Conference Agenda

BIOMECHANICAL PROPERTIES OF 3D PRINTABLE MATERIAL USABLE FOR SYNTHETIC PERSONALIZED HEALTHY HUMAN AORTA

S. LIN¹, G. Tarris², C. Bernard², M. Kafi^1,2, P. M. Walker^1,2, D. M. Marín-Castrillón¹, C. Gobled³, A. Boucher¹, B. Presles¹, M. C. Morgant², A. Lalande^1,2, O. Bouchot^1,2

¹ICMUB, University of Burgundy, Dijon, France; ²University Hospital of Dijon, Dijon, France; ³ENNOIA company, Besançon, France

TOWARDS THE DEVELOPMENT OF A ZEBRAFISH ACTION POTENTIAL MODEL

L. Cestariolo¹, J. M. Ferrero², Z. Long³, T A. Quinn³, J. F. Rodriguez Matas¹

¹Politecnico di Milano, Italy; ²Universitat Politecnica de Valencia, Spain; ³Dalhousie University, Canada

ANISOTROPIC PROPERTY CHARACTERIZATION OF HUMAN CAROTID PLAQUES BY USING INVERSE FINITE ELEMENT MODELING

S. Guvenir Torun¹, B. Kaaij^1,2, P. de Miguel Munoz^1,2, H. Crielaard¹, H. J. Verhagen¹, G.-J. Kremers¹, A. F. van der Steen¹, A. C. Akyildiz^1,2

¹Erasmus Medical Center, Rotterdam, The Netherlands; ²Delft University of Technology, Delft, The Netherlands

AORTIC CALCIFICATIONS LOCALLY AFFECT DISSECTION BEHAVIOR

C. L. Donahue¹, R. Badal², V. H. Barocas¹

¹Department of Biomedical Engineering, University of Minnesota - Twin Cities, USA; ²Department of Mechanical Engineering, University of Minnesota - Twin Cities, USA

MEASUREMENT OF HIGH STRAIN TENSILE FAILURE PROPERTIES OF CAROTID PLAQUE EMBOLUS ANALOGS

J. Monclova, T. Barraclough, V. Kannojiya, F. Costanzo, S. Simon, K. Manning

The Pennsylvania State University, United States of America

MODULAR CONTROLLER FOR PREDICTIVE SIMULATIONS OF HUMAN STANCE AND GAIT

D. Muñoz, G. Severini

University College Dublin, Ireland

UNRAVELLING ADAPTATION STRATEGIES IN SIT-TO-WALK USING PREDICTIVE NEUROMUSCULAR SIMULATIONS

E. van der Kruk, T. Geijtenbeek

Delft University of Technology, Netherlands, The

EFFECT OF VISION AND SURFACE SLOPE ON POSTURAL SWAY IN HEALTHY ADULTS

M. Aghapour¹, N. Affenzeller¹, C. Peham², C. Lutonsky¹, A. Tichy³, B. Bockstahler¹

¹Section of Physical Therapy, Small Animal Surgery, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna,; ²Movement Science Group, Equine Surgery, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna; ³Platform Bioinformatics and Biostatistics, Department for Biomedical Services, University of Veterinary Medicine, Vienna

CAN ALTERED MOTOR CONTROL DECREASE JOINT LOADS IN PEOPLE WITH TYPICAL AND INCREASED ANTEVERSION ANGLES?

H. Kainz¹, W. Koller¹, D. Deimel¹, A. Kranzl², B. Goncalves¹

¹University of Vienna, Department of Biomechanics, Vienna, Austria; ²Orthopedic Hospital Speising, Gait Laboratory, Vienna, Austria

DYNAMIC STABILITY DURING VIRTUAL HEIGHT EXPOSURE IN CHILDREN WITH CEREBRAL PALSY – A CASE-CONTROL PILOT STUDY

R. Lohss^1,2, R. Winter¹, B. Göpfert^1,2, R. Visscher^2,3, R. Brunner^1,2, P. Cattin², C.-C. Hasler¹, E. Viehweger^1,2

¹University Children's Hospital Basel, Switzerland; ²University of Basel, Switzerland; ³ETH Zurich, Switzerland

