Micro-multiphysics agent-based modeling for the exploration of bone remodeling mechanisms and mechanoregulation in aging

R. Müller

In silico experiments on the role of osteocyte mechanosensing and communication in bone adaptation and damage repair

T. Adachi

Energy consumption using coupled colloidal clusters

A. Ehrmann, C. P. Goodrich

Probing the physical basis of human mitotic spindle self-organization using data from electron microscopy

S. Maddu, W. Conway, M. J. Shelley, D. Needleman

Self-organization of microtubules through hydrodynamic interactions drives cell-spanning rotational flows

D. Stein

A novel computationally efficient approach to evaluate mechanical properties of soft tissues from clinical imaging data

A. Pourasghar, T. Wong, M. Simon, J. C. Brigham

Efficient Bayesian approaches for forward and backward uncertainty propagation targeting complex biomechanical models and expensive legacy solvers

J. Nitzler, G. Robalo Rei, M. Dinkel, W. A. Wall

Global and local strain properties of skin during wound healing

S. Medina-Lombardero, C. Bain, A. Pellicoro, H. Rocliffe, J. Cash, R. Reuben, M. Crichton

Image-based micromechanical modelling of skin dermis

J. Li, O. Katsamenis, G. Limbert

A historical perspective on 50 years of modeling bone adaptation

S. Shefelbine

Three-scale modelling approach of cancellous bone remodelling

I. Schmidt, P. Pivonka, P. Steinmann, A. Papastavrou

Longitudinal HR-pQCT-derived remodelling and mechanoregulation – the pathway to mechanical biomarkers

C. J. Collins

In silico model for cortical bone resorption in disuse condition

H. Shekhar, J. Prasad

Computational modelling of leukocyte dynamics in microfluidic devices for rapid sepsis detection

C. Mallorie, T. Krüger

Biomechanics and mechanobiology of the lymphatic vessels

B. Kaoui

A computational model of chemically and mechanically induced platelet plug formation

G. Cardillo, A. Barakat

Physics of the extreme deformation of red blood cells in splenic slits

A. Moreau, F. Yaya, A. Charrier, E. Helfer, Z. Peng, A. Viallat

Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over several growth conditions and cell lines

P. Van Liedekerke, J. Neitsch, T. Johann, K. Alessandri, P. Nassoy, D. Drasdo

A single-cell mechanical model to study epithelial homeostasis during embryogenesis

J. Vangheel, B. Smeets

Computational modelling of magnetic nanoparticle-mediated drug delivery in a multiphase porous media tumour model

B. Wirthl, C. Janko, B. A. Schrefler, C. Alexiou, W. A. Wall

Continuum-mechanical- and data-driven simulations of brain tumours

M. Suditsch, T. Ricken, A. Wagner

Predicting cancer cell mechanics based on cell phenotype and the microenvironment

E. T. Karabay, S. I. Fraley, P. Katira

Modeling bacterial biofilm architecture in function of extracellular matrix production

T. Belpaire, J. Meesters, B. Lories, H. Steenackers, B. Smeets

CFD modelling in the myocardial bridge for experimental conditions and virtual blood flow for specific patient

B. Melka, K. Psiuk-Maksymowicz, D. Borys, Z. Ostrowski, M. Rojczyk, M. Gracka, W. P. Adamczyk, R. A. Bialecki

Effect of blood viscosity change on the prediction of recanalization in coil embolized intracranial aneurysms

H. Kanebayashi, S. Fujimura, K. Masuda, T. Ishibashi, H. Takao, Y. Murayama, M. Yamamoto

Unlocking cardiac sympathovagal balance: insights from a mathematical model and autonomic markers

M. Haberbusch, F. Moscato

Fluid-structure-interaction simulation of bioprosthetic aortic valve using an anisotropic hyperelastic leaflet material model

B. C. Riebartsch, P. Werner, M. Ghodrati, P. Aigner, H. Schima, F. Moscato

Hemodynamic investigation on thin-walled regions in intracranial aneurysms by using CFD and image analysis

