Conference Agenda

11:00am - 11:24am

NMR studies of RNA-mediated processes

D'Souza, Victoria

Harvard University, United States of America

11:24am - 11:36am

Detailed structural characterization of novel antivirals bound to stem 3 of the SARS-CoV-2 pseudoknot RNA

Adam, Jennifer¹; Kaiser, Frank¹; Schoth, Julian²; Richter, Christian¹; Jonker, Henry¹; Weigand, Julia²; Ferner, Jan-Peter¹; Schwalbe, Harald¹

1: Institute for Organic Chemistry and Chemical Biology, University Frankfurt; 2: Institute of Pharmaceutical Chemistry, Philipps-University Marburg

11:36am - 11:48am

Atomic Details of Orthosteric and Allosteric Inhibition of a Thermophilic Cas9 by an Anti-CRISPR on Distinct Motional Timescales

Knight, Alexa¹; Pindi, Chinmai²; Palermo, Giulia²; Lisi, George^1,3

1: Brown University, Dept. of Molecular Biology, Cell Biology & Biochemistry, USA; 2: Department of Bioengineering, University of California Riverside, USA; 3: Giuliani RNA Center, Brown University, USA

11:48am - 12:12pm

Structure and RNA recognition of nM RNA-binding small molecules

Varani, Gabriele

University of Washington, United States of America

12:12pm - 12:24pm

NMR Reveals Novel Dynamics in the Catalytic Core of a Theta Ribozyme

Fonyó, Máté; Johannsen, Silke; Sigel, Roland K.O.

University of Zurich, Switzerland

12:24pm - 12:36pm

Binding mode investigation of a photoswitchable azo compound binding to the SMN2 exon 7 5’-ss:U1 RNA

Herr, Alexander¹; Abendroth, Frank²; Jonker, Henry¹; Wirmer-Bartoschek, Julia¹; Richter, Christian¹; Wacker, Anna³; Vázquez, Olalla²; Schwalbe, Harald¹

1: Institute of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt/Main, Hesse 60438, Germany; 2: Department of Chemistry, University of Marburg, Marburg, Hesse 35043, Germany; 3: Max Planck Institute for Terrestrial Microbiology, Marburg, Hesse 35043, Germany

12:36pm - 1:00pm

Protonated nucleotides in RNA - what, where, when and why!

Wöhnert, Jens

Institute of Molecular Biosciences, Goethe-University Frankfurt, Germany