Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view with abstracts (if available).
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Session Overview |
| Date: Monday, 26/Aug/2024 | ||
| 1:00pm - 2:00pm |
ECI Registration |
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| 2:00pm - 5:00pm |
Registration |
EBEC ECI Session Location: Room B Chair: Karin de Punder Chair: Omar Torres-Quesada Speakers: Enrique Rodriguez; Ana Pfleger; Amina Djurabekova; Oleksii Zdorevskyi; Luca Merono; Mercedes Esparza-Perusquía; Tiziano Mazza; Sami Mohammed; Maximilian Sichrovsky; Scott Jones; Margareta Scherr; Julia Hofmann; Omar Torres-Quesada; Julia Moldaschl Subtle changes in respiratory function produce big differences in life-history traits in stressed mitonuclear fly lines 2:12pm - 2:24pm Fluctuations in light induce flexibility in algal photosynthesis and primary metabolism 2:24pm - 2:36pm Analysis of the Atomistic MD Simulations of CI+CIII2 Interactions and Associated Lipid Binding 2:36pm - 2:48pm Long-range charge transfer in respiratory complex I: insights from multi-scale molecular dynamics simulations 2:48pm - 3:00pm Energy coupling in Escherichia coli complex I 3:00pm - 3:12pm What we have learned about the dimeric complex V, and what it could still teach us 3:12pm - 3:24pm Unveiling the Modulation of MRP2 Activity: Insights from Phosphorylation and Drug Interactions 3:24pm - 3:36pm Mutational analysis of the mammalian mitochondrial Ca2+/H+ exchanger TMBIM5/MICS1 3:36pm - 3:48pm Identification of the Inhibitor Binding Site of the Human Mitochondrial Pyruvate Carrier 3:48pm - 4:00pm Nucleotide specificity of human uncoupling protein 1 inhibition 4:00pm - 4:12pm From Childhood Trauma to immunocellular health: Unveiling the Link between Adverse Experiences and Depression 4:12pm - 4:24pm Fueling success: Harnessing liver bioenergetics in clinical- and long-term machine perfusion 4:24pm - 4:36pm Mitochondrial bioenergetic profiling reveals off-target effects of kinase inhibitors in cancer cell models 4:36pm - 4:48pm Explorative analysis of mitochondrial function in Long-COVID patients compared to a control group |
| 5:00pm - 5:15pm |
Break Location: 1st Floor |
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| 5:15pm - 5:30pm |
EBEC2024 Welcome Location: Room A Erich Gnaiger |
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| 5:30pm - 6:15pm |
Peter Mitchell Memorial lecture Location: Room A Ferdinando Palmieri The SLC25 mitochondrial carrier family: identification, properties and physiopathology |
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| 6:15pm - 6:45pm |
A tribute to Mårten Wikström Location: Room A Sir John Walker |
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| 6:45pm - 10:00pm |
Welcome Reception |
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| Date: Tuesday, 27/Aug/2024 | ||
| 8:45am - 9:00am |
Arrival |
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| 9:00am - 10:30am |
Keynotes: Science communication Location: Room A Chair: Patricia Kane Chair: Richard Porter Reproducible and useful research: obstacles and progress 9:30am - 10:00am Ambiguity in Science 10:00am - 10:30am Energy transformation in bioenergetics systems. A historical perspective |
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| 10:30am - 11:20am |
Break Location: 1st Floor |
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| 11:20am - 12:40pm |
Keynotes: Science communication Location: Room A Chair: Paolo Bernardi Chair: Irene Vercellino Flawed science: cleaning up the scientific record 11:40am - 12:00pm Why do top journals accept papers containing fundamental bioenergetic errors? 12:00pm - 12:20pm Addressing the ambiguity crisis in bioenergetics and thermodynamics 12:20pm - 12:40pm Can science be better than the language that reports it? |
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| 12:40pm - 1:40pm |
Lunch/Poster session 1 Lunch location: Ground Floor Poster location: 1st Floor Estimation of pKa values in membrane bound proteins Exploring the proton translocation mechanism in Complex I by integrative biophysical methods Contribution of proton ATPase in the formation of the proton motive force during fermentation of mixed carbon sources Defining the role of slight acidic conditions on membrane potential and pH variations of Thermus scotoductus K1 cells in presence of different sugars Plasticity of mitochondrial proton leak in adults and newborn mice as a possible strategy for high altitude adaptation. Persulfide Dioxygenase from Pseudomonas aeruginosa unveils a novel crosstalk mechanism between the bioenergetically-relevant gaseous signaling molecules nitric oxide and hydrogen sulfide Evolution of heme biosynthesis in prokaryotes Subtle changes in respiratory function produce big differences in life-history traits in stressed mitonuclear fly lines Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life Mechanism of hydrogen evolution in the membrane-bound hydrogenase Structure and function of a 1-MDa electron-confurcating/bifurcating, dearomatising enzyme complex from obligate anaerobic bacteria High voltage rock’n’roll – A complex approach to protein electron transfer far from equilibrium. Structural basis of HydBC modularity and its diversity in anaerobic bacteria. As stress responses, the extremophile yeast Rhodotorula mucilaginosa, expresses a highly branched respiratory chain and increases carotenoid synthesis. Photodegradation measured by high-resolution respirometry in leaf preparations Photoprotective strategies in Chlamydomonas reinhardtii: The role of flavodiiron proteins under contrasting oxygen tension Is charge recombination at the origin of Photosystem II photoinhibition? Dissection of the Molecular Mechanism of Cytochrome b561 and its Physiological Function in Cells Structures of multiple states of the nicotinamide nucleotide transhydrogenase from Escherichia coli Bioenergetics and quantitative biology applied to biotechnology Exploring yeast diversity for ethanol-fueled industrial biotechnology High resolution structures of respiratory Complex I from Yarrowia lipolytica under turnoverc onditions Phosphate Regulates the Acute Changes in Complex V Association in Skeletal Muscle Mitochondria During Calcium Overload. In situ structure and rotary states of mitochondrial ATP synthase in whole cells The respiratory complexes structure and function in Sulfolobus acidocaldarius The respirasome plays an important role in the control of mitochondrial ROS production in Ustilago maydis Conformational coupling of electron transfer and ion translocation in Na+-NQR of Vibrio cholerae Quinone and inhibitor binding in Escherichia coli complex I Function of Escherichia coli bd-I and bd-II oxidase Differences in oxidoreductase activity of cytochromes bd-I and bd-II oxidases from Mycobacterium smegmatis and Cryo-EM structure of cyt. bd-II. Cryo-EM structure of respiratory cytochrome bcc-aa3 supercomplex from Corynebacterium glutamicum Conformational dynamics of cyanobacterial NDH Effect of an essential arginine mutation (R473C) on the catalytic reaction of cytochrome c oxidase from Paracoccus denitrificans. Characterization through UV/Vis and electrochemical-FTIR spectroscopy Isolation, Purification and Cryo-Electron Microscopy Structure determination of the Mycobacterium tuberculosis Cytochrome bcc:aa3 Supercomplex Maintained respiratory chain capacity in mice with severely reduced levels of mitochondrial respirasomes Study of kinetic NADH flux in rat heart mitochondria of stroke-prone or stroke-resistant spontaneously hypertensive rats and the effect of saline diet Amino acid metabolism targets ATP-dependent inhibition of CytOx Investigation of the glycerol-3-phosphate:quinone oxidoreductases from Staphylococcus aureus and Pseudomonas aeruginosa The studies on the catalytic cycle of Cytochrome c oxidase Mutations F408DM and F396DN effect the activity of E. coli complex I Long-range charge transfer in respiratory complex I: insights from multi-scale molecular dynamics simulations Sulfide:quinone oxidoreductase from the multidrug resistant pathogen Pseudomonas aeruginosa Energy coupling in Escherichia coli complex I Electron transfer in E. coli respiratory complex I Redox chemistry of the FMN-cofactor in respiratory complex I The regulation of ATPase activity by K+ ions in gut isolated E. coli strains and its role in propionic acid sensing Effects of supramolecular organization of the ATP synthase on mitochondrial bioenergetics and ultrastructure Conversion of the ATP synthase into the Permeability Transition Pore requires the C-terminal domain of subunit e Playing with Power: Increasing ATP Synthase Activity in E. coli Rotary Mechanism of the F1-ATPase Catalytic Dwell The interface between monomers of the F1FO-ATP synthase dimer confers resistance against heavy metals Structural reorganization of mammalian F-type ATP synthase in the presence of Ca2+ Utilizing ATeam Fluorescent Proteins for Assessing ATP Synthesis and Hydrolysis In Vitro and in Isolated Yeast Mitochondria Atomic insights into the F-ATP synthase ε-induced ATP hydrolysis inhibition of the pathogen Acinetobacter baumannii. Interplay between Mitochondrial ATP Synthase Reverse Activity and Ultrastructure Bioenergetic Properties of Microbes as Potential Target for Antibacterial Activity of Plant-Based Compounds Molecular basis for leucinostatin A toxicity in mammals Physiological role of ATP3-M23K mutation and its impact on yeast mitochondrial ATPase activity Structures of TOM holo complex from Chaetomium thermophilum The role of the Escherichia coli FocA and FocB formate channels in proton flux during fermentation of mixed carbon sources Microglia-specific deletion of Kv1.3 potassium channel attenuates loss of dopaminergic neurons upon neurotoxicity in a Parkinson model Over-expression, purification and transport assay of the human SLC38A2 (SNAT2) transporter: an open window for testing ligands Predictive Insights into Protonation States of Key Residues in Bioenergetic Proteins Using Conventional and Constant-pH MD Simulations Straight from the heart – infrared light regulation of mitochondrial large conductance Ca2+-activated potassium channel activity in