K. Masuda, S. Fujimura, S. Kakizaki, T. Ishibashi, H. Takao, Y. Murayama, M. Yamamoto

Physiologically valid models of cardiac electromechanics with clinical applications

C. M Augustin, M. A. Gsell, G. Plank

Effect of materials selection on the performance of a coronary stent - an in silico approach

G. Karanasiou, P. Siogkas, N. Tachos, V. Loukas, A. Sakellarios, C. Katsouras, A. Semertzioglou, L. Michalis, D. Fotiadis

A continuum mechanics approach to assess the tensile properties of lamin rods

S. Avril, C. Hellmich, J. Kalliauer

Establishing the hierarchical structure of spider silk from molecular to centimeter length scales

H. C. Schniepp

Molecular origin of mechanobiology of breast and prostate cancer bone metastasis

D. Katti, S. Jaswandkar, H. Gaikwad, K. Katti

Peptide and peptide-mimetics targeting biohybrid interfaces for therapeutic intervention of oral diseases

C. Tamerler

Protein interactions informs translation pathway for disease mitigation and regeneration

C. Chen, C. Tamerler, M. L Snead

Role of fluid-flow induced shear stresses on bone metastasis

K. Katti, H. Jasuja, S. V. Jaswandkar, D. R. Katti

3D-meniscua-regeneration: from μCT imaging to 3D printing

A.-C. Moser, J. Fritz, A. Otahal, K. Schneider, A. Teuschl, S. Nehrer

Comparison of patient-specific knee joint motion modelling using position-based dynamics and finite element methods

A. Rörich, K. Izadpanah, E. Theilen, L. Walczak, T. Lange, C. Huber, J. Georgii

Computational model of guided growth in immature skeleton for custom-made correction of deformities

J. Mateos Arriola, M. A. González Ballester, J. Noailly

Constitutive modeling of active skeletal muscle in a continuum-mechanical model of the human shoulder

L. Engelhardt, R. Sachse, R. Burgkart, W. A. Wall

Development of individual rib implants using thorax FEM simulations and 3D printing technology

A. Gradischar, C. Lebschy, W. Krach, M. Krall, M. Fediuk, A. Gieringer, J. Lindenmann, D. Auinger, F. Smolle-Jüttner, N. Hammer, B. Beyer, U. Schäfer

Predicting femoral bone strength after cephalomedullary nail removal with FE models using pre-operative CT scans

A. Synek, G. M. Schwarz, A. G. Reisinger, S. Huber, S. Nuernberger, L. Hirtler, J. G. Hofstaetter, D. H. Pahr

Validation of nonlinear μFE models of cortical bone using SR-μCT imaging and digital volume correlation

M. Peña Fernández, S. McPhee, U. Wolfram

A novel data-driven constitutive model for individual collagen fibrils based on hypoelasticity

Y. Chiang, C. Hellmich, P. J. Thurner

Homeostatic, stress-driven, isotropic growth in soft tissues: a hypoelastic micromechanical framework

F. Galbiati, C. Morin, S. Avril

In silico study of the mechanical characterization of atherosclerotic tissues in coronary arteries

A. T. Latorre Molins, M. Á. Martínez Barca, E. Peña Baquedano

Numerical investigation of efficiency of bionic-inspired shape memory polymer stents

L. Virag, M. Mijatović, I. Karšaj

Simple approach for ultrasound-based AAA stiffness estimation including the effects of surrounding tissues and probe pressure

M. I. Bracco, L. Rouet, M. E. Biancolini, S. Avril

Cervical spine segmentation for tissue engineering applications

D. A. Santos, A. P. G. Castro, P. R. Fernandes

Design and finite element analysis of a Voronoi-based ceramic scaffold for bone tissue engineering with enhanced strength

L. D'Andrea, A. De Cet, D. Gastaldi, P. Vena

Computational analysis of the compressive behaviour of TPMS scaffolds for bone tissue engineering

F. Todescato, R. B. Ruben, P. R. Fernandes, P. Vena, A. P. G. Castro

Fracture of compression-dominated ceramic-based bone scaffold through the phase field model