THE EFFECT OF IMPLANT DESIGN ON SUPPORT MOMENT ASYMMETRY IN TOTAL KNEE ARTHROPLASTY PATIENTS DURING SIT/STAND TASKS

N. S. Ryan¹, A. Poirier^1,2, E. Kowalski¹, M. Lamontagne¹

¹University of Ottawa, Canada; ²Université de Technologie de Compiègne, France

KNEE JOINT PIVOT MOTION PATTERN DURING WALKING BEFORE AND AFTER UNICOMPARTMENTAL ARTHROPLASTY

R. Courteille¹, L. Chèze², C. Batailler³, S. Lustig³, N. Hagemeister¹

¹LIO, École de technologie Supérieure, Montréal, Canada; ²Univ Eiffel, Univ Lyon 1, LBMC UMR_T 9406, F-69622 Lyon, France; ³Hôpital de la Croix Rousse, Lyon, France

MUSCLE FUNCTION AFTER MODIFIED SURGICAL TREATMENT OF COMPLETE HAMSTRING AVULSIONS IN AN ELDERLY POPULATION

M. Mauch^1,2, C. Nüesch^1,2,3,4, L. Bühl^1,2, T. Chocholac¹, A. Mündermann^1,2,3, K. Stoffel¹

¹Department of Orthopedics and Traumatology, University Hospital Basel, Switzerland; ²Department of Biomedical Engineering, University of Basel, Switzerland; ³Department of Clinical Research, University of Basel, Switzerland; ⁴Department of Spine Surgery, University Hospital Basel, Switzerland

SIMILAR KNEE MECHANICS BUT DIFFERENT MUSCLE ACTIVITY: TIME FOR AUGMENTED ACL REPAIR AS ALTERNATIVE ACL SURGERY

L. Bühl^1,2,3, S. Müller^1,2,3, C. Nüesch^1,2,3,4, K. A. Boyer⁵, E. Casto⁶, C. Egloff^1,2,3, A. Mündermann^1,2,3,4

¹Universitätsspital Basel, Universität Basel, Basel, Switzerland; ²University Basel, Department of Biomedical Engineering, Basel, Switzerland; ³Department of Clinical Research, University of Basel, Basel, Switzerland; ⁴Department of Spine Surgery, University Hospital Basel, Basel, Switzerland; ⁵Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts, United States; ⁶Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, United States

REAL WORLD GAIT ASSESSMENT IN PEOPLE BEFORE ACL SURGERY USING IMU AND STATISTICAL PARAMETRIC MAPPING

T. Yona¹, B. Peskin², A. G. Fischer¹

¹Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel; ²Rambam medical center, Department of Orthopaedics, Haifa, Israel

EXPERIMENTAL STUDY ON DENTAL PROSTHESES RETRIEVAL TOOLS: REMOVAL EFFICIENCY AND POTENTIAL PATIENTS’ DISCOMFORT

A. T. Lugas^1,2, G. Schierano³, A. L. Audenino^1,2, C. Bignardi^1,2, M. Terzini^1,2

¹PolitoBIOMed Lab, Politecnico di Torino, Turin, Italy; ²Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; ³Department of Surgical Science, c.i.r. Dental School, University of Turin, Turin, Italy

PRIMARY FIXATION OF DENTAL IMPLANTS IN BONE SURROGATE IN RELATION TO INSERTION TORQUE - BIOMECHANICAL EVALUATION

B. Yang¹, A. Irastorza-Landa², P. Heuberger², H.-L. Ploeg¹

¹Queen's University, Canada; ²Nobel Biocare Service AG, Switzerland

NUMERICAL INVESTIGATION ON THE PRIMARY AND SECONDARY STABILITY OF ROOT-ANALOGUE-IMPLANTS

M. Aldesoki¹, L. Keilig^1,2, I. Dörsam^1,2, C. Bourauel¹

¹Oral Technology, University Hospital Bonn, Germany; ²Department of Prosthetic Dentistry, Preclinical Education and Materials Science, University Hospital Bonn, Germany

A SEMI-ANALYTICAL MODEL FOR STRESSES IN THE PERIODONTAL LIGAMENT FOR A TOOTH UNDER LOADING

L. R. Pavey, G. Tabor, P. Young

University of Exeter, United Kingdom

AUTOMATIC REAL-TIME TOOL FOR THE PATIENT-SPECIFIC PERFORMANCE EVALUATION OF IMPLANT-SUPPORTED DENTAL REHABILITATION TREATMENT

M. Sterba^1,2, M. Nakhaei¹, L. Badih¹, P.-J. Arnoux², J.-M. Foletti^2,3, M. Behr²

¹Glad Medical, France; ²Laboratoire de Biomécanique Appliquée, UMRT 24, Marseille, France; ³Department of Oral and maxillofacial Surgery, APHM, Conception University Hospital, Marseille, France.

