Predictive Potential of Perfusate-Derived MicroRNAs during Normothermic Machine Perfusion for Outcome after Liver Transplantation

Lisa Kamauf, Jule Dingfelder, Laurin Rauter, Nikolaus Becker, Moriz Riha, Julian Flavio Müller, Felix Hammer-Purgstall-Bernd, Matthias Hackl, Gabriela Berlakovich, Patrick Starlinger, Georg Györi, David Pereyra

Department of General Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria

Transcriptomic Landscape of Grafts Not Meeting Criteria For Transplantation During Normothermic Machine Perfusion

Jule Dingfelder^1,2, Laurin Rauter¹, Nikolaus Becker¹, Moriz Riha^1,2, Flavio Müller¹, Lisa Kamauf¹, Matthias Hackl³, Hubert Hackl⁴, Raphael Gronauer⁴, Thomas Soliman¹, Gabriela Berlakovich¹, Patrick Starlinger⁵, Georg Györi¹, David Pereyra^1,2,5

1: Department of General Surgery, Division of Transplantation, Medical University of Vienna, Vienna, Austria; 2: Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Vienna, Austria; 3: TAmiRNA GmbH, Vienna, Austria; 4: Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; 5: Department of Surgery, Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic Rochester,Rochester, USA

Nature-Inspired Ice-free Subzero Kidney Preservation Facilitates Commercial Transatlantic Organ Transpor

Anne Heberle¹, Marlene Pühringer¹, Amanda Loftin², Julia Hofmann¹, Theresa Hautz¹, Stefan Schneeberger¹, Siavash Khaki², Narges Lamsehchi², Xiaoxi Wei³, Mark Kline³, Byoung Chol Oh², Gerald Brandacher¹

1: Medical University Innsbruck, Österreich; 2: Johns Hopkins University School of Medicine, Baltimore, MD, US; 3: X-Therma Inc., Hercules, CA

Optimizing Liver Graft Selection during Hypothermic Oxygenated Machine Perfusion using Perfusate Sodium and Lactate Measurements

Julian Flavio Müller, David Pereyra, Jule Dingfelder, Nikolaus Becker, Moriz Riha, Lisa Kamauf, Felix Hammer-Purgstall-Bernd, Monika Aiad, Jakob Mayr, Laurin Rauter, Hadeza Lu Seidu, Lea Katharina Breitsching

Medizinische Universität Wien, Klinische Abteilung für Transplantation

Large Animal Model of Kidney Transplantation to Optimize Static Cold Storage

Attila Rutai¹, Dániel Érces¹, László Juhász¹, Krisztina Spisák¹, Eszter Mán², Zoltán Hódi², Emil Terhes², Mihály Boros¹, Andrea Szabó¹, Gabriella Varga¹

1: Institute of Surgical Research, University of Szeged, Szeged, Hungary; 2: Department of Surgery, University of Szeged, Szeged, Hungary

Preclinical evaluation of a novel, fully absorbable magnesium-based annuloplasty ring with antibacterial properties

Lukas Weber¹, Marjan Enayati¹, Jelena Horky¹, Carina Kampleitner^2,3,4, Mariangela Fedel⁵, Christian Grasl⁶, Christopher Riedmüller¹, Claudia Höchsmann⁷, Michael Prückler¹, Simone Braeuer⁸, Stephan Handschuh⁹, Marc Schneider¹, John Bekhit¹, Bruno Mora¹⁰, Laszlo Sajti⁵, Manfred Bammer¹, Ingrid Walter⁷, Martin Glösmann⁹, Gunda Koellensperger¹¹, Stefan Tangl^2,4, Helga Bergmeister¹, Bruno K. Podesser¹

1: Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria; 2: Karl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria; 3: Ludwig Boltzmann Institute for Traumatology. The Research Center in Cooperation with AUVA, Vienna, Austria; 4: Austrian Cluster for Tissue Regeneration, Vienna, Austria; 5: RHP Technology GmbH, Seibersdorf, Austria; 6: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 7: Institute of Morphology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria; 8: Institute of Analytical Chemistry, BOKU University, Vienna, Austria; 9: VetCore Facility for Research / Imaging Unit, University of Veterinary Medicine Vienna, Vienna, Austria; 10: Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria; 11: Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria

Assessment of AAV3B transduction efficacy by Oxford Nanopore Sequencing Technologies in a liver normothermic machine perfusion model

Juliane Gasser^1,6, Julia Hofmann¹, Stefan H. Lung^2,5,6, Lena Prantl^2,6, Nicolas Nacke^2,5, Martin Hermann^1,3, Bettina Zelger⁴, Nina Feichtner², Verena Hackl¹, Felix J. Krendl¹, Andras T. Meszaros¹, Anne Heberle¹, Florian Blum^2,5, Katharina Calana², Simon Mathis³, Judith Martini³, Thomas Resch¹, Stefan Schneeberger¹, Heribert Stoiber^2,5, Theresa Hautz¹

1: organLife Organ Regeneration Center of Excellence and Daniel Swarovski Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria; 2: Institute of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria; 3: Department of Anesthesia and Critical Care Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.; 4: Department of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria; 5: Lysomab GmbH, 6020 Innsbruck, Austria; 6: VASCage – Research Centre on Vascular Ageing and Stroke, 6020 Innsbruck, Austria

Defining a reliable liver injury model as a platform for translational normothermic machine perfusion (NMP) research.

Anna Lea Fleischmann^1,2, Anne Heberle^1,2, Simon Mathis^2,3, Judith Martini^2,3, Gabriel Putzer^2,3, Christina Bogensperger^1,2, Julia Hofmann^1,2, Andras Meszaros^1,2, Theresa Hautz², Benno Cardini^1,2, Rupert Oberhuber^1,2, Gabriel Nervo^1,2, Sabrina Fürst^1,2, Stefan Scheidl¹, Christoph Profanter¹, Martina Falchetti^1,2, Martin Hermann^1,2, Bettina Zelger⁴, Steffen Ormanns⁴, Marlene Pühringer^1,2, Stefan Schneeberger^1,2, Gerald Brandacher^1,2, Thomas Resch^1,2

1: Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2: OrganLife, Organ Regeneration Center of Excellence, Innsbruck, Austria; 3: Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Austria; 4: Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria

Combination of mitochondrial Flavin mononucleotide and endothelial Syndecan-1 measured during hypothermic oxygenated machine perfusion improves prediction of early allograft dysfunction following liver transplantation

Nikolaus Becker, Jule Dingfelder, Moriz Riha, Laurin Rauter, Flavio Julian Müller, Lisa Kamauf, Felix Hammer-Purgstall, Monika Aiad, Jakob Mayr, Hadeza Lu Seidu, Gabriela Berlakovich, David Pereyra, Georg Györi

Abteilung für Transplantation, Medizinische Universität Wien, Österreich

Circulating microRNA–Based HepatomiR® P-Score as a Novel Biomarker for Donor Organ Quality in Liver Transplantation

Moriz Riha, Tobias Zott, Susanna Skalicky, Laurin Rauter, Jule Dingfelder, Lea Breitschnig, Nikolaus Becker, Alice Assinger, Gabriela Berlakovich, Georg Gyoeri, Matthias Hackl, Gerd Silberhummer, Patrick Starlinger, David Pereyra

Medizinische Universität Wien, Österreich

Project Funding

Bruno Podesser

Good Scientific Practice

Gerald Brandacher

How can we learn from methhological errors and negative results?

Andrea Szabó