Conference Agenda

Topical Meetings and Sessions:

TOM 1 - Silicon Photonics and Guided-Wave Optics
TOM 2 - Computational, Adaptive and Freeform Optics
TOM 3 - Optical System Design, Tolerancing and Manufacturing
TOM 4 - Bio-Medical Optics
TOM 5 - Resonant Nanophotonics
TOM 6 - Optical Materials: crystals, thin films, organic molecules and polymers, syntheses, characterization and devices
TOM 7 - Thermal radiation and energy management
TOM 8 - Nonlinear and Quantum Optics
TOM 9 - Optics at Nanoscale (ONS)
TOM 10 - Optical Microsystems (OMS)
TOM 11 - Waves in Complex Photonic Media
TOM 12 - Optofluidics
TOM 13 - Ultrafast Optical Technologies and Applications
TOM 14 - Advances and Applications of Optics and Photonics
EU Project Session
Early Stage Researcher Session organised by SIOF
Grand Challenges of Photonics Session

More information on the Topical Meetings

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Session Overview
TOM9 S05: Optics at Nanoscale (ONS): Sensing
Wednesday, 15/Sept/2021:
8:15 - 9:45

Session Chair: Concita Sibilia, Università di Roma La Sapienza, Italy
Location: Aula 8

1st Floor

8:15 - 8:30
ID: 194 / TOM9 S05: 1
TOM 9 Optics at Nanoscale (ONS)

Towards Nanoscale imaging with Attosecond Pulses: Holography-enhanced broadband lensless imaging in the XUV

Sici Wang1,2, Wilhelm Eschen1,2, Chang Liu1,2, Michael Steinert2, Thomas Pertsch2,3, Jens Limpert1,2,3, Jan Rothhardt1,2,3

1Helmholtz-Institute Jena; 2Institute of Applied Physics, Friedrich-Schiller-University Jena; 3Fraunhofer Institute of Applied Optics and Precision Engineering

We present our recent advances in holography-enhanced lensless imaging in the extreme ultraviolet. By combining multi-reference Fourier-Transform holography with a broadband phase retrieval algorithm, we were able to demonstrate a spatial resolution of 34 nm with an XUV bandwidth as large as 5.5 eV supporting a Fourier-limited pulse duration of 380 as. This demonstrates the feasibility of lensless imaging far beyond the temporal coherence limit and paves the way for ultrafast imaging with high spatial and temporal resolution.

8:30 - 9:00
ID: 517 / TOM9 S05: 2
TOM 9 Optics at Nanoscale (ONS)

Surface wave photonic crystal biochips for cancer biomarkers detection

Francesco Michelotti1, Alberto Sinibaldi1, Agostino Occhicone1, Tommaso Pileri1, Patrizio Giacomini2, Matteo Allegretti2, Norbert Danz3, Peter Munzert3

1Department of Basic and Applied Science for Engineering, SAPIENZA University of Rome, Rome, Italy; 2Regina Elena National Cancer Institute IRE, IRCCS, Rome, 00144, Italy; 3Fraunhofer Institute for Applied Optics and Precision Engineering IOF, Jena, Germany

The increasing demand for non-invasive diagnostic tools drives the development of novel approaches for biomarkers detection. Sensors based on Bloch surface waves (BSW) sustained by 1D photonic crystals were demonstrated as a practical route to improve the resolution. We developed BSW biochips operating either in a label-free manner, by tracking the BSW resonance, or by resonant fluorescence excitation/detection of suitable labels. The detection of the breast cancer ERBB2 clinical biomarker is demonstrated, with a fluorescence resolution below 0.5ng/ml for ERBB2 in cell lysates, below the 15ng/ml threshold in human serum.

9:00 - 9:15
ID: 316 / TOM9 S05: 3
TOM 9 Optics at Nanoscale (ONS)

Nanofluidic sensing with nanostripe gratings on a free-standing SiN waveguide

Giacomo Manzato1, Maria Caterina Giordano1, Marco Centini2, Francesco Buatier de Mongeot1

1Università degli Studi di Genova, Italy; 2Sapienza Università di Roma, Italy

We demonstrate versatile nanofabrication of Au nanostripe gratings supported on free-standing Si3N4 membranes. By exploiting high resolution nanolithography, a fine tuning of the photonic modes is achieved across the VIS-NIR spectrum, coupling the incident light into multiple guided modes in the thin supporting membrane (200 nm). Tracking their spectral shift is a straightforward application of the system as a nanofluidic refractive index sensor, measuring the signal of transmitted light in a simple optical microscopy configuration, with good RI sensitivity (180nm/RIU) competitive with respect to the state of art nanofluidic sensors.

9:15 - 9:45
ID: 349 / TOM9 S05: 4
TOM 9 Optics at Nanoscale (ONS)

Diagnostic potential of disorder: development of an innovative nanostructured platform for rapid, label-free and low-cost analysis of genomic DNA

Valentina Mussi1, Mario Ledda2, Davide Polese1, Luca Maiolo1, Debadrita Paria3, Ishan Barman3, Maria Grazia Lolli2, Antonella Lisi2, Emilio Nicola Maria Cirillo4, Claudio Durastanti4, Annalisa Convertino1

1Institute for Microelectronics and Microsystems, National Research Council, Rome, Italy; 2Institute of Translational Pharmacology, National Research Council, Rome, Italy; 3Department of Mechanical Engineering, Johns Hopkins University, Baltimore, USA; 4Department of Basic and Applied Sciences for Engineering, Sapienza University, Rome, Italy

A novel diagnostic platform will be presented for reliable, quick, and label-free analysis of genomic DNA. The technique leverages the unique capability of a disordered array of silver coated silicon nanowires (Ag/SiNWs) to interact with biomolecules, and Raman spectroscopy. The analysis is performed by depositing aqueous droplets of target DNA on the Ag/SiNWs, and acquiring Raman maps after sample dehydration. Principal component analysis is then applied to distinguish healthy and cancer cell DNA, the discrimination being only related to spectral features associated to the interfacing between DNA and the NWs.