VALIDATION OF A DIGITAL TWIN TO QUANTIFY THE LEVEL OF MOTOR CONTROL SUBOPTIMALITY IN PATIENTS

G. Davico^1,2, D. Princelle^1,2, M. Viceconti^1,2

¹Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Italy; ²Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Italy

KNEE FLEXION ANGLE ESTIMATION BASED ON FUNCTIONALLY INSTEAD OF ANATOMICALLY DEFINED COORDINATE SYSTEMS

J. De Schutter¹, A. Verduyn¹, M. Vochten¹, E. Aertbeliën¹, A. Ancillao²

¹KU Leuven & Flanders Make, Belgium; ²TU Wien, Austria

EVALUATION OF MARKERLESS MOTION CAPTURE USING MUSKULOSKELETAL MODELS

S. Auer¹, L. Gschoßmann¹, S. Dendorfer^1,2

¹Laboratory for Biomechanics, OTH Regensburg, Germany; ²Regensburg Center of Health Sciences and Technology, Germany

A FRAME ORIENTATION OPTIMISATION METHOD TO ENABLE VALID KINEMATIC COMPARISONS: ASSESSING IMU-BASED KNEE KINEMATICS

A. Ortigas Vásquez^1,2, W. R. Taylor³, A. Maas^1,2, M. Woiczinski², T. M. Grupp^1,2, A. Sauer^1,2

¹Research and Development, Aesculap AG, Tuttlingen, Germany; ²Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Centre Munich (MUM), Campus Grosshadern, Ludwig Maximilians University Munich, Munich, Germany; ³Laboratory for Movement Biomechanics, ETH Zurich, Switzerland

MIMU BASED POSTUROGRAPHY: COMPARISON OF METHODS

A. Guiotto¹, E. Pegolo¹, Z. Sawacha^1,2

¹Dept of Information Engineering, University of Padova, Italy; ²Dept of Medicine, University of Padova, Italy

WHAT MECHANICAL QUANTITY DO CELLS REGULATE IN SOFT TISSUES?

C. J. Cyron^1,2

¹Hamburg University of Technology, Germany; ²Helmholtz-Zentrum Hereon, Germany

MODELING AND SIMULATION OF TISSUE GROWTH CAUSED BY CELL PROLIFERATION DURING MORPHOGENESIS

Y. Yokoyama¹, Y. Kameo^1,2, T. Adachi^1,2

¹Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Japan; ²Institute for Life and Medical Sciences, Kyoto University, Japan

A HOMOGENIZED CONSTRAINED MIXTURE MODEL FOR HEART VALVE GROWTH AND REMODELING

E. Middendorp^1,2, F. Bräu^3,4, F. P. Baaijens^1,2, J. D. Humphrey⁵, C. J. Cyron^6,7, S. Loerakker^1,2

¹Department of Biomedical Engineering, Eindhoven University of Technology, the Netherlands; ²Institute of Complex Molecular Systems, Eindhoven University of Technology, the Netherlands; ³Singapore Eye Research Institute, Singapore National Eye Center, Singapore; ⁴Singapore-MIT Alliance for Research and Technology, Singapore; ⁵Department of Biomedical Engineering, Yale University, USA; ⁶Institute for Continuum and Material Mechanics, Hamburg University of Technology, Germany; ⁷Institute for Material Systems Modeling, Helmholtz-Zentrum, Germany

PARAMETER SENSITIVITY AND OPTIMIZATION OF THE MECHANO-IMMUNO-DRIVEN MODEL OF ENDOGENOUS TISSUE RESTORATION

H. Shirazi¹, T. Vervenne¹, L. Maes¹, A. Hendrickx², B. Meuris², N. Famaey¹

¹Department of Mechanical Engineering, KU Leuven, Belgium; ²Experimental Cardiac Surgery, KU Leuven, Belgium