cardiomyocytes of Guinea Pig Unveiling the Modulation of MRP2 Activity: Insights from Phosphorylation and Drug Interactions Molecular dynamics simulations of a histidine switch in Mrp antiporter complex Tracking the progression of folding events during cell-free expression of rhodopsins into nanodiscs by SEIRAS Impact of menthol on ATPase activity and ion flux in antibiotic-resistant Escherichia coli The role of the CRP global regulator in proton flux of Escherichia coli under different glucose concentrations Calcium increases mitochondrial ATP levels by a respiration-independent mechanism mediated by calcium-regulated mitochondrial ATP-Mg2+/Pi carriers in proliferating cells Identification of the Inhibitor Binding Site of the Human Mitochondrial Pyruvate Carrier Characterising the ligand interactions and properties of purified UCP1 isoforms Nucleotide specificity of human uncoupling protein 1 inhibition Uncoupling Protein 1: biochemical and biophysical studies of the proton transport mechanism. Deficiencies of Riboflavin transporter 2 in the rare neurodegenerative disorder RTD2 are accompanied by ER stress responses and calcium homeostasis derangements Voltage Dependent Anion-selective Channel (VDAC), the gatekeeper of mitochondria, as a signaling hub for Noncommunicable chronic diseases (NCDs) Understanding respiratory complex I assembly: A structural approach The 3D architecture of pancreatic β-cells from ATPIF1 knockout mice A novel interactor of the NAM-forming element TSPO unveils an axis organising mito-nuclear Ca2+ signal transduction in neurons Mitofusin 1 and 2 deletion results in extensive mitochondria-ER/SR remodeling and compromises skeletal muscle function Regulation of mitochondrial morphology and bioenergetics in pancreatic β-cells via OMA1 protease activity |
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| 1:40pm - 2:40pm |
Lunch/Poster session 2 Lunch location: Ground Floor Poster location: 1st Floor Investigating the proton translocation mechanism of Complex I from the bottom-up Biological charge transfer far from equilibrium: electron migration and entropically driven proton dislocation Crosstalk between electron transfer and proton pumping – exploring the coupling elements in the long-range redox-driven proton pump of respiratory Complex I Synthesis of membrane protein-like redox-active mineral «green rust » through size and hydrophobicity functionnalization with amino acids No enzyme (or pathway) is an island: metals, prosthetic groups and coenzymes Elucidating the redox-driven sodium pumping mechanism of the ancient Rnf complex Exploring Wolbachia spp. infection in Drosophila melanogaster Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation Time-Resolved Serial Femtosecond Crystallography of Cytochrome c Oxidase by use of a photolabile oxygen cage and novel insights of the catalytic site from high level multiconfigurational ab initio calculations Mechanisms of Short-Circuit Suppression in the bc1 Complex Thermodynamic landscape of the redox-centers in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima An opposite sensitivity of DBMIB and DNP-INT, inhibitors of the plastoquinol oxidation in the cytochrome b6f complex, to the thylakoid lumenal pH Probing the Dynamics of the Fucoxanthin-Chlorophyll a/c (FCPs) Proteins of the Marine Diatoms Fragilariopsis sp and P. tricornutum Structural analysis of dimeric photosystem II complexes Investigation of “high-energy” metastable state of the oxidized (OH) bovine cytochrome c oxidase: proton uptake and reaction with H2O2 Characterization of the ubiquinone reaction cavity in mitochondrial respiratory complex I using artificial ligands The structure of a catalytically inactive Paracoccus denitrificans complex I mutant under turnover conditions. Respiratory supercomplexes act early to support complex I assembly Acute Reorganization of Complex V in Response to Calcium in Mammalian Heart Mitochondria Analysis of the Atomistic MD Simulations of CI+CIII2 Interactions and Associated Lipid Binding Unusual succinate dehydrogenase (SdhABEF) of the thermoacidophilic archaeon Sulfolobus acidocaldarius High-resolution structural studies of the cytochrome c oxidase catalytic cycle Homology modeling of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii reveals unexpected functionalities Insights into the assembly of mitochondrial respiratory complex III Inhibition and substrate binding site analysis of the obligate respiratory chain supercomplex of Actinobacteria The levels and activation state of the pyruvate dehydrogenase complex modulate the SCAFI-dependent organization of the mitochondrial respiratory chain Unveiling the Complex problem with Mdivi-1 Electrochemical studies of the cytochrome bd oxidase from the anaerobic sulfate-reducing bacterium Solidesulfovibrio fructosivorans Destabilizing the superassembly between mitochondrial complexes I and III Respiratory complex I in menaquinone-containing anaerobic bacteria Probing the reactions of Cytochrome c oxidase -Y280H, -W272H and -Y167F with O2 and H2O2 by UV-Raman spectroscopy Structural characterisation of the energy-conserving methyltransferase of a methylotrophic methanogenic archaeon Complex I of the thermophilic fungus Chaetomium thermophilum under turnover Correlating functional and structural analysis of the complex I deactive transition in proteoliposomes Mitochondrial quinone redox state is a marker of mitochondrial metabolism Identification of proteins involved in intracellular ubiquinone trafficking in Saccharomyces cerevisiae using synthetic ubiquinone probe Proton uptake in cytochrome bd -I from E. coli: electrocatalytic and spectroscopic investigations on D58 variants F1FO ATP synthase mediated reorganization of cristae architecture related to mitochondrial permeability transition pore Assembly of the F1-catalytic domain of human ATP synthase What we have learned about the dimeric complex V, and what it could still teach us Investigating the functions of ATP synthase subunits e and g in Drosophila melanogaster Two mutant forms of the inhibitor protein IF1 that are recurrent in lung cancers cause highly aggressive and death-resistant phenotypes Physiological impact of inhibition of FOF1 ATPase activity in yeast The ζ subunit from the F1FO-ATP synthase of Sinorhizobium meliloti is pH sensitive, as revealed by 2D-NMR Rotary Dynamics of Yeast V1-ATPase by High Resolution Single-Molecule Studies Highly potent anti-NTM inhibitors targeting the oxidative phosphorylation pathway of a broad spectrum of non-tuberculous mycobacterial pathogens Rotation as promotor of F1Fo-ATP synthase membrane preference location Mutagenesis in the Mrp antiporter from Bacillus pseudofirmus identifies residues critical for the histidine switch mechanism Characterizing the role of cysteine residues in the biogenesis and maturation of VDAC3 Mechanism of the NhaA antiporter from constant pH molecular dynamics simulations A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria Insights into Drosophila OXPHOS: Characterization and Functional Analysis of Mitochondrial Phosphate Carrier Isoforms CG9090 and CG4994 Unfolding the molecular mechanism of a novel membrane potential-coupled inorganic carbon-concentrating transporter Mutational analysis of the mammalian mitochondrial Ca2+/H+ exchanger TMBIM5/MICS1 Mitochondrial dysfunction in human bronchial epithelial cells lacking the BKCa channel Characterization of photosynthetic efficiency under impaired manganese and/or calcium transport over the thylakoid membrane in Arabidopsis thaliana Assessing the relative role of adenine nucleotide translocator and ATP synthase in the permeability transition Dissecting the conformational complexity and mechanism of a bacterial heme transporter Calcium-dependent mitochondrial Aspartate/Glutamate Carriers (AGCs), but not MCU, regulate proliferation in cells engaged in the Warburg effect Mitochondrial Bioavailability of Mitoquinol Mesylate Orally Administered to Mice Diflunisal activates AMP-activated protein kinase and stimulates glucose uptake, glycolysis and oxidation of glucose and oleic acid in skeletal muscle cells Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling. The role of central cavity arginine residues in UCP1 proton leak. The role of COX6B subunit in the assembly and function of cytochrome c oxidase The dynamic exchange of subunits in Complex I is essential for its function in differentiated cells Volume electron microscopy of the mitochondrial network in pancreatic beta cells Cristae narrowing by stabilized ATP-synthase dimeric rows upon glucose-stimulated insulin secretion depends on e and g subunits of membrane FO-moiety Mitochondria-ER contact sites contribution to the metabolic reprogramming accompanying the shift from proliferative to quiescent phenotype in HepG2/C3A cells IMPAIRED MITOCHONDRIAL METABOLISM AND ER-MITOCHONDRIA CONTACT SITES AFFECT SIGNALING IN CANCER CELLS. |
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| 2:40pm - 4:00pm |
Bioenergetic organelle biogenesis, protein assembly and function Location: Room A Chair: Manuel Gutiérrez Aguilar Chair: Ilka Wittig The 6 B’s of CoQ10 Therapeutic Development: BPM31510, Bioenergetics, Biophysics, Bench, Bedside, and Back Again 3:00pm - 3:20pm Structural basis of complex I assembly and cardiolipin remodeling in mitochondria 3:20pm - 3:40pm The assembly of mitochondrial respiratory complex III 3:40pm - 4:00pm Correlating functional and structural analysis of the complex I deactive transition in proteoliposomes |
Functions of apoptotic proteins beyond apoptosis Location: Room B Chair: Gyorgy Hajnoczky Chair: Erin Seifert Keeping mitochondria in shape: a matter of life and death 3:00pm - 3:20pm Pro-apoptotic Bax and Bak proteins modulate mitochondrial respiration via regulation of TEFM expression. 3:20pm - 3:40pm Bcl-xL helps to keep mitochondria connected with the endoplasmic reticulum 3:40pm - 4:00pm The Janus Faces of MCL-1: Metabolic Regulator by Day and Death Antagonist by Night |
| 4:00pm - 4:50pm |
Break Location: 1st Floor |
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| 4:50pm - 5:50pm |
