Conference Agenda
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Daily Overview |
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GR1_2_4: Pitch oral & WG Monitoring and surveillance of physical activity Group Meeting Location: Glass room 1 Session Chair: Pauliina Husu | |
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3:58pm - 4:01pm
Associations of device-assessed physical activity and sedentary behaviour with mental health and quality of life in a rare genetic metabolic condition, Fabry disease 1: Brunel University of London, United Kingdom; 2: Royal Free London NHS Foundation Trust, United Kingdom; 3: University College London, United Kingdom Purpose: Fabry disease is an inherited metabolic disorder affecting breakdown of glycolipids in cell lysosomes leading to multi-organ disease, particularly the brain, heart and kidneys. This study evaluated associations of physical activity and sedentary behaviour with mental health and quality of life (QoL) in adults with Fabry disease. Methods: Cross-sectional design study with N=94 adults with Fabry disease. Sitting, standing and stepping were measured using the activPAL4™. Outcomes were the Hospital Anxiety and Depression Scale and the EuroQol five-dimension questionnaire. Analysis was correlations and multiple linear regression. Results: Time in stepping bouts >10 minutes was correlated with anxiety (r = −0.185). Daily stepping time (r = −0.216), daily steps (r = −0.224) and time in stepping bouts of >2, 5 and 10 minutes (r = −0.265, −0.293 and −0.220, respectively) were correlated with depression. Daily sitting time and prolonged sitting time were adversely correlated with QoL (r = −0.184 and r = −0.150, respectively); increased stepping time, number of steps, and time stepping in bouts of >2 and 5 minutes were correlated favourably (r = 0.337, 0.328, 0.219 and 0.211, respectively). Time in stepping bouts >5 minutes predicted lower depression (β = −0.269). Higher daily steps predicted improved QoL (β = 0.267). Conclusions: Increased stepping is beneficially associated with depression and QoL in adults with Fabry disease, whereas higher sitting time was associated with lower QoL. Stepping bouts lasting at least 2 to 10 minutes could be particularly important for optimal management. Funding source: Society for Mucopolysaccharide Diseases (reference CSAC-BAI.BRU.202110). | |