RECONCILING THE MESO- AND MICRO-SCALE MECHANICAL PROPERTIES OF LUNG TISSUE USING COMPUTATIONAL MODELING

E. Dimbath¹, L. de Castro Brás², S. George², A. Vadati²

¹Duke University, USA; ²East Carolina University, USA

DEVELOPMENT OF A 2-SEGMENT FOOT MODEL FOR KINEMATIC MEASUREMENT OF MEDICAL GAIT ANALYSIS

L. Bauer, M. Hamberger, W. Böcker, H. Polzer, S. F. Baumbach

LMU University Hospital Munich, Germany

HEEL PAD COMPRESSION AND IMPACT DURING GAIT USING ULTRASONOGRAPHY AND IMU SENSORS: A PILOT STUDY

T. Gerbrands, L. Schluter

Fontys University of Apllied Sciences, The Netherlands

A NEW SYNERGY-BASED FOOT MODEL: DESCRIPTION OF ARCHES MOBILITY IN HEALTY AND FLAT FEET DURING GAIT

M. Conconi¹, N. Sancisi¹, C. Belvedere², A. Leardini²

¹Dept. of Industrial Engineering – DIN, University of Bologna, Italy; ²Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

AN EXPLORATORY APPROACH TO MUSCULAR FATIGUE ASSESSMENT DURING EXOSKELETON-ASSISTED GAIT

S. Pizzocaro^1,2, R. Baptista^2,3, F. Salvaggio^2,4, C. Cavallo^2,3, S. Galasso^2,3,5, M. Schmid¹, A. M. De Nunzio^2,3

¹Dep. of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy; ²Dep. of Research and Development, LUNEX International University, Differdange, Luxembourg; ³Luxembourg Health & Sport Sciences Research Institute ASBL, Differdange, Luxembourg; ⁴Dep. of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; ⁵Dep. of Electrical and Information Engineering, University of Cassino and Southern Lazio, Cassino, Italy

IN WATER AND ON LAND FORWARD AND BACKWARD SPATIOTEMPORAL GAIT CHARACTERISTICS

C. Monoli^1,2, M. Galli², J. A. Tuhtan¹

¹Tallinn University of Technology, Department of Computer System, Tallinn 12616, Estonia; ²Politecnico di Milano, Department of Electronics, Information and Bioengineering, Milano 20133, Italy

KINETICS OF RAT LOCOMOTION NEGOTIATING ACTIVE PERTUBATIONS

E. Andrada¹, D. Arnold², M. S. Fischer¹

¹Friedrich-Schiller-University Jena, Germany; ²University Hospital of Jena, ENT department, Germany

A THERMODYNAMIC FRAMEWORK FOR SARCOMERE FORMATION IN CARDIOMYOCYTES SPREAD ON MICRO-PATTERNED SUBSTRATES

R. J Coleman, P. McGarry

University of Galway, Ireland

TISSUE SCALE AGENT-BASED MODEL OF THE TENSION-MEDIATED REVERSIBLE FIBROBLAST TO MYOFIBROBLAST TRANSITION

Z. Karagöz, A. Carlier

Maastricht University, the Netherlands

MATRIX STIFFNESS-TGF-Β1 INTERPLAY REGULATES CARDIAC FIBROBLAST CONTRACTILITY

L. Hermans^1,2, A. van der Pol^1,2, V. Conte^1,2, C. Bouten^1,2

¹Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; ²Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands

GUIDING CARDIAC FIBROBLAST ORGANIZATION BY STIFFNESS PATTERNS OF GELMA HYDROGELS

I. Jorba^1,2, S. Gussenhoven¹, B. Groenen¹, A. van der Pol^1,2, M.-J. Goumans³, N. Kurniawan^1,2, C. Bouten^1,2

¹Department of Biomedical Engineering,Eindhoven University of Technology, Eindhoven, The Netherlands; ²Institute for Complex Molecular Systems (ICMS), Eindhoven, The Netherlands; ³Leiden University Medical Centre, Department of Cell and Chemical Biology and Center for Biomedical Genetics, Leiden, The Netherlands

