Conference Agenda
Overview and details of the sessions of this conference. Please select a date or location to show only sessions at that day or location. Please select a single session for detailed view (with abstracts and downloads if available).
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Session Overview | |
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Location: Auditorium 004 199 Places |
| Date: Monday, 30/June/2025 | |
| 1:30pm - 3:30pm |
P450 Structure: Symposia 2 Structure of P450 and non-heme Oxygenases Location: Auditorium 004 Chair: Dr. Emily Scott, University of Michigan, United States of America Chair: Prof. Shingo Nagano, Tottori University, Japan What NMR teaches us about P450 structure, dynamics and function. 2:00pm - 2:30pm Cytochrome P450 7B1 structure and analysis of mutations causing disease 2:30pm - 3:00pm Engineering efficient peroxygenase activity into cytochrome P450 Enzymes for selective C-H bond hydroxylations 3:00pm - 3:30pm Structure and mechanism of plant 2-oxoglutarate-dependent dioxygenases catalyzing α-tomatine oxidation |
| Date: Tuesday, 01/July/2025 | |
| 10:00am - 11:30am |
P450 Biophysics: Symposia 4: P450 Biophysics Location: Auditorium 004 Chair: Prof. Gianfranco Gilardi, University of Torino, United Kingdom Direct Isolation and Reconstitution of Cytochrome Proteins in Polymer-Based Nanodiscs 10:30am - 11:00am Hydroxylation and lyase reaction mechanisms in CYP17A1 11:00am - 11:30am Biased P450 activation by controlling P450 oxidoreductase conformational sampling: A single molecule and machine learning perspective |
| 12:00pm - 1:00pm |
P450 Biophysics 2: Symposia 4: P450 Biophysics continued Location: Auditorium 004 Chair: Prof. Gianfranco Gilardi, University of Torino, United Kingdom Focusing the computational microscope on the dynamics of mammalian cytochrome P450s and their redox partners 12:30pm - 12:45pm Elucidating Biochemistry of Cytochrome P450 2U1 with respect to Lipid and Xenobiotic Metabolism 12:45pm - 1:00pm Docking predictivity determinants for the P450 flexible active site |
| 2:00pm - 4:00pm |
P450 Catalytic Mechanisms: Symposia 6 Catalytic Mechanisms of Cytochrome P450 Location: Auditorium 004 Chair: Prof. John C Hackett, Florida International University, United States of America Applications of small angle scattering to delineate P450-membrane and redox partner interactions. 2:30pm - 3:00pm Mechanistic insights from new(ish) radical clock mechanistic probes 3:00pm - 3:30pm Cofactor-free hydroxylation of aliphatic C–H bonds by bacterial cytochrome P450 and peroxygenase enzymes 3:30pm - 4:00pm Emerging roles of extrahepatic cytochrome p450s in lipid and drug metabolism |
| Date: Wednesday, 02/July/2025 | |
| 10:00am - 12:00pm |
Novel P450 Reactions and functio: Symposia 8 Novel P450 Reactions and functions Location: Auditorium 004 Chair: Prof. Shengying Li, Shandong University, China, People's Republic of New reactions and mechanisms of CYP152 peroxygenases 10:30am - 11:00am Enhancing the efficacy of NK cell therapy against glioblastoma by suppressing CYP17A1 activity 11:00am - 11:30am P450 inhibition and carbon monoxide: possible pharmacological implications. 11:30am - 11:45am Hydroxylation and epoxidation of terpenoid alcohols by engineered bacterial cytochrome P450 11:45am - 12:00pm Major factors influencing C–H bond hydroxylation reaction of branched alkanes by bacterial CYP102A1 enzymes |
| Date: Thursday, 03/July/2025 | |
| 9:00am - 10:30am |