Bioenergetic organelle biogenesis, protein assembly and function Location: Room A Chair: Carola Hunte Chair: Volker Zickermann Organization and mechanisms of OXPHOS biogenesis 5:10pm - 5:30pm Mitochondrial machineries for import and assembly of proteins 5:30pm - 5:50pm Infrared Nanoscopy and Tomography of Intracellular Structures |
Short oral presentations II Location: Room B Chair: Karin Busch Chair: Tomas Mracek Bioenergetic Atlas of Small Intestinal Mucosal Mitochondria 5:00pm - 5:10pm Bioenergetic and Metabolic Profiling of a Triple Negative Breast Cancer Cell Line and its High Invasive Isogenic Subtype. 5:10pm - 5:20pm Visualization of the metabolic switch in neuronal mitochondria during differentiation 5:20pm - 5:30pm A novel mechanism of mitochondrial impairment after brain ischemia/reperfusion. 5:30pm - 5:40pm Clinical-grade human induced pluripotent stem cell models for understanding mitochondrial structural abnormalities, bioenergetics and differentiation potential in mitochondrial diseases 5:40pm - 5:50pm Spinal delivery of an AAV-vector stably expressing the VDAC1 mitochondrial protein restores cellular respiration in an ALS model mouse |
| 5:50pm - 6:40pm |
Short oral presentations I Location: Room A Proton pathways and quantum effects in the Q-cycle of cytochrome bc1 6:00pm - 6:10pm Cyanide Insensitive Oxidase contributes to Pseudomonas aeruginosa tolerance to hydrogen sulfide and nitric oxide 6:10pm - 6:20pm Substeps during subunit rotation in single FoF1-ATP synthase trapped in solution 6:20pm - 6:30pm Mitochondrial ATP synthase as a novel therapeutic drug target in neurodegenerative and ischemic heart diseases 6:30pm - 6:40pm Mitochondria without oxygen: Biochemical adaptations for the normoxia-hypoxia transition in animals |
Short oral presentations II continued Location: Room B Ketone bodies resume mitochondrial respiration in neuronal progenitors from iPSCs of patients with AGC1 deficiency 6:00pm - 6:10pm Whole-body Ndufs4 knockout mice with isolated complex I deficiency engage a futile adaptive brain response 6:10pm - 6:20pm Cellular protection and preservation of bioenergetics by the novel compound SBT-589 in a fibroblast model of Leigh syndrome 6:20pm - 6:30pm Ketogenic diet mitigates the pathogenic phenotype in TMEM70 deficient animal models 6:30pm - 6:40pm Mass spectrometry proteomics fingerprinting on hair identifies mitochondrial proteins that correlate with mitochondrial bioenergetics in immune cells: A multidisciplinary study to unravel novel biomarker candidates of major depressive disorder |
| 7:30pm | Baskerville Willy concert Location: mariatheresia |
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| Date: Wednesday, 28/Aug/2024 | |||
| 8:45am - 9:00am |
Arrival |
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| 9:00am - 10:30am |
Keynotes: Respiratory complexes and supercomplexes I Location: Room A Chair: Hana Hansikova Chair: Leonid Sazanov The rotary mechanism of ATP synthase; how it is regulated and influences the assembly of the enzyme 9:30am - 10:00am High resolution cryoEM structures of terminal oxidases 10:00am - 10:30am SCAF1 drives the compositional diversity of mammalian respirasomes |
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| 10:30am - 10:45am |
Group photo 10:30 - 10:45 am Location: Outside room A |
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| 10:45am - 11:20am |
Break Location: 1st Floor |
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| 11:20am - 12:40pm |
Respiratory complexes and supercomplexes II Location: Room A Chair: Pia Ädelroth Chair: Nils-Göran Larsson High-resolution cryoEM of ATP synthase within and from mitochondria 11:40am - 12:00pm Molecular basis of energy production in mitochondria and bacteria by integrating cryo electron microscopy, biochemistry and computer simulations 12:00pm - 12:20pm Mechanistic principles of long-range charge transfer in the mycobacterial III2IV2 supercomplex 12:20pm - 12:40pm Respiratory complexes and supercomplexes of the model yeast S. cerevisiae |
From mitochondrial monitoring in organ transplantation to mitochondrial transplantation Location: Room B Chair: Julia Hofmann Chair: Andrea Schlegel Treating Cardiac Arrest and Ischemic Injury with Mitochondrial Transplantation: Challenges and Opportunities to Save Lives 11:40am - 12:00pm Current practice of mitochondrial monitoring in organ transplantation 12:00pm - 12:20pm The quest for the mechanism(s) driving clinical ischemia-reperfusion injury - reductive rather than oxidative stress? 12:20pm - 12:40pm Mitochondrial Injury assessed in Bile during Normothermic Machine Perfusion predicts Biliary Complications after Liver Transplantation |
Mitochondrial pathologies – finding solutions Location: Room C Chair: Valerio Carelli Chair: Claudia Zanna Introduction 11:30am - 12:00pm The optic nerve: the tip of the iceberg of mito-neurodegeneration 12:00pm - 12:20pm MicroRNAs Modulation: a novel frontier in the treatment of mitochondrial optic neuropathies 12:20pm - 12:40pm NAM as a neuroprotective therapeutic intervention for mitochondrial optic neuropathies |
| 12:40pm - 1:40pm |
Lunch/Poster session 1 Lunch location: Ground Floor Poster location: 1st Floor Investigating the proton translocation mechanism of Complex I from the bottom-up Biological charge transfer far from equilibrium: electron migration and entropically driven proton dislocation Crosstalk between electron transfer and proton pumping – exploring the coupling elements in the long-range redox-driven proton pump of respiratory Complex I Synthesis of membrane protein-like redox-active mineral «green rust » through size and hydrophobicity functionnalization with amino acids No enzyme (or pathway) is an island: metals, prosthetic groups and coenzymes Elucidating the redox-driven sodium pumping mechanism of the ancient Rnf complex Exploring Wolbachia spp. infection in Drosophila melanogaster Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation Time-Resolved Serial Femtosecond Crystallography of Cytochrome c Oxidase by use of a photolabile oxygen cage and novel insights of the catalytic site from high level multiconfigurational ab initio calculations Mechanisms of Short-Circuit Suppression in the bc1 Complex Thermodynamic landscape of the redox-centers in the electron-confurcating [FeFe]-Hydrogenase (HydABC) of Thermotoga maritima An opposite sensitivity of DBMIB and DNP-INT, inhibitors of the plastoquinol oxidation in the cytochrome b6f complex, to the thylakoid lumenal pH Probing the Dynamics of the Fucoxanthin-Chlorophyll a/c (FCPs) Proteins of the Marine Diatoms Fragilariopsis sp and P. tricornutum Structural analysis of dimeric photosystem II complexes Investigation of “high-energy” metastable state of the oxidized (OH) bovine cytochrome c oxidase: proton uptake and reaction with H2O2 Characterization of the ubiquinone reaction cavity in mitochondrial respiratory complex I using artificial ligands The structure of a catalytically inactive Paracoccus denitrificans complex I mutant under turnover conditions. Respiratory supercomplexes act early to support complex I assembly Acute Reorganization of Complex V in Response to Calcium in Mammalian Heart Mitochondria Analysis of the Atomistic MD Simulations of CI+CIII2 Interactions and Associated Lipid Binding Unusual succinate dehydrogenase (SdhABEF) of the thermoacidophilic archaeon Sulfolobus acidocaldarius High-resolution structural studies of the cytochrome c oxidase catalytic cycle Homology modeling of the Na+-translocating NADH:quinone oxidoreductase and quinol:fumarate reductase from Prevotella bryantii reveals unexpected functionalities Insights into the assembly of mitochondrial respiratory complex III Inhibition and substrate binding site analysis of the obligate respiratory chain supercomplex of Actinobacteria The levels and activation state of the pyruvate dehydrogenase complex modulate the SCAFI-dependent organization of the mitochondrial respiratory chain Unveiling the Complex problem with Mdivi-1 Electrochemical studies of the cytochrome bd oxidase from the anaerobic sulfate-reducing bacterium Solidesulfovibrio fructosivorans Destabilizing the superassembly between mitochondrial complexes I and III Respiratory complex I in menaquinone-containing anaerobic bacteria Probing the reactions of Cytochrome c oxidase -Y280H, -W272H and -Y167F with O2 and H2O2 by UV-Raman spectroscopy Structural characterisation of the energy-conserving methyltransferase of a methylotrophic methanogenic archaeon Complex I of the thermophilic fungus Chaetomium thermophilum under turnover Correlating functional and structural analysis of the complex I deactive transition in proteoliposomes Mitochondrial quinone redox state is a marker of mitochondrial metabolism Identification of proteins involved in intracellular ubiquinone trafficking in Saccharomyces cerevisiae using synthetic ubiquinone probe Proton uptake in cytochrome bd -I from E. coli: electrocatalytic and spectroscopic investigations on D58 variants F1FO ATP synthase mediated reorganization of cristae architecture related to mitochondrial permeability transition pore Assembly of the F1-catalytic domain of human ATP synthase What we have learned about the dimeric complex V, and what it could still teach us Investigating the functions of ATP synthase subunits e and g in Drosophila melanogaster Two mutant forms of the inhibitor protein IF1 that are recurrent in lung cancers cause highly aggressive and death-resistant phenotypes Physiological impact of inhibition of FOF1 ATPase activity in yeast The ζ subunit from the F1FO-ATP synthase of Sinorhizobium meliloti is pH sensitive, as revealed by 2D-NMR Rotary Dynamics of Yeast V1-ATPase by High Resolution Single-Molecule Studies Highly potent anti-NTM inhibitors targeting the oxidative phosphorylation pathway of a broad spectrum of non-tuberculous mycobacterial pathogens Rotation as promotor of F1Fo-ATP synthase membrane preference location Mutagenesis in the Mrp antiporter from Bacillus pseudofirmus identifies residues critical for the histidine switch mechanism Characterizing the role of cysteine residues in the biogenesis and maturation of VDAC3 Mechanism of the NhaA antiporter from constant pH molecular dynamics simulations A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria Insights into Drosophila OXPHOS: Characterization and Functional Analysis of Mitochondrial Phosphate Carrier Isoforms CG9090 and CG4994 Unfolding the molecular mechanism of a novel membrane potential-coupled inorganic carbon-concentrating transporter Mutational analysis of the mammalian mitochondrial Ca2+/H+ exchanger TMBIM5/MICS1 Mitochondrial dysfunction in human bronchial epithelial cells lacking the BKCa channel Characterization of photosynthetic efficiency under impaired manganese and/or calcium transport over the thylakoid membrane in Arabidopsis thaliana Assessing the relative role of adenine nucleotide translocator and ATP synthase in the permeability transition Dissecting the conformational complexity and mechanism of a bacterial heme transporter Calcium-dependent mitochondrial Aspartate/Glutamate Carriers (AGCs), but not MCU, regulate proliferation in cells engaged in the Warburg effect Mitochondrial Bioavailability of Mitoquinol Mesylate Orally Administered to Mice Diflunisal activates AMP-activated protein kinase and stimulates glucose uptake, glycolysis and oxidation of glucose and oleic acid in skeletal muscle cells Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling. The role of central cavity arginine residues in UCP1 proton leak. The role of COX6B subunit in the assembly and function of cytochrome c oxidase The dynamic exchange of subunits in Complex I is essential for its function in differentiated cells Volume electron microscopy of the mitochondrial network in pancreatic beta cells Cristae narrowing by stabilized ATP-synthase dimeric rows upon glucose-stimulated insulin secretion depends on e and g subunits of membrane FO-moiety Mitochondria-ER contact sites contribution to the metabolic reprogramming accompanying the shift from proliferative to quiescent phenotype in HepG2/C3A cells IMPAIRED MITOCHONDRIAL METABOLISM AND ER-MITOCHONDRIA CONTACT SITES AFFECT SIGNALING IN CANCER CELLS. |
EBEC International Scientific Committee meeting Location: Meeting Room 6 - 1st floor |
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| 1:40pm - 2:40pm |
Lunch/Poster session 2 Lunch location: Ground Floor Poster location: 1st Floor Estimation of pKa values in membrane bound proteins Exploring the proton translocation mechanism in Complex I by integrative biophysical methods Contribution of proton ATPase in the formation of the proton motive force during fermentation of mixed carbon sources Defining the role of slight acidic conditions on membrane potential and pH variations of Thermus scotoductus K1 cells in presence of different sugars Plasticity of mitochondrial proton leak in adults and newborn mice as a possible strategy for high altitude adaptation. Persulfide Dioxygenase from Pseudomonas aeruginosa unveils a novel crosstalk mechanism between the bioenergetically-relevant gaseous signaling molecules nitric oxide and hydrogen sulfide Evolution of heme biosynthesis in prokaryotes Subtle changes in respiratory function produce big differences in life-history traits in stressed mitonuclear fly lines Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life Mechanism of hydrogen evolution in the membrane-bound hydrogenase Structure and function of a 1-MDa electron-confurcating/bifurcating, dearomatising enzyme complex from obligate anaerobic bacteria High voltage rock’n’roll – A complex approach to protein electron transfer far from equilibrium. Structural basis of HydBC modularity and its diversity in anaerobic bacteria. As stress responses, the extremophile yeast Rhodotorula mucilaginosa, expresses a highly branched respiratory chain and increases carotenoid synthesis. Photodegradation measured by high-resolution respirometry in leaf preparations Photoprotective strategies in Chlamydomonas reinhardtii: The role of flavodiiron proteins under contrasting oxygen tension Is charge recombination at the origin of Photosystem II photoinhibition? Dissection of the Molecular Mechanism of Cytochrome b561 and its Physiological Function in Cells Structures of multiple states of the nicotinamide nucleotide transhydrogenase from Escherichia coli Bioenergetics and quantitative biology applied to biotechnology Exploring yeast diversity for ethanol-fueled industrial biotechnology High resolution structures of respiratory Complex I from Yarrowia lipolytica under turnoverc onditions Phosphate Regulates the Acute Changes in Complex V Association in Skeletal Muscle Mitochondria During Calcium Overload. In situ structure and rotary states of mitochondrial ATP synthase in whole cells The respiratory complexes structure and function in Sulfolobus acidocaldarius The respirasome plays an important role in the control of mitochondrial ROS production in Ustilago maydis Conformational coupling of electron transfer and ion translocation in Na+-NQR of Vibrio cholerae Quinone and inhibitor binding in Escherichia coli complex I Function of Escherichia coli bd-I and bd-II oxidase Differences in oxidoreductase activity of cytochromes bd-I and bd-II oxidases from Mycobacterium smegmatis and Cryo-EM structure of cyt. bd-II. Cryo-EM structure of respiratory cytochrome bcc-aa3 supercomplex from Corynebacterium glutamicum Conformational dynamics of cyanobacterial NDH Effect of an essential arginine mutation (R473C) on the catalytic reaction of cytochrome c oxidase from Paracoccus denitrificans. Characterization through UV/Vis and electrochemical-FTIR spectroscopy Isolation, Purification and Cryo-Electron Microscopy Structure determination of the Mycobacterium tuberculosis Cytochrome bcc:aa3 Supercomplex Maintained respiratory chain capacity in mice with severely reduced levels of mitochondrial respirasomes Study of kinetic NADH flux in rat heart mitochondria of stroke-prone or stroke-resistant spontaneously hypertensive rats and the effect of saline diet Amino acid metabolism targets ATP-dependent inhibition of CytOx Investigation of the glycerol-3-phosphate:quinone oxidoreductases from Staphylococcus aureus and Pseudomonas aeruginosa The studies on the catalytic cycle of Cytochrome c oxidase Mutations F408DM and F396DN effect the activity of E. coli complex I Long-range charge transfer in respiratory complex I: insights from multi-scale molecular dynamics simulations Sulfide:quinone oxidoreductase from the multidrug resistant pathogen Pseudomonas aeruginosa Energy coupling in Escherichia coli complex I Electron transfer in E. coli respiratory complex I Redox chemistry of the FMN-cofactor in respiratory complex I The regulation of ATPase activity by K+ ions in gut isolated E. coli strains and its role in propionic acid sensing Effects of supramolecular organization of the ATP synthase on mitochondrial bioenergetics and ultrastructure Conversion of the ATP synthase into the Permeability Transition Pore requires the C-terminal domain of subunit e Playing with Power: Increasing ATP Synthase Activity in E. coli Rotary Mechanism of the F1-ATPase Catalytic Dwell The interface between monomers of the F1FO-ATP synthase dimer confers resistance against heavy metals Structural reorganization of mammalian F-type ATP synthase in the presence of Ca2+ Utilizing ATeam Fluorescent Proteins for Assessing ATP Synthesis and Hydrolysis In Vitro and in Isolated Yeast Mitochondria Atomic insights into the F-ATP synthase ε-induced ATP hydrolysis inhibition of the pathogen Acinetobacter baumannii. Interplay between Mitochondrial ATP Synthase Reverse Activity and Ultrastructure Bioenergetic Properties of Microbes as Potential Target for Antibacterial Activity of Plant-Based Compounds Molecular basis for leucinostatin A toxicity in mammals Physiological role of ATP3-M23K mutation and its impact on yeast mitochondrial ATPase activity Structures of TOM holo complex from Chaetomium thermophilum The role of the Escherichia coli FocA and FocB formate channels in proton flux during fermentation of mixed carbon sources Microglia-specific deletion of Kv1.3 potassium channel attenuates loss of dopaminergic neurons upon neurotoxicity in a Parkinson model Over-expression, purification and transport assay of the human SLC38A2 (SNAT2) transporter: an open window for testing ligands Predictive Insights into Protonation States of Key Residues in Bioenergetic Proteins Using Conventional and Constant-pH MD Simulations Straight from the heart – infrared light regulation of mitochondrial large conductance Ca2+-activated potassium channel activity in cardiomyocytes of Guinea Pig Unveiling the Modulation of MRP2 Activity: Insights from Phosphorylation and Drug Interactions Molecular dynamics simulations of a histidine switch in Mrp antiporter complex Tracking the progression of folding events during cell-free expression of rhodopsins into nanodiscs by SEIRAS Impact of menthol on ATPase activity and ion flux in antibiotic-resistant Escherichia coli The role of the CRP global regulator in proton flux of Escherichia coli under different glucose concentrations Calcium increases mitochondrial ATP levels by a respiration-independent mechanism mediated by calcium-regulated mitochondrial ATP-Mg2+/Pi carriers in proliferating cells Identification of the Inhibitor Binding Site of the Human Mitochondrial Pyruvate Carrier Characterising the ligand interactions and properties of purified UCP1 isoforms Nucleotide specificity of human uncoupling protein 1 inhibition Uncoupling Protein 1: biochemical and biophysical studies of the proton transport mechanism. Deficiencies of Riboflavin transporter 2 in the rare neurodegenerative disorder RTD2 are accompanied by ER stress responses and calcium homeostasis derangements Voltage Dependent Anion-selective Channel (VDAC), the gatekeeper of mitochondria, as a signaling hub for Noncommunicable chronic diseases (NCDs) Understanding respiratory complex I assembly: A structural approach The 3D architecture of pancreatic β-cells from ATPIF1 knockout mice A novel interactor of the NAM-forming element TSPO unveils an axis organising mito-nuclear Ca2+ signal transduction in neurons Mitofusin 1 and 2 deletion results in extensive mitochondria-ER/SR remodeling and compromises skeletal muscle function Regulation of mitochondrial morphology and bioenergetics in pancreatic β-cells via OMA1 protease activity |
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| 2:40pm - 4:00pm |
Respiratory complexes and supercomplexes II Location: Room A Chair: Ville Kaila Chair: Amandine Marechal The respiratory chain of Mycobacterium smegmatis 3:00pm - 3:20pm Cooperative assembly of respiratory supercomplexes 3:20pm - 3:40pm Respiratory chain heterogeneity for healthy metabolism 3:40pm - 4:00pm Effects on mammalian in vivo metabolism caused by altered interactions and levels of the individual OXPHOS complexes |
Mitochondrial physiology and pathology I Location: Room B Chair: Nazzareno Capitanio Chair: Ildiko Szabo Mitochondrial bioenergetics in hypoxia: there is more than OXPHOS 3:00pm - 3:20pm Breath to breath adaptation to hypoxia - acute mitochondrial oxygen sensing in the pulmonary vascular system 3:20pm - 3:40pm Innovations in Mitochondrial Research: Exploring Exercise-Induced Mitochondrial Adaptations in Skeletal Muscle 3:40pm - 4:00pm The Impacts of Sex, Early Life Adversities, Drug Use, and Age-Related Disease on Mitochondria: New Insights from Human Cohort Studies |
Mitochondrial pathologies – finding solutions Location: Room C Chair: Alessia Indrieri Chair: Carlo Viscomi OPA1 dominant optic atrophy – from disease mechanisms to novel therapies 3:00pm - 3:20pm Unbiased screenings and drug delivery approaches identify small molecule therapies for ADOA 3:20pm - 3:40pm Drug repositioning to treat mitochondrial dysfunctions associated with OPA1 mutations 3:40pm - 4:00pm Recreating Leber’s Hereditary Optic Neuropathy in iPS derived Neurons: Shedding Light on Pathogenic Mechanisms to Combat Blindness |
| 4:00pm - 4:50pm |
Break Location: 1st Floor |
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| 4:50pm - 6:30pm |
Calcium homeostasis Location: Room A Chair: Brian Glancy Chair: Karin Nowikovsky Mitochondrial Ca2+ handling in epithelial cells 5:10pm - 5:30pm Loss of TMEM65 causes mitochondrial disease mediated by mitochondrial calcium 5:30pm - 5:50pm Mitochondrial phosphate carrier depletion in skeletal muscle and Ca2+ homeostasis 5:50pm - 6:10pm Novel insights on the mitochondrial Ca2+/H+ exchanger TMBIM5 6:10pm - 6:30pm In Memory of Sergio Papa |
Bioenergetics and infectious diseases Location: Room B Chair: Julia Fritz-Steuber Chair: Gerhard Grüber The Na+ -translocating NADH:quinone oxidoreductase from pathogenic bacteria: essential redox pump and promising target for antibiotics 5:10pm - 5:30pm Draw me an oxidoreductase reacting with quinones 5:30pm - 5:50pm Targeting energy of life for eradication of antimicrobial resistant pathogens 5:50pm - 6:10pm Discovery of dual-targeting bioenergetic inhibitors to produce fast-acting antimicrobials for the rapid treatment of tuberculosis disease 6:10pm - 6:30pm The energy metabolism as a drug target for respiratory viral infections |
Mitochondrial pathologies – finding solutions Location: Room C Chair: Marcela Votruba Chair: Patrick Yu-Wai-Man AAV-based therapy for mitochondrial diseases and optic neuropathies 5:10pm - 5:30pm Novel cellular models of SLC25A38-related congenital sideroblastic anemia shed light on mitochondrial physiology and pave the way for therapeutic strategies. 5:30pm - 5:50pm Perspectives 5:50pm - 6:30pm Round table discussion |
| Date: Thursday, 29/Aug/2024 | ||
| 8:45am - 9:00am |
Arrival |
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| 9:00am - 10:30am |
Keynotes: Organelle dynamics Location: Room A Chair: Francesca Giordano Chair: William F. Martin Mitochondrial medicine in the pandemic era 9:30am - 10:00am Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization 10:00am - 10:30am The role of MICOS in respiratory chain assembly |
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| 10:30am - 11:20am |
Break Location: 1st Floor |
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| 11:20am - 12:40pm |
Organelle evolution and dynamics Location: Room A Chair: Heike Rampelt Chair: Luca Scorrano Why bioenergetic organelles contain their own genomes and genetic systems 11:40am - 12:00pm GTP before ATP: The very early evolution of energy currencies preserved in modern metabolism 12:00pm - 12:20pm “Menage a trois”: structure and functions of the three-way mitochondria-ER-lipid droplet junction 12:20pm - 12:40pm Mitochondrial regulation of muscle stem cells in diseases and aging |
Utilization and dissipation of the pmF: ATPases (F-type, V-type) and UCPs Location: Room B Chair: Valentina Giorgio Chair: Steven Hand Reversible Disassembly of V-ATPases in Aging and Disease 11:40am - 12:00pm Structural studies on Bacillus PS3 F1-ATPase 12:00pm - 12:20pm Engineering of ATP synthase to enhance H+/ATP ratio 12:20pm - 12:40pm FOF1-ATP synthase: When it pays to go in reverse |
| 12:40pm - 1:40pm |
Lunch/Poster session 1 Lunch location: Ground Floor Poster location: 1st Floor Light-scattering assay of mitochondrial permeability transition in intact cells Regulation of mitochondrial hydrogen sulfide metabolism by endogenous modulators of persulfide dioxygenase Liver-targeted gene therapy prevents chronic hypothermia and doubles survival in complex III deficient mice Src kinase interacts with stomatin-like protein 2 UV-induced dyscoupling and inhibition of the electron transfer system: a challenge for NADH autofluorescence redox studies New VDAC1-antagonist molecules promote patients’-derived cancer organoid death through mitochondrial-dependent metabolic interference Characterization of the longitudinal effects of electroconvulsive therapy on mitochondrial bioenergetics in immune cells from patients with major depressive disorder Mutant PTPMT1 disrupts cardiolipin metabolism and mitochondrial bioenergetics leading to a neurodevelopmental syndrome A novel pathogenic mutation in the ATP5MC3 gene of ATP synthase causing dystonia is associated with autophagic and lysosomal alteration. Cytochrome c oxidase deficiency in two patients due to mutations in COX10 Mitochondrial fatty acid β-oxidation is an essential component of fatty acid-stimulated insulin secretion Electron transport disturbances in kynurenine aminotransferase knockout mice Src Kinase modulates brain metabolism and behavior in a cell type specific manner Mitochondrial malfunctions in alpha-ketoglutarate dehydrogenase heterozygous knock-out mice are associated with minor behavioural abnormalities and decreased performance on fatigue test The Role of Complex I in the Development of Insulin Resistance Lon protease preserves mitochondrial integrity in endothelial inflammation Mitochondrial dysfunction over time triggered by Alpha-Synuclein accumulation in dopaminergic neurons of the Substantia Nigra Exogen ketosis induced by 1,3-butanediol administration to rats affects mitochondrial functionality and proteome. Bilirubin ameliorates liver steatosis in in vitro model of MASLD Nucleotide homeostasis in OXPHOS deficiency: the contributing roles of MYC and the integrated stress response Characterizing Daily Variability in PBMC Mitochondrial Respiration: A Diagnostic Perspective Nicotinamide nucleotide transhydrogenase (NNT) dysfunction impacts on lipid metabolism, and neuromuscular junction (NMJ) in M. gastrocnemius of 24-day-old mice Electron transfer pathways and coupling control in OXPHOS analysis of mouse and human mitochondrial preparations Mild and advanced liver ischemia differentially affect the cellular acyl-CoA metabolome Metabolic substrate conditions direct activity of nicotinamide nucleotide transhydrogenase (NNT), thereby modifying mitochondrial pyruvate metabolism Respiration under Stress: Is the Kadenbach – Theorem still valid? Ironing out protein synthesis: METTL17 is an Fe-S cluster checkpoint for mitochondrial translation Imeglimin in protection against ischemic brain injury: effects on mitochondrial functions Arsenic-based antineoplastic drugs kill cancer cells that thrive without OXPHOS Mito-DREADD: a new tool to improve brain mitochondrial performance and rescue cognitive deficits Impaired Bioenergetics and Mitophagy Form a Vicious Cycle that Drives Aging Mitochondrial Overheating during Early Insulin Resistance is Related to Elevated ATP Synthase Activity DRP1-Bcl-xL interaction in the chemotherapeutic induced cellular senescence progression of colorectal cancer. Hydrogen sulfide oxidation by sulfide:quinone reductase supports mitochondrial ATP production when complex I is inhibited The effect of glucose on mitochondrial respiration in hepatocellular carcinoma cells BRAIN MITOCHONDRIAL FUNCTION AND SYNAPTIC PLASTICITY ARE INFLUENCED BY THE DIETARY INTAKE OF MILK IN A RAT MODEL Pathogenic cardiolipin alterations in Barth Syndrome enhance the cellular resistance against ferroptosis Defense against oxidative stress during mitochondrial transitions into anoxia for an invertebrate extremophile Mitochondrial cytochrome c oxidase subunit 4 isoform 2 (Cox4i2) promotes hypoxia-induced reduction of the electron transport system in pulmonary arterial smooth muscle cells Spatial polymorphism has an effect on the transition in mitochondrial states that occurs due to glutamate-induced reactive oxygen species production in neurons Ethanol Blunts the Reoxygenation Capacity of H2O2 Dismutation by Catalase Characterising the molecular architecture of the archaeal ACDS superassembly Insertion of non-heme iron in cytochrome c-dependent nitric oxide reductase Oxygenic phosphorylation under anaerobic conditions Cytochrome b561 (CybB) reduces Escherichia coli membrane hyperpolarization by producing periplasmic superoxide. Mitochondrial Cytochrome c Oxidase Subunit 4 Isoform 2 Regulates T-cell activation and inflammation during viral infection Fueling success: Harnessing liver bioenergetics in clinical- and long-term machine perfusion Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics Toasts and Tests: Exploring Alcohol Culture's Impact on Mitochondria Diets modify the phenotypic outcomes of a hypomorphic AIFM1 mutation Modelling MERRF in 3D cortical organoids: manipulating patient-derived iPSCs to gain insight on prospective pre-clinical therapeutic strategies Novel Small-Molecule Improves Mitochondrial Function and Mitophagy in a Complex III Deficiency Model Potential Use of MIF Parameters in Diagnostics in Advanced Stages of Parkinson's Disease. MicroRNA-181a/b modulation as possible therapeutic strategy for Autosomal Dominant Optic Atrophy Mitochondrial bioenergetic profiling reveals off-target effects of kinase inhibitors in cancer cell models Downregulation of two mitochondria-related miRNAs ameliorates the Leigh syndrome phenotype in Ndufs4 KO mice Effect of pharmacological intervention – do changes in proteom reflect on alterations in bioenergetic parameters in fibroblasts from patients with Neurodegeneration with Brain Iron Accumulation (NBIA)? Regulation of CO2 acquisition by diatoms: study of an atypical carbonic anhydrase Replenishing NAD+ content recovers morphofunctional aspects of mitochondria in the arcuate nucleus of obese mice Cell Geometry and Membrane Protein Crowding are Major Constraints on Phenotype Mitochondrial free radical detection via modulation of photoluminescence from nitrogen vacancies in diamond-based quantum sensors Formation of I2+III2 Supercomplex Rescues Respiratory Chain Defects Structural insights into the assembly of Complex IV Suppressing Hydrogen Sulfide Production Affects Mitochondrial Biogenesis and Mitochondria Function in Breast Cancer Knockout of the mitochondrial complex III ubiquinol-cytochrome c reductase hinge protein inhibits acute but not chronic oxygen sensing in the pulmonary vasculature MIMAS, a mitochondrial multifunctional mega-assembly MMP-7 mediated Proteolytic processing Mitochondria-targeting EGFR T790M/L858R C-terminal fragments involved in EGFR axes modulate cancer stem cell transformation Non-canonical role of ubiquinone in maintaining morphology and function of mitochondrial DNA nucleoids Snapshots of acetyl-CoA synthesis, the final step of CO2 fixation in the Wood-Ljungdahl pathway Explorative analysis of mitochondrial function in Long-COVID patients compared to a control group We have reached mitochondria for the first time in nearly 200 years |
EBEC National Scientific Committee meeting Location: Meeting Room 6 - 1st floor |
| 1:40pm - 2:40pm |
Lunch/Poster session 2 Lunch location: Ground Floor Poster location: 1st Floor NAC partially prevents mitochondrial impairment and oxidative stress in cardiac cells induced by the administration of extracellular vesicles derived from nephrectomy 5/6 rats Stability of mitochondrial respiration medium used in high-resolution respirometry with living and permeabilized cells Metabolic Changes in Breast Cancer Cells: The Role of Glycerolipid Metabolism in the Development of Tamoxifen Resistance High-resolution respirometry for measurement of fatty acid β-oxidation in brain mitochondria. A comparative study and application in ischemia and aging The cleavage of Cyclophilin D N-terminus potentiates its ability to bind ATP Synthase Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration Exploring the link between ER Stress and mitochondrial dysfunction: The role of IRE1α in Neuroblastoma SH-SY5Y Cells and the Impact of STF-083010 A thioamidated peptide from Amycolatopsis alba affects tumor growth and stemness by targeting FoF1-ATPase, and inducing mitochondrial dysfunction and oxidative stress The respiratory profile of tafazzin-deficient cells is robust against lipid supplementation-induced alterations of mitochondrial membranes Mitochondrial Complement 1q Binding Protein (C1qbp) interacts with Cyclophilin D and regulates mouse heart Oxidative Phosphorylation and Permeability Transition The influence of popular drugs inhibiting the synthesis of coenzyme Q, statins and bisphosphonates, on the oxygen metabolism of cells Redox signaling upon β-like oxidation of branched-chain keto acids essentially stimulates insulin secretion in pancreatic β-cells Lead optimization of specific OPA1 inhibitors enhancing cytochrome c release and cell death Molecular Mechanisms behind Reduced ATP Synthase Function in Senescent Cardiomyocytes Saliva as a Non-invasive Sampling Biomarker to Measure Mitochondrial Respirometry in Humans Choline Oxidation Supporting ATP Export from Complex I-Inhibited Mitochondria Can Be Partially Maintained by NQO1-Mediated NAD+ Provision Lipid droplet associated mitochondria contribute to the deficiency in the electron transport chain in obese mice Mitochondrial phospholipase iPLA2γ links lipid intake to fatty acid-stimulated insulin secretion in vivo Tissue-specific behaviour differences in the Mitochondrial Permeability Transition Pore. Liver versus Heart Mitochondria. The energy nanosensor AMPfret, expressed stably in HEK cells, provides insights into toxic stress responses and heterogeneity within clonal cell populations Bioenergetic deficits in cellular models of Citrin Deficiency Biochemical and computational approaches to dissect the effect of MT-CYB pathogenic mutations on respiratory chain activity and assembly Neuron death upon brain injury with emphasis on mitochondria: are they a victim or a criminal? Transglutaminase type 2 modulates melanoma mitochondrial metabolism during phenotype switching Interpretation of 31P-MRS Assessment of ΔGATP:JATP Elasticity in Human Skeletal Muscle Requires Estimation of the Oxidative Fuel Mixture Insights into Mitochondrial Protection in Ischemic/pharmacological Preconditioning Through a Modified Glibenclamide Lacking the Sulphonylurea Portion Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies Outer membrane vesicle of Klebsiella pneumoniae decrease bactericidal properties of alveolar macrophages Peripheral blood mononuclear cell bioenergetics and skeletal muscle mitochondrial function in individuals with and without type 2 diabetes Unique pattern of energy metabolism in endothelial cells from liver sinusoids with oxidative phosphorylation but not glycolysis as a major pathway for ATP generation Human knock-down of COQ8A in HEK293 (COQ8A-KD) recapitulates mild mitochondrial-deficiency phenotype of female ARCA2 patient Respiratory complex I deficiency triggers OMA1-mediated integrated stress response and affects lipid homeostasis during glucose restriction The crossroad between mitochondrial architecture and metabolism From Childhood Trauma to immunocellular health: Unveiling the Link between Adverse Experiences and Depression Novel phenotype of COASY deficiency is characterized by fatal neonatal hepathopathy with severe hypoglycaemia, hyperammonaemia and lactic acidosis Using a multi-omics approach to generate hypotheses for follow-up studies on the tissue specific mechanisms involved in mitochondrial disease Redox interaction between mitochondria and safranin in the absence of oxygen Comprehensive Evaluation of Acute Physiological and Psychological Responses to a Short-Term High-Altitude Exposure at 2500 Meters The impact of acetic acid stress on growth parameters and sodium flux of Saccharomyces cerevisiae strains under varying oxygen conditions Mitochondrial bioenergetics of mammalian synthetic respiratory chain containing alternative quinol oxidase Remission cytochrome spectroscopy reveals the mode of action of bedaquiline in living mycobacteria Menaquinone-specific oxidation by M. tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond Regulation of innate immune cell differentiation by mitochondrial nicotinamide adenine dinucleotide (NAD+) levels Assessment of Mitochondrial Donor Injury Guides Decision Making for Liver Acceptance with Tailored Preservation Concepts Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome Preserving mitochondria by miR-181a/b modulation as therapeutic strategy for Stargardt disease Genetic variants of NQO1 affect the expression and activity of the protein, which determines the efficacy of idebenone treatment in Leber's hereditary optic neuropathy A high-content in vitro screening identifies new mitophagy-activating compounds Potential use of MiF parameters in diagnostics of newly-identified PD candidates Extrahepatic reductive stress in mitochondrial complex I deficient mice augmented by ketogenesis. Mitochondria-derived peptide MOTS-c treatment restores mitochondrial function in type 2 diabetic heart Mitochondria-targeted antioxidants and selective peroxisome proliferator-activated receptor delta (PPARδ) agonist improve bioenergetics in glutaric acidemia type 1 patient’s fibroblasts Beta-hydroxybutyrate mitigates bioenergetic deficits in the Tafazzin shRNA mouse model of Barth Syndrome Bioenergetic implications in a cellular model depicting the progression from steatosis to steatosis with inflammation A computational study to investigate the pathogenicity of single or combinations of respiratory Complex I variants Structure of Vo domain of V/A-ATPase and MD simulation for rotation of rotor ring by proton motive force. CryoEM evaluation of COX7A isoforms Unravelling the Molecular Mechanisms of Toxoplasma gondii Complex II: Progress and Challenges Mitochondrial peptide SCARI regulates Supercomplex assembly via Complex I turnover Deciphering pathological phenotypes associated with a single large deletion of mtDNA by in vitro modelling in cardiomyocytes and transcriptomic profiling Metformin restores mitochondrial bioenergetics, activates AMPK/PGC-1α pathway, and modulates mitochondrial dynamics in MOCS1-deficient fibroblasts Theory of torques and fast states in single-molecule observation of a rotary motor Bilirubin-Induced Modulation of Mitochondrial Respiration in HEK293T Cells Different catalytic states of plant cytochrome b6f revealed by high-resolution cryo-EM structures Coenzyme Q (ubiquinone) at the crossroads of metabolic pathways in the mitochondrial respiratory system Coenzyme Q Redox Poise in Sarcopenic Obesity Bioenergetic Cost on Zebrafish Intestine Caused by a Ubiquitous Pollutant, Glyphosate |
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| 2:40pm - 4:00pm |
Mitochondrial physiology and pathology II Location: Room A Chair: Andrey Kozlov Chair: Natascha Sommer MitoClock: the Circadian Nature of Mitochondrial Respiration 3:00pm - 3:20pm Redox cycler based therapeutic option against mitochondrial pathologies linked to respiratory chain dysfunction 3:20pm - 3:40pm Metabolic dysfunction in fibroblasts derived from patients with mitochondrial membrane protein-associated neurodegeneration - hope for pharmacological treatment? |
