Reasons for Liver Discard After Normothermic Machine Perfusion: A single Center Experience

Paula Van Appeldorn, Felix Krendl, Alexander Kofler, Lukas Prommegger, Rupert Oberhuber, Stefan Schneeberger, Benno Cardini

Medizinische Universität Innsbruck, Österreich

Normothermic liver machine perfusion improves access to liver transplantation: Insights from a large Eurotransplant center

Alexander Kofler¹, Lukas Prommegger¹, Georg A. Jakobitsch¹, Maria R. Troppmair², Florian Ponholzer¹, Manuel Maglione¹, Thomas Resch¹, Benno Cardini¹, Heinz Zoller², Stefan Schneeberger¹, Rupert Oberhuber¹, Felix J. Krendl¹

1: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria; 2: Department of Internal Medicine I - Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria

Trends in organ utilization: A decade-long comparative analysis between Eurotransplant and the United States

Alexander Kofler¹, Felix J. Krendl^1,2, Lukas Prommegger¹, Gerald Brandacher¹, Benno Cardini¹, Annemarie Weißenbacher¹, Rupert Oberhuber¹, Stefan Schneeberger¹

1: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria; 2: Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, United States

Folate Status as a potential modulator of liver fibrosis in a MAFLD/MASH rat model

Christine Mölzer, Paula Richwien, Denisa Zrubecká, Katharina Wöran, Friedrich Jakse, Gerhard Prager, Magdalena Mairinger

Medizinische Universität Wien, Österreich

EFFECTS OF METABOLIC-BARIATRIC SURGERY ON INTESTINAL PERMEABILITY AND MASLD - A RODENT MODEL

Paula Richwien, Christine Mölzer, Denisa Zrubecká, Katharina Wöran, Friedrich Jakse, Gerhard Prager, Magdalena Mairinger

Medizinische Universität Wien, Österreich

Kleintiermodelle / Small animal models

Nina Pilat

Großtiermodelle / Large animal models

Thomas Resch

Menschliche Organe / Human organs

Julia Hofmann

Predictive Potential of Perfusate-Derived MicroRNAs during Normothermic Machine Perfusion for Outcome after Liver Transplantation

Lisa Kamauf, Jule Dingfelder, Laurin Rauter, Nikolaus Becker, Moriz Riha, Julian Flavio Müller, Felix Hammer-Purgstall-Bernd, Matthias Hackl, Gabriela Berlakovich, Patrick Starlinger, Georg Györi, David Pereyra

Department of General Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria

Transcriptomic Landscape of Grafts Not Meeting Criteria For Transplantation During Normothermic Machine Perfusion

Jule Dingfelder^1,2, Laurin Rauter¹, Nikolaus Becker¹, Moriz Riha^1,2, Flavio Müller¹, Lisa Kamauf¹, Matthias Hackl³, Hubert Hackl⁴, Raphael Gronauer⁴, Thomas Soliman¹, Gabriela Berlakovich¹, Patrick Starlinger⁵, Georg Györi¹, David Pereyra^1,2,5

1: Department of General Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria; 2: Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Vienna, Austria; 3: TAmiRNA GmbH, Vienna, Austria; 4: Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; 5: Department of Surgery, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic Rochester,Rochester, USA

Nature-Inspired Ice-free Subzero Kidney Preservation Facilitates Commercial Transatlantic Organ Transpor

Anne Heberle¹, Marlene Pühringer¹, Amanda Loftin², Julia Hofmann¹, Theresa Hautz¹, Stefan Schneeberger¹, Siavash Khaki², Narges Lamsehchi², Xiaoxi Wei³, Mark Kline³, Byoung Chol Oh², Gerald Brandacher¹

1: Medical University Innsbruck, Österreich; 2: Johns Hopkins University School of Medicine, Baltimore, MD, US; 3: X-Therma Inc., Hercules, CA

Optimizing Liver Graft Selection during Hypothermic Oxygenated Machine Perfusion using Perfusate Sodium and Lactate Measurements

Julian Flavio Müller, David Pereyra, Jule Dingfelder, Nikolaus Becker, Moriz Riha, Lisa Kamauf, Felix Hammer-Purgstall-Bernd, Monika Aiad, Jakob Mayr, Laurin Rauter, Hadeza Lu Seidu, Lea Katharina Breitsching

Medizinische Universität Wien, Klinische Abteilung für Transplantation

Large Animal Model of Kidney Transplantation to Optimize Static Cold Storage

Attila Rutai¹, Dániel Érces¹, László Juhász¹, Krisztina Spisák¹, Eszter Mán², Zoltán Hódi², Emil Terhes², Mihály Boros¹, Andrea Szabó¹, Gabriella Varga¹

