IMPACT OF COMBINED MECHANICAL LOADING AND OSTEOPOROSIS TREATMENT ON MURINE OSTEOCYTE LACUNAR MORPHOLOGY

S. Lindenmann, Z. Li, F. A. Schulte, C. Weigt, F. M. Lambers, G. A. Kuhn, N. Mathavan, R. Müller

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland

BONE MATRIX PROTEINS AS KEY REGULATORS OF THE SKELETAL MECHANO-RESPONSE

M. Fontcuberta-Rigo¹, S. Shimochi¹, P. Puigbò^1,2, M. Nakamura^1,3,4

¹University of Turku, Finland; ²Autonomous University of Barcelona, Spain; ³Tokyo Medical and Dental University, Japan; ⁴Tohoku University, Japan

TIME-LAPSED GENE MECHANOREGULATION ANALYSIS DURING BONE FRACTURE HEALING

F. Correia Marques¹, A. Singh¹, N. Mathavan¹, D. Günther¹, E. Wehrle^1,2, R. Müller¹

¹Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; ²AO Research Institute Davos, Davos Platz, Switzerland

PATIENT SPECIFIC MECHANOBIOLOGICAL MODEL OF BONE ADAPTION IN VERTEBRAE WITH MULTIPLE MYELOMA

F. Gibson^1,2, R. Andrews¹, M. Lawson¹, J. Shelton³, S. Molloy⁴, X. Li^1,2, E. Dall'Ara^1,2, S. Verbruggen³

¹The University of Sheffield, United Kingdom; ²Insigneo Institute, The University of Sheffield, United Kingdom; ³Queen Mary University of London, United Kingdom; ⁴Royal National Orthopaedic Hospital, London, United Kingdom

MECHANICAL NICHE VISCOELASTICITY GENERATES PRO-INFLAMMATORY AND REPARATIVE MACROPHAGE PHENOTYPES

R. S. Knecht¹, D. J. Mooney^3,4, K. Schmidt-Bleek^1,2, G. N. Duda^1,2

¹Julius Wolff Institute, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Germany; ²Berlin Institute of Health Center for Regenerative Therapies at Charité – Universitätsmedizin Berlin; ³John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston MA, USA; ⁴Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA