Conference Agenda

Viruses are known to plan a causative role in the establishments of certain cancers. These most commonly present in lower- and middle-income countries where. In this effort I will describe both our long-standing efforts to develop new clinical diagnostic methods for these cancers and a history of the technologies and interventions we have put in place. I will focus on our efforts with Kaposi’s Sarcoma over the last 5 years at various clinical sites in sub-Saharan Africa center in Uganda.

SARS-CoV-2 detection was demonstrated by optical nano-slot waveguides. The optical field of the slot waveguide mode was calculated by Finite difference method (FDM) simulation. For TE polarized light, the optical field was strongly confined inside the slot section, and the field intensity was 14x higher than TM polarized light showing an extended evanescent wave. The light confinement significantly enhanced the optical sensitivity because of the strong interaction between the probe light and the analyte. The nanofluidic waveguide devices offer a compact prototype for fast virus identification.

Integrated optofluidic waveguide devices have proven to be highly attractive for ultrasensitive detection of molecular biomarkers. Here, we discuss the use of liquid-core waveguide chips for clinical detection of SARS-CoV-2 infection with single molecule sensitivity.Two fundamentally different approaches based on fluorescence detection and trapping-assisted nanopore sensing are described, and a number of key advances are demonstrated. These include the first single protein fluorescence assay, dual detection of both RNAs and proteins, and nanopore detection with over 1,000x enhanced rates.