Conference Agenda

Session

P450 Regulation: Regulatory mechanisms of Cytochrome P450

Time:

Friday, 04/July/2025:

10:00am - 12:00pm

Session Chair: Prof. Petr Pavek, Charles University, Faculty of Pharmacy, Czech Republic

Location: Auditorium 003

199 Places

Session Topics:

13. Regulatory mechanisms of Cytochrome P450

Presentations

10:00am - 10:30am

Pregnane X receptor (PXR) antagonists in the regulation of cytochrome P450 genes

Petr Pavek

10:30am - 11:00am

Humanisation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) for modelling consequences of P450 induction in vivo

A Kenneth Macleod, Yury Kapelyukh, Kevin D. Read, C. Roland Wolf

University of Dundee, United Kingdom

11:00am - 11:15am

Regulation of adrenal androgen production by thyroid hormones

Philipp Augsburger, Therina du Toit, Suzanne Smit, Christa Flück

11:15am - 11:30am

Post-Translational Modifications of CYP4F11 by 4-Hydroxynonenal: ω-Hydroxylation Impairment and Potential Role in Immunosuppression

Oleksii Skorokhod

The contribution has been accepted as poster

PGE2-induced CYP1B1 activation might enhance neuronal excitation to promote glioblastoma progression and therapy resistance

Dear. Chih-Jie Shen, Dear. Wen-Chang Chang, Dear. Tsung-I Hsu

11:30am - 11:45am

The novel third-generation antipsychotic drug brexpiprazole modulate cytochrome P450 enzymes in the liver.

Przemysław Jan Danek, Renata Pukło, Władysława Anna Daniel

11:45am - 12:00pm

Cytochrome P450 activity in sepsis: Insights into gene expression and enzymatic dysfunction

Fellanza Halimi, Jolien Vandewalle, Tineke Vanderhaeghen, Charlotte Cuypers, Bruna Alonso, Marc Cherlet, Bruno Garcia, Antoine Herpain, Steven Timmermans, Claude Libert, Stijn Schauvliege, Siska Croubels