Utilization and dissipation of the pmF: ATPases (F-type, V-type) and UCPs Location: Room B Chair: Giuseppe Fiermonte Chair: Alena Zíková IF1, the endogenous inhibitor of F1Fo-ATPase, does not inhibit the ATP synthesis activity in cancer cells 3:00pm - 3:20pm Energetic challenges during cellular arrest in an invertebrate extremophile: Features of the F1Fo ATP synthase 3:20pm - 3:40pm An update on our understanding of the mitochondrial permeability transition 3:40pm - 4:00pm Bioenergetic Efficiency in Cell Fate and Survival |
| 4:00pm - 4:50pm |
Break Location: 1st Floor |
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| 4:50pm - 6:30pm |
Small molecule transport, transporters, and channels Location: Room A Chair: Cesare Indiveri Chair: Sotiria Tavoulari Dissecting the charge movements during adenine nucleotide exchange by mitochondrial ADP/ATP carrier 5:10pm - 5:30pm Cellular Glutathione Compartmentalization and Regulation: A Study of the Mitochondrial Transporter SLC25A39 5:30pm - 5:50pm ATP dependence and antiport/uniport switch of the essential amino acid transporter SLC7A5 (LAT1): molecular basis and pathophysiology 5:50pm - 6:10pm Mitochondrial potassium channels: new properties and functions. 6:10pm - 6:30pm Mechanism of the NhaA antiporter from constant pH molecular dynamics simulations (oral presentation) |
Structure and function of utilization and dissipation of the pmF Location: Room B Chair: Christopher Axelrod Chair: Ambre Bertholet The atomic resolution structure of UCP1 5:10pm - 5:30pm Regulating the activity of mouse and human UCP1 5:30pm - 5:50pm The Use of the Patch-Clamp Technique to Study the Thermogenic Capacity of Mitochondria 5:50pm - 6:10pm Mechanism of proton transport in SLC25 family proteins 6:10pm - 6:30pm UCP2 and UCP3: fraternal twins with distinct metabolic functions |
| Date: Friday, 30/Aug/2024 | ||
| 8:45am - 9:00am |
Arrival |
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| 9:00am - 10:30am |
From quantum physics and quantum information chemistry to quantum biology of respiratory and photosynthetic electron transfer. 80 years after Erwin Schrödinger's 'What is Life?' Location: Room A Chair: Gary Cecchini Chair: Ana Patricia Gamiz-Hernandez 80 years after Erwin Schrödinger's What is Life? 9:10am - 9:30am Bioenergetic myths of cellular energy transduction 9:30am - 9:50am What is a feeling? A bioenergetic explanation. 9:50am - 10:10am Low Magnetic Fields Stimulates Cardiac Mitochondrial Bioenergetics with a Bell-Shaped Response, Possibly Through the Radical Pair Mechanism. 10:10am - 10:30am A protet-based model for oxidative and photosynthetic phosphorylation |
Bioenergetics and biosynthesis involving bioblasts of photosynthetic organisms Location: Room B Chair: Anja Krieger-Liszkay Chair: Alfred William RUTHERFORD The evolution of assembly complexity of earth’s most important CO2 fixing enzyme. Photosynthetic microorganisms and marine eukaryotes: a bioorganic approach for bioremediation The synergies between alternative photosynthetic electron pathways sustain CO2 fixation in an ever-changing environment. Photosynthetic flexibility enables balancing primary metabolism for algal growth |
| 10:30am - 11:20am |
Break Location: 1st Floor |
|
| 11:20am - 12:40pm |
Mechanistic aspects of electron transfer and electron bifurcation Location: Room A Chair: Thorsten Friedrich Chair: Petra Hellwig Quantum Electron Tunneling in the Respiratory Chain: A Case for Quantum Biology 11:40am - 12:00pm Molecular basis of efficient quinone turnover in photosynthetic and respiratory cytochromes bc 12:00pm - 12:20pm Dissecting the Wood-Ljungdahl Pathway - Molecular Basis of Anaerobic Metabolism 12:20pm - 12:40pm Quinone chemistry in E. coli respiratory complex I |
Bioenergetics and biosynthesis involving bioblasts of photosynthetic organisms Location: Room B Chair: Thomas Roach Chair: Alba Timon-Gomez Oxygenic photosynthesis with less energy: breaking the red limit 11:40am - 12:00pm A complex and dynamic redox network regulating oxygen reduction at photosystem I 12:00pm - 12:20pm Redox regulation of chloroplast antioxidant network and ATP-synthase activity by the CDSP32 thioredoxin 12:20pm - 12:40pm Structural insights into photosystem II assembly |
| 12:40pm - 1:40pm |
Lunch/Poster session 1 Lunch location: Ground Floor Poster location: 1st Floor NAC partially prevents mitochondrial impairment and oxidative stress in cardiac cells induced by the administration of extracellular vesicles derived from nephrectomy 5/6 rats Stability of mitochondrial respiration medium used in high-resolution respirometry with living and permeabilized cells Metabolic Changes in Breast Cancer Cells: The Role of Glycerolipid Metabolism in the Development of Tamoxifen Resistance High-resolution respirometry for measurement of fatty acid β-oxidation in brain mitochondria. A comparative study and application in ischemia and aging The cleavage of Cyclophilin D N-terminus potentiates its ability to bind ATP Synthase Effect of selected fluorophores on equine skeletal muscle mitochondrial respiration Exploring the link between ER Stress and mitochondrial dysfunction: The role of IRE1α in Neuroblastoma SH-SY5Y Cells and the Impact of STF-083010 A thioamidated peptide from Amycolatopsis alba affects tumor growth and stemness by targeting FoF1-ATPase, and inducing mitochondrial dysfunction and oxidative stress The respiratory profile of tafazzin-deficient cells is robust against lipid supplementation-induced alterations of mitochondrial membranes Mitochondrial Complement 1q Binding Protein (C1qbp) interacts with Cyclophilin D and regulates mouse heart Oxidative Phosphorylation and Permeability Transition The influence of popular drugs inhibiting the synthesis of coenzyme Q, statins and bisphosphonates, on the oxygen metabolism of cells Redox signaling upon β-like oxidation of branched-chain keto acids essentially stimulates insulin secretion in pancreatic β-cells Lead optimization of specific OPA1 inhibitors enhancing cytochrome c release and cell death Molecular Mechanisms behind Reduced ATP Synthase Function in Senescent Cardiomyocytes Saliva as a Non-invasive Sampling Biomarker to Measure Mitochondrial Respirometry in Humans Choline Oxidation Supporting ATP Export from Complex I-Inhibited Mitochondria Can Be Partially Maintained by NQO1-Mediated NAD+ Provision Lipid droplet associated mitochondria contribute to the deficiency in the electron transport chain in obese mice Mitochondrial phospholipase iPLA2γ links lipid intake to fatty acid-stimulated insulin secretion in vivo Tissue-specific behaviour differences in the Mitochondrial Permeability Transition Pore. Liver versus Heart Mitochondria. The energy nanosensor AMPfret, expressed stably in HEK cells, provides insights into toxic stress responses and heterogeneity within clonal cell populations Bioenergetic deficits in cellular models of Citrin Deficiency Biochemical and computational approaches to dissect the effect of MT-CYB pathogenic mutations on respiratory chain activity and assembly Neuron death upon brain injury with emphasis on mitochondria: are they a victim or a criminal? Transglutaminase type 2 modulates melanoma mitochondrial metabolism during phenotype switching Interpretation of 31P-MRS Assessment of ΔGATP:JATP Elasticity in Human Skeletal Muscle Requires Estimation of the Oxidative Fuel Mixture Insights into Mitochondrial Protection in Ischemic/pharmacological Preconditioning Through a Modified Glibenclamide Lacking the Sulphonylurea Portion Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies Outer membrane vesicle of Klebsiella pneumoniae decrease bactericidal properties of alveolar macrophages Peripheral blood mononuclear cell bioenergetics and skeletal muscle mitochondrial function in individuals with and without type 2 diabetes Unique pattern of energy metabolism in endothelial cells from liver sinusoids with oxidative phosphorylation but not glycolysis as a major pathway for ATP generation Human knock-down of COQ8A in HEK293 (COQ8A-KD) recapitulates mild mitochondrial-deficiency phenotype of female ARCA2 patient Respiratory complex I deficiency triggers OMA1-mediated integrated stress response and affects lipid homeostasis during glucose restriction The crossroad between mitochondrial architecture and metabolism From Childhood Trauma to immunocellular health: Unveiling the Link between Adverse Experiences and Depression Novel phenotype of COASY deficiency is characterized by fatal neonatal hepathopathy with severe hypoglycaemia, hyperammonaemia and lactic acidosis Using a multi-omics approach to generate hypotheses for follow-up studies on the tissue specific mechanisms involved in mitochondrial disease Redox interaction between mitochondria and safranin in the absence of oxygen Comprehensive Evaluation of Acute Physiological and Psychological Responses to a Short-Term High-Altitude Exposure at 2500 Meters The impact of acetic acid stress on growth parameters and sodium flux of Saccharomyces cerevisiae strains under varying oxygen conditions Mitochondrial bioenergetics of mammalian synthetic respiratory chain containing alternative quinol oxidase Remission cytochrome spectroscopy reveals the mode of action of bedaquiline in living mycobacteria Menaquinone-specific oxidation by M. tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond Regulation of innate immune cell differentiation by mitochondrial nicotinamide adenine dinucleotide (NAD+) levels Assessment of Mitochondrial Donor Injury Guides Decision Making for Liver Acceptance with Tailored Preservation Concepts Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome Preserving mitochondria by miR-181a/b modulation as therapeutic strategy for Stargardt disease Genetic variants of NQO1 affect the expression and activity of the protein, which determines the efficacy of idebenone treatment in Leber's hereditary optic neuropathy A high-content in vitro screening identifies new mitophagy-activating compounds Potential use of MiF parameters in diagnostics of newly-identified PD candidates Extrahepatic reductive stress in mitochondrial complex I deficient mice augmented by ketogenesis. Mitochondria-derived peptide MOTS-c treatment restores mitochondrial function in type 2 diabetic heart