THE EFFECT OF STRAIN ANISOTROPY ON THE INTERPLAY BETWEEN NOTCH SIGNALING AND VASCULAR SMOOTH MUSCLE CELLS

C. Karakaya^1,2, E. van den Hurk¹, C. Bouten^1,2, C. Sahlgren^1,2,3, S. Loerakker^1,2

¹Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands; ²Institute for Complex Molecular Systems, Eindhoven University of Technology, The Netherlands; ³Faculty of Science and Engineering, Biosciences, Åbo Akademi University, Finland

MECHANOREGULATION OF BONE FORMATION DURING NON-UNIONS IN PREMATURELY AGEING MICE

J. J. Kendall¹, V. Baumann¹, N. Mathavan¹, E. Wehrle^1,2, R. Müller¹

¹ETH Zurich, Zurich, Switzerland; ²AO Research Institute Davos, Davos Platz, Switzerland

MECHANOBIOCHEMICAL BASED ORTHOTROPIC BONE REMODELING AROUND UNCEMENTED ACETABULAR COMPONENT

C. Mullakkara Saviour, B. Mathai, S. Gupta

Indian Institute of Technology Kharagpur, India

MECHANO-BIOLOGY OF TISSUE REGENERATION WITHIN SCAFFOLDS IN LARGE BONE DEFECTS COMORBID WITH TYPE 2 DIABETES

M. Jaber, D. Dias, P. S. Poh, G. N. Duda, S. Checa

Center for Musculoskeletal Biomechanics and Regeneration (Julius Wolff Institute), Charité – Universitätsmedizin Berlin, Berlin, Germany, Germany

PREMATURELY AGED POLGA MICE EXHIBIT DEGENERATED OSTEOCYTE NETWORK AND MECHANOSENSATION

D. Yilmaz¹, T. Parajasingam¹, L. Gregorio¹, C. P. Gehre¹, F. Correia Marques¹, X.-H. Qin¹, E. Wehrle^1,2, G. A. Kuhn¹, R. Müller¹

¹ETH Zurich, Zurich, Switzerland; ²AO Research Institute Davos, Davos Platz, Switzerland

POST-TRAUMATIC FIBRIL REORIENTATION IN CARTILAGE: ADAPTIVE IN SILICO MODEL VALIDATED AGAINST IN VITRO OA MODEL

S. A. Elahi¹, R. Castro Viñuelas¹, P. Tanska², R. K. Korhonen², R. Lories¹, N. Famaey¹, I. Jonkers¹

¹KU Leuven, Belgium; ²University of Eastern Finland, Finland

MECHANOBIOLOGY OF CANCER PROGRESSION

M. T. Raimondi

Dept. of Chemistry, Materials and Chemical Engineering "G.Natta", Politecnico di Milano, Italy

CHANGES IN CELLULAR STIFFNESS RELATED TO CANCER-INDUCED CYTOSKELETON REORGANIZATION

L. Orlová¹, J. Gumulec², J. Burša¹

¹Brno University of Technology, Department of Biomechanics, Czech Republic; ²Masaryk University, Department of Pathophysiology, Brno, Czech Republic

AN INTEGRATED FINITE ELEMENT AND AGENT-BASED MODEL TO ANALYSE MECHANOSENSITIVE TUMOUR GROWTH

I. Senthilkumar^1,2,3, E. Howley^1,3, E. McEvoy²

¹School of Computer Science, University of Galway, Ireland; ²Discipline of Biomedical Engineering, University of Galway, Ireland; ³Data Science Institute, University of Galway, Ireland

MIGRATION AND TRACTION FORCE CHARACTERIZATION OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS ON STIFFNESS-TUNABLE SUBSTRATES

S. Gabetti¹, S. Marino¹, G. Serino¹, C. Vaghi², M. Tosini¹, A. L. Audenino¹, A. Fiorio Pla², T. Ohashi³, D. Massai¹

¹PoliToBIOMedLab and Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy; ²Department of Life Sciences and Systems Biology, Università di Torino, Italy; ³Faculty of Engineering, Hokkaido University, Sapporo, Japan

