ramakrishnan1, William F. Heinz2, Valentin Magidson2, Xiaobing Zuo3, Yun-Xing Wang1
1Center for Structural Biology, Centre for Cancer Research, National Cancer Institute, Frederick, MD-21702, USA.; 2Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.; 3X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA
Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72
Nobutaka Numoto1, Kunio Hirata2, Chizuru Akatsu3, Takeshi Tsubata3, Nobutoshi Ito1
1Department of Structural Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; 2RIKEN SPring-8 Center, Hyogo, Japan; 3Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
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