A. De Cet, L. D'Andrea, D. Gastaldi, P. Vena

Numerical analysis and fabrication of auxetic tissue-engineered scaffolds for skin wound healing applications

O. Lecina Tejero, M. Á. Pérez, E. García-Gareta, J. Iamsamang, A. Gonçalves, M. Dias Castilho, C. Borau

Numerical simulation of electro-stimulative bone implants - a multiscale perspective

H. Raben, R. Appali, A. K. Fontes Gomes, U. van Rienen

Bone adaptation: role of interstitial fluid flow and pore pressure

S. Singh, S. J. Singh, J. Prasad

An innovative web-based learning platform for improving knowledge and skills in fracture healing simulation in application to literature comparison of in-vivo data

L. Engelhardt, F. Niemeyer, K. Urban, U. Simon

Relating strain threshold and bone formation rate to exogenous forcing frequency

J. Prasad, S. Singh, H. Shekhar

Challenges in modeling the morphogenesis of human-cell-based organoids

D. Camacho Gómez, I. Gonçalves, M. J. Gomez-Benito, S. Hervas-Raluy, M. A. Perez, P. Guerrero, C. Borau, J. M. García Aznar

Communications among bone cells in response to physical forces: role of extracellular ATP and its derivatives

S. Komarova

A computational model of the intracellular interactions after acto-myosin activation

A. A. Karkhaneh Yousefi, S. Avril

Isolated structures in the actin cortex: a theory of solitude

L. Barberi, K. Kruse

Cytoskeletal networks at interfaces

A. Zampetaki, S. Fürthauer

Multiscale framework for estimating elastic response of cytoskeleton during intracellular transport

J. Köry, N. A. Hill, X. Luo, P. S. Stewart

Application of the Kalman filter for estimation of material parameters of arteries

M. Ł. Mesek, J. Sturdy, Z. Ostrowski, R. Białecki

Biomechanical analysis of aortic roots: differences between tricuspid and bicuspid aortic valve patients

P. Mortensen, A. Pouch, A. Aggarwal

Estimation of material parameters of the arterial wall through inverse modeling with a 1D model of the artery

J. Sturdy, A. Sinek, M. Mesek, W. Adamczyk, Z. Ostrowski, R. Białecki

Multifidelity Monte Carlo estimates of Sobol sensitivity indices to investigate the hemodynamic response of the common carotid artery

F. Schäfer, D. Schiavazzi, J. Sturdy

Towards a coupled multiphase porous media approach for modeling air flow, blood flow and gas exchange in the human lungs

L. J. Köglmeier, C. M. Geitner, B. Z. Temür, B. Wirthl, W. A. Wall

A continuum model to predict mechanosensing of fibroblast cells adhered on different materials

W. Yang, M. Luo, Y. Gao, X. Feng, J. Chen

Modelling vascular tone regulation: a chemo-mechano-biological approach integrating molecular and systemic mechanisms

M. Marino, B. Sauty, G. Vairo

A micromechanics-informed beam model of growing wood structures

A. Wagner, S. Scheiner

In vivo and in silico red blood cell lingering and partitioning in the microcirculation

Y. Rashidi, G. Simionato, Q. Zhou, T. John, T. Krüger, L. Kaestner, M. W. Laschke, M. D. Menger, C. Wagner, A. Darras

The effect of glycocalyx alteration on red blood cells aggregation

M. Jin, M. Abbasi, C. Misbah

Time-dependent and transient states of red blood cells

S. Gekle

Red cell movement as a clinical mechanical marker in sickle cell disease

M. Sahun, E. Bernit, S. Atwell, A. Hornung, A. Charrier, E. Helfer, C. Badens, A. Viallat

Spatio-temporal regulation of cortical bone remodeling: new insights through four-dimensional imaging of rabbit models

D. Cooper, K. Harrison, L. Loundagin, X. Wei, P. Pivonka

Shedding light on old bones: modern imaging methods elucidate early tetrapod skeletal evolution over the water-land transition