Mitochondria-targeted antioxidants and selective peroxisome proliferator-activated receptor delta (PPARδ) agonist improve bioenergetics in glutaric acidemia type 1 patient’s fibroblasts Beta-hydroxybutyrate mitigates bioenergetic deficits in the Tafazzin shRNA mouse model of Barth Syndrome Bioenergetic implications in a cellular model depicting the progression from steatosis to steatosis with inflammation A computational study to investigate the pathogenicity of single or combinations of respiratory Complex I variants Structure of Vo domain of V/A-ATPase and MD simulation for rotation of rotor ring by proton motive force. CryoEM evaluation of COX7A isoforms Unravelling the Molecular Mechanisms of Toxoplasma gondii Complex II: Progress and Challenges Mitochondrial peptide SCARI regulates Supercomplex assembly via Complex I turnover Deciphering pathological phenotypes associated with a single large deletion of mtDNA by in vitro modelling in cardiomyocytes and transcriptomic profiling Metformin restores mitochondrial bioenergetics, activates AMPK/PGC-1α pathway, and modulates mitochondrial dynamics in MOCS1-deficient fibroblasts Theory of torques and fast states in single-molecule observation of a rotary motor Bilirubin-Induced Modulation of Mitochondrial Respiration in HEK293T Cells Different catalytic states of plant cytochrome b6f revealed by high-resolution cryo-EM structures Coenzyme Q (ubiquinone) at the crossroads of metabolic pathways in the mitochondrial respiratory system Coenzyme Q Redox Poise in Sarcopenic Obesity Bioenergetic Cost on Zebrafish Intestine Caused by a Ubiquitous Pollutant, Glyphosate |
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| 1:40pm - 2:40pm |
Lunch/Poster session 2 Lunch location: Ground Floor Poster location: 1st Floor Light-scattering assay of mitochondrial permeability transition in intact cells Regulation of mitochondrial hydrogen sulfide metabolism by endogenous modulators of persulfide dioxygenase Liver-targeted gene therapy prevents chronic hypothermia and doubles survival in complex III deficient mice Src kinase interacts with stomatin-like protein 2 UV-induced dyscoupling and inhibition of the electron transfer system: a challenge for NADH autofluorescence redox studies New VDAC1-antagonist molecules promote patients’-derived cancer organoid death through mitochondrial-dependent metabolic interference Characterization of the longitudinal effects of electroconvulsive therapy on mitochondrial bioenergetics in immune cells from patients with major depressive disorder Mutant PTPMT1 disrupts cardiolipin metabolism and mitochondrial bioenergetics leading to a neurodevelopmental syndrome A novel pathogenic mutation in the ATP5MC3 gene of ATP synthase causing dystonia is associated with autophagic and lysosomal alteration. Cytochrome c oxidase deficiency in two patients due to mutations in COX10 Mitochondrial fatty acid β-oxidation is an essential component of fatty acid-stimulated insulin secretion Electron transport disturbances in kynurenine aminotransferase knockout mice Src Kinase modulates brain metabolism and behavior in a cell type specific manner Mitochondrial malfunctions in alpha-ketoglutarate dehydrogenase heterozygous knock-out mice are associated with minor behavioural abnormalities and decreased performance on fatigue test The Role of Complex I in the Development of Insulin Resistance Lon protease preserves mitochondrial integrity in endothelial inflammation Mitochondrial dysfunction over time triggered by Alpha-Synuclein accumulation in dopaminergic neurons of the Substantia Nigra Exogen ketosis induced by 1,3-butanediol administration to rats affects mitochondrial functionality and proteome. Bilirubin ameliorates liver steatosis in in vitro model of MASLD Nucleotide homeostasis in OXPHOS deficiency: the contributing roles of MYC and the integrated stress response Characterizing Daily Variability in PBMC Mitochondrial Respiration: A Diagnostic Perspective Nicotinamide nucleotide transhydrogenase (NNT) dysfunction impacts on lipid metabolism, and neuromuscular junction (NMJ) in M. gastrocnemius of 24-day-old mice Electron transfer pathways and coupling control in OXPHOS analysis of mouse and human mitochondrial preparations Mild and advanced liver ischemia differentially affect the cellular acyl-CoA metabolome Metabolic substrate conditions direct activity of nicotinamide nucleotide transhydrogenase (NNT), thereby modifying mitochondrial pyruvate metabolism Respiration under Stress: Is the Kadenbach – Theorem still valid? Ironing out protein synthesis: METTL17 is an Fe-S cluster checkpoint for mitochondrial translation Imeglimin in protection against ischemic brain injury: effects on mitochondrial functions Arsenic-based antineoplastic drugs kill cancer cells that thrive without OXPHOS Mito-DREADD: a new tool to improve brain mitochondrial performance and rescue cognitive deficits Impaired Bioenergetics and Mitophagy Form a Vicious Cycle that Drives Aging Mitochondrial Overheating during Early Insulin Resistance is Related to Elevated ATP Synthase Activity DRP1-Bcl-xL interaction in the chemotherapeutic induced cellular senescence progression of colorectal cancer. Hydrogen sulfide oxidation by sulfide:quinone reductase supports mitochondrial ATP production when complex I is inhibited The effect of glucose on mitochondrial respiration in hepatocellular carcinoma cells BRAIN MITOCHONDRIAL FUNCTION AND SYNAPTIC PLASTICITY ARE INFLUENCED BY THE DIETARY INTAKE OF MILK IN A RAT MODEL Pathogenic cardiolipin alterations in Barth Syndrome enhance the cellular resistance against ferroptosis Defense against oxidative stress during mitochondrial transitions into anoxia for an invertebrate extremophile Mitochondrial cytochrome c oxidase subunit 4 isoform 2 (Cox4i2) promotes hypoxia-induced reduction of the electron transport system in pulmonary arterial smooth muscle cells Spatial polymorphism has an effect on the transition in mitochondrial states that occurs due to glutamate-induced reactive oxygen species production in neurons Ethanol Blunts the Reoxygenation Capacity of H2O2 Dismutation by Catalase Characterising the molecular architecture of the archaeal ACDS superassembly Insertion of non-heme iron in cytochrome c-dependent nitric oxide reductase Oxygenic phosphorylation under anaerobic conditions Cytochrome b561 (CybB) reduces Escherichia coli membrane hyperpolarization by producing periplasmic superoxide. Mitochondrial Cytochrome c Oxidase Subunit 4 Isoform 2 Regulates T-cell activation and inflammation during viral infection Fueling success: Harnessing liver bioenergetics in clinical- and long-term machine perfusion Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics Toasts and Tests: Exploring Alcohol Culture's Impact on Mitochondria Diets modify the phenotypic outcomes of a hypomorphic AIFM1 mutation Modelling MERRF in 3D cortical organoids: manipulating patient-derived iPSCs to gain insight on prospective pre-clinical therapeutic strategies Novel Small-Molecule Improves Mitochondrial Function and Mitophagy in a Complex III Deficiency Model Potential Use of MIF Parameters in Diagnostics in Advanced Stages of Parkinson's Disease. MicroRNA-181a/b modulation as possible therapeutic strategy for Autosomal Dominant Optic Atrophy Mitochondrial bioenergetic profiling reveals off-target effects of kinase inhibitors in cancer cell models Downregulation of two mitochondria-related miRNAs ameliorates the Leigh syndrome phenotype in Ndufs4 KO mice Effect of pharmacological intervention – do changes in proteom reflect on alterations in bioenergetic parameters in fibroblasts from patients with Neurodegeneration with Brain Iron Accumulation (NBIA)? Regulation of CO2 acquisition by diatoms: study of an atypical carbonic anhydrase Replenishing NAD+ content recovers morphofunctional aspects of mitochondria in the arcuate nucleus of obese mice Cell Geometry and Membrane Protein Crowding are Major Constraints on Phenotype Mitochondrial free radical detection via modulation of photoluminescence from nitrogen vacancies in diamond-based quantum sensors Formation of I2+III2 Supercomplex Rescues Respiratory Chain Defects Structural insights into the assembly of Complex IV Suppressing Hydrogen Sulfide Production Affects Mitochondrial Biogenesis and Mitochondria Function in Breast Cancer Knockout of the mitochondrial complex III ubiquinol-cytochrome c reductase hinge protein inhibits acute but not chronic oxygen sensing in the pulmonary vasculature MIMAS, a mitochondrial multifunctional mega-assembly MMP-7 mediated Proteolytic processing Mitochondria-targeting EGFR T790M/L858R C-terminal fragments involved in EGFR axes modulate cancer stem cell transformation Non-canonical role of ubiquinone in maintaining morphology and function of mitochondrial DNA nucleoids Snapshots of acetyl-CoA synthesis, the final step of CO2 fixation in the Wood-Ljungdahl pathway Explorative analysis of mitochondrial function in Long-COVID patients compared to a control group We have reached mitochondria for the first time in nearly 200 years |
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| 3:00pm - 8:00pm |
Alpbach Schrödinger Satellite Location: Alpbach |
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| Date: Saturday, 31/Aug/2024 | |
| 9:00am - 9:10am |
Arrival |
| 9:10am - 10:30am |
Keynotes: Respiratory complexes and supercomplexes III Location: Room A Chair: Laszlo Tretter Chair: Cristina Ugalde Structure and mechanism of the energy-coupled nicotinamide nucleotide transhydrogenase from E. coli 9:30am - 9:50am Deciphering the molecular mechanism of proton-electron coupling in the Complex I machinery 9:50am - 10:10am Respiratory supercomplexes act early to support complex I assembly. 10:10am - 10:30am Innovations in Bacterial Breathing: Hardwired Respirasomes |
| 10:30am - 11:20am |
Break Location: 1st Floor |
| 11:20am - 11:50am |
Keynotes: Respiratory complexes and supercomplexes III Location: Room A Chair: Elena E. Pohl Chair: Salvador Uribe-Carvajal Complex I mechanism - the latest developments |
| 11:50am - 12:20pm |
EBEC2024 summary and awards Location: Room A Erich Gnaiger |
| 12:20pm - 12:35pm |
EBEC2026 Location: Room A Ville Kaila |