DATA-DRIVEN 3D TRACTION FORCE MICROSCOPY IN FIBRILLAR HYDROGELS

J. Barrasa Fano¹, A. Apolinar Fernández², P. Pérez Alcántara², I. Muntz³, G. Koenderink³, J. A. Sanz Herrera², H. Van Oosterwyck¹

¹KU Leuven, Belgium; ²Universidad de Sevilla; ³TU Delft

MECHANOBIOLOGY FOR CLINICAL CANCER PROGNOSIS: CONTEMPORARY SCIENCE AND FUTURE, APPLICATIVE PROSPECTS

D. Weihs

Technion-Israel Institute of Technology, Israel

GENERATION OF TRANSGENIC MICE EXPRESSING FRET-BASED TENSION SENSOR: MASUREMENT WITH CONVENTIONAL CLSM

T. Matsumoto¹, J. Wang¹, E. Maeda¹, Y. Tsujimura², H. Yokota², T. Kitaguchi³

¹Nagoya University, Japan; ²RIKEN Center for Advanced Photonics, Japan; ³Tokyo Institute of Technology, Japan

3D PHOTOPOLYMERIZED SCAFFOLD PORE SIZE REGULATES MESENCHYMAL STEM CELL PHENOTYPE

E. Jacchetti¹, T. Baldissera¹, B. Barzghini¹, L. Messa^2,3, C. Cereda⁴, S. Carelli^2,4, M. Raimondi¹

¹Department of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Italy.; ²Pediatric Research Center "Romeo ed Enrica Invernizzi", Department of Biomedical and Clinical Sciences, University of Milano, Milano, Italy; ³Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy; ⁴Center of Functional Genomics and Rare Diseases, Buzzi Childen's Hospital, Milano, Italy

THE ROLE OF ANATOMICAL LOCATION IN SCAFFOLD-INDUCED HEALING OF CRANIOFACIAL BONE DEFECTS

L. Lafuente-Gracia^1,2, M. Barzegari¹, A. Carlier³, L. Geris^1,2,4

¹Biomechanics section, Department of Mechanical engineering, KU Leuven, Belgium; ²Prometheus: Division of Skeletal Tissue Engineering, KU Leuven, Belgium; ³Department cBITE, MERLN Institute, Maastricht University, The Netherlands; ⁴Biomechanics research unit, GIGA in silico medicine, University of Liège, Belgium

TIME-DEPENDENT COMPUTATIONAL MODEL OF CARTILAGE MECHANOBIOLOGY DURING INJURIOUS AND CYCLIC LOADING

A. S. A. Eskelinen¹, J. P. Kosonen¹, A. Esrafilian¹, G. A. Orozco², C. Florea¹, A. J. Grodzinsky³, P. Tanska¹, R. K. Korhonen¹

¹University of Eastern Finland, Finland; ²Lund University, Sweden; ³Massachusetts Institute of Technology, USA

A MECHANOBIOLOGICAL MODEL TO SIMULATE ANTIOXIDATIVE TREATMENT IN IMPACTED CARTILAGE

J. P Kosonen¹, A. S A Eskelinen¹, G. A Orozco^1,2, J. E Goetz³, M. C Coleman³, A. J Grodzinsky⁴, P. Tanska¹, R. K Korhonen¹

¹University of Eastern Finland, Finland; ²Lund University, Sweden; ³University of Iowa, USA; ⁴Massachusetts Institute of Technology, USA

GENETIC ALGORITHM TO CALIBRATE A MULTISCALE COMPUTER MODEL OF BONE FRACTURE HEALING

E. Borgiani^1,2, G. Nasello², K. Schmidt-Bleek³, L. Geris^1,2

¹Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium; ²Prometheus, division of Skeletal Tissue Engineering, KU Leuven, Belgium; ³Julius Wolff Institut, Charité Universitätsmedizin Berlin, Germany

ACCRUAL OF OSTEOCLAST PRECURSORS DRIVES BONE LOSS AFTER DENOSUMAB DISCONTINUATION: A DIGITAL TWIN STUDY

C. Ledoux¹, D. Boaretti¹, J. J. Kendall¹, R. Müller¹, C. J. Collins^1,2

¹Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; ²Virginia Tech, Blacksburg, United States