A. Clement

Studies of Melbourne bones, and the shape and size of voxels in LM, CSLM, XMT and SEM: cross-correlative microscopies

A. Boyde

Cellular organization and interplay of human bone remodeling events

T. L. Andersen

Scaling of osteocyte lacuna density and its implications for the tissue-specific metabolic rate of bone

T. Bromage, B. Colohan, B. Hu

Multiscale and multidisciplinary perspectives on bone growth, remodeling and adaptation

H. M. Goldman

Biomechanical analysis of the fetal membrane under different off-plane collagen fibers

D. S. Fidalgo, M. Oyen, D. Oliveira, M. Parente, R. Natal, K. Myers

Nanoscale behavior and characterization of collagen in the human broad ligament of the uterus using small-angle X-ray scattering and histology

A. vom Scheidt, J. A. Niestrawska, G. G. Schulze-Tanzil, B. Sochor, M. Schwartzkopf, S. V. Roth, K. Schneider, D. Möbius, B. Ondruschka, N. Hammer

Predicting pelvic floor injuries during childbirth using machine learning and finite element simulations

R. Moura, D. Oliveira, M. Parente, R. Natal Jorge

Strain-driven anisotropic growth: a constitutive model for solid tumors

M. R. Carvalho, J. P. S. Ferreira, M. Parente

Surrogate modelling of the constitutive behaviour of hyperelastic materials based on artificial neural networks

E. Carvalho, J. Ferreira, M. P. L. Parente

Determining in vivo biomechanical properties of the bladder in patients with and without urinary incontinence

E. Silva, S. Brandão, N. Ferreira, F. Pinheiro, A. A. Fernandes

Coupled agent-based and finite-element models for analysis of force-sensitive cell and tumour growth

I. Senthilkumar, E. Howley, E. McEvoy

A novel contact-mechanics based model for endothelial permeability

P. Keshavanarayana, E. Moeendarbary, F. Spill

A new tool to simultaneously determine cell mechanics and cell-to-surface adhesion

M. Luo, W. Yang, J. M. G. Higgins, J. Chen

In-silico modelling of prostate cancer growth

Á. Pérez-Benito, S. Hervas-Raluy, M. Á. Pérez

A new numerical algorithm to simulate angiogenesis during tumour growth

M. I. Araújo Barbosa, J. A. Oliveira Belinha, R. Natal Jorge, A. Xavier de Carvalho

Insights into the biomechanics and clinical implications of neuroblastoma tumour evolution modelling

S. Hervas-Raluy, D. Sainz-DeMena, M. J. Gomez-Benito, J. M. Garcia-Aznar

Application of machine learning algorithms for shear stress classification of hip implant surface topographies

A. Vulović, T. Geroski, N. Filipović

Automatic segmentation of 3D cell volumes based on 2D U-Net convolutional neural network

O. Pavić, L. Dašić, J. Barrasa-Fano, H. Van Oosterwyck, N. Filipović

Combining deep learning and meshing techniques for automatic segmentation and 3D reconstruction of atherosclerotic carotid arteries

S. Tomasevic, T. Djukic, B. Arsic, M. Anic, B. Gakovic, I. Koncar, N. Filipovic

Hierarchical physically based machine learning in material science: the case study of spider silk

V. Fazio, N. M. Pugno, O. Giustolisi, G. Puglisi

Improving the accuracy of peripheral artery plaque progression models with artificial intelligence

L. Spahic, L. Benolic, S. Ur Rehman Qamar, V. Simić, B. Miličević, M. Milošević, T. Geroski, N. Filipović

Integration of Huxley muscle surrogate model based on physics-informed neural network into finite element solver

B. Milicevic, M. Milosevic, M. Ivanovic, B. Stojanovic, M. Kojic, N. Filipovic

A coupled multiphysics approach for modeling in-stent restenosis

K. Manjunatha, M. Behr, F. Vogt, S. Reese

Modelling of thrombosis in aortic dissection with the theory of porous media

I. Gupta, M. Schanz

Sensitivity study of a computational model for endovascular coil deployment in cerebral aneurysms