1: Institute of Surgical Research, University of Szeged, Szeged, Hungary; 2: Department of Surgery, University of Szeged, Szeged, Hungary

Preclinical evaluation of a novel, fully absorbable magnesium-based annuloplasty ring with antibacterial properties

Lukas Weber¹, Marjan Enayati¹, Jelena Horky¹, Carina Kampleitner^2,3,4, Mariangela Fedel⁵, Christian Grasl⁶, Christopher Riedmüller¹, Claudia Höchsmann⁷, Michael Prückler¹, Simone Braeuer⁸, Stephan Handschuh⁹, Marc Schneider¹, John Bekhit¹, Bruno Mora¹⁰, Laszlo Sajti⁵, Manfred Bammer¹, Ingrid Walter⁷, Martin Glösmann⁹, Gunda Koellensperger¹¹, Stefan Tangl^2,4, Helga Bergmeister¹, Bruno K. Podesser¹

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria; 2: Karl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria; 3: Ludwig Boltzmann Institute for Traumatology. The Research Center in Cooperation with AUVA, Vienna, Austria; 4: Austrian Cluster for Tissue Regeneration, Vienna, Austria; 5: RHP Technology GmbH, Seibersdorf, Austria; 6: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 7: Institute of Morphology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria; 8: Institute of Analytical Chemistry, BOKU University, Vienna, Austria; 9: VetCore Facility for Research / Imaging Unit, University of Veterinary Medicine Vienna, Vienna, Austria; 10: Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria; 11: Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria

Assessment of AAV3B transduction efficacy by Oxford Nanopore Sequencing Technologies in a liver normothermic machine perfusion model

Juliane Gasser^1,6, Julia Hofmann¹, Stefan H. Lung^2,5,6, Lena Prantl^2,6, Nicolas Nacke^2,5, Martin Hermann^1,3, Bettina Zelger⁴, Nina Feichtner², Verena Hackl¹, Felix J. Krendl¹, Andras T. Meszaros¹, Anne Heberle¹, Florian Blum^2,5, Katharina Calana², Simon Mathis³, Judith Martini³, Thomas Resch¹, Stefan Schneeberger¹, Heribert Stoiber^2,5, Theresa Hautz¹

1: organLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria; 2: Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria; 3: Department of Anesthesia and Critical Care Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.; 4: Department of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria; 5: Lysomab GmbH, 6020 Innsbruck, Austria; 6: VASCage – Research Centre on Vascular Ageing and Stroke, 6020 Innsbruck, Austria

Defining a reliable liver injury model as a platform for translational normothermic machine perfusion (NMP) research.

Anna Lea Fleischmann^1,2, Anne Heberle^1,2, Simon Mathis^2,3, Judith Martini^2,3, Gabriel Putzer^2,3, Christina Bogensperger^1,2, Julia Hofmann^1,2, Andras Meszaros^1,2, Theresa Hautz², Benno Cardini^1,2, Rupert Oberhuber^1,2, Gabriel Nervo^1,2, Sabrina Fürst^1,2, Stefan Scheidl¹, Christoph Profanter¹, Martina Falchetti^1,2, Martin Hermann^1,2, Bettina Zelger⁴, Steffen Ormanns⁴, Marlene Pühringer^1,2, Stefan Schneeberger^1,2, Gerald Brandacher^1,2, Thomas Resch^1,2

1: Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2: OrganLife, Organ Regeneration Center of Excellence, Innsbruck, Austria; 3: Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Austria; 4: Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria

Combination of mitochondrial Flavin mononucleotide and endothelial Syndecan-1 measured during hypothermic oxygenated machine perfusion improves prediction of early allograft dysfunction following liver transplantation

Nikolaus Becker, Jule Dingfelder, Moriz Riha, Laurin Rauter, Flavio Julian Müller, Lisa Kamauf, Felix Hammer-Purgstall, Monika Aiad, Jakob Mayr, Hadeza Lu Seidu, Gabriela Berlakovich, David Pereyra, Georg Györi

Abteilung für Transplantation, Medizinische Universität Wien, Österreich

Circulating microRNA–Based HepatomiR® P-Score as a Novel Biomarker for Donor Organ Quality in Liver Transplantation

Moriz Riha, Tobias Zott, Susanna Skalicky, Laurin Rauter, Jule Dingfelder, Lea Breitschnig, Nikolaus Becker, Alice Assinger, Gabriela Berlakovich, Georg Gyoeri, Matthias Hackl, Gerd Silberhummer, Patrick Starlinger, David Pereyra

Medizinische Universität Wien, Österreich

Project Funding

Bruno Podesser

Good Scientific Practice

Gerald Brandacher

How can we learn from methhological errors and negative results?

