Cross-laminated timber (CLT) is a structural member composed of layers of wood glued together perpendicular. When compared to common concrete or steel structures, CLT structures are considered lightweight, which makes them more prone to vibrations that can cause discomfort to people inside buildings made of CLT. It is therefore desirable to reduce the vulnerability of CLT components to vibration by implementing smart measures, such as passive or active control mechanisms, without changing the design of the CLT structure. This paper presents a study on the feasibility of active vibration control of CLT panels based on laboratory tests and mathematical modelling. In the laboratory tests, external excitation is applied by electrodynamic shakers. The resulting CLT-shakers assembly is an electromechanical system, i.e., a system composed of a mechanical and an electromagnetic subsystem, which interact through coupling elements. First, system identification is performed to obtain the parameters composing the CLT-shakers system, which are both mechanical (such as mass, damping and stiffness elements) and electromagnetic (such as inductance and resistance) in origin, where a mathematical model of the whole electromechanical system is compared with experimental data of the multi-input multi-output system excited by both shakers with independent white noise inputs. Active vibration control depends on an external power supply and requires a set of actuators and sensors. In this study, active vibration control of the CLT panel is performed by using one of the shakers for excitation and the other one for control. A setup where the target point of vibration mitigation and actuator are not positioned in the same location in the CLT panel is used, known as non-collocated control. This non-collocated configuration poses additional challenges in the control process and will be examined in more detail. Both Velocity Feedback and Optimal Control are conducted, presenting two different approaches to non-collocated vibration control.