F. Holzberger, M. Muhr, B. Wohlmuth

Image-based simulation of left ventricular hemodynamics: a numerical framework towards clinical feasibility

K. Vellguth, L. Obermeier, M. Wiegand, F. Hellmeier, L. Goubergrits

A structural numerical simulation preliminary study of a left atrial appendage

S. Valvez, M. Oliveira-Santos, M. A. Neto, A. P. Piedade, L. Gonçalves, A. M. Amaro

Computational prediction of elastic properties of material jetted multimaterials

E. Kornfellner, M. Königshofer, L. Krainz, A. Krause, E. Unger, F. Moscato

Effects of clinical CT imaging and image processing on anatomic 3D model accuracy and their relevance for clinical applications

M. Frank, A. Strassl, E. Unger, L. Hirtler, B. Eckhart, M. Königshofer, A. Stoegner, A. Nia, D. Popp, K. Staats, F. Kainberger, R. Windhager, F. Moscato, E. Benca

Development of a biomechanical device to support the fixation and adjustment for Chevron Osteotomy

M. Santos, E. Cortesão Seiça, P. Carvalhais, L. Roseiro

Acoustic wave propulsion of fluids in tissues - homogenization and nonlinearity

E. Rohan, F. Moravcová, V. Lukeš

Modelling flow and transport in liver micro-architecture: towards a multi-functional digital twin

P. Kottman, E. Rohan, D. Drasdo, I. Vignon-Clementel

CANCELLED! Role of flexo-piezo-electricity in bone interstitial fluid flow

T. Lemaire, B. Flament, E. Rohan

Cellular responses to substrate topography: opportunities for computational modeling

A. Barakat

From bone cell population models to in-silico trials of osteoporosis treatments

P. Pivonka

A multiscale and multiphase digital twin of function-perfusion processes in the human liver

T. Ricken, L. Lambers, A. Mielke, L. Mandl, S. Gerhäusser

Studying the impact of drug metabolism on the liver tissue: An integrated PBPK-continuum biomechanical modeling approach

M. König, S. Gerhäusser, L. Mandl, L. Lambers, H.-M. Tautenhahn, T. Ricken

Staging of ischemia reperfusion injury during liver transplantation using continuum-biomechanical modeling

L. Mandl, S. Gerhäusser, L. Lambers, M. König, H.-M. Tautenhahn, U. Dahmen, T. Ricken

Time-dependent behavior of inflated tubular structures applicable to arterial soft tissue

H. Topol, M. Stoffel, B. Markert

Chiral active liquid crystals

A. Maitra

Synchronization in collectively moving inanimate and living active matter

M. Riedl, J. Merrin, M. Sixt, B. Hof

Structural states and Hamiltonian conservation laws in biological active flows

N. Oppenheimer, M. Shelley, D. Stein, M. Y. Ben Zion, Y. Shoham

Theory for synchronization driven flows in bulk and on surfaces

B. Chakrabarti, S. Fuerthauer

Turing patterns as a model for predicting morphogen expression in joint formation

E. Comellas, S. Ben Tahar, J. J Muñoz, S. J Shefelbine

A continuum mathematical framework for cell phenotypic plasticity using internal variables: simulating glioblastoma adaptation to hypoxia

M. Pérez-Aliacar, J. Ayensa-Jiménez, M. Doblaré

Modification and interactions of chemical and biomechanical instability modes in a model of small GTPase signalling molecule

M. Leda, A. Goryachev

Red blood cell and calcium dynamics from endothelial cells

A. K. Nayak, S. L. Das, C. Misbah

Multi-scale modeling of the humidity-induced response of spider silk

N. Cohen, M. Levin, C. Eisenbach

An asymptotic homogenisation approach for nonlinear viscoelastic composites

A. Roque-Piedra, R. Rodriguez-Ramos, R. Penta, A. Ramirez-Torres

Optimal unit cell design using neural networks and multiscale techniques

A. Pais, J. L. Alves, J. Belinha

Periodic rhomboidal cells for symmetry-preserving homogenization and isotropic metamaterials