P450 and Steroid Metabolism: Symposia 10 P450 and Steroid Metabolism Location: Auditorium 004 Chair: Prof. Amit Pandey, University of Bern, Switzerland Chair: Prof. Toshiyuki Sakaki, Toyama Prefectural University, Japan Cytochromes P450 as targets and biocatalysts for detoxification of steroid-mimicking endocrine disruptors. 9:30am - 10:00am What happens after electron transfer to human cytochrome P450 17A1? |
| 11:00am - 1:00pm |
P450 and Steroid Metabolism 2: Symposia 10 P450 and Steroid Metabolism Continued Location: Auditorium 004 Chair: Prof. Amit Pandey, University of Bern, Switzerland Chair: Prof. Toshiyuki Sakaki, Toyama Prefectural University, Japan Novel vitamin D hydroxylation activity by the CYP3A4 variant I301T causing Type 3 rickets. 11:30am - 11:45am Traumatic brain injury alters the metabolic microenvironment and potentially impacts neuronal activity through the cholesterol metabolic enzyme Cyp46a1 11:45am - 12:00pm Mapping the metabolism of adrenal 11-oxy androgens in human primary hepatocytes 12:00pm - 12:15pm Inducible Cyp51 knockout model revels sterol imbalance and hepatic alterations in adult mouse liver 12:15pm - 12:30pm From lanosterol to desmosterol: Sterol-specific modulation of hepatic signalling and gene networks |
| 2:00pm - 4:00pm |
P450 regulation by partners: Symposia 12 P450 Regulation by interacting proteins Location: Auditorium 004 Chair: Dr. Galina Lepesheva, Vanderbilt University, United States of America Chair: Dr. Yuji Ishii, Kyushu University, Japan Cryo-EM reveals an ensemble of CPR conformations in solution 2:25pm - 2:50pm Maternal TCDD exposure causes growth retardation in rat fetus: Potential involvement of pregnancy-specific TCDD-dependent CYP3A1 induction Presentations of the Symposium Maternal TCDD exposure causes growth retardation in rat fetus: Potential involvement of pregnancy-specific TCDD-dependent CYP3A1 induction 2:50pm - 3:20pm Unraveling the molecular complexity of cytochrome P450 oxidoreductase: From enzyme mechanisms to liver disease 3:20pm - 3:35pm Impact of Val334Ile and Val472Leu variants on cytochrome P450 oxidoreductase activity 3:35pm - 3:50pm First functional expression of a lichen cytochrome P450 enzymes enables in vitro usnic acid biosynthesis |
| Date: Friday, 04/July/2025 | |
| 10:00am - 12:00pm |
P450 in Drug Metabolism: Symposia 14Cytochrome P450 in Drug Metabolism Location: Auditorium 004 Chair: Prof. Jed Noah Lampe, University of Colorado, United States of America Drug metabolism and cytochrome P450 across species 10:25am - 10:55am Drug Metabolism in the Pathobiome: The Impact of P. aeruginosa Cytochrome P450 Metabolism of Drugs and Endogenous Metabolites 10:55am - 11:25am New antifungals and new understanding of resistance in fungal pathogens. 11:25am - 11:55am Understanding CYP450-mediated drug bioactivation in the brain using mass spectrometry imaging. |
| 1:00pm - 2:30pm |
Short Talks: Symposia 16 Short Talks Location: Auditorium 004 Chair: Dr. Therina Du Toit, University Hospital Bern, Switzerland Chair: Prof. Giovanna Di Nardo, University of Torino, Italy Determining the role of an acidic residue in Cytochrome P450: Insights into the function of CYP2S1 1:15pm - 1:30pm Proliferation-Competent Primary-Like Hepatocytes as Platform to Investigate Drug-Drug Interactions and Hepatotoxicity 1:30pm - 1:45pm P450 library screening for the oxyfunctionalization of N-heterocycles 1:45pm - 2:00pm Terminal hydroxylation of hydrocarbons by CYP153A36 from Acinetobacter radioresistens 2:00pm - 2:15pm Fasting enhances diclofenac hepatotoxicity via the induction of multiple cytochrome p450 enzymes and glutathione depletion in mice 2:15pm - 2:30pm In vitro drug-drug interactions between oxycodone and commonly co-consumed drugs in rat and human liver microsomes |
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