Andrea Szabó

Analysis of inflammatory response in patients undergoing elective Thoracic Endovascular Aortic Repair from 2017 until 2023 - a single-centre retrospective observational study

Alina Stanger¹, Kathrin Freystätter², Andrea Finster², Lukas Resemann², Frieda Kainz², Dominik Wiedemann², Felix Nagel²

1: Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria; 2: Division of Cardiosurgery, University Hospital St. Pölten, Dunant-Platz 1, 3100 St. Pölten, Austria

Sex-Dependent Discrepancies in molecular fingerprint of Left Ventricular Reverse Remodeling after Surgical Aortic Valve Replacement

Frieda-Maria Kainz^1,2, Lukas Resemann², Michael Soritz¹, Jutta Pusch², Casey Zacharias², Dominik Wiedemann², Christoph Holzinger^1,2, Attila Kiss¹, Peter Pokreisz¹, Bruno K. Podesser^1,2

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria; 2: Department of Cardiac Surgery, University Clinic St. Pölten and Karl Landsteiner University of Health Sciences, Sankt Pölten, Austria

A Paradigm Shift in Surgical Education: Objective, Data-Driven Training for Medical Students

Karl Heinrich Schneider¹, Nico geropp¹, Leon Neumann¹, Lorenzo Civilla², Francesco Moscato², David Santer¹

1: Zentrum für Biomedizinische Forschung und Translationale Chirurgie, Medizinische Universität Wien, Austria; 2: Zentrum für Medizinische Physik und Biomedizinische Technik, Medizinische Universität Wien, Austria

Single-Cell RNA Sequencing of Human Sural Nerve Explants Reveals Temporal Reprogramming and Functional Diversity of Repair Schwann Cells

Tamara Weiss¹, Hannes Kühtreiber², Michael Mildner², Christine Radtke¹

1: Universitätsklinik für Plastische, Rekonstruktive und Ästhetische Chirurgie, Medizinische Universität Wien, Österreich; 2: Universitätsklinik für Dermatologie, Medizinische Universität Wien

Spotlighting Lymphatics in the Healing of Small-Diameter Vascular Grafts

Sabrina Rohringer¹, Virginia Pach¹, Anna-Maria Schmitt¹, Christian Grasl², Bruno K. Podesser¹, Helga Bergmeister¹

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Österreich; 2: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria

Proteomics-Guided Development of Tunable Placental ECM Bioinks for Cardiac Tissue Engineering

Felix Pointner^1,2, Marvin Dötzlhofer¹, Alexander Cserinko¹, Sabrina Rohringer^1,2, Helga Bergmeister^1,2, Bruno K. Podesser^1,2, Marjan Enayati^1,2, Karl H. Schneider^1,2

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Austria; 2: Austrian Cluster for Tissue Regeneration, Vienna, Austria

The role of 5-methyltetrahydrofolate in hepatic stellate cell activation in vitro

Denisa Zrubecká, Magdalena Mairinger, Paula Richwien, Gerhard Prager, Christine Mölzer

Medizinische Universität Wien, Austria

Perivascular Adipose Tissue as Key Regulator of Integration and Remodeling during Synthetic Vascular Graft Healing

Anna-Maria Schmitt¹, Sabrina Rohringer¹, Sophie J. Specht¹, Selin Topcu¹, Christian Grasl², Ingrid Walter³, Bruno K. Podesser¹, Helga Bergmeister¹

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria; 2: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 3: Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria

The impact of colorectal cancer on monocyte subsets in a humanized mouse model

Maria Amparo Sahagun Cortez¹, Viktoria Knöbl¹, Selina Wutzl¹, Wolfgang M. Bauer², Batuhan O. Ağargün¹, Alex Farr³, Wolf Eilenberg¹, Dietmar Herndler-Brandstetter⁴, Christoph Neumayer¹, Christine Brostjan¹

1: Medical University of Vienna, Department of General Surgery, Division of Vascular Surgery; 2: Medical University of Vienna, Department of Dermatology; 3: Medical University of Vienna, Department of Obstetrics and Gynecology; 4: Medical University of Vienna, Department of Medicine I, Cancer Research Institute

Feasibility of Microdialysis in normothermic ex-situ heart perfusion – a porcine model

Victoria Ennen, Nina Hofmann, Lauma Putnina, Lukas Stastny, Natalie Huemer, Alexandra Ampferer, Florian Sommerauer, Gabriel Putzer, Judith Martini, Raimund Helbok, Julia Dumfarth

TirolKliniken, Österreich