G. G. Giusteri, R. Penta

Development and simulation of a detailed modelling human leg – application in in silico orthopedics

O. Avci, A. Ranjan, A. C. Yildiz

Exploring bone remodelling via a novel micromorphic approach

A. Titlbach, A. Papastavrou, A. McBride, P. Steinmann

Electro-mechanical modeling and simulation of the human heart

T. Gerach, J. Krauß, C. Wieners, A. Loewe

Numerical treatment and sensitivity analysis of a cell-based mathematical model of tissue regeneration

E. Grosjean, B. Simeon

Turing patterns in growing three-dimensional domains

S. Ben Tahar, E. Comellas, J. J Muñoz, S. J Shefelbine

Variational modeling of biomechanical systems

M. Liero, D. Peschka

A combined mathematical-computational tool for the fracture behaviour of hierarchical fibre bundles

D. Liprandi, J. O. Wolff

Influence of mounting-induced pre-stretches on the material characterization of soft tissue

T. Škugor, L. Virag, I. Karšaj, G. Sommer

Mechanical and structural mapping of the human dura mater

J. A. Niestrawska, M. Rodewald, C. Schultz, E. Quansah, T. Meyer-Zedler, M. Schmitt, J. Popp, N. Hammer

Mechanical properties of collagen-based bioresorbable composite material for pulmonary artery banding

Z. Petřivý, L. Horný, H. Chlup, Z. Sobotka, J. Kronek, T. Suchý, L. Vištejnová, E. Kuželová Košťáková

Mechanical properties of venous aneurysmatic tissue

Z. Sobotka, L. Horný, H. Chlup, J. Kronek, Z. Petřivý, N. Petrová, P. Baláž

Numerical analysis of the compression behaviour of cell spheroids

D. Giannopoulos, M. Schlittler, R. Coppini, C. Palandri, P. Stefàno, P. J. Thurner, A. Rossini, O. G. Andriotis

Symmetry-constraint Compact Tension test for mechanical fracture characterisation of biological soft tissue

M. Alloisio, C. T. Gasser

Piezoelectric excitation of bone metabolism scrutinized by means of multiscale modeling

E. Kornfellner, S. Scheiner

Doing it right - bone mineral measurements with X-ray micro-tomography

D. Mills

Anisotropic properties of peri-implant bone tissue are affected by collagen fibre orientation

L. Colabella, S. Naili, S. Le Cann, G. Haiat

3D analytical beam theory for magnesium pin-implanted rat femur

L. Pircher, T. Grünewald, H. Lichtenegger, M. Liebi, A. Weinberg, C. Hellmich

A stochastic cellular automaton model to simulate bone remodeling

A.-D. Heller, A. Valleriani, A. Cipitria, S. A. E. Young

Study of effects of bone turnover and mineralisation kinetics on BMDD through a discrete statistical bone remodelling model

N. M. Castoldi, E. Pickering, M. Antico, V. Sansalone, D. Cooper, P. Pivonka

The long way round: from applications to fundamental features of apatites

C. E Greenwood, E. L Arnold, S. B Gosling, S. Beckett, R. Scott, K. D Rogers

Development of a novel stochastic finite element solver to predict variation in bone mechanics considering the uncertain bone mineral density

S. Pouresmaeeli, P. Bhattacharya

Dynamic 3D mechanical numerical modeling for human sperm motility through the female reproductive system to predict sperm chance of reaching the oocyte

M. Nassir, M. Levi, N. Shaked

Mechanical properties and constitutive modelling of deep fascia

A. Aparici, E. Peña Baquedano, M. M. Perez

Multi-modal imaging-based computational bone strength assessment incorporating pre-existing ‘hidden’ microporosity

S. McPhee, L. Kershaw, C. Daniel, M. Peña Fernández, S. Taylor, U. Wolfram

Bipedal neuromusculoskeletal model for biomechanical simulations of sit-to-stand movement

D. Mosconi, A. Siqueira

Mechanics: a new tool for cancer biology

K. S. Katti, D. R. Katti