Introduction to session

Susan Kay Buchanan, Michael Parker

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Isabel Moraes¹, Peter J. Judge², Juan F. Bada Juarez², Danny Axford³, Tristan Kwan¹, Anthony Watts²

¹National Physical Laboratory, Teddington, TW11 0LW, UK; ²Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK; ³Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK

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An ER translocon for multi-pass membrane protein biogenesis

Philip T McGilvray¹, S Andrei Anghel¹, Arunkumar Sundaram¹, Frank Zhong¹, Michael J Trnka², James R Fuller¹, Hong Hu¹, Alma L Burlingame², Robert J Keenan¹

¹University of Chicago, Chicago, United States of America; ²University of California, San Francisco, United States of America

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To eat or not to eat: Cryo-EM structure of melanocortin receptor 4 reveals mechanism of a “hunger switch” initiating satiety signaling.

Oksana Degtjarik¹, Hadar Israeli^1,2, Li F. Chan³, Danny Ben-Zvi², Masha Y. Niv⁴, Peter J. McCormick³, Moran Shalev-Benami¹

¹Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK; ⁴Faculty of Agriculture, The Hebrew University, Israel

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Unravelling the molecular architecture of the Commander assembly

Michael David Healy¹, Joanna Sacharz², Tristan Croll³, David A Stroud², Brett M Collins¹

¹The University of Queensland, Brisbane, Australia; ²University of Melbourne, Melbourne, Australia; ³Cambridge Institute fo Medical Research, Cambridge, United Kingdom

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Two-component pore formation by the novel CDCL proteins ALY short and ALY long from Elizabethkingia anophelis

Bronte A Johnstone¹, Sara L Lawrence², Michelle P Christie¹, Rodney K Tweten³, Craig J Morton¹, Michael W Parker^1,2

¹Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia; ²ACRF Rational Drug Discovery Centre, St. Vincent’s Institute of Medical Research, Fitzroy, VIC 3065, Australia
; ³Department of Microbiology and Immunology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA

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Mechanistic insights into the synergistic activation ofthe RXR–PXR heterodimer by endocrinedisruptor mixtures

Vanessa Delfosse¹, Tiphaine Huet¹, Deborah Harrus¹, Meritxell Granell¹, Maxime Bourguet², Caroline Gardia-Parège³, Barbara Chiavarina³, Marina Grimaldi³, Sébastien Le Mével⁴, Pauline Blanc¹, David Huang¹, Jakub Gruszczyk¹, Barbara Demeneix⁴, Sarah Cianférani², Jean-Baptiste Fini⁴, Patrick Balaguer³, William Bourguet¹

¹Center for Structural Biology, Montpellier, France; ²Laboratoire de Spectrométrie de Masse Bioorganique, Strasbourg, France; ³Institut de Recherche en Cancérologie, Montpellier, France; ⁴Muséum National d'Histoire Naturelle, Paris, France

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